library(ggplot2)
library(zeallot)
library(data.table)
library(parallelDist)
library(tidyr)
library(tidyverse)
library(caret)
theme_set(theme_bw())
library(COTAN)
library(stringr)
library(nnet)
options(parallelly.fork.enable = TRUE)
inDir <- file.path("Data/MouseCortexFromLoom/")
#setLoggingLevel(2)
#setLoggingFile(file.path(inDir, "MixingClustersGDI_ForebrainDorsal.log"))
outDir <- file.path("Data/MouseCortexFromLoom/NotCTSingleClusters/")
if (!file.exists(outDir)) {
dir.create(outDir)
}
result.df <- data.frame()Not Uniform Transcriptomic clusters with Logistic Regression
Preamble
In this part we want to show that if COTAN detects more division for cluster defined by other methods, this division is consitent and real. To test it we will use a simple logistic regression.
Cluster 525 e15.0
e15.0 <- readRDS(paste0(inDir,"e15.0_ForebrainDorsal.cotan.RDS")
cells <- getClusterizationData(e15.0,clName = "CL_original.clusters")[[1]][getClusterizationData(e15.0,clName = "CL_original.clusters")[[1]] == "525"]
cells <-names(cells)
write.csv(getRawData(e15.0)[,cells],paste0(outDir,"cl525/RawDataCL525.csv"))
cl525 <- automaticCOTANObjectCreation(raw = getRawData(e15.0)[,cells],
GEO = "Loom",
sequencingMethod = "10X",
sampleCondition = "cl525",
cores = 10,saveObj = T,
outDir = "Data/MouseCortexFromLoom/NotCTSingleClusters/",
calcCoex = T) OriginalCluster CellNumber COTANClusterNumber Accuracy
1 Cl525E15.0 826 3 <NA>cl525GDI <- calculateGDI(cl525)
subsetGDICl525 <- cl525GDI[cl525GDI$sum.raw.norm > 7,]
top.GDI.genes <- rownames(subsetGDICl525[order(subsetGDICl525$GDI,decreasing = T),])[1:50]
GDIPlot(cl525,genes = "",GDIIn = cl525GDI)
list.cl.CT <- cellsUniformClustering(cl525, GDIThreshold = 1.43, cores = 10L,
saveObj = TRUE, outDir = outDir)
cl525 <- addClusterization(cl525, clName = "split",
clusters = list.cl.CT$clusters,
coexDF = list.cl.CT$coex, override = TRUE)
table(list.cl.CT$clusters)c(mergedClusters, mergedCoexDF) %<-%
mergeUniformCellsClusters(cl525, clusters = list.cl.CT$clusters,
GDIThreshold = 1.43, batchSize = 4L, cores = 10L,
saveObj = TRUE, outDir = outDir)
cl525 <- addClusterization(cl525, clName = "merge",
clusters = mergedClusters,
coexDF = mergedCoexDF,
override = TRUE)
saveRDS(cl525,paste0(outDir,"cl525.cotan.RDS"))
table(str_split(names(mergedClusters),pattern = "_",simplify = T)[,1],mergedClusters)So there isn’t a perfect separation due to the cell bar code.
cl525ClsMarkers <- findClustersMarkers(cl525,n = 200,adjustmentMethod = "BH")
head(cl525ClsMarkers) CL Gene DEA adjPVal IsMarker logFoldCh
1 1 Rps12 -0.4819441 1.557394e-39 0 -0.6040561
2 1 Gm2000 -0.4778070 4.048141e-39 0 -0.6592709
3 1 Uqcrq -0.4527215 4.377038e-35 0 -0.6017733
4 1 Atp5e -0.4512791 5.642611e-35 0 -0.6855895
5 1 Rpl12 -0.4431532 9.247019e-34 0 -0.5511911
6 1 Rps25 -0.4312821 5.759166e-32 0 -0.5430405data <- getNormalizedData(cl525)
data <- data[!rowSums(as.matrix(data)) < 1,]
data <- log(data*10000+1)
row_stdev <- apply(data, 1, sd, na.rm=TRUE)
row_stdev <- row_stdev[order(row_stdev,decreasing = T)]
genes.to.keep <- c(names(row_stdev[1:100]),top.GDI.genes)
data.small <- data[rownames(data) %in% genes.to.keep,]
#data <- t(as.matrix(data))
data.small <- t(as.matrix(data.small))
COTAN_Cl.code <- getClusterizationData(cl525)[[1]]
#COTAN_Cl.code[COTAN_Cl.code == "A549"] <- 0
#COTAN_Cl.code[COTAN_Cl.code == "CCL-185-IG"] <- 1
COTAN_Cl.code <- as.numeric(COTAN_Cl.code)
data.small <- cbind(data.small,COTAN_Cl.code)
data.small <- as.data.frame(data.small)
# Split the data into training and test set
set.seed(123)
training.samples <- data.small[,"COTAN_Cl.code"] %>%
createDataPartition(p = 0.8, list = FALSE)
train.data <- data.small[training.samples, ]
test.data <- data.small[-training.samples, ]
head(train.data) Mllt3 Cdh11 Flrt2 Fry Gtdc1
10X73_3_A_1:CCATCGTGAGGAGCx 10.812807 0.000000 10.525132 9.426573 10.119680
10X73_3_A_1:GCCGACGAAGTCACx 9.954078 0.000000 9.260978 0.000000 9.954078
10X74_4_A_1:GCATTGGAACACACx 9.585297 11.194680 10.683864 9.585297 0.000000
10X73_3_A_1:GGCGACACGTTCAGx 0.000000 0.000000 8.845407 8.845407 8.845407
10X74_4_A_1:TAGTGGTGGCGTTAx 0.000000 0.000000 0.000000 9.080972 0.000000
10X73_3_A_1:CAGCACCTTTCATCx 9.889364 8.790854 9.483925 0.000000 9.483925
Ier2 Sla Cadps Kcnk10 Bcl2
10X73_3_A_1:CCATCGTGAGGAGCx 0.000000 9.426573 0.00000 9.426573 9.426573
10X73_3_A_1:GCCGACGAAGTCACx 0.000000 9.260978 0.00000 0.000000 10.359527
10X74_4_A_1:GCATTGGAACACACx 9.585297 9.585297 10.27841 0.000000 0.000000
10X73_3_A_1:GGCGACACGTTCAGx 0.000000 8.845407 0.00000 0.000000 0.000000
10X74_4_A_1:TAGTGGTGGCGTTAx 10.179509 9.080972 0.00000 9.080972 9.080972
10X73_3_A_1:CAGCACCTTTCATCx 10.177034 0.000000 0.00000 0.000000 8.790854
Dlgap1 Atxn1 Foxp1 Frmd4b Alcam
10X73_3_A_1:CCATCGTGAGGAGCx 0.000000 9.426573 10.11968 11.035946 0.00000
10X73_3_A_1:GCCGACGAAGTCACx 0.000000 0.000000 0.00000 9.260978 10.64720
10X74_4_A_1:GCATTGGAACACACx 0.000000 0.000000 10.27841 0.000000 0.00000
10X73_3_A_1:GGCGACACGTTCAGx 0.000000 0.000000 10.45473 8.845407 0.00000
10X74_4_A_1:TAGTGGTGGCGTTAx 0.000000 9.774063 0.00000 9.080972 10.17951
10X73_3_A_1:CAGCACCTTTCATCx 8.790854 9.483925 0.00000 0.000000 11.09330
Gria1 Lrrtm3 Glp2r Cpe Ntrk2
10X73_3_A_1:CCATCGTGAGGAGCx 0.000000 0.000000 0.000000 0.000000 9.426573
10X73_3_A_1:GCCGACGAAGTCACx 0.000000 9.260978 0.000000 9.260978 9.260978
10X74_4_A_1:GCATTGGAACACACx 9.585297 9.585297 0.000000 0.000000 0.000000
10X73_3_A_1:GGCGACACGTTCAGx 9.538482 10.637047 9.538482 0.000000 0.000000
10X74_4_A_1:TAGTGGTGGCGTTAx 0.000000 9.774063 10.179509 9.080972 10.179509
10X73_3_A_1:CAGCACCTTTCATCx 8.790854 0.000000 0.000000 10.400170 9.483925
Mmp16 Cadm2 Lsamp Nkain2 Pak3
10X73_3_A_1:CCATCGTGAGGAGCx 9.426573 10.525132 10.52513 9.426573 0.000000
10X73_3_A_1:GCCGACGAAGTCACx 0.000000 10.359527 0.00000 9.954078 0.000000
10X74_4_A_1:GCATTGGAACACACx 0.000000 9.585297 0.00000 0.000000 9.585297
10X73_3_A_1:GGCGACACGTTCAGx 8.845407 10.454730 0.00000 9.538482 10.924723
10X74_4_A_1:TAGTGGTGGCGTTAx 9.774063 9.774063 0.00000 0.000000 9.774063
10X73_3_A_1:CAGCACCTTTCATCx 8.790854 9.889364 10.40017 9.889364 9.483925
Sorbs2 Rspo3 Dcc Elavl4 Fam171b
10X73_3_A_1:CCATCGTGAGGAGCx 0.000000 0.000000 0.000000 10.119680 9.426573
10X73_3_A_1:GCCGACGAAGTCACx 9.260978 9.260978 9.954078 0.000000 9.260978
10X74_4_A_1:GCATTGGAACACACx 0.000000 10.683864 9.585297 0.000000 0.000000
10X73_3_A_1:GGCGACACGTTCAGx 0.000000 8.845407 0.000000 8.845407 9.538482
10X74_4_A_1:TAGTGGTGGCGTTAx 9.774063 9.080972 9.080972 0.000000 9.080972
10X73_3_A_1:CAGCACCTTTCATCx 10.582486 0.000000 8.790854 0.000000 0.000000
Ptprs Nav2 Prickle1 Srgap3 Pak7
10X73_3_A_1:CCATCGTGAGGAGCx 0.000000 0.000000 0.000000 0.000000 9.426573
10X73_3_A_1:GCCGACGAAGTCACx 9.954078 9.954078 0.000000 0.000000 10.359527
10X74_4_A_1:GCATTGGAACACACx 9.585297 0.000000 0.000000 10.278410 0.000000
10X73_3_A_1:GGCGACACGTTCAGx 0.000000 0.000000 0.000000 0.000000 9.538482
10X74_4_A_1:TAGTGGTGGCGTTAx 0.000000 0.000000 0.000000 0.000000 0.000000
10X73_3_A_1:CAGCACCTTTCATCx 10.400170 10.582486 8.790854 9.483925 8.790854
Akap6 Epha3 Dlg2 Bend6 Msra
10X73_3_A_1:CCATCGTGAGGAGCx 10.812807 9.426573 10.525132 0.000000 0.000000
10X73_3_A_1:GCCGACGAAGTCACx 0.000000 9.260978 9.260978 9.954078 9.954078
10X74_4_A_1:GCATTGGAACACACx 9.585297 0.000000 0.000000 0.000000 10.278410
10X73_3_A_1:GGCGACACGTTCAGx 0.000000 0.000000 0.000000 8.845407 10.791194
10X74_4_A_1:TAGTGGTGGCGTTAx 9.774063 9.774063 0.000000 9.080972 9.080972
10X73_3_A_1:CAGCACCTTTCATCx 8.790854 10.582486 8.790854 8.790854 0.000000
Cnih3 B3gat1 Kcnq5 Tle4 St3gal1
10X73_3_A_1:CCATCGTGAGGAGCx 0.000000 0.000000 0.000000 0.000000 10.119680
10X73_3_A_1:GCCGACGAAGTCACx 9.260978 9.260978 9.260978 9.954078 0.000000
10X74_4_A_1:GCATTGGAACACACx 0.000000 0.000000 9.585297 0.000000 10.278410
10X73_3_A_1:GGCGACACGTTCAGx 8.845407 0.000000 8.845407 0.000000 8.845407
10X74_4_A_1:TAGTGGTGGCGTTAx 9.774063 0.000000 0.000000 10.179509 0.000000
10X73_3_A_1:CAGCACCTTTCATCx 8.790854 8.790854 10.400170 0.000000 8.790854
Adamts18 Adamts3 Gm17750 Cnr1 Dscam
10X73_3_A_1:CCATCGTGAGGAGCx 9.426573 10.119680 9.426573 0.000000 9.426573
10X73_3_A_1:GCCGACGAAGTCACx 10.359527 0.000000 0.000000 0.000000 9.260978
10X74_4_A_1:GCATTGGAACACACx 0.000000 0.000000 9.585297 0.000000 9.585297
10X73_3_A_1:GGCGACACGTTCAGx 0.000000 9.538482 9.943923 9.943923 0.000000
10X74_4_A_1:TAGTGGTGGCGTTAx 9.080972 9.080972 0.000000 0.000000 10.467181
10X73_3_A_1:CAGCACCTTTCATCx 9.483925 0.000000 8.790854 8.790854 8.790854
Runx1t1 Tshz3 Nr4a2 Tox Cd200
10X73_3_A_1:CCATCGTGAGGAGCx 11.824395 0.000000 0.000000 9.426573 9.426573
10X73_3_A_1:GCCGACGAAGTCACx 0.000000 9.260978 0.000000 0.000000 9.260978
10X74_4_A_1:GCATTGGAACACACx 12.293284 0.000000 0.000000 9.585297 9.585297
10X73_3_A_1:GGCGACACGTTCAGx 9.538482 9.943923 8.845407 10.637047 0.000000
10X74_4_A_1:TAGTGGTGGCGTTAx 0.000000 0.000000 0.000000 0.000000 0.000000
10X73_3_A_1:CAGCACCTTTCATCx 0.000000 0.000000 0.000000 8.790854 0.000000
Clstn2 Fat3 Kcnh7 Tenm1 Fam155a
10X73_3_A_1:CCATCGTGAGGAGCx 0.00000 0.000000 10.812807 10.119680 9.426573
10X73_3_A_1:GCCGACGAAGTCACx 10.87034 0.000000 9.260978 0.000000 9.954078
10X74_4_A_1:GCATTGGAACACACx 10.97154 10.278410 0.000000 0.000000 0.000000
10X73_3_A_1:GGCGACACGTTCAGx 0.00000 0.000000 0.000000 8.845407 0.000000
10X74_4_A_1:TAGTGGTGGCGTTAx 10.17951 9.080972 0.000000 0.000000 0.000000
10X73_3_A_1:CAGCACCTTTCATCx 10.58249 10.870162 0.000000 0.000000 8.790854
Cacnb4 Usp29 Lmo3 Ntm Atp1a3
10X73_3_A_1:CCATCGTGAGGAGCx 0.000000 0.000000 0.000000 9.426573 0.000000
10X73_3_A_1:GCCGACGAAGTCACx 0.000000 9.260978 0.000000 0.000000 0.000000
10X74_4_A_1:GCATTGGAACACACx 0.000000 9.585297 0.000000 11.887821 10.683864
10X73_3_A_1:GGCGACACGTTCAGx 8.845407 0.000000 0.000000 10.637047 0.000000
10X74_4_A_1:TAGTGGTGGCGTTAx 0.000000 0.000000 9.080972 0.000000 9.080972
10X73_3_A_1:CAGCACCTTTCATCx 8.790854 9.889364 0.000000 9.483925 0.000000
Caly Foxp2 Hist3h2ba Edil3 Enox1
10X73_3_A_1:CCATCGTGAGGAGCx 0.000000 11.035946 10.119680 0.000000 0.000000
10X73_3_A_1:GCCGACGAAGTCACx 9.260978 10.870340 9.260978 0.000000 9.260978
10X74_4_A_1:GCATTGGAACACACx 0.000000 0.000000 9.585297 0.000000 0.000000
10X73_3_A_1:GGCGACACGTTCAGx 8.845407 0.000000 10.454730 0.000000 0.000000
10X74_4_A_1:TAGTGGTGGCGTTAx 10.179509 9.080972 10.467181 0.000000 0.000000
10X73_3_A_1:CAGCACCTTTCATCx 0.000000 11.093302 9.483925 9.889364 9.889364
Atrnl1 Dock3 Cacna1c Tmem178b Gria3
10X73_3_A_1:CCATCGTGAGGAGCx 9.426573 9.426573 9.426573 10.525132 0.000000
10X73_3_A_1:GCCGACGAAGTCACx 0.000000 9.954078 0.000000 0.000000 9.260978
10X74_4_A_1:GCATTGGAACACACx 0.000000 0.000000 9.585297 10.278410 0.000000
10X73_3_A_1:GGCGACACGTTCAGx 10.231594 8.845407 9.943923 8.845407 0.000000
10X74_4_A_1:TAGTGGTGGCGTTAx 9.080972 0.000000 9.080972 9.080972 0.000000
10X73_3_A_1:CAGCACCTTTCATCx 10.177034 8.790854 8.790854 9.889364 9.889364
Trim2 Robo1 Apba1 Cacna1e Rgs6
10X73_3_A_1:CCATCGTGAGGAGCx 0.000000 11.372414 0.000000 0.000000 10.525132
10X73_3_A_1:GCCGACGAAGTCACx 9.954078 0.000000 0.000000 9.260978 9.260978
10X74_4_A_1:GCATTGGAACACACx 9.585297 9.585297 9.585297 0.000000 0.000000
10X73_3_A_1:GGCGACACGTTCAGx 8.845407 8.845407 10.454730 0.000000 8.845407
10X74_4_A_1:TAGTGGTGGCGTTAx 9.774063 0.000000 0.000000 0.000000 10.179509
10X73_3_A_1:CAGCACCTTTCATCx 9.889364 9.483925 0.000000 8.790854 0.000000
Trim17 Polr1d Uqcrq Hspa5 Rpl26
10X73_3_A_1:CCATCGTGAGGAGCx 9.426573 0.000000 0.000000 0.000000 10.11968
10X73_3_A_1:GCCGACGAAGTCACx 0.000000 9.260978 0.000000 9.954078 11.34034
10X74_4_A_1:GCATTGGAACACACx 9.585297 10.278410 10.683864 9.585297 10.68386
10X73_3_A_1:GGCGACACGTTCAGx 9.538482 9.943923 9.538482 8.845407 10.79119
10X74_4_A_1:TAGTGGTGGCGTTAx 0.000000 10.179509 9.774063 0.000000 10.46718
10X73_3_A_1:CAGCACCTTTCATCx 9.889364 8.790854 0.000000 10.177034 11.18861
Rpl5 Psma2 Rtraf Rps10 Rps17
10X73_3_A_1:CCATCGTGAGGAGCx 10.119680 0.000000 0.000000 10.119680 10.119680
10X73_3_A_1:GCCGACGAAGTCACx 9.954078 10.359527 10.359527 10.870340 10.647201
10X74_4_A_1:GCATTGGAACACACx 0.000000 9.585297 0.000000 9.585297 9.585297
10X73_3_A_1:GGCGACACGTTCAGx 9.943923 10.454730 10.637047 9.943923 10.924723
10X74_4_A_1:TAGTGGTGGCGTTAx 9.080972 10.467181 10.179509 10.690319 10.690319
10X73_3_A_1:CAGCACCTTTCATCx 9.889364 10.177034 8.790854 10.870162 10.177034
Rpl12 Rps15a Rplp1 Rpl22 Rps12
10X73_3_A_1:CCATCGTGAGGAGCx 0.000000 0.000000 10.812807 9.426573 9.426573
10X73_3_A_1:GCCGACGAAGTCACx 9.260978 10.359527 9.954078 10.647201 10.647201
10X74_4_A_1:GCATTGGAACACACx 0.000000 9.585297 9.585297 0.000000 0.000000
10X73_3_A_1:GGCGACACGTTCAGx 10.231594 11.330182 10.924723 10.454730 10.231594
10X74_4_A_1:TAGTGGTGGCGTTAx 9.774063 11.160314 10.467181 10.467181 9.774063
10X73_3_A_1:CAGCACCTTTCATCx 10.177034 10.987943 9.889364 10.582486 9.483925
Rps26 Rps24 Rps13 Rps3 Snrpd2
10X73_3_A_1:CCATCGTGAGGAGCx 9.426573 9.426573 11.03595 10.525132 10.119680
10X73_3_A_1:GCCGACGAAGTCACx 10.647201 11.206807 10.64720 9.954078 0.000000
10X74_4_A_1:GCATTGGAACACACx 9.585297 10.683864 10.68386 9.585297 9.585297
10X73_3_A_1:GGCGACACGTTCAGx 11.243172 11.243172 11.24317 11.243172 9.538482
10X74_4_A_1:TAGTGGTGGCGTTAx 11.278096 11.645817 10.69032 10.690319 0.000000
10X73_3_A_1:CAGCACCTTTCATCx 10.400170 11.275621 10.73663 9.889364 9.483925
Snrpg Rps21 Sub1 Slc25a5 Jun
10X73_3_A_1:CCATCGTGAGGAGCx 0.000000 10.119680 10.119680 9.426573 0.000000
10X73_3_A_1:GCCGACGAAGTCACx 0.000000 0.000000 10.647201 0.000000 10.647201
10X74_4_A_1:GCATTGGAACACACx 10.971540 10.278410 9.585297 0.000000 9.585297
10X73_3_A_1:GGCGACACGTTCAGx 9.538482 9.538482 8.845407 9.943923 8.845407
10X74_4_A_1:TAGTGGTGGCGTTAx 10.179509 10.467181 10.179509 0.000000 9.774063
10X73_3_A_1:CAGCACCTTTCATCx 9.483925 9.889364 9.483925 10.987943 0.000000
Uqcrh Rpl38 Tspan5 Igf1r Atox1
10X73_3_A_1:CCATCGTGAGGAGCx 10.119680 0.000000 9.426573 0.000000 0.000000
10X73_3_A_1:GCCGACGAAGTCACx 9.260978 9.954078 0.000000 9.260978 9.260978
10X74_4_A_1:GCATTGGAACACACx 9.585297 10.278410 9.585297 0.000000 0.000000
10X73_3_A_1:GGCGACACGTTCAGx 9.538482 9.943923 0.000000 8.845407 8.845407
10X74_4_A_1:TAGTGGTGGCGTTAx 10.467181 9.774063 9.080972 0.000000 9.080972
10X73_3_A_1:CAGCACCTTTCATCx 9.889364 8.790854 10.177034 0.000000 8.790854
Rps25 Pfdn5 Rps28 Pomp Cox7a2l
10X73_3_A_1:CCATCGTGAGGAGCx 9.426573 10.119680 10.525132 9.426573 9.426573
10X73_3_A_1:GCCGACGAAGTCACx 0.000000 10.647201 9.260978 0.000000 10.647201
10X74_4_A_1:GCATTGGAACACACx 0.000000 9.585297 0.000000 0.000000 9.585297
10X73_3_A_1:GGCGACACGTTCAGx 10.454730 11.410224 10.231594 9.943923 10.791194
10X74_4_A_1:TAGTGGTGGCGTTAx 11.278096 10.690319 0.000000 9.774063 10.179509
10X73_3_A_1:CAGCACCTTTCATCx 10.177034 9.889364 9.889364 0.000000 9.483925
Rps18 Rpl34 Rps29 Atp5j Gm2000
10X73_3_A_1:CCATCGTGAGGAGCx 9.426573 9.426573 0.000000 9.426573 0.000000
10X73_3_A_1:GCCGACGAAGTCACx 11.052658 9.954078 9.954078 9.260978 0.000000
10X74_4_A_1:GCATTGGAACACACx 0.000000 9.585297 9.585297 0.000000 0.000000
10X73_3_A_1:GGCGACACGTTCAGx 9.943923 10.791194 11.243172 9.943923 9.538482
10X74_4_A_1:TAGTGGTGGCGTTAx 10.690319 10.179509 9.774063 9.080972 10.690319
10X73_3_A_1:CAGCACCTTTCATCx 9.889364 10.582486 10.177034 10.582486 10.400170
Ptk2 Pfn1 Rpl27 Atp5j2 Jund
10X73_3_A_1:CCATCGTGAGGAGCx 9.426573 9.426573 10.119680 0.000000 0.000000
10X73_3_A_1:GCCGACGAAGTCACx 0.000000 9.954078 10.870340 10.359527 10.359527
10X74_4_A_1:GCATTGGAACACACx 9.585297 0.000000 0.000000 10.278410 0.000000
10X73_3_A_1:GGCGACACGTTCAGx 8.845407 10.231594 10.924723 9.943923 10.454730
10X74_4_A_1:TAGTGGTGGCGTTAx 0.000000 9.080972 10.179509 0.000000 9.774063
10X73_3_A_1:CAGCACCTTTCATCx 8.790854 10.177034 9.483925 9.889364 10.582486
Rpl35 Sbf2 Dusp1 Atp5e Ndufc1
10X73_3_A_1:CCATCGTGAGGAGCx 9.426573 0.000000 0.000000 10.119680 10.119680
10X73_3_A_1:GCCGACGAAGTCACx 11.340336 0.000000 9.260978 0.000000 10.359527
10X74_4_A_1:GCATTGGAACACACx 9.585297 0.000000 0.000000 9.585297 9.585297
10X73_3_A_1:GGCGACACGTTCAGx 11.147863 8.845407 9.538482 0.000000 9.943923
10X74_4_A_1:TAGTGGTGGCGTTAx 11.383455 9.774063 9.080972 10.179509 0.000000
10X73_3_A_1:CAGCACCTTTCATCx 11.355662 8.790854 8.790854 0.000000 8.790854
Rpl35a Ttc28 Sumo1 Srp14 Calr
10X73_3_A_1:CCATCGTGAGGAGCx 0.000000 10.119680 10.525132 9.426573 0.000000
10X73_3_A_1:GCCGACGAAGTCACx 9.954078 9.260978 0.000000 10.870340 9.260978
10X74_4_A_1:GCATTGGAACACACx 10.971540 0.000000 0.000000 0.000000 10.683864
10X73_3_A_1:GGCGACACGTTCAGx 10.454730 9.943923 8.845407 10.231594 9.538482
10X74_4_A_1:TAGTGGTGGCGTTAx 10.467181 0.000000 9.774063 9.080972 9.080972
10X73_3_A_1:CAGCACCTTTCATCx 9.889364 10.177034 10.177034 8.790854 9.483925
Dynlrb1 Timm8b Swi5 Ubl5 Xist
10X73_3_A_1:CCATCGTGAGGAGCx 10.525132 9.426573 9.426573 0.000000 10.812807
10X73_3_A_1:GCCGACGAAGTCACx 10.359527 9.954078 9.954078 0.000000 9.954078
10X74_4_A_1:GCATTGGAACACACx 0.000000 9.585297 0.000000 0.000000 0.000000
10X73_3_A_1:GGCGACACGTTCAGx 10.637047 9.538482 9.943923 10.454730 10.454730
10X74_4_A_1:TAGTGGTGGCGTTAx 9.774063 10.467181 9.774063 10.179509 0.000000
10X73_3_A_1:CAGCACCTTTCATCx 10.987943 9.483925 9.483925 8.790854 11.188610
Dctn3 Tbca Plcb1 Ube2e2 Ndufa6
10X73_3_A_1:CCATCGTGAGGAGCx 0.000000 9.426573 0.000000 0.000000 0.000000
10X73_3_A_1:GCCGACGAAGTCACx 0.000000 9.260978 9.260978 9.260978 9.260978
10X74_4_A_1:GCATTGGAACACACx 0.000000 10.278410 0.000000 9.585297 9.585297
10X73_3_A_1:GGCGACACGTTCAGx 9.538482 9.943923 0.000000 8.845407 9.538482
10X74_4_A_1:TAGTGGTGGCGTTAx 10.467181 9.774063 0.000000 0.000000 10.179509
10X73_3_A_1:CAGCACCTTTCATCx 9.483925 9.483925 10.870162 8.790854 0.000000
Serf1 Clasp2 Atp5o.1 Atp6v1g1 Cox7c
10X73_3_A_1:CCATCGTGAGGAGCx 10.119680 10.525132 0.000000 9.426573 0.000000
10X73_3_A_1:GCCGACGAAGTCACx 10.359527 0.000000 9.954078 10.647201 10.870340
10X74_4_A_1:GCATTGGAACACACx 9.585297 9.585297 0.000000 10.278410 10.278410
10X73_3_A_1:GGCGACACGTTCAGx 9.538482 9.538482 10.637047 10.231594 9.943923
10X74_4_A_1:TAGTGGTGGCGTTAx 10.179509 0.000000 0.000000 9.080972 11.278096
10X73_3_A_1:CAGCACCTTTCATCx 9.889364 10.400170 9.483925 8.790854 10.400170
COTAN_Cl.code
10X73_3_A_1:CCATCGTGAGGAGCx 2
10X73_3_A_1:GCCGACGAAGTCACx 2
10X74_4_A_1:GCATTGGAACACACx 1
10X73_3_A_1:GGCGACACGTTCAGx 3
10X74_4_A_1:TAGTGGTGGCGTTAx 2
10X73_3_A_1:CAGCACCTTTCATCx 3train.data$COTAN_Cl.code <- as.factor(train.data$COTAN_Cl.code)
test.data$COTAN_Cl.code <- as.factor(test.data$COTAN_Cl.code)
# Fit the model
#model <- glm( COTAN_Cl.code ~., data = train.data, family = binomial,control = list(maxit = 75))
model <- multinom(COTAN_Cl.code ~ ., data = train.data, maxit = 500)# weights: 456 (302 variable)
initial value 727.281335
iter 10 value 149.467006
iter 20 value 144.360899
iter 30 value 132.731875
iter 40 value 90.384826
iter 50 value 82.420514
iter 60 value 77.185594
iter 70 value 56.263874
iter 80 value 50.423463
iter 90 value 46.538673
iter 100 value 34.109745
iter 110 value 29.731988
iter 120 value 11.248129
iter 130 value 8.008341
iter 140 value 4.510408
iter 150 value 1.640137
iter 160 value 0.232066
iter 170 value 0.003377
iter 180 value 0.000135
final value 0.000077
convergedprobabilities <- predict(model, newdata = test.data, type = "probs")
# Find the class with the highest probability for each case
predicted.classes <- apply(probabilities, 1, which.max)
# Adjust predicted classes to match your factor levels
levels <- levels(train.data$COTAN_Cl.code)
predicted.classes <- levels[predicted.classes]
# Calculate model accuracy
accuracy <- mean(predicted.classes == test.data$COTAN_Cl.code)
result.df[nrow(result.df),"Accuracy"] <- accuracy
print(accuracy)[1] 0.7865854So also a simple logistic regression confirm that this cluster is in fact formed by four different cell populations.
Now lets try to search the identity of these cells.
Since COTAN can detect also very lowly expressed genes, but all the literature methods not, the online methods are bias for highly expressed genes. So, we will take all genes detected as enriched by COTAN and filter also for the highly expressed ones.
top <- cl525ClsMarkers[cl525ClsMarkers$Gene %in% rownames(cl525GDI[cl525GDI$sum.raw.norm > 7,]) & cl525ClsMarkers$Score > 0,]
top[1] CL Gene DEA adjPVal IsMarker logFoldCh
<0 rows> (or 0-length row.names)write.csv(top,paste0(outDir,"cl525/TopClustersMarkers.csv"))Cluster 511 e15.0
cells <- getClusterizationData(e15.0,clName = "CL_original.clusters")[[1]][getClusterizationData(e15.0,clName = "CL_original.clusters")[[1]] == "511"]
cells <-names(cells)
cl511 <- automaticCOTANObjectCreation(raw = getRawData(e15.0)[,cells],
GEO = "Loom",
sequencingMethod = "10X",
sampleCondition = "cl511",
cores = 10,saveObj = T,
outDir = "Data/MouseCortexFromLoom/NotCTSingleClusters/",
calcCoex = T) OriginalCluster CellNumber COTANClusterNumber Accuracy
1 Cl525E15.0 826 3 0.786585365853659
2 Cl511E15.0 540 2 <NA>cl511GDI <- calculateGDI(cl511)
subsetGDIcl511 <- cl511GDI[cl511GDI$sum.raw.norm > 7,]
top.GDI.genes <- rownames(subsetGDIcl511[order(subsetGDIcl511$GDI,decreasing = T),])[1:50]
GDIPlot(cl511,genes = "",GDIIn = cl511GDI)
list.cl.CT <- cellsUniformClustering(cl511, GDIThreshold = 1.43, cores = 10L,
saveObj = TRUE, outDir = outDir)
cl511 <- addClusterization(cl511, clName = "split",
clusters = list.cl.CT$clusters,
coexDF = list.cl.CT$coex, override = TRUE)
table(list.cl.CT$clusters)c(mergedClusters, mergedCoexDF) %<-%
mergeUniformCellsClusters(cl511, clusters = list.cl.CT$clusters,
GDIThreshold = 1.43, batchSize = 4L, cores = 10L,
saveObj = TRUE, outDir = outDir)
cl511 <- addClusterization(cl511, clName = "merge",
clusters = mergedClusters,
coexDF = mergedCoexDF,
override = TRUE)
saveRDS(cl511,paste0(outDir,"cl511.cotan.RDS"))
table(str_split(names(mergedClusters),pattern = "_",simplify = T)[,1],mergedClusters)data <- getNormalizedData(cl511)
data <- data[!rowSums(as.matrix(data)) < 1,]
data <- log(data*10000+1)
row_stdev <- apply(data, 1, sd, na.rm=TRUE)
row_stdev <- row_stdev[order(row_stdev,decreasing = T)]
genes.to.keep <- c(names(row_stdev[1:100]),top.GDI.genes)
data.small <- data[rownames(data) %in% genes.to.keep,]
#data <- t(as.matrix(data))
data.small <- t(as.matrix(data.small))
COTAN_Cl.code <- getClusterizationData(cl511)[[1]]
#COTAN_Cl.code[COTAN_Cl.code == "A549"] <- 0
#COTAN_Cl.code[COTAN_Cl.code == "CCL-185-IG"] <- 1
COTAN_Cl.code <- as.numeric(COTAN_Cl.code)-1
data.small <- cbind(data.small,COTAN_Cl.code)
data.small <- as.data.frame(data.small)
# Split the data into training and test set
set.seed(123)
training.samples <- data.small[,"COTAN_Cl.code"] %>%
createDataPartition(p = 0.8, list = FALSE)
train.data <- data.small[training.samples, ]
test.data <- data.small[-training.samples, ]
head(train.data) Flrt2 Smarca2 Srgap1 Sla Cadps
10X74_4_A_1:CAGCGTCTCCTCGTx 0.000000 0.000000 0.000000 0.000000 0.000000
10X74_4_A_1:GTCCACTGTCCTCGx 0.000000 0.000000 0.000000 10.471506 0.000000
10X64_3_A_1:ACGCCGGAGGATTCx 9.207514 9.207514 10.306059 0.000000 9.207514
10X73_3_A_1:GTTAACCTTGTCGAx 8.878654 8.878654 9.571731 0.000000 0.000000
10X74_4_A_1:CGTGATGAGAAGGCx 8.985081 9.678166 10.371281 0.000000 0.000000
10X73_3_A_1:AAGCACTGCTTCGCx 0.000000 9.028611 10.127143 9.721698 9.028611
Kcnk10 Itpr1 Klhl29 Elmod1 Nin
10X74_4_A_1:CAGCGTCTCCTCGTx 0.000000 0 10.627557 9.528994 10.915233
10X74_4_A_1:GTCCACTGTCCTCGx 0.000000 0 9.778387 0.000000 9.778387
10X64_3_A_1:ACGCCGGAGGATTCx 9.207514 0 9.900611 0.000000 9.207514
10X73_3_A_1:GTTAACCTTGTCGAx 0.000000 0 0.000000 8.878654 0.000000
10X74_4_A_1:CGTGATGAGAAGGCx 0.000000 0 8.985081 8.985081 8.985081
10X73_3_A_1:AAGCACTGCTTCGCx 10.127143 0 0.000000 9.028611 0.000000
Kcnn2 Adgrb3 Foxp1 Alcam Mtss1
10X74_4_A_1:CAGCGTCTCCTCGTx 0.000000 9.528994 0.000000 9.528994 0.000000
10X74_4_A_1:GTCCACTGTCCTCGx 0.000000 0.000000 0.000000 0.000000 0.000000
10X64_3_A_1:ACGCCGGAGGATTCx 0.000000 11.153338 9.207514 10.593733 9.207514
10X73_3_A_1:GTTAACCTTGTCGAx 9.571731 10.264844 9.571731 0.000000 8.878654
10X74_4_A_1:CGTGATGAGAAGGCx 0.000000 10.083610 8.985081 8.985081 10.083610
10X73_3_A_1:AAGCACTGCTTCGCx 0.000000 0.000000 9.028611 0.000000 9.028611
Fam213a Ralgps2 Ptn Cadm2 Frmd4a
10X74_4_A_1:CAGCGTCTCCTCGTx 9.528994 0.000000 0.000000 10.222104 9.528994
10X74_4_A_1:GTCCACTGTCCTCGx 0.000000 9.778387 0.000000 0.000000 0.000000
10X64_3_A_1:ACGCCGGAGGATTCx 0.000000 9.207514 9.207514 9.207514 9.207514
10X73_3_A_1:GTTAACCTTGTCGAx 0.000000 0.000000 11.586574 10.487980 8.878654
10X74_4_A_1:CGTGATGAGAAGGCx 0.000000 0.000000 0.000000 8.985081 0.000000
10X73_3_A_1:AAGCACTGCTTCGCx 0.000000 9.028611 0.000000 10.127143 10.820270
Nkain2 Tenm3 Grip1 Tanc2 Syt11
10X74_4_A_1:CAGCGTCTCCTCGTx 0.000000 0.000000 10.915233 0.000000 0.000000
10X74_4_A_1:GTCCACTGTCCTCGx 9.778387 10.876962 9.778387 9.778387 9.778387
10X64_3_A_1:ACGCCGGAGGATTCx 0.000000 9.207514 0.000000 0.000000 9.207514
10X73_3_A_1:GTTAACCTTGTCGAx 0.000000 0.000000 8.878654 8.878654 8.878654
10X74_4_A_1:CGTGATGAGAAGGCx 0.000000 9.678166 8.985081 8.985081 0.000000
10X73_3_A_1:AAGCACTGCTTCGCx 0.000000 10.127143 0.000000 9.028611 0.000000
Srgap3 Pak7 Mapk10 Sobp Bhlhe22
10X74_4_A_1:CAGCGTCTCCTCGTx 9.528994 0.000000 10.222104 9.528994 0.000000
10X74_4_A_1:GTCCACTGTCCTCGx 10.471506 9.778387 0.000000 0.000000 9.778387
10X64_3_A_1:ACGCCGGAGGATTCx 9.900611 0.000000 0.000000 0.000000 0.000000
10X73_3_A_1:GTTAACCTTGTCGAx 9.571731 8.878654 10.487980 8.878654 0.000000
10X74_4_A_1:CGTGATGAGAAGGCx 9.678166 0.000000 8.985081 9.678166 0.000000
10X73_3_A_1:AAGCACTGCTTCGCx 0.000000 10.820270 0.000000 0.000000 9.721698
Epha3 Adgrl3 Dok5 Satb2 Hs6st2
10X74_4_A_1:CAGCGTCTCCTCGTx 0.000000 0.000000 0.000000 0.00000 0.000000
10X74_4_A_1:GTCCACTGTCCTCGx 0.000000 10.471506 0.000000 0.00000 0.000000
10X64_3_A_1:ACGCCGGAGGATTCx 0.000000 0.000000 0.000000 0.00000 9.207514
10X73_3_A_1:GTTAACCTTGTCGAx 9.571731 9.571731 10.487980 11.36343 8.878654
10X74_4_A_1:CGTGATGAGAAGGCx 8.985081 8.985081 0.000000 0.00000 0.000000
10X73_3_A_1:AAGCACTGCTTCGCx 0.000000 0.000000 9.028611 0.00000 12.024229
X5730522E02Rik Msra Spock1 Enc1
10X74_4_A_1:CAGCGTCTCCTCGTx 9.528994 0.000000 9.528994 0.00000
10X74_4_A_1:GTCCACTGTCCTCGx 0.000000 0.000000 0.000000 10.47151
10X64_3_A_1:ACGCCGGAGGATTCx 0.000000 0.000000 0.000000 0.00000
10X73_3_A_1:GTTAACCTTGTCGAx 0.000000 0.000000 8.878654 10.26484
10X74_4_A_1:CGTGATGAGAAGGCx 10.371281 8.985081 0.000000 0.00000
10X73_3_A_1:AAGCACTGCTTCGCx 10.414815 10.820270 10.414815 0.00000
Fam110b Sybu Lmo1 Dscam Rab3c
10X74_4_A_1:CAGCGTCTCCTCGTx 9.528994 10.627557 9.528994 10.222104 0.000000
10X74_4_A_1:GTCCACTGTCCTCGx 0.000000 10.471506 0.000000 9.778387 0.000000
10X64_3_A_1:ACGCCGGAGGATTCx 0.000000 9.207514 0.000000 0.000000 0.000000
10X73_3_A_1:GTTAACCTTGTCGAx 8.878654 8.878654 8.878654 8.878654 8.878654
10X74_4_A_1:CGTGATGAGAAGGCx 8.985081 0.000000 8.985081 8.985081 8.985081
10X73_3_A_1:AAGCACTGCTTCGCx 0.000000 0.000000 9.028611 0.000000 9.028611
Mir124.2hg Clstn2 Fat3 Kcnh7 Usp29
10X74_4_A_1:CAGCGTCTCCTCGTx 0.000000 10.222104 10.627557 10.222104 0.000000
10X74_4_A_1:GTCCACTGTCCTCGx 10.471506 10.876962 9.778387 0.000000 0.000000
10X64_3_A_1:ACGCCGGAGGATTCx 9.207514 10.306059 10.816872 9.207514 0.000000
10X73_3_A_1:GTTAACCTTGTCGAx 8.878654 8.878654 9.571731 8.878654 0.000000
10X74_4_A_1:CGTGATGAGAAGGCx 8.985081 0.000000 0.000000 0.000000 0.000000
10X73_3_A_1:AAGCACTGCTTCGCx 0.000000 0.000000 10.414815 10.127143 9.028611
Cd47 Ryr3 Neto2 Ppm1e Mdga2
10X74_4_A_1:CAGCGTCTCCTCGTx 10.222104 0.000000 9.528994 0.000000 9.528994
10X74_4_A_1:GTCCACTGTCCTCGx 0.000000 0.000000 9.778387 9.778387 10.471506
10X64_3_A_1:ACGCCGGAGGATTCx 9.207514 0.000000 0.000000 9.207514 10.306059
10X73_3_A_1:GTTAACCTTGTCGAx 0.000000 8.878654 9.571731 11.517582 0.000000
10X74_4_A_1:CGTGATGAGAAGGCx 9.678166 10.083610 8.985081 9.678166 10.083610
10X73_3_A_1:AAGCACTGCTTCGCx 0.000000 10.414815 9.721698 9.721698 9.721698
Serpini1 Ralyl Nrcam Robo2 Csrnp3
10X74_4_A_1:CAGCGTCTCCTCGTx 0.000000 10.222104 0.000000 0.000000 10.627557
10X74_4_A_1:GTCCACTGTCCTCGx 0.000000 10.471506 10.471506 0.000000 0.000000
10X64_3_A_1:ACGCCGGAGGATTCx 9.207514 0.000000 9.900611 10.593733 10.306059
10X73_3_A_1:GTTAACCTTGTCGAx 9.571731 8.878654 9.977173 8.878654 9.571731
10X74_4_A_1:CGTGATGAGAAGGCx 8.985081 10.371281 8.985081 0.000000 0.000000
10X73_3_A_1:AAGCACTGCTTCGCx 0.000000 10.637953 0.000000 0.000000 0.000000
Hist3h2ba Jakmip1 Edil3 Enox1 Rprm
10X74_4_A_1:CAGCGTCTCCTCGTx 10.62756 0.000000 0.000000 10.222104 10.627557
10X74_4_A_1:GTCCACTGTCCTCGx 0.00000 0.000000 10.471506 9.778387 0.000000
10X64_3_A_1:ACGCCGGAGGATTCx 10.30606 9.207514 9.900611 9.207514 0.000000
10X73_3_A_1:GTTAACCTTGTCGAx 10.95797 9.571731 0.000000 0.000000 8.878654
10X74_4_A_1:CGTGATGAGAAGGCx 10.93088 10.083610 8.985081 10.594419 10.594419
10X73_3_A_1:AAGCACTGCTTCGCx 11.10795 0.000000 9.028611 9.721698 9.028611
Olfm1 Tmem178b Gng3 Cntn2 Scg3
10X74_4_A_1:CAGCGTCTCCTCGTx 0.000000 0.000000 9.528994 0.000000 0.000000
10X74_4_A_1:GTCCACTGTCCTCGx 9.778387 0.000000 9.778387 0.000000 9.778387
10X64_3_A_1:ACGCCGGAGGATTCx 9.207514 0.000000 0.000000 0.000000 0.000000
10X73_3_A_1:GTTAACCTTGTCGAx 8.878654 8.878654 10.670297 8.878654 8.878654
10X74_4_A_1:CGTGATGAGAAGGCx 0.000000 0.000000 8.985081 0.000000 9.678166
10X73_3_A_1:AAGCACTGCTTCGCx 0.000000 9.028611 0.000000 9.028611 0.000000
Gnao1 Serp2 Pcdh9 Trim2 Nrg1
10X74_4_A_1:CAGCGTCTCCTCGTx 9.528994 10.222104 10.222104 9.528994 0.000000
10X74_4_A_1:GTCCACTGTCCTCGx 9.778387 9.778387 9.778387 0.000000 0.000000
10X64_3_A_1:ACGCCGGAGGATTCx 9.207514 0.000000 10.816872 0.000000 0.000000
10X73_3_A_1:GTTAACCTTGTCGAx 9.571731 9.571731 10.264844 9.571731 9.571731
10X74_4_A_1:CGTGATGAGAAGGCx 8.985081 9.678166 9.678166 8.985081 8.985081
10X73_3_A_1:AAGCACTGCTTCGCx 9.028611 9.721698 10.127143 9.721698 9.028611
Ppfia2 Cacna2d1 Uqcrq Bex3 Ran
10X74_4_A_1:CAGCGTCTCCTCGTx 0.000000 0.000000 0.000000 10.627557 0.000000
10X74_4_A_1:GTCCACTGTCCTCGx 0.000000 0.000000 0.000000 9.778387 10.876962
10X64_3_A_1:ACGCCGGAGGATTCx 0.000000 9.900611 9.900611 11.153338 10.306059
10X73_3_A_1:GTTAACCTTGTCGAx 10.670297 11.181114 10.957974 10.264844 10.824445
10X74_4_A_1:CGTGATGAGAAGGCx 9.678166 0.000000 8.985081 9.678166 9.678166
10X73_3_A_1:AAGCACTGCTTCGCx 9.028611 0.000000 10.414815 10.414815 10.637953
Atp5c1 Eif3k Ppp1cb Ndufaf2 Hmgb3
10X74_4_A_1:CAGCGTCTCCTCGTx 9.528994 9.528994 10.222104 0.000000 9.528994
10X74_4_A_1:GTCCACTGTCCTCGx 0.000000 9.778387 0.000000 0.000000 0.000000
10X64_3_A_1:ACGCCGGAGGATTCx 10.999190 10.306059 9.207514 0.000000 9.207514
10X73_3_A_1:GTTAACCTTGTCGAx 10.957974 10.264844 8.878654 9.977173 9.977173
10X74_4_A_1:CGTGATGAGAAGGCx 10.083610 10.594419 0.000000 10.594419 0.000000
10X73_3_A_1:AAGCACTGCTTCGCx 9.721698 0.000000 0.000000 9.028611 0.000000
Rps10 Rae1 Mbd3 Eif3c Hnrnpab
10X74_4_A_1:CAGCGTCTCCTCGTx 0.00000 0.000000 10.222104 9.528994 9.528994
10X74_4_A_1:GTCCACTGTCCTCGx 10.87696 0.000000 9.778387 10.876962 9.778387
10X64_3_A_1:ACGCCGGAGGATTCx 10.81687 0.000000 0.000000 9.207514 10.306059
10X73_3_A_1:GTTAACCTTGTCGAx 10.82444 0.000000 9.977173 0.000000 9.977173
10X74_4_A_1:CGTGATGAGAAGGCx 10.77674 8.985081 0.000000 8.985081 9.678166
10X73_3_A_1:AAGCACTGCTTCGCx 10.12714 9.028611 0.000000 9.028611 10.414815
Rpl12 Rps15a Rpl13a Rpl31 Rplp1
10X74_4_A_1:CAGCGTCTCCTCGTx 0.000000 10.22210 0.00000 10.222104 10.22210
10X74_4_A_1:GTCCACTGTCCTCGx 10.876962 0.00000 10.87696 10.876962 11.16464
10X64_3_A_1:ACGCCGGAGGATTCx 10.999190 10.59373 11.28687 10.999190 10.81687
10X73_3_A_1:GTTAACCTTGTCGAx 8.878654 11.18111 10.82444 9.977173 11.27642
10X74_4_A_1:CGTGATGAGAAGGCx 10.930884 11.62402 10.93088 10.930884 10.93088
10X73_3_A_1:AAGCACTGCTTCGCx 9.721698 11.59345 10.97442 10.637953 10.82027
Hspe1 Rps12 Ranbp1 Rpl39 Rps26
10X74_4_A_1:CAGCGTCTCCTCGTx 0.000000 9.528994 10.627557 0.000000 10.222104
10X74_4_A_1:GTCCACTGTCCTCGx 0.000000 9.778387 0.000000 0.000000 9.778387
10X64_3_A_1:ACGCCGGAGGATTCx 0.000000 10.593733 9.207514 0.000000 9.207514
10X73_3_A_1:GTTAACCTTGTCGAx 9.977173 10.264844 10.487980 9.571731 11.586574
10X74_4_A_1:CGTGATGAGAAGGCx 10.371281 10.371281 9.678166 0.000000 11.549915
10X73_3_A_1:AAGCACTGCTTCGCx 9.028611 10.414815 10.127143 9.028611 10.974418
Rplp2 Rps13 Rps3 Rps20 Snrpg
10X74_4_A_1:CAGCGTCTCCTCGTx 10.22210 10.91523 10.22210 9.528994 9.528994
10X74_4_A_1:GTCCACTGTCCTCGx 10.47151 10.87696 10.87696 9.778387 0.000000
10X64_3_A_1:ACGCCGGAGGATTCx 11.40465 11.28687 10.81687 10.593733 10.306059
10X73_3_A_1:GTTAACCTTGTCGAx 11.07575 10.95797 11.07575 10.957974 10.487980
10X74_4_A_1:CGTGATGAGAAGGCx 10.77674 11.54991 11.46987 11.064413 8.985081
10X73_3_A_1:AAGCACTGCTTCGCx 11.22573 11.42640 10.41482 9.721698 9.721698
Rps21 Nme1 Uqcrh Rpl38 Rps3a1
10X74_4_A_1:CAGCGTCTCCTCGTx 9.528994 0.000000 9.528994 0.000000 11.13837
10X74_4_A_1:GTCCACTGTCCTCGx 0.000000 10.876962 9.778387 0.000000 10.47151
10X64_3_A_1:ACGCCGGAGGATTCx 10.593733 9.900611 10.593733 10.306059 11.77237
10X73_3_A_1:GTTAACCTTGTCGAx 8.878654 9.977173 9.571731 8.878654 10.95797
10X74_4_A_1:CGTGATGAGAAGGCx 10.371281 10.930884 0.000000 9.678166 11.62402
10X73_3_A_1:AAGCACTGCTTCGCx 10.127143 9.721698 9.721698 10.637953 11.10795
Rps25 Pfdn5 Saraf Rps28 Rps27
10X74_4_A_1:CAGCGTCTCCTCGTx 10.62756 0.000000 0.000000 9.528994 11.320692
10X74_4_A_1:GTCCACTGTCCTCGx 10.47151 9.778387 0.000000 10.471506 9.778387
10X64_3_A_1:ACGCCGGAGGATTCx 10.59373 10.593733 9.207514 10.593733 11.153338
10X73_3_A_1:GTTAACCTTGTCGAx 10.67030 10.264844 8.878654 9.571731 10.670297
10X74_4_A_1:CGTGATGAGAAGGCx 11.18219 10.776736 9.678166 11.064413 10.776736
10X73_3_A_1:AAGCACTGCTTCGCx 10.12714 11.225729 9.028611 10.974418 10.974418
Rpl37 Gnaq Pomp Rps18 Rpl34
10X74_4_A_1:CAGCGTCTCCTCGTx 10.915233 0.000000 0.000000 10.627557 9.528994
10X74_4_A_1:GTCCACTGTCCTCGx 9.778387 9.778387 0.000000 9.778387 9.778387
10X64_3_A_1:ACGCCGGAGGATTCx 11.510009 9.207514 10.816872 10.306059 9.207514
10X73_3_A_1:GTTAACCTTGTCGAx 11.276423 10.264844 9.977173 8.878654 10.957974
10X74_4_A_1:CGTGATGAGAAGGCx 11.549915 0.000000 10.371281 11.624022 10.371281
10X73_3_A_1:AAGCACTGCTTCGCx 10.974418 9.721698 10.414815 11.225729 10.820270
Rps29 Ppdpf Pfn1 Rpl27 Atp5j2
10X74_4_A_1:CAGCGTCTCCTCGTx 10.22210 0.000000 10.222104 10.627557 9.528994
10X74_4_A_1:GTCCACTGTCCTCGx 0.00000 9.778387 10.876962 0.000000 10.471506
10X64_3_A_1:ACGCCGGAGGATTCx 10.81687 0.000000 9.900611 10.816872 0.000000
10X73_3_A_1:GTTAACCTTGTCGAx 10.95797 10.670297 11.075755 9.977173 9.977173
10X74_4_A_1:CGTGATGAGAAGGCx 10.59442 9.678166 8.985081 10.930884 9.678166
10X73_3_A_1:AAGCACTGCTTCGCx 10.82027 9.028611 10.414815 10.127143 10.414815
Pdia3 Rpl35 Sbf2 Crip2 Tpt1
10X74_4_A_1:CAGCGTCTCCTCGTx 9.528994 10.22210 0.000000 10.222104 9.528994
10X74_4_A_1:GTCCACTGTCCTCGx 10.876962 0.00000 10.471506 0.000000 9.778387
10X64_3_A_1:ACGCCGGAGGATTCx 9.207514 10.30606 0.000000 10.999190 10.306059
10X73_3_A_1:GTTAACCTTGTCGAx 9.571731 11.07575 9.977173 10.670297 11.075755
10X74_4_A_1:CGTGATGAGAAGGCx 8.985081 11.28755 8.985081 9.678166 10.776736
10X73_3_A_1:AAGCACTGCTTCGCx 10.820270 11.10795 0.000000 10.127143 11.107948
Rpl35a X4930402H24Rik Ppm1l Itfg1 Large1
10X74_4_A_1:CAGCGTCTCCTCGTx 0.00000 9.528994 0.000000 0.000000 0.000000
10X74_4_A_1:GTCCACTGTCCTCGx 0.00000 9.778387 0.000000 10.876962 9.778387
10X64_3_A_1:ACGCCGGAGGATTCx 0.00000 0.000000 0.000000 9.207514 9.207514
10X73_3_A_1:GTTAACCTTGTCGAx 10.95797 9.977173 0.000000 9.977173 0.000000
10X74_4_A_1:CGTGATGAGAAGGCx 11.28755 8.985081 8.985081 0.000000 0.000000
10X73_3_A_1:AAGCACTGCTTCGCx 10.82027 0.000000 9.028611 0.000000 0.000000
Ktn1 Ddah2 Sumo1 Nipsnap3b Dynlrb1
10X74_4_A_1:CAGCGTCTCCTCGTx 0.000000 10.222104 10.222104 0.000000 9.528994
10X74_4_A_1:GTCCACTGTCCTCGx 10.876962 0.000000 0.000000 0.000000 0.000000
10X64_3_A_1:ACGCCGGAGGATTCx 0.000000 10.816872 10.816872 9.207514 10.306059
10X73_3_A_1:GTTAACCTTGTCGAx 8.878654 8.878654 9.977173 9.571731 9.977173
10X74_4_A_1:CGTGATGAGAAGGCx 0.000000 10.083610 10.083610 0.000000 10.930884
10X73_3_A_1:AAGCACTGCTTCGCx 9.028611 10.637953 9.721698 9.721698 10.127143
Svbp Tmem57 Acat2 Hmgcs1 Prmt2
10X74_4_A_1:CAGCGTCTCCTCGTx 9.528994 9.528994 9.528994 9.528994 0.000000
10X74_4_A_1:GTCCACTGTCCTCGx 9.778387 9.778387 0.000000 9.778387 0.000000
10X64_3_A_1:ACGCCGGAGGATTCx 10.306059 0.000000 10.306059 0.000000 0.000000
10X73_3_A_1:GTTAACCTTGTCGAx 10.264844 8.878654 8.878654 9.977173 0.000000
10X74_4_A_1:CGTGATGAGAAGGCx 10.776736 8.985081 8.985081 8.985081 9.678166
10X73_3_A_1:AAGCACTGCTTCGCx 9.028611 9.721698 9.721698 0.000000 0.000000
Kif1a Atp5o.1 Atp6v1g1 Camta1 Tnrc6c
10X74_4_A_1:CAGCGTCTCCTCGTx 0.000000 10.222104 0.000000 9.528994 0.000000
10X74_4_A_1:GTCCACTGTCCTCGx 0.000000 9.778387 10.471506 0.000000 0.000000
10X64_3_A_1:ACGCCGGAGGATTCx 0.000000 10.593733 11.153338 9.207514 0.000000
10X73_3_A_1:GTTAACCTTGTCGAx 9.571731 10.670297 10.264844 9.571731 8.878654
10X74_4_A_1:CGTGATGAGAAGGCx 0.000000 9.678166 10.371281 0.000000 0.000000
10X73_3_A_1:AAGCACTGCTTCGCx 0.000000 10.127143 9.721698 9.028611 10.127143
Kifap3 COTAN_Cl.code
10X74_4_A_1:CAGCGTCTCCTCGTx 10.915233 0
10X74_4_A_1:GTCCACTGTCCTCGx 10.471506 0
10X64_3_A_1:ACGCCGGAGGATTCx 0.000000 1
10X73_3_A_1:GTTAACCTTGTCGAx 8.878654 1
10X74_4_A_1:CGTGATGAGAAGGCx 0.000000 1
10X73_3_A_1:AAGCACTGCTTCGCx 0.000000 1# Fit the model
model <- glm( COTAN_Cl.code ~., data = train.data, family = binomial,control = list(maxit = 50))
# Summarize the model
summary(model)
Call:
glm(formula = COTAN_Cl.code ~ ., family = binomial, data = train.data,
control = list(maxit = 50))
Coefficients:
Estimate Std. Error z value Pr(>|z|)
(Intercept) -1.049e+02 2.871e+06 0 1
Flrt2 6.629e-01 8.691e+04 0 1
Smarca2 4.075e-01 5.965e+04 0 1
Srgap1 -1.196e-01 6.491e+04 0 1
Sla 2.034e-01 6.556e+04 0 1
Cadps -8.866e-02 6.676e+04 0 1
Kcnk10 -4.246e-01 8.725e+04 0 1
Itpr1 -1.009e+00 6.868e+04 0 1
Klhl29 1.590e-01 6.882e+04 0 1
Elmod1 3.142e-01 9.102e+04 0 1
Nin -1.495e-01 6.106e+04 0 1
Kcnn2 -1.893e-01 6.106e+04 0 1
Adgrb3 1.495e-01 7.922e+04 0 1
Foxp1 -2.477e-01 1.008e+05 0 1
Alcam 6.261e-01 7.361e+04 0 1
Mtss1 -8.110e-02 8.371e+04 0 1
Fam213a -2.518e-01 7.716e+04 0 1
Ralgps2 -5.499e-01 8.683e+04 0 1
Ptn 2.736e-01 1.076e+05 0 1
Cadm2 -3.845e-01 8.437e+04 0 1
Frmd4a -9.663e-02 7.256e+04 0 1
Nkain2 3.780e-01 8.739e+04 0 1
Tenm3 8.697e-02 9.268e+04 0 1
Grip1 1.791e-01 8.187e+04 0 1
Tanc2 -3.292e-01 6.503e+04 0 1
Syt11 -7.403e-01 8.730e+04 0 1
Srgap3 2.804e-01 6.623e+04 0 1
Pak7 -1.187e-01 8.320e+04 0 1
Mapk10 4.246e-01 6.620e+04 0 1
Sobp -3.389e-01 6.542e+04 0 1
Bhlhe22 -1.175e-01 8.535e+04 0 1
Epha3 -3.949e-02 1.025e+05 0 1
Adgrl3 -3.242e-01 8.414e+04 0 1
Dok5 4.329e-01 8.442e+04 0 1
Satb2 6.319e-01 1.010e+05 0 1
Hs6st2 -2.440e-01 8.496e+04 0 1
X5730522E02Rik -1.205e-02 7.793e+04 0 1
Msra 2.379e-01 1.022e+05 0 1
Spock1 3.863e-01 5.638e+04 0 1
Enc1 1.667e-01 7.319e+04 0 1
Fam110b -2.383e-01 6.774e+04 0 1
Sybu -8.298e-02 6.530e+04 0 1
Lmo1 1.633e-01 8.353e+04 0 1
Dscam -1.470e-01 6.781e+04 0 1
Rab3c -1.161e-01 1.103e+05 0 1
Mir124.2hg -4.476e-01 5.715e+04 0 1
Clstn2 6.641e-02 1.335e+05 0 1
Fat3 -6.251e-02 7.592e+04 0 1
Kcnh7 -1.409e-01 7.908e+04 0 1
Usp29 5.262e-01 6.689e+04 0 1
Cd47 1.150e-01 7.403e+04 0 1
Ryr3 5.436e-02 7.676e+04 0 1
Neto2 -5.954e-01 7.823e+04 0 1
Ppm1e 2.734e-02 5.762e+04 0 1
Mdga2 -3.037e-01 6.828e+04 0 1
Serpini1 -2.279e-01 6.710e+04 0 1
Ralyl -3.333e-01 6.759e+04 0 1
Nrcam 2.232e-01 1.150e+05 0 1
Robo2 2.814e-01 9.011e+04 0 1
Csrnp3 1.767e-01 7.869e+04 0 1
Hist3h2ba -3.469e-01 7.690e+04 0 1
Jakmip1 1.356e-01 7.326e+04 0 1
Edil3 -2.647e-01 7.989e+04 0 1
Enox1 -4.503e-01 6.109e+04 0 1
Rprm -1.513e-01 1.041e+05 0 1
Olfm1 -6.746e-01 7.031e+04 0 1
Tmem178b -6.360e-01 6.559e+04 0 1
Gng3 -5.081e-01 8.182e+04 0 1
Cntn2 -2.800e-01 7.506e+04 0 1
Scg3 1.798e-01 5.612e+04 0 1
Gnao1 1.006e+00 4.654e+04 0 1
Serp2 5.087e-01 8.963e+04 0 1
Pcdh9 9.910e-02 5.588e+04 0 1
Trim2 2.664e-01 8.437e+04 0 1
Nrg1 2.084e-01 6.518e+04 0 1
Ppfia2 -6.617e-01 8.399e+04 0 1
Cacna2d1 -8.806e-02 7.202e+04 0 1
Uqcrq 2.511e-01 1.384e+05 0 1
Bex3 -1.669e-01 1.273e+05 0 1
Ran 6.620e-01 1.443e+05 0 1
Atp5c1 -3.353e-02 1.578e+05 0 1
Eif3k 4.805e-01 9.930e+04 0 1
Ppp1cb 1.551e-01 8.017e+04 0 1
Ndufaf2 3.192e-01 7.689e+04 0 1
Hmgb3 -1.110e-01 1.016e+05 0 1
Rps10 1.630e+00 1.090e+05 0 1
Rae1 5.199e-01 6.981e+04 0 1
Mbd3 -1.298e-01 9.411e+04 0 1
Eif3c 2.232e-01 8.238e+04 0 1
Hnrnpab 1.182e-01 1.083e+05 0 1
Rpl12 1.191e+00 9.106e+04 0 1
Rps15a 1.110e+00 2.237e+05 0 1
Rpl13a 8.337e-01 1.355e+05 0 1
Rpl31 -8.657e-01 1.168e+05 0 1
Rplp1 -1.786e+00 1.248e+05 0 1
Hspe1 1.058e+00 8.584e+04 0 1
Rps12 4.517e-01 1.105e+05 0 1
Ranbp1 -1.202e-01 1.214e+05 0 1
Rpl39 -1.539e-01 8.027e+04 0 1
Rps26 7.116e-01 1.420e+05 0 1
Rplp2 2.593e-02 1.459e+05 0 1
Rps13 1.006e+00 2.209e+05 0 1
Rps3 1.605e-01 2.148e+05 0 1
Rps20 6.931e-01 7.584e+04 0 1
Snrpg 5.178e-01 1.196e+05 0 1
Rps21 2.324e-01 1.049e+05 0 1
Nme1 3.016e-01 8.911e+04 0 1
Uqcrh 9.312e-01 1.231e+05 0 1
Rpl38 1.087e+00 1.152e+05 0 1
Rps3a1 8.552e-01 2.686e+05 0 1
Rps25 -5.472e-01 1.139e+05 0 1
Pfdn5 1.396e+00 1.746e+05 0 1
Saraf 1.785e-01 6.476e+04 0 1
Rps28 1.238e+00 7.323e+04 0 1
Rps27 1.297e+00 1.003e+05 0 1
Rpl37 3.752e-01 1.768e+05 0 1
Gnaq -8.034e-01 7.836e+04 0 1
Pomp 4.339e-01 1.233e+05 0 1
Rps18 6.575e-01 1.207e+05 0 1
Rpl34 -2.467e-01 1.259e+05 0 1
Rps29 -3.668e-02 9.681e+04 0 1
Ppdpf -2.466e-01 1.106e+05 0 1
Pfn1 6.434e-01 2.141e+05 0 1
Rpl27 -4.516e-01 1.775e+05 0 1
Atp5j2 -1.048e+00 8.517e+04 0 1
Pdia3 -3.402e-02 6.777e+04 0 1
Rpl35 -3.067e-01 2.143e+05 0 1
Sbf2 9.417e-02 5.697e+04 0 1
Crip2 -3.933e-01 1.004e+05 0 1
Tpt1 1.063e+00 1.331e+05 0 1
Rpl35a 9.226e-01 7.634e+04 0 1
X4930402H24Rik 9.828e-02 8.299e+04 0 1
Ppm1l -1.593e-01 7.842e+04 0 1
Itfg1 -5.603e-02 6.805e+04 0 1
Large1 -6.845e-01 9.282e+04 0 1
Ktn1 -8.549e-02 5.866e+04 0 1
Ddah2 -6.620e-01 8.598e+04 0 1
Sumo1 1.256e+00 8.659e+04 0 1
Nipsnap3b -1.015e-01 6.388e+04 0 1
Dynlrb1 -8.849e-02 1.269e+05 0 1
Svbp -6.846e-01 1.063e+05 0 1
Tmem57 2.613e-01 8.641e+04 0 1
Acat2 -4.663e-02 6.863e+04 0 1
Hmgcs1 6.751e-02 8.690e+04 0 1
Prmt2 2.628e-01 7.913e+04 0 1
Kif1a -7.816e-01 7.952e+04 0 1
Atp5o.1 1.438e+00 8.623e+04 0 1
Atp6v1g1 -5.073e-01 1.624e+05 0 1
Camta1 -1.516e-01 8.179e+04 0 1
Tnrc6c -3.085e-01 6.284e+04 0 1
Kifap3 -7.520e-01 5.213e+04 0 1
(Dispersion parameter for binomial family taken to be 1)
Null deviance: 5.1795e+02 on 431 degrees of freedom
Residual deviance: 2.7747e-10 on 281 degrees of freedom
AIC: 302
Number of Fisher Scoring iterations: 28# Make predictions
probabilities <- model %>% predict(test.data, type = "response")
predicted.classes <- ifelse(probabilities > 0.5, "1", "0")
# Model accuracy
accuracy <- mean(predicted.classes == test.data$COTAN_Cl.code)
result.df[nrow(result.df),"Accuracy"] <- accuracy
accuracy[1] 0.9166667So also in this case a logistic regression confirm the difference in cell population detected by COTAN.
cl511ClsMarkers <- findClustersMarkers(cl511,n = 200,adjustmentMethod = "BH")
cl511ClsMarkers CL Gene DEA adjPVal IsMarker logFoldCh
1 1 Rps12 -0.4631574 6.179304e-23 0 -0.6825116
2 1 Atp5e -0.4421507 5.491674e-21 0 -0.6826112
3 1 Rpl12 -0.4249280 2.145989e-19 0 -0.5752903
4 1 Gm2000 -0.4178094 8.266734e-19 0 -0.7062262
5 1 Rpl27 -0.4101463 3.545306e-18 0 -0.4851285
6 1 Rpl35 -0.4095642 3.545306e-18 0 -0.6420850
7 1 Rpl38 -0.3944000 8.478137e-17 0 -0.4901851
8 1 Rpl34 -0.3839938 6.783729e-16 0 -0.5340951
9 1 Rpl13a -0.3816076 9.935167e-16 0 -0.4674161
10 1 Rps27 -0.3776191 2.046247e-15 0 -0.5241613
11 1 Rps3 -0.3674962 1.463958e-14 0 -0.5091646
12 1 Rps21 -0.3610531 4.848936e-14 0 -0.4306092
13 1 Rps13 -0.3572065 9.536353e-14 0 -0.4967312
14 1 Rps29 -0.3548193 1.410408e-13 0 -0.4107293
15 1 Uqcrh -0.3468007 6.147911e-13 0 -0.4208264
16 1 Rps15a -0.3458429 6.912919e-13 0 -0.5734880
17 1 Pfdn5 -0.3412558 1.543625e-12 0 -0.4357714
18 1 Uqcr10 -0.3369860 3.225511e-12 0 -0.4964385
19 1 Rps26 -0.3311185 8.957326e-12 0 -0.5340777
20 1 Rps18 -0.3305680 9.404136e-12 0 -0.4596902
21 1 Tpt1 -0.3299757 9.821432e-12 0 -0.4076206
22 1 Pomp -0.3298025 9.821432e-12 0 -0.4368943
23 1 Uqcrq -0.3293949 1.011334e-11 0 -0.4547596
24 1 Rps10 -0.3272393 1.429376e-11 0 -0.4795864
25 1 Timm8b -0.3243765 2.202010e-11 0 -0.4229584
26 1 Rps25 -0.3237942 2.352031e-11 0 -0.4375944
27 1 Pfn1 -0.3207294 3.901832e-11 0 -0.4524917
28 1 Atp6v1g1 -0.3200480 4.247356e-11 0 -0.3852555
29 1 Snrpd2 -0.3191408 4.809087e-11 0 -0.4236104
30 1 Hist3h2ba -0.3189606 4.809087e-11 0 -0.4143786
31 1 Rpl37 -0.3182726 5.113078e-11 0 -0.5620636
32 1 Ndufs6 -0.3181898 5.113078e-11 0 -0.4034311
33 1 Atp5o.1 -0.3180827 5.113078e-11 0 -0.4328550
34 1 Snrpd1 -0.3153742 7.959216e-11 0 -0.4110424
35 1 Dynlrb1 -0.3138158 1.013177e-10 0 -0.4016523
36 1 Uqcr11 -0.3127960 1.175129e-10 0 -0.3977030
37 1 Rpl35a -0.3107331 1.629691e-10 0 -0.4733195
38 1 Btf3 -0.3105683 1.633253e-10 0 -0.3262416
39 1 Swi5 -0.3089875 2.084660e-10 0 -0.3992487
40 1 Rps20 -0.3085851 2.163449e-10 0 -0.4357840
41 1 Rps28 -0.3084818 2.163449e-10 0 -0.3976983
42 1 Rpl31 -0.3080980 2.255272e-10 0 -0.3883420
43 1 Ndufa7 -0.3058711 3.210511e-10 0 -0.3983718
44 1 Tbca -0.3008359 7.277351e-10 0 -0.4041754
45 1 Snrpb -0.3004162 7.631375e-10 0 -0.3556668
46 1 Rplp2 -0.2994340 8.784554e-10 0 -0.3876488
47 1 Rpl28 -0.2980796 1.052945e-09 0 -0.4146471
48 1 Uqcc2 -0.2963589 1.340886e-09 0 -0.5371598
49 1 Rpl36 -0.2959873 1.397320e-09 0 -0.3646947
50 1 Edf1 -0.2907873 3.178356e-09 0 -0.3900142
51 1 Fkbp3 -0.2887652 4.309332e-09 0 -0.3556366
52 1 Rps24 -0.2855195 6.948539e-09 0 -0.4770224
53 1 Gpx4 -0.2835266 9.334702e-09 0 -0.3245309
54 1 Bex3 -0.2811619 1.303730e-08 0 -0.3180195
55 1 Rps16 -0.2797315 1.599893e-08 0 -0.4247866
56 1 Tomm7 -0.2794463 1.619178e-08 0 -0.4093449
57 1 Hspe1 -0.2791884 1.656933e-08 0 -0.3462706
58 1 Chchd1 -0.2776055 2.048508e-08 0 -0.4354694
59 1 Rpl17 -0.2772519 2.129819e-08 0 -0.5191041
60 1 Atp5k -0.2762977 2.391943e-08 0 -0.4740455
61 1 Svbp -0.2760335 2.454234e-08 0 -0.3014819
62 1 Atp5c1 -0.2745657 3.024473e-08 0 -0.2363772
63 1 Eif3k -0.2733174 3.508935e-08 0 -0.3840566
64 1 Sumo1 -0.2733073 3.508935e-08 0 -0.2914956
65 1 Timm13 -0.2727718 3.702865e-08 0 -0.3686286
66 1 Mrpl30 -0.2720558 4.017398e-08 0 -0.4749261
67 1 Sem1 -0.2709400 4.629720e-08 0 -0.3741535
68 1 Usmg5 -0.2698157 5.342106e-08 0 -0.3823320
69 1 Rpl22 -0.2684437 6.472822e-08 0 -0.3428325
70 1 Snrpg -0.2676395 7.204825e-08 0 -0.3005801
71 1 Snrpf -0.2669220 7.916026e-08 0 -0.3441404
72 1 Txn1 -0.2665875 8.218961e-08 0 -0.3887734
73 1 Rps3a1 -0.2649592 1.008742e-07 0 -0.4636491
74 1 Nol7 -0.2647717 1.025205e-07 0 -0.4529087
75 1 Myl12b -0.2633126 1.217868e-07 0 -0.3769849
76 1 Rpl7a -0.2628953 1.276785e-07 0 -0.3803800
77 1 Cirbp -0.2626861 1.302382e-07 0 -0.2427524
78 1 Ndufv3 -0.2624217 1.339336e-07 0 -0.3777157
79 1 Rps27l -0.2612837 1.563403e-07 0 -0.5679664
80 1 Rpl37a -0.2606170 1.704016e-07 0 -0.5219644
81 1 Cycs -0.2595830 1.938262e-07 0 -0.3851088
82 1 Rpl36a -0.2587267 2.134566e-07 0 -0.2850982
83 1 Anapc13 -0.2587054 2.134566e-07 0 -0.4999552
84 1 Smdt1 -0.2574564 2.478866e-07 0 -0.3049345
85 1 Sdhb -0.2573936 2.478866e-07 0 -0.3655544
86 1 Mrpl52 -0.2566519 2.729649e-07 0 -0.3746260
87 1 Ranbp1 -0.2564555 2.745307e-07 0 -0.2617357
88 1 X0610012G03Rik -0.2564191 2.745307e-07 0 -0.4450968
89 1 Csnk2b -0.2562342 2.750654e-07 0 -0.3913248
90 1 Rps17 -0.2562178 2.750654e-07 0 -0.4469891
91 1 Chchd2 -0.2560472 2.793599e-07 0 -0.4363077
92 1 Rpl21 -0.2552685 3.066352e-07 0 -0.3799537
93 1 Hmgb1 -0.2548369 3.231737e-07 0 -0.3340397
94 1 Mrpl28 -0.2536164 3.806468e-07 0 -0.4316112
95 1 Rtraf -0.2534402 3.869427e-07 0 -0.2697156
96 1 Cops9 -0.2500670 5.951063e-07 0 -0.3814245
97 1 Atox1 -0.2499292 5.970482e-07 0 -0.4098502
98 1 Rplp1 -0.2493355 6.431863e-07 0 -0.4307723
99 1 Hnrnpc -0.2478595 7.764310e-07 0 -0.2664530
100 1 Mrps17 -0.2474809 8.116952e-07 0 -0.4752512
101 1 Vapa -0.2468766 8.721894e-07 0 -0.2749610
102 1 Hmgn1 -0.2467652 8.754427e-07 0 -0.2649146
103 1 Rps23 -0.2450458 1.067455e-06 0 -0.4578971
104 1 Atp5h -0.2448166 1.093425e-06 0 -0.3256882
105 1 Tmem256 -0.2442493 1.164429e-06 0 -0.3865038
106 1 Dctpp1 -0.2439550 1.203392e-06 0 -0.2977997
107 1 Hnrnpab -0.2435611 1.243292e-06 0 -0.2954051
108 1 Pcbp2 -0.2424633 1.432268e-06 0 -0.3170388
109 1 Tceal9 -0.2415600 1.595730e-06 0 -0.2648281
110 1 Lamtor5 -0.2396741 2.026750e-06 0 -0.4350606
111 1 Ndufb10 -0.2369256 2.845753e-06 0 -0.2863959
112 1 Cox7c -0.2369182 2.845753e-06 0 -0.2824851
113 1 Oaz1 -0.2366414 2.932600e-06 0 -0.2739040
114 1 Scand1 -0.2362110 3.045776e-06 0 -0.4189525
115 1 Polr2j -0.2362091 3.045776e-06 0 -0.2842206
116 1 Rpl10 -0.2359108 3.147805e-06 0 -0.4748902
117 1 Pfdn4 -0.2355480 3.280891e-06 0 -0.4199890
118 1 Rps19 -0.2350084 3.456874e-06 0 -0.5025216
119 1 Rpl10a -0.2349587 3.458358e-06 0 -0.3144984
120 1 Nme1 -0.2348907 3.468223e-06 0 -0.2836137
121 1 Arpc3 -0.2343649 3.670787e-06 0 -0.3467814
122 1 Ran -0.2336881 3.939102e-06 0 -0.2541407
123 1 Rnf7 -0.2330448 4.257928e-06 0 -0.3808571
124 1 Bex2 -0.2329246 4.299934e-06 0 -0.2931452
125 1 Snrpd3 -0.2324171 4.517130e-06 0 -0.4085823
126 1 Gm10260 -0.2324063 4.517130e-06 0 -0.3556503
127 1 Cox7b -0.2323683 4.517130e-06 0 -0.2699185
128 1 H2afz -0.2321814 4.601751e-06 0 -0.3482270
129 1 Ddah2 -0.2317266 4.853274e-06 0 -0.3249683
130 1 Tbcb -0.2312374 5.112467e-06 0 -0.2296635
131 1 Atp5j2 -0.2304235 5.636766e-06 0 -0.2909852
132 1 Cox6b1 -0.2303935 5.636766e-06 0 -0.2710346
133 1 Atp5j -0.2299245 5.889998e-06 0 -0.2785515
134 1 Uqcrfs1 -0.2295070 6.115004e-06 0 -0.2729393
135 1 Txnl4a -0.2284923 6.924840e-06 0 -0.4264706
136 1 Mrps24 -0.2284003 6.969881e-06 0 -0.4010231
137 1 X1110004F10Rik -0.2278742 7.413813e-06 0 -0.2576501
138 1 Mif -0.2278143 7.431771e-06 0 -0.3175502
139 1 Mrpl18 -0.2263196 8.711184e-06 0 -0.3538738
140 1 Crip2 -0.2262740 8.717744e-06 0 -0.2328728
141 1 Hsbp1 -0.2253209 9.566588e-06 0 -0.2581882
142 1 Rpl19 -0.2253162 9.566588e-06 0 -0.3885120
143 1 Rps11 -0.2251889 9.657436e-06 0 -0.3842770
144 1 Rpl23a -0.2250230 9.813642e-06 0 -0.4333352
145 1 Ubl5 -0.2248595 9.969336e-06 0 -0.3088737
146 1 Ndufab1 -0.2238181 1.114580e-05 0 -0.3859670
147 1 Atp5g1 -0.2231727 1.188843e-05 0 -0.2660431
148 1 Rps6 -0.2231526 1.188843e-05 0 -0.3939822
149 1 Eif3h -0.2230063 1.205170e-05 0 -0.2308491
150 1 Pdcd5 -0.2227795 1.232027e-05 0 -0.3465369
151 1 Zfp706 -0.2225782 1.248254e-05 0 -0.2112568
152 1 Abracl -0.2213980 1.419549e-05 0 -0.2750669
153 1 Pfdn6 -0.2209395 1.476171e-05 0 -0.4071708
154 1 Prdx5 -0.2209157 1.476171e-05 0 -0.2559431
155 1 Calm3 -0.2207705 1.494358e-05 0 -0.2573251
156 1 Rex1bd -0.2205505 1.528890e-05 0 -0.4203590
157 1 Esd -0.2203731 1.556032e-05 0 -0.2975594
158 1 Psma2 -0.2203299 1.557673e-05 0 -0.2819089
159 1 Dynll1 -0.2199227 1.610340e-05 0 -0.3676117
160 1 Rpl15 -0.2194056 1.680821e-05 0 -0.2895195
161 1 Glrx3 -0.2183435 1.868363e-05 0 -0.1083442
162 1 Selenow -0.2181378 1.885712e-05 0 -0.3930863
163 1 Gpx1 -0.2178310 1.949947e-05 0 -0.5381608
164 1 Ndufa2 -0.2176474 1.980926e-05 0 -0.3264260
165 1 Sec61b -0.2175938 1.983788e-05 0 -0.3811968
166 1 Mrpl58 -0.2174523 1.995077e-05 0 -0.4914635
167 1 Psma7 -0.2172906 2.020019e-05 0 -0.2739562
168 1 Bcas2 -0.2172874 2.020019e-05 0 -0.3158613
169 1 Srp14 -0.2170688 2.066579e-05 0 -0.2990073
170 1 Nop10 -0.2166143 2.148915e-05 0 -0.3118031
171 1 Rpl27a -0.2166118 2.148915e-05 0 -0.2738241
172 1 Eif2s2 -0.2163760 2.189740e-05 0 -0.2296548
173 1 Trappc2l -0.2156588 2.366951e-05 0 -0.3406024
174 1 H3f3a -0.2155267 2.374037e-05 0 -0.3079225
175 1 Gtf2h5 -0.2153756 2.409031e-05 0 -0.3434282
176 1 Sub1 -0.2151238 2.465546e-05 0 -0.2508421
177 1 Naca -0.2145087 2.636167e-05 0 -0.3565910
178 1 Rpl7 -0.2135409 2.888891e-05 0 -0.3706477
179 1 Ppdpf -0.2133283 2.942934e-05 0 -0.3391216
180 1 Rpl24 -0.2132538 2.959067e-05 0 -0.4690503
181 1 Gm10076 -0.2127651 3.115539e-05 0 -0.4772046
182 1 Ndufb2 -0.2126279 3.145520e-05 0 -0.3525210
183 1 Cox7a2 -0.2122745 3.258735e-05 0 -0.2379424
184 1 Rpl18 -0.2119888 3.360081e-05 0 -0.2748972
185 1 Rpl5 -0.2112880 3.615233e-05 0 -0.2924973
186 1 Jund -0.2110193 3.712070e-05 0 -0.2279356
187 1 Ndufc1 -0.2110091 3.712070e-05 0 -0.3252872
188 1 Ndufb4 -0.2104183 3.954536e-05 0 -0.3979775
189 1 Rps27a -0.2103446 3.976090e-05 0 -0.4295827
190 1 Slirp -0.2102817 3.992712e-05 0 -0.4121032
191 1 Fau -0.2100702 4.080285e-05 0 -0.4027868
192 1 Ndufb8 -0.2095109 4.343912e-05 0 -0.2659853
193 1 Txndc17 -0.2090668 4.521167e-05 0 -0.3694520
194 1 Rpl32 -0.2083948 4.832366e-05 0 -0.5548520
195 1 Ap2s1 -0.2082741 4.880111e-05 0 -0.2605882
196 1 Gabarap -0.2080173 4.988644e-05 0 -0.2959616
197 1 Smarcb1 -0.2080058 4.988644e-05 0 -0.2851375
198 1 H2afj -0.2078339 5.073976e-05 0 -0.3315896
199 1 Cacybp -0.2065095 5.741582e-05 0 -0.2614856
200 1 Grm8 -0.2057302 6.118469e-05 0 -0.4215947
201 1 Spock1 0.3251712 1.987472e-11 0 0.4817711
202 1 Itfg1 0.2992721 8.834105e-10 0 0.3776583
203 1 Serinc1 0.2965515 1.325342e-09 0 0.3825097
204 1 Mdga2 0.2874687 5.199010e-09 0 0.4623846
205 1 Ctsz 0.2824571 1.084179e-08 0 0.3565810
206 1 Ryr3 0.2794415 1.619178e-08 0 0.4376830
207 1 Ntrk3 0.2778532 2.002950e-08 0 0.3451647
208 1 Mef2c 0.2768192 2.241673e-08 0 0.3636640
209 1 Atp6ap2 0.2740521 3.223350e-08 0 0.3668009
210 1 Sec11a 0.2731492 3.545140e-08 0 0.3837498
211 1 Kat6b 0.2721583 4.007938e-08 0 0.4746228
212 1 Atp6ap1 0.2712290 4.490246e-08 0 0.4142084
213 1 Ctnnd2 0.2699332 5.314820e-08 0 0.3439896
214 1 E2f7 0.2657007 9.256857e-08 0 0.8375014
215 1 Sez6 0.2651659 9.898526e-08 0 0.3790612
216 1 Tspan6 0.2641584 1.109053e-07 0 0.3765847
217 1 App 0.2634301 1.217868e-07 0 0.3262137
218 1 Mmp16 0.2632929 1.217868e-07 0 0.4886848
219 1 Pcdh7 0.2605192 1.710786e-07 0 0.5049982
220 1 Tspan3 0.2587958 2.134566e-07 0 0.2605555
221 1 Aplp1 0.2586314 2.136606e-07 0 0.3496143
222 1 Tmem131l 0.2581351 2.272127e-07 0 0.3784208
223 1 Tspan14 0.2564934 2.745307e-07 0 0.3872160
224 1 Igfbp2 0.2563489 2.748074e-07 0 0.3220609
225 1 Arpp21 0.2559159 2.821614e-07 0 0.4396613
226 1 Cadm1 0.2524424 4.414279e-07 0 0.4311111
227 1 Slc1a3 0.2518736 4.739210e-07 0 0.5677610
228 1 Qsox1 0.2518176 4.739210e-07 0 0.9440026
229 1 Srgap1 0.2516320 4.824444e-07 0 0.3802237
230 1 Dclk2 0.2499866 5.970152e-07 0 0.4091429
231 1 Nin 0.2489162 6.763137e-07 0 0.3054527
232 1 Txndc12 0.2468470 8.721894e-07 0 0.4258825
233 1 Ssbp2 0.2459584 9.673892e-07 0 0.3774376
234 1 Hspa5 0.2459273 9.673892e-07 0 0.3800562
235 1 St7 0.2456147 1.002214e-06 0 0.4031442
236 1 Rpn2 0.2451179 1.064678e-06 0 0.3923588
237 1 Tusc3 0.2444387 1.142901e-06 0 0.3801631
238 1 Tanc2 0.2438393 1.213928e-06 0 0.3503723
239 1 Cntn1 0.2437268 1.224079e-06 0 0.4232511
240 1 Kirrel3 0.2422930 1.455623e-06 0 0.4714545
241 1 Stmn4 0.2398730 1.986851e-06 0 0.3311401
242 1 Nfasc 0.2394718 2.068456e-06 0 0.4271409
243 1 Copa 0.2370049 2.845753e-06 0 0.3776922
244 1 Tmem59 0.2363463 3.029398e-06 0 0.2633921
245 1 Psap 0.2354093 3.320500e-06 0 0.3226806
246 1 Slc8a1 0.2351693 3.405560e-06 0 0.2340766
247 1 Nrg3 0.2345848 3.588172e-06 0 0.3859916
248 1 Cdh2 0.2342571 3.700757e-06 0 0.3735728
249 1 Nptn 0.2336952 3.939102e-06 0 0.3492779
250 1 Scg5 0.2327820 4.355076e-06 0 0.3128342
251 1 Sgip1 0.2314536 4.999485e-06 0 0.3421051
252 1 Arl6ip1 0.2302790 5.689163e-06 0 0.3017192
253 1 Aig1 0.2299854 5.875742e-06 0 0.2858523
254 1 Dnajc1 0.2298029 5.950542e-06 0 0.3192334
255 1 Eya3 0.2295743 6.094840e-06 0 0.4881567
256 1 Scn2a 0.2275217 7.673573e-06 0 0.3877597
257 1 Neto2 0.2272724 7.854626e-06 0 0.3386953
258 1 Ccnl2 0.2272571 7.854626e-06 0 0.2805397
259 1 Snd1 0.2266029 8.489998e-06 0 0.4687846
260 1 Itch 0.2264309 8.632912e-06 0 0.4055109
261 1 Smg5 0.2258127 9.194418e-06 0 0.4186320
262 1 Dhcr24 0.2257498 9.221748e-06 0 0.5983321
263 1 Atp2b1 0.2256716 9.267149e-06 0 0.3856881
264 1 Ctsb 0.2253026 9.566588e-06 0 0.3407802
265 1 Nav3 0.2247291 1.008567e-05 0 0.2492735
266 1 Fam214a 0.2245914 1.021286e-05 0 0.5798609
267 1 Hs2st1 0.2245436 1.022577e-05 0 0.4343860
268 1 Acvr1 0.2237108 1.124361e-05 0 0.4732941
269 1 Gm43507 0.2233813 1.166148e-05 0 0.6365634
270 1 Tmtc1 0.2227560 1.232027e-05 0 0.5203901
271 1 Slc39a10 0.2227061 1.234105e-05 0 0.4692922
272 1 Chga 0.2220755 1.322746e-05 0 0.4003207
273 1 Nell2 0.2219452 1.338310e-05 0 0.3165228
274 1 Tox 0.2217236 1.369482e-05 0 0.2845122
275 1 Tmem185b 0.2212082 1.446869e-05 0 0.6700758
276 1 Arnt 0.2211667 1.447939e-05 0 0.5088107
277 1 Ttc17 0.2209047 1.476171e-05 0 0.4843724
278 1 Anks1b 0.2202085 1.574453e-05 0 0.2459429
279 1 Tmbim6 0.2201693 1.575400e-05 0 0.2638407
280 1 Slc38a10 0.2199521 1.610340e-05 0 0.3700007
281 1 Olfm2 0.2198541 1.617231e-05 0 0.3518482
282 1 Kcnq5 0.2195847 1.664727e-05 0 0.4272948
283 1 Kcnk10 0.2194963 1.675960e-05 0 0.3138762
284 1 P3h4 0.2194473 1.679117e-05 0 0.8099715
285 1 Tmem35a 0.2192435 1.707587e-05 0 0.4109415
286 1 Boc 0.2191374 1.722917e-05 0 0.6010687
287 1 Akt3 0.2187568 1.797847e-05 0 0.2628117
288 1 Por 0.2186967 1.800140e-05 0 0.4889486
289 1 Carmil1 0.2186805 1.800140e-05 0 0.2887406
290 1 Mtdh 0.2182782 1.875823e-05 0 0.2807799
291 1 Slc6a15 0.2181696 1.885712e-05 0 0.4716892
292 1 Leprot 0.2181468 1.885712e-05 0 0.2951880
293 1 Slc20a1 0.2176376 1.980926e-05 0 0.4314969
294 1 Klf12 0.2175271 1.992265e-05 0 0.4983598
295 1 H2.D1 0.2174530 1.995077e-05 0 0.3639213
296 1 Saraf 0.2170315 2.068118e-05 0 0.3081942
297 1 Tmem184c 0.2168042 2.118017e-05 0 0.3225185
298 1 Fgf14 0.2165924 2.148915e-05 0 0.2876250
299 1 Tmem108 0.2165529 2.151223e-05 0 0.3562990
300 1 Lrp11 0.2160417 2.271805e-05 0 0.3773354
301 1 Ldb2 0.2156172 2.366951e-05 0 0.2939618
302 1 Syt1 0.2155833 2.366951e-05 0 0.3450811
303 1 Cacna1c 0.2155815 2.366951e-05 0 0.3207911
304 1 Csmd2 0.2151751 2.459131e-05 0 0.3452957
305 1 Grik2 0.2145339 2.636167e-05 0 0.4514875
306 1 Rcn2 0.2144294 2.652000e-05 0 0.2854721
307 1 Grin2b 0.2143889 2.655527e-05 0 0.3129156
308 1 Os9 0.2141573 2.720820e-05 0 0.3525981
309 1 Fnbp1l 0.2141115 2.726253e-05 0 0.2614826
310 1 Elovl5 0.2136834 2.859818e-05 0 0.5763508
311 1 Rnf145 0.2135605 2.888891e-05 0 0.3942400
312 1 Tnrc6c 0.2134860 2.897903e-05 0 0.2655012
313 1 Ift172 0.2131423 2.988534e-05 0 0.7273950
314 1 Setbp1 0.2126505 3.145520e-05 0 0.2808616
315 1 Lrpap1 0.2123968 3.222429e-05 0 0.2556996
316 1 Cdkl5 0.2119231 3.375163e-05 0 0.3911032
317 1 Tmem63b 0.2116532 3.473486e-05 0 0.3875314
318 1 Clstn2 0.2109563 3.723062e-05 0 0.3872830
319 1 Calr 0.2092966 4.440350e-05 0 0.2802238
320 1 Cdc14b 0.2092583 4.446097e-05 0 0.7198813
321 1 Dock3 0.2090612 4.521167e-05 0 0.3741515
322 1 Ddx50 0.2090289 4.523908e-05 0 0.2860189
323 1 Ormdl3 0.2087933 4.635939e-05 0 0.3832619
324 1 Foxp2 0.2083850 4.832366e-05 0 0.5684095
325 1 Ntrk2 0.2080868 4.972509e-05 0 0.5329103
326 1 Magi1 0.2076794 5.148581e-05 0 0.4553671
327 1 Rgma 0.2076559 5.148581e-05 0 0.5780725
328 1 Ergic2 0.2075656 5.187083e-05 0 0.2655840
329 1 Zfp846 0.2071862 5.404855e-05 0 0.2995412
330 1 Sybu 0.2070890 5.449645e-05 0 0.3264942
331 1 Dync1i1 0.2069879 5.481618e-05 0 0.3032658
332 1 Camkv 0.2069864 5.481618e-05 0 0.4211762
333 1 Llgl1 0.2068048 5.581613e-05 0 0.4266499
334 1 Alg6 0.2066856 5.642350e-05 0 0.9009502
335 1 Lnpk 0.2063438 5.814647e-05 0 0.3247704
336 1 Gm20517 0.2063231 5.814647e-05 0 1.1410193
337 1 Spon1 0.2063231 5.814647e-05 0 1.0616953
338 1 Trpm3 0.2061229 5.929493e-05 0 0.6898117
339 1 Pgrmc1 0.2061031 5.929493e-05 0 0.3026805
340 1 Ctsl 0.2060444 5.952276e-05 0 0.2874709
341 1 B3galt1 0.2059271 6.015918e-05 0 0.3441872
342 1 B3galt2 0.2057494 6.118469e-05 0 0.3838402
343 1 Ldlrad4 0.2054385 6.309715e-05 0 0.3296407
344 1 Cpe 0.2052019 6.465516e-05 0 0.3516827
345 1 Emc3 0.2049225 6.619369e-05 0 0.3590846
346 1 Ttc19 0.2048293 6.671582e-05 0 0.4082099
347 1 Adamts18 0.2044224 6.971209e-05 0 0.3869474
348 1 Scube1 0.2040749 7.193151e-05 0 0.4709928
349 1 Fry 0.2033546 7.767694e-05 0 0.2718307
350 1 Csmd3 0.2030060 8.037958e-05 0 0.5650582
351 1 Cd200 0.2028440 8.133106e-05 0 0.2797321
352 1 Flrt2 0.2028171 8.133106e-05 0 0.4293102
353 1 Atraid 0.2028083 8.133106e-05 0 0.3129678
354 1 Alkbh1 0.2026368 8.267641e-05 0 0.4014083
355 1 Gm26835 0.2023977 8.449163e-05 0 0.4222330
356 1 Phactr1 0.2021293 8.687322e-05 0 0.2632504
357 1 Foxp1 0.2015481 9.229412e-05 0 0.2580225
358 1 Cacna1e 0.2014218 9.336938e-05 0 0.3844196
359 1 Ssr2 0.2012809 9.461454e-05 0 0.2615975
360 1 Dopey1 0.2009499 9.769588e-05 0 0.3199163
361 1 Hivep2 0.2003740 1.034248e-04 0 0.3244790
362 1 Gdpd1 0.1999223 1.085345e-04 0 0.2925950
363 1 Tmem132a 0.1998304 1.093707e-04 0 0.2428495
364 1 Ssh2 0.1996881 1.108396e-04 0 0.3329310
365 1 Cxadr 0.1995267 1.124015e-04 0 0.3356759
366 1 Zdhhc20 0.1994962 1.124015e-04 0 0.3232686
367 1 Cspg5 0.1994202 1.128686e-04 0 0.5253050
368 1 Ascc3 0.1988958 1.180109e-04 0 0.3602826
369 1 Myo9a 0.1987511 1.196295e-04 0 0.3474970
370 1 Nedd4l 0.1981704 1.269985e-04 0 0.2870636
371 1 Scaf8 0.1978388 1.307762e-04 0 0.3909157
372 1 Rbl2 0.1974549 1.356099e-04 0 0.7665457
373 1 Nemp1 0.1974446 1.356099e-04 0 0.5981904
374 1 B3galnt1 0.1973052 1.373818e-04 0 0.4204007
375 1 Slitrk5 0.1971875 1.388396e-04 0 0.4541803
376 1 Fat3 0.1970097 1.409003e-04 0 0.2584599
377 1 Pdia6 0.1960866 1.555464e-04 0 0.2786742
378 1 Rnf215 0.1960722 1.555464e-04 0 0.4738305
379 1 Serpini1 0.1960223 1.556320e-04 0 0.3356833
380 1 Plppr1 0.1957434 1.597088e-04 0 0.2795475
381 1 Sbf2 0.1955265 1.623747e-04 0 0.3006908
382 1 Rnf112 0.1954556 1.632493e-04 0 0.8890006
383 1 Trio 0.1952968 1.653238e-04 0 0.2908840
384 1 Slc38a9 0.1947229 1.752457e-04 0 0.3353488
385 1 Meg3 0.1946101 1.770021e-04 0 0.3784197
386 1 Adcy3 0.1943568 1.811160e-04 0 0.5909601
387 1 Epha7 0.1943252 1.813108e-04 0 0.4107213
388 1 St7l 0.1940574 1.849371e-04 0 0.3886257
389 1 Arxes1 0.1939779 1.860660e-04 0 0.4383596
390 1 Lrrtm3 0.1939585 1.860660e-04 0 0.5679511
391 1 R3hdm4 0.1936969 1.905676e-04 0 0.2734504
392 1 Tia1 0.1936105 1.919255e-04 0 0.2339791
393 1 Dst 0.1934045 1.958332e-04 0 0.2589698
394 1 Mycbp2 0.1933357 1.968488e-04 0 0.2335223
395 1 Mgat2 0.1927568 2.086952e-04 0 0.2780917
396 1 Gpc6 0.1926176 2.112865e-04 0 0.5501739
397 1 Trpv2 0.1925152 2.127680e-04 0 1.1914960
398 1 Lamp1 0.1923454 2.157697e-04 0 0.2363786
399 1 Ktn1 0.1923440 2.157697e-04 0 0.3159114
400 1 Tmem9b 0.1918165 2.269125e-04 0 0.3040203
401 2 Spock1 -0.3251727 1.986918e-11 0 -0.4817711
402 2 Itfg1 -0.2992747 8.830343e-10 0 -0.3776583
403 2 Serinc1 -0.2965425 1.327300e-09 0 -0.3825097
404 2 Mdga2 -0.2874719 5.196375e-09 0 -0.4623846
405 2 Ctsz -0.2824553 1.084481e-08 0 -0.3565810
406 2 Ryr3 -0.2794362 1.620516e-08 0 -0.4376830
407 2 Ntrk3 -0.2778571 2.001761e-08 0 -0.3451647
408 2 Mef2c -0.2768284 2.238544e-08 0 -0.3636640
409 2 Atp6ap2 -0.2740471 3.225774e-08 0 -0.3668009
410 2 Sec11a -0.2731475 3.546047e-08 0 -0.3837498
411 2 Kat6b -0.2721645 4.004189e-08 0 -0.4746228
412 2 Atp6ap1 -0.2712336 4.487202e-08 0 -0.4142084
413 2 Ctnnd2 -0.2699454 5.305199e-08 0 -0.3439896
414 2 E2f7 -0.2656917 9.269129e-08 0 -0.8375014
415 2 Sez6 -0.2651659 9.898528e-08 0 -0.3790612
416 2 Tspan6 -0.2641542 1.109735e-07 0 -0.3765847
417 2 App -0.2634345 1.218616e-07 0 -0.3262137
418 2 Mmp16 -0.2632887 1.218616e-07 0 -0.4886848
419 2 Pcdh7 -0.2605182 1.711040e-07 0 -0.5049982
420 2 Tspan3 -0.2587857 2.135807e-07 0 -0.2605555
421 2 Aplp1 -0.2586243 2.138782e-07 0 -0.3496143
422 2 Tmem131l -0.2581374 2.271400e-07 0 -0.3784208
423 2 Tspan14 -0.2564871 2.746660e-07 0 -0.3872160
424 2 Igfbp2 -0.2563473 2.748693e-07 0 -0.3220609
425 2 Arpp21 -0.2559070 2.825174e-07 0 -0.4396613
426 2 Cadm1 -0.2524469 4.411479e-07 0 -0.4311111
427 2 Slc1a3 -0.2518730 4.741182e-07 0 -0.5677610
428 2 Qsox1 -0.2517963 4.753354e-07 0 -0.9440026
429 2 Srgap1 -0.2516370 4.821080e-07 0 -0.3802237
430 2 Dclk2 -0.2499856 5.967449e-07 0 -0.4091429
431 2 Nin -0.2489245 6.755454e-07 0 -0.3054527
432 2 Txndc12 -0.2468445 8.724833e-07 0 -0.4258825
433 2 Ssbp2 -0.2459592 9.670182e-07 0 -0.3774376
434 2 Hspa5 -0.2459301 9.670182e-07 0 -0.3800562
435 2 St7 -0.2456164 1.001978e-06 0 -0.4031442
436 2 Rpn2 -0.2451161 1.064941e-06 0 -0.3923588
437 2 Tusc3 -0.2444311 1.144088e-06 0 -0.3801631
438 2 Tanc2 -0.2438380 1.214142e-06 0 -0.3503723
439 2 Cntn1 -0.2437246 1.224446e-06 0 -0.4232511
440 2 Kirrel3 -0.2422936 1.455520e-06 0 -0.4714545
441 2 Stmn4 -0.2398701 1.987621e-06 0 -0.3311401
442 2 Nfasc -0.2394724 2.068306e-06 0 -0.4271409
443 2 Copa -0.2370107 2.844142e-06 0 -0.3776922
444 2 Tmem59 -0.2363461 3.029473e-06 0 -0.2633921
445 2 Psap -0.2354175 3.316905e-06 0 -0.3226806
446 2 Slc8a1 -0.2351684 3.405950e-06 0 -0.2340766
447 2 Nrg3 -0.2345814 3.589783e-06 0 -0.3859916
448 2 Cdh2 -0.2342556 3.701484e-06 0 -0.3735728
449 2 Nptn -0.2336996 3.937207e-06 0 -0.3492779
450 2 Scg5 -0.2327845 4.353659e-06 0 -0.3128342
451 2 Sgip1 -0.2314531 4.999791e-06 0 -0.3421051
452 2 Arl6ip1 -0.2302800 5.688491e-06 0 -0.3017192
453 2 Aig1 -0.2299782 5.881194e-06 0 -0.2858523
454 2 Dnajc1 -0.2298092 5.945769e-06 0 -0.3192334
455 2 Eya3 -0.2295670 6.100529e-06 0 -0.4881567
456 2 Scn2a -0.2275122 7.682828e-06 0 -0.3877597
457 2 Neto2 -0.2272673 7.854185e-06 0 -0.3386953
458 2 Ccnl2 -0.2272576 7.854185e-06 0 -0.2805397
459 2 Snd1 -0.2266094 8.483010e-06 0 -0.4687846
460 2 Itch -0.2264373 8.625908e-06 0 -0.4055109
461 2 Smg5 -0.2258205 9.185318e-06 0 -0.4186320
462 2 Dhcr24 -0.2257463 9.225802e-06 0 -0.5983321
463 2 Atp2b1 -0.2256641 9.275968e-06 0 -0.3856881
464 2 Ctsb -0.2253017 9.567604e-06 0 -0.3407802
465 2 Nav3 -0.2247205 1.009659e-05 0 -0.2492735
466 2 Fam214a -0.2245869 1.021576e-05 0 -0.5798609
467 2 Hs2st1 -0.2245514 1.021576e-05 0 -0.4343860
468 2 Acvr1 -0.2237028 1.125479e-05 0 -0.4732941
469 2 Gm43507 -0.2233956 1.164069e-05 0 -0.6365634
470 2 Tmtc1 -0.2227576 1.231783e-05 0 -0.5203901
471 2 Slc39a10 -0.2227101 1.233483e-05 0 -0.4692922
472 2 Chga -0.2220672 1.324119e-05 0 -0.4003207
473 2 Nell2 -0.2219414 1.338939e-05 0 -0.3165228
474 2 Tox -0.2217279 1.368759e-05 0 -0.2845122
475 2 Tmem185b -0.2212111 1.446357e-05 0 -0.6700758
476 2 Arnt -0.2211700 1.447350e-05 0 -0.5088107
477 2 Ttc17 -0.2209115 1.475035e-05 0 -0.4843724
478 2 Anks1b -0.2201991 1.575077e-05 0 -0.2459429
479 2 Tmbim6 -0.2201709 1.575077e-05 0 -0.2638407
480 2 Slc38a10 -0.2199636 1.609008e-05 0 -0.3700007
481 2 Olfm2 -0.2198471 1.618613e-05 0 -0.3518482
482 2 Kcnq5 -0.2195901 1.663637e-05 0 -0.4272948
483 2 Kcnk10 -0.2195041 1.674338e-05 0 -0.3138762
484 2 P3h4 -0.2194235 1.681993e-05 0 -0.8099715
485 2 Tmem35a -0.2192482 1.706599e-05 0 -0.4109415
486 2 Boc -0.2191264 1.725252e-05 0 -0.6010687
487 2 Akt3 -0.2187650 1.796032e-05 0 -0.2628117
488 2 Por -0.2187058 1.800550e-05 0 -0.4889486
489 2 Carmil1 -0.2186786 1.800550e-05 0 -0.2887406
490 2 Mtdh -0.2182809 1.875207e-05 0 -0.2807799
491 2 Slc6a15 -0.2181638 1.884053e-05 0 -0.4716892
492 2 Leprot -0.2181450 1.884053e-05 0 -0.2951880
493 2 Slc20a1 -0.2176394 1.980493e-05 0 -0.4314969
494 2 Klf12 -0.2175232 1.993214e-05 0 -0.4983598
495 2 H2.D1 -0.2174584 1.994929e-05 0 -0.3639213
496 2 Saraf -0.2170244 2.069912e-05 0 -0.3081942
497 2 Tmem184c -0.2167978 2.119660e-05 0 -0.3225185
498 2 Fgf14 -0.2165954 2.148125e-05 0 -0.2876250
499 2 Tmem108 -0.2165627 2.148689e-05 0 -0.3562990
500 2 Lrp11 -0.2160405 2.272142e-05 0 -0.3773354
501 2 Ldb2 -0.2156147 2.367654e-05 0 -0.2939618
502 2 Cacna1c -0.2155847 2.367654e-05 0 -0.3207911
503 2 Syt1 -0.2155790 2.367654e-05 0 -0.3450811
504 2 Csmd2 -0.2151655 2.462000e-05 0 -0.3452957
505 2 Grik2 -0.2145322 2.631314e-05 0 -0.4514875
506 2 Rcn2 -0.2144319 2.651186e-05 0 -0.2854721
507 2 Grin2b -0.2143914 2.654737e-05 0 -0.3129156
508 2 Os9 -0.2141584 2.720479e-05 0 -0.3525981
509 2 Fnbp1l -0.2141045 2.728537e-05 0 -0.2614826
510 2 Elovl5 -0.2136772 2.861939e-05 0 -0.5763508
511 2 Rnf145 -0.2135561 2.893633e-05 0 -0.3942400
512 2 Tnrc6c -0.2134906 2.896283e-05 0 -0.2655012
513 2 Ift172 -0.2131292 2.993213e-05 0 -0.7273950
514 2 Setbp1 -0.2126523 3.147019e-05 0 -0.2808616
515 2 Lrpap1 -0.2123979 3.222011e-05 0 -0.2556996
516 2 Cdkl5 -0.2119296 3.372541e-05 0 -0.3911032
517 2 Tmem63b -0.2116461 3.476450e-05 0 -0.3875314
518 2 Clstn2 -0.2109588 3.721956e-05 0 -0.3872830
519 2 Calr -0.2093031 4.436976e-05 0 -0.2802238
520 2 Cdc14b -0.2092744 4.437711e-05 0 -0.7198813
521 2 Dock3 -0.2090558 4.523928e-05 0 -0.3741515
522 2 Ddx50 -0.2090289 4.523928e-05 0 -0.2860189
523 2 Ormdl3 -0.2087976 4.633580e-05 0 -0.3832619
524 2 Foxp2 -0.2083742 4.838465e-05 0 -0.5684095
525 2 Ntrk2 -0.2080832 4.974629e-05 0 -0.5329103
526 2 Magi1 -0.2076817 5.144462e-05 0 -0.4553671
527 2 Rgma -0.2076627 5.144462e-05 0 -0.5780725
528 2 Ergic2 -0.2075678 5.185736e-05 0 -0.2655840
529 2 Zfp846 -0.2071885 5.403425e-05 0 -0.2995412
530 2 Sybu -0.2070879 5.450360e-05 0 -0.3264942
531 2 Dync1i1 -0.2069837 5.486586e-05 0 -0.3032658
532 2 Camkv -0.2069786 5.486586e-05 0 -0.4211762
533 2 Llgl1 -0.2068022 5.583319e-05 0 -0.4266499
534 2 Alg6 -0.2066740 5.649948e-05 0 -0.9009502
535 2 Lnpk -0.2063485 5.810123e-05 0 -0.3247704
536 2 Gm20517 -0.2063298 5.810123e-05 0 -1.1410193
537 2 Spon1 -0.2063298 5.810123e-05 0 -1.0616953
538 2 Trpm3 -0.2061208 5.923166e-05 0 -0.6898117
539 2 Pgrmc1 -0.2061123 5.923166e-05 0 -0.3026805
540 2 Ctsl -0.2060428 5.953423e-05 0 -0.2874709
541 2 B3galt1 -0.2059237 6.018295e-05 0 -0.3441872
542 2 B3galt2 -0.2057491 6.121111e-05 0 -0.3838402
543 2 Ldlrad4 -0.2054362 6.311424e-05 0 -0.3296407
544 2 Cpe -0.2051983 6.468208e-05 0 -0.3516827
545 2 Emc3 -0.2049214 6.620182e-05 0 -0.3590846
546 2 Ttc19 -0.2048220 6.677153e-05 0 -0.4082099
547 2 Adamts18 -0.2044280 6.966750e-05 0 -0.3869474
548 2 Scube1 -0.2040851 7.184739e-05 0 -0.4709928
549 2 Fry -0.2033530 7.769159e-05 0 -0.2718307
550 2 Csmd3 -0.2030058 8.038151e-05 0 -0.5650582
551 2 Cd200 -0.2028380 8.131483e-05 0 -0.2797321
552 2 Flrt2 -0.2028239 8.131483e-05 0 -0.4293102
553 2 Atraid -0.2028083 8.131483e-05 0 -0.3129678
554 2 Alkbh1 -0.2026408 8.263928e-05 0 -0.4014083
555 2 Gm26835 -0.2023891 8.457433e-05 0 -0.4222330
556 2 Phactr1 -0.2021275 8.689090e-05 0 -0.2632504
557 2 Foxp1 -0.2015461 9.231480e-05 0 -0.2580225
558 2 Cacna1e -0.2014118 9.347565e-05 0 -0.3844196
559 2 Ssr2 -0.2012752 9.467585e-05 0 -0.2615975
560 2 Dopey1 -0.2009604 9.757977e-05 0 -0.3199163
561 2 Hivep2 -0.2003663 1.035141e-04 0 -0.3244790
562 2 Gdpd1 -0.1999246 1.085061e-04 0 -0.2925950
563 2 Tmem132a -0.1998393 1.092617e-04 0 -0.2428495
564 2 Ssh2 -0.1996800 1.109416e-04 0 -0.3329310
565 2 Cxadr -0.1995205 1.125124e-04 0 -0.3356759
566 2 Zdhhc20 -0.1994903 1.125124e-04 0 -0.3232686
567 2 Cspg5 -0.1994159 1.127918e-04 0 -0.5253050
568 2 Ascc3 -0.1988892 1.180975e-04 0 -0.3602826
569 2 Myo9a -0.1987439 1.197252e-04 0 -0.3474970
570 2 Nedd4l -0.1981619 1.271194e-04 0 -0.2870636
571 2 Scaf8 -0.1978457 1.306755e-04 0 -0.3909157
572 2 Rbl2 -0.1974622 1.356527e-04 0 -0.7665457
573 2 Nemp1 -0.1974417 1.356527e-04 0 -0.5981904
574 2 B3galnt1 -0.1973076 1.373451e-04 0 -0.4204007
575 2 Slitrk5 -0.1971726 1.390696e-04 0 -0.4541803
576 2 Fat3 -0.1970110 1.408803e-04 0 -0.2584599
577 2 Pdia6 -0.1960923 1.555679e-04 0 -0.2786742
578 2 Rnf215 -0.1960710 1.555679e-04 0 -0.4738305
579 2 Serpini1 -0.1960175 1.557135e-04 0 -0.3356833
580 2 Plppr1 -0.1957489 1.596118e-04 0 -0.2795475
581 2 Sbf2 -0.1955199 1.624925e-04 0 -0.3006908
582 2 Rnf112 -0.1954497 1.633550e-04 0 -0.8890006
583 2 Trio -0.1952979 1.653021e-04 0 -0.2908840
584 2 Slc38a9 -0.1947198 1.753063e-04 0 -0.3353488
585 2 Meg3 -0.1946128 1.769487e-04 0 -0.3784197
586 2 Adcy3 -0.1943549 1.811538e-04 0 -0.5909601
587 2 Epha7 -0.1943130 1.815532e-04 0 -0.4107213
588 2 St7l -0.1940499 1.850877e-04 0 -0.3886257
589 2 Arxes1 -0.1939825 1.859845e-04 0 -0.4383596
590 2 Lrrtm3 -0.1939625 1.859845e-04 0 -0.5679511
591 2 R3hdm4 -0.1936960 1.905873e-04 0 -0.2734504
592 2 Tia1 -0.1936068 1.920028e-04 0 -0.2339791
593 2 Dst -0.1934066 1.957878e-04 0 -0.2589698
594 2 Mycbp2 -0.1933442 1.966651e-04 0 -0.2335223
595 2 Mgat2 -0.1927482 2.088898e-04 0 -0.2780917
596 2 Gpc6 -0.1926238 2.112472e-04 0 -0.5501739
597 2 Trpv2 -0.1925211 2.126335e-04 0 -1.1914960
598 2 Lamp1 -0.1923446 2.157594e-04 0 -0.2363786
599 2 Ktn1 -0.1923444 2.157594e-04 0 -0.3159114
600 2 Tmem9b -0.1918146 2.269600e-04 0 -0.3040203
601 2 Rps12 0.4631549 6.183206e-23 0 0.6825116
602 2 Atp5e 0.4421521 5.489863e-21 0 0.6826112
603 2 Rpl12 0.4249284 2.145813e-19 0 0.5752903
604 2 Gm2000 0.4178124 8.261193e-19 0 0.7062262
605 2 Rpl27 0.4101575 3.538517e-18 0 0.4851285
606 2 Rpl35 0.4095728 3.538517e-18 0 0.6420850
607 2 Rpl38 0.3944075 8.464359e-17 0 0.4901851
608 2 Rpl34 0.3839933 6.784492e-16 0 0.5340951
609 2 Rpl13a 0.3816079 9.934717e-16 0 0.4674161
610 2 Rps27 0.3776182 2.046629e-15 0 0.5241613
611 2 Rps3 0.3675068 1.460826e-14 0 0.5091646
612 2 Rps21 0.3610482 4.853602e-14 0 0.4306092
613 2 Rps13 0.3572064 9.536627e-14 0 0.4967312
614 2 Rps29 0.3548155 1.411443e-13 0 0.4107293
615 2 Uqcrh 0.3468014 6.147145e-13 0 0.4208264
616 2 Rps15a 0.3458384 6.918806e-13 0 0.5734880
617 2 Pfdn5 0.3412500 1.545294e-12 0 0.4357714
618 2 Uqcr10 0.3369872 3.224794e-12 0 0.4964385
619 2 Rps26 0.3311064 8.977031e-12 0 0.5340777
620 2 Rps18 0.3305636 9.411567e-12 0 0.4596902
621 2 Tpt1 0.3299694 9.825250e-12 0 0.4076206
622 2 Pomp 0.3298004 9.825250e-12 0 0.4368943
623 2 Uqcrq 0.3294012 1.010187e-11 0 0.4547596
624 2 Rps10 0.3272417 1.428769e-11 0 0.4795864
625 2 Timm8b 0.3243726 2.203535e-11 0 0.4229584
626 2 Rps25 0.3237953 2.351562e-11 0 0.4375944
627 2 Pfn1 0.3207365 3.896942e-11 0 0.4524917
628 2 Atp6v1g1 0.3200504 4.245618e-11 0 0.3852555
629 2 Snrpd2 0.3191388 4.805527e-11 0 0.4236104
630 2 Hist3h2ba 0.3189649 4.805527e-11 0 0.4143786
631 2 Rpl37 0.3182724 5.123125e-11 0 0.5620636
632 2 Ndufs6 0.3181885 5.123125e-11 0 0.4034311
633 2 Atp5o.1 0.3180715 5.123125e-11 0 0.4328550
634 2 Snrpd1 0.3153652 7.971523e-11 0 0.4110424
635 2 Dynlrb1 0.3138211 1.012249e-10 0 0.4016523
636 2 Uqcr11 0.3127887 1.176600e-10 0 0.3977030
637 2 Rpl35a 0.3107299 1.630574e-10 0 0.4733195
638 2 Btf3 0.3105600 1.635550e-10 0 0.3262416
639 2 Swi5 0.3089918 2.083158e-10 0 0.3992487
640 2 Rps20 0.3085745 2.163595e-10 0 0.4357840
641 2 Rps28 0.3084814 2.163595e-10 0 0.3976983
642 2 Rpl31 0.3080905 2.258154e-10 0 0.3883420
643 2 Ndufa7 0.3058712 3.210445e-10 0 0.3983718
644 2 Tbca 0.3008336 7.280122e-10 0 0.4041754
645 2 Snrpb 0.3004187 7.628240e-10 0 0.3556668
646 2 Rplp2 0.2994367 8.780648e-10 0 0.3876488
647 2 Rpl28 0.2980768 1.053428e-09 0 0.4146471
648 2 Uqcc2 0.2963570 1.341309e-09 0 0.5371598
649 2 Rpl36 0.2959874 1.397297e-09 0 0.3646947
650 2 Edf1 0.2907784 3.182905e-09 0 0.3900142
651 2 Fkbp3 0.2887636 4.310446e-09 0 0.3556366
652 2 Rps24 0.2855186 6.949575e-09 0 0.4770224
653 2 Gpx4 0.2835273 9.333670e-09 0 0.3245309
654 2 Bex3 0.2811669 1.302731e-08 0 0.3180195
655 2 Rps16 0.2797322 1.599726e-08 0 0.4247866
656 2 Tomm7 0.2794532 1.620516e-08 0 0.4093449
657 2 Hspe1 0.2791867 1.657357e-08 0 0.3462706
658 2 Chchd1 0.2776050 2.048674e-08 0 0.4354694
659 2 Rpl17 0.2772637 2.125977e-08 0 0.5191041
660 2 Atp5k 0.2763011 2.390680e-08 0 0.4740455
661 2 Svbp 0.2760304 2.455412e-08 0 0.3014819
662 2 Atp5c1 0.2745608 3.026725e-08 0 0.2363772
663 2 Eif3k 0.2733197 3.506397e-08 0 0.3840566
664 2 Sumo1 0.2733121 3.506397e-08 0 0.2914956
665 2 Timm13 0.2727683 3.704806e-08 0 0.3686286
666 2 Mrpl30 0.2720637 4.012608e-08 0 0.4749261
667 2 Sem1 0.2709451 4.626165e-08 0 0.3741535
668 2 Usmg5 0.2698205 5.338295e-08 0 0.3823320
669 2 Rpl22 0.2684403 6.476015e-08 0 0.3428325
670 2 Snrpg 0.2676331 7.211655e-08 0 0.3005801
671 2 Snrpf 0.2669184 7.920313e-08 0 0.3441404
672 2 Txn1 0.2665795 8.228619e-08 0 0.3887734
673 2 Rps3a1 0.2649696 1.007190e-07 0 0.4636491
674 2 Nol7 0.2647710 1.025313e-07 0 0.4529087
675 2 Myl12b 0.2633170 1.218616e-07 0 0.3769849
676 2 Rpl7a 0.2628980 1.276278e-07 0 0.3803800
677 2 Cirbp 0.2626801 1.303533e-07 0 0.2427524
678 2 Ndufv3 0.2624191 1.339840e-07 0 0.3777157
679 2 Rps27l 0.2612859 1.562914e-07 0 0.5679664
680 2 Rpl37a 0.2606248 1.702086e-07 0 0.5219644
681 2 Cycs 0.2595888 1.936645e-07 0 0.3851088
682 2 Rpl36a 0.2587217 2.135807e-07 0 0.2850982
683 2 Anapc13 0.2587014 2.135807e-07 0 0.4999552
684 2 Smdt1 0.2574554 2.478030e-07 0 0.3049345
685 2 Sdhb 0.2573959 2.478030e-07 0 0.3655544
686 2 Mrpl52 0.2566472 2.731507e-07 0 0.3746260
687 2 Ranbp1 0.2564576 2.746660e-07 0 0.2617357
688 2 X0610012G03Rik 0.2564156 2.746660e-07 0 0.4450968
689 2 Csnk2b 0.2562380 2.751587e-07 0 0.3913248
690 2 Rps17 0.2562154 2.751587e-07 0 0.4469891
691 2 Chchd2 0.2560482 2.793180e-07 0 0.4363077
692 2 Rpl21 0.2552768 3.062727e-07 0 0.3799537
693 2 Hmgb1 0.2548389 3.230834e-07 0 0.3340397
694 2 Mrpl28 0.2536180 3.805588e-07 0 0.4316112
695 2 Rtraf 0.2534456 3.866532e-07 0 0.2697156
696 2 Cops9 0.2500709 5.947902e-07 0 0.3814245
697 2 Atox1 0.2499329 5.967449e-07 0 0.4098502
698 2 Rplp1 0.2493323 6.434789e-07 0 0.4307723
699 2 Hnrnpc 0.2478592 7.764553e-07 0 0.2664530
700 2 Mrps17 0.2474735 8.125236e-07 0 0.4752512
701 2 Vapa 0.2468733 8.724833e-07 0 0.2749610
702 2 Hmgn1 0.2467629 8.757159e-07 0 0.2649146
703 2 Rps23 0.2450356 1.068941e-06 0 0.4578971
704 2 Atp5h 0.2448179 1.093221e-06 0 0.3256882
705 2 Tmem256 0.2442495 1.164388e-06 0 0.3865038
706 2 Dctpp1 0.2439548 1.203424e-06 0 0.2977997
707 2 Hnrnpab 0.2435671 1.242278e-06 0 0.2954051
708 2 Pcbp2 0.2424629 1.432352e-06 0 0.3170388
709 2 Tceal9 0.2415540 1.597013e-06 0 0.2648281
710 2 Lamtor5 0.2396744 2.026684e-06 0 0.4350606
711 2 Ndufb10 0.2369275 2.844142e-06 0 0.2863959
712 2 Cox7c 0.2369225 2.844142e-06 0 0.2824851
713 2 Oaz1 0.2366477 2.930192e-06 0 0.2739040
714 2 Scand1 0.2362155 3.049012e-06 0 0.4189525
715 2 Polr2j 0.2362011 3.049012e-06 0 0.2842206
716 2 Rpl10 0.2359047 3.150343e-06 0 0.4748902
717 2 Pfdn4 0.2355440 3.282597e-06 0 0.4199890
718 2 Rps19 0.2350001 3.457301e-06 0 0.5025216
719 2 Rpl10a 0.2349610 3.457301e-06 0 0.3144984
720 2 Nme1 0.2348924 3.467459e-06 0 0.2836137
721 2 Arpc3 0.2343591 3.673533e-06 0 0.3467814
722 2 Ran 0.2336918 3.937207e-06 0 0.2541407
723 2 Rnf7 0.2330433 4.258758e-06 0 0.3808571
724 2 Bex2 0.2329252 4.299581e-06 0 0.2931452
725 2 Snrpd3 0.2324127 4.521549e-06 0 0.4085823
726 2 Gm10260 0.2324024 4.521549e-06 0 0.3556503
727 2 Cox7b 0.2323608 4.521549e-06 0 0.2699185
728 2 H2afz 0.2321811 4.601972e-06 0 0.3482270
729 2 Ddah2 0.2317245 4.854571e-06 0 0.3249683
730 2 Tbcb 0.2312379 5.112130e-06 0 0.2296635
731 2 Atp5j2 0.2304200 5.634610e-06 0 0.2909852
732 2 Cox6b1 0.2303965 5.634610e-06 0 0.2710346
733 2 Atp5j 0.2299308 5.885226e-06 0 0.2785515
734 2 Uqcrfs1 0.2295095 6.113070e-06 0 0.2729393
735 2 Txnl4a 0.2284938 6.923514e-06 0 0.4264706
736 2 Mrps24 0.2283968 6.972967e-06 0 0.4010231
737 2 X1110004F10Rik 0.2278692 7.418587e-06 0 0.2576501
738 2 Mif 0.2278012 7.444171e-06 0 0.3175502
739 2 Mrpl18 0.2263135 8.717060e-06 0 0.3538738
740 2 Crip2 0.2262746 8.717060e-06 0 0.2328728
741 2 Hsbp1 0.2253249 9.567604e-06 0 0.2581882
742 2 Rpl19 0.2253114 9.567604e-06 0 0.3885120
743 2 Rps11 0.2251894 9.656863e-06 0 0.3842770
744 2 Rpl23a 0.2250285 9.806820e-06 0 0.4333352
745 2 Ubl5 0.2248612 9.967272e-06 0 0.3088737
746 2 Ndufab1 0.2238209 1.114197e-05 0 0.3859670
747 2 Atp5g1 0.2231648 1.188149e-05 0 0.2660431
748 2 Rps6 0.2231573 1.188149e-05 0 0.3939822
749 2 Eif3h 0.2229958 1.206753e-05 0 0.2308491
750 2 Pdcd5 0.2227854 1.231783e-05 0 0.3465369
751 2 Zfp706 0.2225725 1.249138e-05 0 0.2112568
752 2 Abracl 0.2213934 1.420354e-05 0 0.2750669
753 2 Pfdn6 0.2209369 1.475035e-05 0 0.4071708
754 2 Prdx5 0.2209109 1.475035e-05 0 0.2559431
755 2 Calm3 0.2207639 1.495591e-05 0 0.2573251
756 2 Rex1bd 0.2205570 1.527669e-05 0 0.4203590
757 2 Esd 0.2203737 1.555921e-05 0 0.2975594
758 2 Psma2 0.2203365 1.556413e-05 0 0.2819089
759 2 Dynll1 0.2199209 1.610702e-05 0 0.3676117
760 2 Rpl15 0.2193999 1.681993e-05 0 0.2895195
761 2 Glrx3 0.2183361 1.870043e-05 0 0.1083442
762 2 Selenow 0.2181498 1.884053e-05 0 0.3930863
763 2 Gpx1 0.2178309 1.949979e-05 0 0.5381608
764 2 Ndufa2 0.2176492 1.980493e-05 0 0.3264260
765 2 Sec61b 0.2175909 1.984489e-05 0 0.3811968
766 2 Mrpl58 0.2174529 1.994929e-05 0 0.4914635
767 2 Psma7 0.2172964 2.021002e-05 0 0.2739562
768 2 Bcas2 0.2172834 2.021002e-05 0 0.3158613
769 2 Srp14 0.2170597 2.068867e-05 0 0.2990073
770 2 Nop10 0.2166123 2.148125e-05 0 0.3118031
771 2 Rpl27a 0.2166058 2.148125e-05 0 0.2738241
772 2 Eif2s2 0.2163714 2.190974e-05 0 0.2296548
773 2 Trappc2l 0.2156572 2.367654e-05 0 0.3406024
774 2 H3f3a 0.2155351 2.371636e-05 0 0.3079225
775 2 Gtf2h5 0.2153738 2.409548e-05 0 0.3434282
776 2 Sub1 0.2151160 2.467880e-05 0 0.2508421
777 2 Naca 0.2145240 2.631314e-05 0 0.3565910
778 2 Rpl7 0.2135255 2.894195e-05 0 0.3706477
779 2 Ppdpf 0.2133232 2.944698e-05 0 0.3391216
780 2 Rpl24 0.2132565 2.958106e-05 0 0.4690503
781 2 Gm10076 0.2127650 3.115580e-05 0 0.4772046
782 2 Ndufb2 0.2126237 3.147088e-05 0 0.3525210
783 2 Cox7a2 0.2122685 3.261049e-05 0 0.2379424
784 2 Rpl18 0.2119882 3.360348e-05 0 0.2748972
785 2 Rpl5 0.2112951 3.612182e-05 0 0.2924973
786 2 Jund 0.2110174 3.713592e-05 0 0.2279356
787 2 Ndufc1 0.2110056 3.713592e-05 0 0.3252872
788 2 Ndufb4 0.2104104 3.958197e-05 0 0.3979775
789 2 Rps27a 0.2103616 3.968123e-05 0 0.4295827
790 2 Slirp 0.2102777 3.994578e-05 0 0.4121032
791 2 Fau 0.2100576 4.086342e-05 0 0.4027868
792 2 Ndufb8 0.2095178 4.340397e-05 0 0.2659853
793 2 Txndc17 0.2090594 4.523928e-05 0 0.3694520
794 2 Rpl32 0.2084089 4.834087e-05 0 0.5548520
795 2 Ap2s1 0.2082742 4.880084e-05 0 0.2605882
796 2 Gabarap 0.2080185 4.986800e-05 0 0.2959616
797 2 Smarcb1 0.2080089 4.986800e-05 0 0.2851375
798 2 H2afj 0.2078390 5.070994e-05 0 0.3315896
799 2 Cacybp 0.2065126 5.739543e-05 0 0.2614856
800 2 Grm8 0.2057265 6.121111e-05 0 0.4215947Cluster 184 e15.0
OriginalCluster CellNumber COTANClusterNumber Accuracy
1 Cl525E15.0 826 3 0.786585365853659
2 Cl511E15.0 540 2 0.916666666666667
3 Cl184E15.0 322 2 <NA>cells <- getClusterizationData(e15.0,clName = "CL_original.clusters")[[1]][getClusterizationData(e15.0,clName = "CL_original.clusters")[[1]] == "184"]
cells <-names(cells)
cl184 <- automaticCOTANObjectCreation(raw = getRawData(e15.0)[,cells],
GEO = "Loom",
sequencingMethod = "10X",
sampleCondition = "cl184",
cores = 10,saveObj = T,
outDir = "Data/MouseCortexFromLoom/NotCTSingleClusters/",
calcCoex = T)cl184GDI <- calculateGDI(cl184)
subsetGDIcl184 <- cl184GDI[cl184GDI$sum.raw.norm > 7,]
top.GDI.genes <- rownames(subsetGDIcl184[order(subsetGDIcl184$GDI,decreasing = T),])[1:50]
GDIPlot(cl184,genes = "",GDIIn = cl184GDI)
list.cl.CT <- cellsUniformClustering(cl184, GDIThreshold = 1.43, cores = 10L,
saveObj = TRUE, outDir = outDir)
cl184 <- addClusterization(cl184, clName = "split",
clusters = list.cl.CT$clusters,
coexDF = list.cl.CT$coex, override = TRUE)
table(list.cl.CT$clusters)c(mergedClusters, mergedCoexDF) %<-%
mergeUniformCellsClusters(cl184, clusters = list.cl.CT$clusters,
GDIThreshold = 1.43, batchSize = 4L, cores = 10L,
saveObj = TRUE, outDir = outDir)
cl184 <- addClusterization(cl184, clName = "merge",
clusters = mergedClusters,
coexDF = mergedCoexDF,
override = TRUE)
saveRDS(cl184,paste0(outDir,"cl184.cotan.RDS"))
table(str_split(names(mergedClusters),pattern = "_",simplify = T)[,1],mergedClusters)data <- getNormalizedData(cl184)
data <- data[!rowSums(as.matrix(data)) < 1,]
data <- log(data*10000+1)
row_stdev <- apply(data, 1, sd, na.rm=TRUE)
row_stdev <- row_stdev[order(row_stdev,decreasing = T)]
genes.to.keep <- c(names(row_stdev[1:100]),top.GDI.genes)
data.small <- data[rownames(data) %in% genes.to.keep,]
#data <- t(as.matrix(data))
data.small <- t(as.matrix(data.small))
COTAN_Cl.code <- getClusterizationData(cl184)[[1]]
#COTAN_Cl.code[COTAN_Cl.code == "A549"] <- 0
#COTAN_Cl.code[COTAN_Cl.code == "CCL-185-IG"] <- 1
COTAN_Cl.code <- as.numeric(COTAN_Cl.code)-1
data.small <- cbind(data.small,COTAN_Cl.code)
data.small <- as.data.frame(data.small)
# Split the data into training and test set
set.seed(123)
training.samples <- data.small[,"COTAN_Cl.code"] %>%
createDataPartition(p = 0.8, list = FALSE)
train.data <- data.small[training.samples, ]
test.data <- data.small[-training.samples, ]
head(train.data) Tfap2c Gpc4 Psph Pbdc1 Mcm6
10X64_3_A_1:CTGTAACTGTGTTGx 9.921146 9.921146 9.515705 0.000000 0.000000
10X74_4_A_1:ATCAAATGTCTCCGx 9.214393 9.214393 9.214393 9.214393 10.312939
10X73_3_A_1:ACAACCGACCCACTx 0.000000 9.799638 9.106546 0.000000 0.000000
10X64_3_A_1:AAACATTGGGTCTAx 9.258303 0.000000 0.000000 9.258303 9.258303
10X64_3_A_1:TTGGTACTAGCGTTx 0.000000 0.000000 0.000000 0.000000 9.878809
10X64_3_A_1:GAAACAGATCTCTAx 0.000000 0.000000 10.225911 0.000000 9.127371
Cdca7 Nmral1 Tipin Fbxl7 Btg2
10X64_3_A_1:CTGTAACTGTGTTGx 9.921146 9.515705 9.921146 8.822632 8.822632
10X74_4_A_1:ATCAAATGTCTCCGx 0.000000 9.214393 0.000000 9.907490 0.000000
10X73_3_A_1:ACAACCGACCCACTx 9.106546 0.000000 0.000000 0.000000 9.106546
10X64_3_A_1:AAACATTGGGTCTAx 9.258303 9.951403 9.258303 10.356852 0.000000
10X64_3_A_1:TTGGTACTAGCGTTx 10.284257 9.185713 10.571931 10.795069 9.878809
10X64_3_A_1:GAAACAGATCTCTAx 9.127371 9.820464 10.225911 10.225911 0.000000
Nrarp Ier2 Rgcc Rlbp1 Gm29260
10X64_3_A_1:CTGTAACTGTGTTGx 9.921146 9.921146 9.921146 10.208816 8.822632
10X74_4_A_1:ATCAAATGTCTCCGx 0.000000 9.214393 10.600612 10.312939 10.823751
10X73_3_A_1:ACAACCGACCCACTx 9.799638 0.000000 10.492757 9.106546 10.715895
10X64_3_A_1:AAACATTGGGTCTAx 9.951403 0.000000 9.258303 9.258303 9.258303
10X64_3_A_1:TTGGTACTAGCGTTx 9.185713 9.878809 0.000000 0.000000 9.185713
10X64_3_A_1:GAAACAGATCTCTAx 0.000000 9.127371 11.324499 0.000000 11.206718
Rgs20 Sfrp1 Nes Msi1 Pantr1
10X64_3_A_1:CTGTAACTGTGTTGx 8.822632 9.921146 0.000000 0.000000 10.20882
10X74_4_A_1:ATCAAATGTCTCCGx 0.000000 11.006069 0.000000 0.000000 10.82375
10X73_3_A_1:ACAACCGACCCACTx 0.000000 11.052361 10.205084 0.000000 11.05236
10X64_3_A_1:AAACATTGGGTCTAx 9.258303 10.644526 0.000000 9.258303 10.86766
10X64_3_A_1:TTGGTACTAGCGTTx 9.185713 0.000000 0.000000 0.000000 10.28426
10X64_3_A_1:GAAACAGATCTCTAx 9.127371 10.919040 9.127371 0.000000 10.91904
Cyr61 Zfp536 Pitpnc1 Polr3h Csmd1
10X64_3_A_1:CTGTAACTGTGTTGx 8.822632 9.515705 0.000000 8.822632 8.822632
10X74_4_A_1:ATCAAATGTCTCCGx 9.907490 9.214393 9.214393 9.214393 9.214393
10X73_3_A_1:ACAACCGACCCACTx 10.205084 9.799638 9.106546 0.000000 10.205084
10X64_3_A_1:AAACATTGGGTCTAx 9.951403 0.000000 0.000000 0.000000 10.867665
10X64_3_A_1:TTGGTACTAGCGTTx 10.795069 0.000000 0.000000 9.185713 9.185713
10X64_3_A_1:GAAACAGATCTCTAx 11.206718 9.127371 10.919040 10.225911 10.919040
Mt3 Sncaip CT025619.1 Slc1a3 Rnf180
10X64_3_A_1:CTGTAACTGTGTTGx 8.822632 9.921146 0.000000 9.515705 0.000000
10X74_4_A_1:ATCAAATGTCTCCGx 9.214393 9.214393 9.907490 9.214393 9.214393
10X73_3_A_1:ACAACCGACCCACTx 9.106546 0.000000 9.106546 9.106546 0.000000
10X64_3_A_1:AAACATTGGGTCTAx 10.356852 0.000000 0.000000 0.000000 0.000000
10X64_3_A_1:TTGGTACTAGCGTTx 9.185713 9.878809 9.185713 0.000000 0.000000
10X64_3_A_1:GAAACAGATCTCTAx 11.073188 0.000000 0.000000 0.000000 9.820464
Ptn Aldoc Fgfbp3 Hes5 Mfge8
10X64_3_A_1:CTGTAACTGTGTTGx 9.515705 10.20882 9.921146 11.125084 0.000000
10X74_4_A_1:ATCAAATGTCTCCGx 11.516888 11.98689 0.000000 9.214393 9.214393
10X73_3_A_1:ACAACCGACCCACTx 10.898213 10.20508 0.000000 9.106546 9.799638
10X64_3_A_1:AAACATTGGGTCTAx 12.349254 11.33766 9.258303 10.356852 9.951403
10X64_3_A_1:TTGGTACTAGCGTTx 10.795069 10.57193 9.878809 9.878809 9.185713
10X64_3_A_1:GAAACAGATCTCTAx 11.835320 11.69222 0.000000 0.000000 0.000000
Maml2 Lpar1 Cadm2 Sema5a Qk
10X64_3_A_1:CTGTAACTGTGTTGx 8.822632 0.000000 0.000000 0.000000 0.000000
10X74_4_A_1:ATCAAATGTCTCCGx 0.000000 0.000000 9.214393 10.600612 0.000000
10X73_3_A_1:ACAACCGACCCACTx 0.000000 9.799638 0.000000 10.492757 9.799638
10X64_3_A_1:AAACATTGGGTCTAx 9.258303 0.000000 10.356852 10.644526 9.951403
10X64_3_A_1:TTGGTACTAGCGTTx 9.185713 0.000000 0.000000 0.000000 0.000000
10X64_3_A_1:GAAACAGATCTCTAx 9.127371 9.127371 10.225911 9.127371 0.000000
Nkain2 Hes6 Rhbdl3 Neurog2 Chd7
10X64_3_A_1:CTGTAACTGTGTTGx 8.822632 8.822632 9.515705 9.515705 0.000000
10X74_4_A_1:ATCAAATGTCTCCGx 9.907490 0.000000 9.907490 0.000000 0.000000
10X73_3_A_1:ACAACCGACCCACTx 9.106546 9.799638 10.205084 0.000000 0.000000
10X64_3_A_1:AAACATTGGGTCTAx 0.000000 0.000000 0.000000 0.000000 0.000000
10X64_3_A_1:TTGGTACTAGCGTTx 0.000000 9.185713 9.185713 0.000000 9.878809
10X64_3_A_1:GAAACAGATCTCTAx 9.820464 0.000000 9.127371 0.000000 0.000000
Msmo1 Igfbpl1 Zmiz1 Kat6b Nfib
10X64_3_A_1:CTGTAACTGTGTTGx 0.000000 11.22039 9.515705 0.000000 11.125084
10X74_4_A_1:ATCAAATGTCTCCGx 9.214393 0.00000 9.214393 10.600612 10.600612
10X73_3_A_1:ACAACCGACCCACTx 0.000000 0.00000 0.000000 10.492757 9.799638
10X64_3_A_1:AAACATTGGGTCTAx 9.258303 0.00000 0.000000 0.000000 9.951403
10X64_3_A_1:TTGGTACTAGCGTTx 0.000000 0.00000 9.185713 9.185713 9.878809
10X64_3_A_1:GAAACAGATCTCTAx 9.127371 0.00000 0.000000 0.000000 10.225911
Fezf2 Dok5 Tenm2 Meis2 Mpped2
10X64_3_A_1:CTGTAACTGTGTTGx 8.822632 9.515705 9.921146 9.515705 11.81822
10X74_4_A_1:ATCAAATGTCTCCGx 0.000000 9.214393 0.000000 10.823751 11.00607
10X73_3_A_1:ACAACCGACCCACTx 0.000000 9.106546 0.000000 10.205084 10.49276
10X64_3_A_1:AAACATTGGGTCTAx 9.258303 9.951403 10.356852 11.049983 0.00000
10X64_3_A_1:TTGGTACTAGCGTTx 0.000000 0.000000 0.000000 9.878809 11.13154
10X64_3_A_1:GAAACAGATCTCTAx 9.127371 9.820464 0.000000 11.206718 10.51358
Gm17750 Kcnh7 Mir670hg Gpc6 Dab1
10X64_3_A_1:CTGTAACTGTGTTGx 8.822632 0.000000 9.515705 0.000000 10.208816
10X74_4_A_1:ATCAAATGTCTCCGx 0.000000 9.907490 10.312939 0.000000 0.000000
10X73_3_A_1:ACAACCGACCCACTx 9.799638 9.799638 0.000000 9.106546 0.000000
10X64_3_A_1:AAACATTGGGTCTAx 9.258303 9.951403 0.000000 9.258303 9.258303
10X64_3_A_1:TTGGTACTAGCGTTx 9.185713 0.000000 0.000000 10.795069 9.185713
10X64_3_A_1:GAAACAGATCTCTAx 0.000000 9.127371 9.820464 0.000000 9.127371
Hist3h2ba Scrn1 Ank2 Bach2 Rbbp7
10X64_3_A_1:CTGTAACTGTGTTGx 8.822632 8.822632 8.822632 10.43195 9.515705
10X74_4_A_1:ATCAAATGTCTCCGx 9.214393 9.214393 9.214393 9.90749 0.000000
10X73_3_A_1:ACAACCGACCCACTx 0.000000 9.106546 9.106546 0.00000 0.000000
10X64_3_A_1:AAACATTGGGTCTAx 0.000000 9.258303 9.951403 0.00000 0.000000
10X64_3_A_1:TTGGTACTAGCGTTx 0.000000 0.000000 0.000000 0.00000 0.000000
10X64_3_A_1:GAAACAGATCTCTAx 0.000000 10.736722 0.000000 0.00000 9.820464
Rpl26 Serbp1 Prmt1 Rack1 Hsp90aa1
10X64_3_A_1:CTGTAACTGTGTTGx 0.00000 10.76842 10.208816 10.431952 11.019725
10X74_4_A_1:ATCAAATGTCTCCGx 11.61220 10.82375 10.600612 10.312939 9.214393
10X73_3_A_1:ACAACCGACCCACTx 11.50434 10.71590 11.303672 10.898213 10.715895
10X64_3_A_1:AAACATTGGGTCTAx 0.00000 10.64453 10.356852 11.049983 10.867665
10X64_3_A_1:TTGGTACTAGCGTTx 0.00000 10.28426 11.265065 0.000000 10.795069
10X64_3_A_1:GAAACAGATCTCTAx 0.00000 10.22591 9.127371 9.127371 10.736722
Ddx39 Cct5 H2afx Lsm3 Ntmt1
10X64_3_A_1:CTGTAACTGTGTTGx 8.822632 10.208816 9.921146 9.515705 10.208816
10X74_4_A_1:ATCAAATGTCTCCGx 9.214393 10.600612 9.907490 9.214393 9.214393
10X73_3_A_1:ACAACCGACCCACTx 0.000000 10.898213 0.000000 0.000000 9.106546
10X64_3_A_1:AAACATTGGGTCTAx 9.258303 10.644526 0.000000 9.258303 9.258303
10X64_3_A_1:TTGGTACTAGCGTTx 0.000000 9.878809 9.185713 9.185713 9.878809
10X64_3_A_1:GAAACAGATCTCTAx 0.000000 10.919040 10.513584 9.820464 0.000000
Hmgb3 Snrnp70 Rfc2 Tuba1b Snrpb
10X64_3_A_1:CTGTAACTGTGTTGx 10.76842 8.822632 0.000000 10.61427 10.208816
10X74_4_A_1:ATCAAATGTCTCCGx 9.90749 9.907490 10.312939 11.16022 10.823751
10X73_3_A_1:ACAACCGACCCACTx 10.49276 9.799638 9.106546 10.89821 10.715895
10X64_3_A_1:AAACATTGGGTCTAx 10.35685 9.258303 0.000000 11.56080 9.951403
10X64_3_A_1:TTGGTACTAGCGTTx 10.57193 0.000000 9.185713 11.67053 10.571931
10X64_3_A_1:GAAACAGATCTCTAx 10.91904 0.000000 9.820464 11.52517 10.225911
Psma7 Pmpcb Srsf3 Rbmxl1 Cdk4
10X64_3_A_1:CTGTAACTGTGTTGx 10.61427 0.000000 10.20882 0.000000 9.515705
10X74_4_A_1:ATCAAATGTCTCCGx 9.90749 9.214393 10.82375 0.000000 11.160217
10X73_3_A_1:ACAACCGACCCACTx 10.49276 0.000000 0.00000 9.106546 11.591351
10X64_3_A_1:AAACATTGGGTCTAx 10.86766 9.258303 11.04998 9.258303 10.644526
10X64_3_A_1:TTGGTACTAGCGTTx 11.13154 0.000000 10.57193 0.000000 11.131536
10X64_3_A_1:GAAACAGATCTCTAx 11.07319 0.000000 0.00000 0.000000 10.736722
Nap1l4 Fam133b Cdc123 Dnajc9 Rpl12
10X64_3_A_1:CTGTAACTGTGTTGx 9.921146 8.822632 9.515705 8.822632 10.768416
10X74_4_A_1:ATCAAATGTCTCCGx 9.214393 9.907490 9.907490 9.907490 10.823751
10X73_3_A_1:ACAACCGACCCACTx 0.000000 9.799638 10.205084 9.106546 11.185891
10X64_3_A_1:AAACATTGGGTCTAx 0.000000 0.000000 9.258303 0.000000 11.049983
10X64_3_A_1:TTGGTACTAGCGTTx 0.000000 10.284257 9.878809 0.000000 9.878809
10X64_3_A_1:GAAACAGATCTCTAx 9.820464 9.127371 9.127371 10.225911 10.225911
Rpl22 Hspe1 Cks1b Snrpg Ppia
10X64_3_A_1:CTGTAACTGTGTTGx 10.768416 10.208816 10.431952 11.22039 10.208816
10X74_4_A_1:ATCAAATGTCTCCGx 9.214393 9.214393 9.214393 10.60061 10.600612
10X73_3_A_1:ACAACCGACCCACTx 9.799638 10.205084 10.205084 11.18589 10.715895
10X64_3_A_1:AAACATTGGGTCTAx 10.644526 11.743122 9.258303 10.35685 9.951403
10X64_3_A_1:TTGGTACTAGCGTTx 10.284257 10.284257 0.000000 10.28426 11.131536
10X64_3_A_1:GAAACAGATCTCTAx 10.225911 10.225911 9.820464 10.73672 10.513584
Cnbp Sub1 Psip1 Eprs Jun
10X64_3_A_1:CTGTAACTGTGTTGx 9.515705 9.921146 10.431952 9.515705 10.61427
10X74_4_A_1:ATCAAATGTCTCCGx 11.006069 9.907490 9.214393 0.000000 10.31294
10X73_3_A_1:ACAACCGACCCACTx 11.303672 10.492757 11.185891 0.000000 10.20508
10X64_3_A_1:AAACATTGGGTCTAx 10.867665 10.356852 9.951403 0.000000 10.35685
10X64_3_A_1:TTGGTACTAGCGTTx 10.977387 10.571931 11.131536 9.878809 11.58352
10X64_3_A_1:GAAACAGATCTCTAx 10.736722 9.127371 10.225911 0.000000 11.07319
Pgrmc1 Arl15 Dach1 Rps25 Dynll1
10X64_3_A_1:CTGTAACTGTGTTGx 10.208816 9.515705 10.431952 11.30740 10.431952
10X74_4_A_1:ATCAAATGTCTCCGx 0.000000 0.000000 0.000000 10.82375 9.907490
10X73_3_A_1:ACAACCGACCCACTx 9.799638 9.799638 0.000000 10.71590 10.898213
10X64_3_A_1:AAACATTGGGTCTAx 0.000000 0.000000 9.258303 11.04998 9.258303
10X64_3_A_1:TTGGTACTAGCGTTx 9.878809 9.185713 9.878809 10.57193 9.185713
10X64_3_A_1:GAAACAGATCTCTAx 0.000000 0.000000 0.000000 10.91904 10.736722
Sem1 Rps28 Eif3f Tspan6 Rpl34
10X64_3_A_1:CTGTAACTGTGTTGx 11.125084 10.768416 10.431952 9.515705 10.43195
10X74_4_A_1:ATCAAATGTCTCCGx 0.000000 0.000000 10.823751 9.214393 11.00607
10X73_3_A_1:ACAACCGACCCACTx 10.492757 10.492757 10.492757 9.106546 10.49276
10X64_3_A_1:AAACATTGGGTCTAx 10.356852 9.951403 10.867665 0.000000 10.35685
10X64_3_A_1:TTGGTACTAGCGTTx 9.878809 10.795069 10.284257 9.878809 10.79507
10X64_3_A_1:GAAACAGATCTCTAx 10.225911 9.127371 9.820464 0.000000 10.22591
Mrps17 Atp5j Higd2a Ddx50 Phf21a
10X64_3_A_1:CTGTAACTGTGTTGx 9.515705 9.921146 9.515705 10.208816 0.00000
10X74_4_A_1:ATCAAATGTCTCCGx 9.214393 9.907490 0.000000 9.907490 0.00000
10X73_3_A_1:ACAACCGACCCACTx 9.799638 9.799638 9.106546 9.799638 0.00000
10X64_3_A_1:AAACATTGGGTCTAx 10.644526 10.644526 9.258303 9.951403 10.35685
10X64_3_A_1:TTGGTACTAGCGTTx 9.185713 9.878809 9.878809 0.000000 0.00000
10X64_3_A_1:GAAACAGATCTCTAx 0.000000 10.225911 9.127371 0.000000 0.00000
Baz2b Elob Btbd1 Ubb H2afz
10X64_3_A_1:CTGTAACTGTGTTGx 8.822632 11.019725 8.822632 10.76842 10.43195
10X74_4_A_1:ATCAAATGTCTCCGx 0.000000 0.000000 0.000000 10.82375 11.29375
10X73_3_A_1:ACAACCGACCCACTx 9.106546 10.492757 9.799638 0.00000 11.05236
10X64_3_A_1:AAACATTGGGTCTAx 0.000000 10.356852 10.356852 10.35685 11.33766
10X64_3_A_1:TTGGTACTAGCGTTx 9.878809 10.284257 9.185713 10.28426 10.28426
10X64_3_A_1:GAAACAGATCTCTAx 0.000000 9.127371 9.127371 10.73672 11.07319
Zfp609 Rpl35a Nt5dc2 mt.Nd4 mt.Nd1
10X64_3_A_1:CTGTAACTGTGTTGx 9.921146 8.822632 8.822632 10.208816 10.208816
10X74_4_A_1:ATCAAATGTCTCCGx 0.000000 10.823751 9.214393 10.312939 9.907490
10X73_3_A_1:ACAACCGACCCACTx 0.000000 11.052361 0.000000 9.799638 10.715895
10X64_3_A_1:AAACATTGGGTCTAx 0.000000 9.258303 9.258303 9.951403 9.951403
10X64_3_A_1:TTGGTACTAGCGTTx 0.000000 0.000000 9.185713 9.878809 9.185713
10X64_3_A_1:GAAACAGATCTCTAx 9.820464 0.000000 9.820464 10.736722 9.820464
Pcm1 Hes1 Ndufc2 Pcna Atp5f1
10X64_3_A_1:CTGTAACTGTGTTGx 0.000000 10.208816 10.768416 0.000000 9.515705
10X74_4_A_1:ATCAAATGTCTCCGx 9.907490 9.214393 10.600612 9.214393 10.312939
10X73_3_A_1:ACAACCGACCCACTx 9.106546 10.715895 9.799638 0.000000 10.715895
10X64_3_A_1:AAACATTGGGTCTAx 9.258303 9.258303 10.356852 9.951403 10.356852
10X64_3_A_1:TTGGTACTAGCGTTx 9.185713 9.185713 9.878809 10.284257 10.284257
10X64_3_A_1:GAAACAGATCTCTAx 9.127371 9.127371 10.513584 9.820464 9.127371
Gsk3b Mtch1 Gpatch8 Map1b Romo1
10X64_3_A_1:CTGTAACTGTGTTGx 0.000000 0.000000 0.000000 9.921146 9.921146
10X74_4_A_1:ATCAAATGTCTCCGx 0.000000 9.214393 9.214393 9.907490 0.000000
10X73_3_A_1:ACAACCGACCCACTx 10.715895 9.106546 0.000000 10.205084 9.106546
10X64_3_A_1:AAACATTGGGTCTAx 9.258303 9.258303 9.258303 10.867665 10.644526
10X64_3_A_1:TTGGTACTAGCGTTx 0.000000 0.000000 9.185713 10.284257 0.000000
10X64_3_A_1:GAAACAGATCTCTAx 9.127371 9.127371 9.127371 9.820464 9.820464
Xist Fdft1 Hmgcs1 Eif1b Sox4
10X64_3_A_1:CTGTAACTGTGTTGx 0.00000 8.822632 8.822632 9.515705 10.431952
10X74_4_A_1:ATCAAATGTCTCCGx 10.60061 9.214393 10.312939 10.600612 10.600612
10X73_3_A_1:ACAACCGACCCACTx 0.00000 9.799638 0.000000 10.492757 10.492757
10X64_3_A_1:AAACATTGGGTCTAx 0.00000 9.258303 9.258303 11.204131 9.258303
10X64_3_A_1:TTGGTACTAGCGTTx 0.00000 9.878809 0.000000 9.185713 0.000000
10X64_3_A_1:GAAACAGATCTCTAx 10.73672 9.820464 9.127371 9.820464 9.127371
Fxyd6 Eef2 Tubb2b Rtn1 Acat1
10X64_3_A_1:CTGTAACTGTGTTGx 0.000000 10.431952 10.90194 0.000000 0.000000
10X74_4_A_1:ATCAAATGTCTCCGx 10.600612 11.411529 11.92235 9.907490 0.000000
10X73_3_A_1:ACAACCGACCCACTx 9.106546 10.492757 10.20508 9.799638 10.205084
10X64_3_A_1:AAACATTGGGTCTAx 9.951403 11.049983 11.74312 9.258303 0.000000
10X64_3_A_1:TTGGTACTAGCGTTx 9.185713 9.878809 11.67053 0.000000 0.000000
10X64_3_A_1:GAAACAGATCTCTAx 9.820464 10.513584 11.07319 10.919040 9.127371
Glrx2 Ndufa4 Cox7c Scg5
10X64_3_A_1:CTGTAACTGTGTTGx 0.000000 10.431952 10.768416 9.515705
10X74_4_A_1:ATCAAATGTCTCCGx 0.000000 10.600612 9.907490 0.000000
10X73_3_A_1:ACAACCGACCCACTx 9.106546 10.715895 10.492757 0.000000
10X64_3_A_1:AAACATTGGGTCTAx 9.258303 9.258303 9.258303 9.258303
10X64_3_A_1:TTGGTACTAGCGTTx 0.000000 10.284257 10.571931 10.284257
10X64_3_A_1:GAAACAGATCTCTAx 0.000000 9.127371 10.225911 0.000000
COTAN_Cl.code
10X64_3_A_1:CTGTAACTGTGTTGx 1
10X74_4_A_1:ATCAAATGTCTCCGx 0
10X73_3_A_1:ACAACCGACCCACTx 1
10X64_3_A_1:AAACATTGGGTCTAx 0
10X64_3_A_1:TTGGTACTAGCGTTx 0
10X64_3_A_1:GAAACAGATCTCTAx 0# Fit the model
model <- glm( COTAN_Cl.code ~., data = train.data, family = binomial,control = list(maxit = 50))
# Summarize the model
summary(model)
Call:
glm(formula = COTAN_Cl.code ~ ., family = binomial, data = train.data,
control = list(maxit = 50))
Coefficients:
Estimate Std. Error z value Pr(>|z|)
(Intercept) 9.110e+01 1.100e+07 0 1
Tfap2c 1.269e+00 8.987e+04 0 1
Gpc4 -6.821e-02 9.506e+04 0 1
Psph 1.573e-01 1.201e+05 0 1
Pbdc1 8.595e-01 1.087e+05 0 1
Mcm6 -4.889e-01 1.543e+05 0 1
Cdca7 -7.372e-01 1.271e+05 0 1
Nmral1 6.463e-01 9.466e+04 0 1
Tipin -1.070e+00 1.682e+05 0 1
Fbxl7 -4.258e-01 7.749e+04 0 1
Btg2 1.586e+00 9.758e+04 0 1
Nrarp -7.463e-01 1.204e+05 0 1
Ier2 -8.686e-01 1.185e+05 0 1
Rgcc 8.656e-01 1.541e+05 0 1
Rlbp1 -6.125e-01 1.847e+05 0 1
Gm29260 -3.715e-01 1.893e+05 0 1
Rgs20 -1.391e+00 1.085e+05 0 1
Sfrp1 3.321e+00 1.832e+05 0 1
Nes 5.768e-01 1.546e+05 0 1
Msi1 -2.990e-01 1.159e+05 0 1
Pantr1 -2.463e+00 3.393e+05 0 1
Cyr61 6.273e-02 1.076e+05 0 1
Zfp536 5.775e-01 9.432e+04 0 1
Pitpnc1 -4.029e-01 1.185e+05 0 1
Polr3h 9.613e-01 9.686e+04 0 1
Csmd1 -8.679e-01 1.555e+05 0 1
Mt3 6.199e-01 6.379e+04 0 1
Sncaip 5.435e-01 7.041e+04 0 1
CT025619.1 -2.551e-01 8.493e+04 0 1
Slc1a3 1.742e-02 9.355e+04 0 1
Rnf180 -1.198e-02 1.378e+05 0 1
Ptn 2.916e+00 3.358e+05 0 1
Aldoc -7.125e-01 2.754e+05 0 1
Fgfbp3 6.299e-01 1.779e+05 0 1
Hes5 -4.311e-01 9.800e+04 0 1
Mfge8 -1.961e+00 1.023e+05 0 1
Maml2 1.907e-02 5.771e+04 0 1
Lpar1 9.757e-01 9.494e+04 0 1
Cadm2 -3.372e+00 1.134e+05 0 1
Sema5a -1.675e+00 1.458e+05 0 1
Qk 1.323e+00 1.343e+05 0 1
Nkain2 -9.102e-01 6.484e+04 0 1
Hes6 5.452e-02 6.297e+04 0 1
Rhbdl3 -9.056e-01 1.287e+05 0 1
Neurog2 1.858e+00 1.775e+05 0 1
Chd7 1.672e+00 1.190e+05 0 1
Msmo1 -1.116e+00 9.372e+04 0 1
Igfbpl1 -1.102e+00 9.733e+04 0 1
Zmiz1 -8.943e-02 1.124e+05 0 1
Kat6b 1.046e-01 9.785e+04 0 1
Nfib 6.736e-01 1.481e+05 0 1
Fezf2 -4.256e-01 1.414e+05 0 1
Dok5 -2.646e-01 6.147e+04 0 1
Tenm2 6.249e-01 1.088e+05 0 1
Meis2 -3.128e+00 4.298e+05 0 1
Mpped2 -1.662e+00 8.711e+04 0 1
Gm17750 8.710e-01 9.417e+04 0 1
Kcnh7 -2.218e+00 6.723e+04 0 1
Mir670hg -3.468e-01 5.711e+04 0 1
Gpc6 -3.642e-01 1.059e+05 0 1
Dab1 1.157e+00 5.199e+04 0 1
Hist3h2ba 5.847e-02 8.058e+04 0 1
Scrn1 5.250e-01 1.096e+05 0 1
Ank2 1.268e-01 7.979e+04 0 1
Bach2 9.614e-01 1.029e+05 0 1
Rbbp7 -8.930e-01 9.675e+04 0 1
Rpl26 8.709e-01 8.948e+04 0 1
Serbp1 6.645e-01 2.959e+05 0 1
Prmt1 1.329e+00 3.342e+05 0 1
Rack1 1.546e+00 1.748e+05 0 1
Hsp90aa1 -1.847e+00 2.365e+05 0 1
Ddx39 1.593e-01 8.123e+04 0 1
Cct5 -8.543e-01 1.388e+05 0 1
H2afx -1.026e+00 4.980e+04 0 1
Lsm3 5.727e-01 7.913e+04 0 1
Ntmt1 1.509e+00 7.867e+04 0 1
Hmgb3 1.084e+00 1.624e+05 0 1
Snrnp70 2.391e-01 9.161e+04 0 1
Rfc2 -5.456e-02 1.359e+05 0 1
Tuba1b -4.150e-01 3.443e+05 0 1
Snrpb 1.624e+00 1.615e+05 0 1
Psma7 -2.890e+00 2.978e+05 0 1
Pmpcb 3.020e-01 1.059e+05 0 1
Srsf3 5.908e-01 1.061e+05 0 1
Rbmxl1 3.515e-01 1.152e+05 0 1
Cdk4 -2.678e+00 4.559e+05 0 1
Nap1l4 -1.278e+00 7.349e+04 0 1
Fam133b 1.006e-01 1.346e+05 0 1
Cdc123 -4.317e-01 6.492e+04 0 1
Dnajc9 -5.143e-01 1.678e+05 0 1
Rpl12 8.145e-01 1.663e+05 0 1
Rpl22 -1.353e+00 1.694e+05 0 1
Hspe1 1.330e+00 4.200e+05 0 1
Cks1b 1.058e-01 1.376e+05 0 1
Snrpg 1.420e-01 2.873e+05 0 1
Ppia -5.161e-01 1.577e+05 0 1
Cnbp 1.928e+00 3.159e+05 0 1
Sub1 -1.771e+00 2.784e+05 0 1
Psip1 -4.159e-01 2.388e+05 0 1
Eprs 9.878e-02 8.837e+04 0 1
Jun -2.926e-01 2.278e+05 0 1
Pgrmc1 5.101e-02 7.627e+04 0 1
Arl15 6.780e-01 7.922e+04 0 1
Dach1 1.080e+00 9.341e+04 0 1
Rps25 3.488e-01 2.584e+05 0 1
Dynll1 -6.168e-01 1.502e+05 0 1
Sem1 1.229e+00 1.703e+05 0 1
Rps28 -1.869e+00 2.408e+05 0 1
Eif3f 2.478e+00 2.076e+05 0 1
Tspan6 -2.873e-01 1.220e+05 0 1
Rpl34 1.559e+00 1.774e+05 0 1
Mrps17 -6.999e-01 7.009e+04 0 1
Atp5j -2.599e+00 1.580e+05 0 1
Higd2a -8.631e-01 8.685e+04 0 1
Ddx50 1.978e-01 6.112e+04 0 1
Phf21a 4.734e-02 1.416e+05 0 1
Baz2b 3.822e-01 1.065e+05 0 1
Elob 1.230e-01 2.714e+05 0 1
Btbd1 -1.736e+00 1.589e+05 0 1
Ubb -2.238e+00 2.281e+05 0 1
H2afz -3.049e-01 1.942e+05 0 1
Zfp609 8.505e-01 1.129e+05 0 1
Rpl35a 4.897e-01 8.416e+04 0 1
Nt5dc2 -1.427e+00 9.207e+04 0 1
mt.Nd4 -7.328e-02 3.175e+05 0 1
mt.Nd1 -1.908e+00 2.255e+05 0 1
Pcm1 5.611e-01 1.108e+05 0 1
Hes1 9.600e-01 1.061e+05 0 1
Ndufc2 -1.419e+00 2.676e+05 0 1
Pcna 4.616e-01 6.297e+04 0 1
Atp5f1 -3.844e-01 1.011e+05 0 1
Gsk3b -1.919e-01 7.113e+04 0 1
Mtch1 1.147e+00 1.202e+05 0 1
Gpatch8 4.568e-01 9.356e+04 0 1
Map1b 1.551e+00 2.419e+05 0 1
Romo1 -5.410e-01 1.238e+05 0 1
Xist -1.305e-01 1.094e+05 0 1
Fdft1 -5.520e-01 7.836e+04 0 1
Hmgcs1 -7.972e-01 8.031e+04 0 1
Eif1b -1.292e+00 1.656e+05 0 1
Sox4 3.599e-01 1.368e+05 0 1
Fxyd6 -1.258e+00 1.080e+05 0 1
Eef2 2.844e+00 3.756e+05 0 1
Tubb2b -1.250e+00 2.711e+05 0 1
Rtn1 -7.304e-01 7.360e+04 0 1
Acat1 -1.269e+00 1.311e+05 0 1
Glrx2 -1.486e-01 8.741e+04 0 1
Ndufa4 1.511e+00 2.772e+05 0 1
Cox7c 2.185e+00 1.839e+05 0 1
Scg5 -3.069e-01 1.030e+05 0 1
(Dispersion parameter for binomial family taken to be 1)
Null deviance: 3.1622e+02 on 257 degrees of freedom
Residual deviance: 5.5839e-10 on 108 degrees of freedom
AIC: 300
Number of Fisher Scoring iterations: 27# Make predictions
probabilities <- model %>% predict(test.data, type = "response")
predicted.classes <- ifelse(probabilities > 0.5, "1", "0")
# Model accuracy
accuracy <- mean(predicted.classes == test.data$COTAN_Cl.code)
result.df[nrow(result.df),"Accuracy"] <- accuracy
accuracy[1] 0.734375So also in this case a logistic regression confirm the difference in cell population detected by COTAN.
cl184ClsMarkers <- findClustersMarkers(cl184,n = 200,adjustmentMethod = "BH")
cl184ClsMarkers CL Gene DEA adjPVal IsMarker logFoldCh
1 1 Neurog2 -0.5831758 1.512459e-21 0 -1.39130757
2 1 Pttg1 -0.4033780 1.887999e-10 0 -1.43150739
3 1 Gadd45g -0.3900940 8.341062e-10 0 -1.47879552
4 1 Cenpa -0.3862799 1.224041e-09 0 -1.29099095
5 1 Ccnb2 -0.3567580 3.493105e-08 0 -1.46159235
6 1 Elavl4 -0.3468155 9.942177e-08 0 -0.75589932
7 1 Hist1h2bc -0.3466218 9.995550e-08 0 -0.86447991
8 1 Ascl1 -0.2878400 2.956244e-05 0 -1.23580955
9 1 Zc3h12c -0.2809135 5.174697e-05 0 -0.71906028
10 1 Rcor2 -0.2747659 8.379956e-05 0 -0.68126225
11 1 Bsg -0.2711846 1.124021e-04 0 -0.16704556
12 1 Chd7 -0.2689249 1.356518e-04 0 -0.45825134
13 1 Btg2 -0.2612303 2.603476e-04 0 -0.57453573
14 1 Dll1 -0.2579497 3.237474e-04 0 -1.48812048
15 1 Palld -0.2522358 4.924999e-04 0 -0.39830033
16 1 Ube2c -0.2475064 6.908938e-04 0 -0.41115299
17 1 Kdm7a -0.2447899 8.183800e-04 0 -1.03349500
18 1 Tpr -0.2430920 9.188377e-04 0 -0.23402062
19 1 Mt2 -0.2426674 9.402582e-04 0 -0.21444711
20 1 Hes6 -0.2422156 9.643956e-04 0 -0.44197418
21 1 Fgd4 -0.2419726 9.724992e-04 0 -0.50218344
22 1 Gpc4 -0.2400377 1.125518e-03 0 -0.31960198
23 1 Mir9.3hg -0.2365443 1.419164e-03 0 -0.19384147
24 1 Hist3h2ba -0.2311223 1.997610e-03 0 -0.34933545
25 1 Cenpe -0.2300613 2.152345e-03 0 -1.45377818
26 1 H1f0 -0.2288964 2.330474e-03 0 -0.30932670
27 1 Knstrn -0.2281237 2.450699e-03 0 -0.68360700
28 1 Atad2b -0.2266648 2.645925e-03 0 -0.42532807
29 1 Igfbpl1 -0.2250937 2.926312e-03 0 -0.50257889
30 1 Jam3 -0.2203988 3.798475e-03 0 -0.41024029
31 1 Slc25a27 -0.2169349 4.818073e-03 0 -0.42497684
32 1 Smim13 -0.2139037 5.765298e-03 0 -0.60289476
33 1 Gng2 -0.2137225 5.810446e-03 0 -0.46536664
34 1 Kdm5b -0.2121057 6.422646e-03 0 -0.36398690
35 1 Cdca3 -0.2100974 7.207400e-03 0 -0.68499462
36 1 Gja1 -0.2085117 7.958071e-03 0 -0.64915425
37 1 Usp3 -0.2070993 8.523113e-03 0 -0.31011816
38 1 Insm1 -0.2063698 8.944107e-03 0 -0.80644302
39 1 Rnf146 -0.2019032 1.166266e-02 0 -0.49655832
40 1 Prag1 -0.1999976 1.308082e-02 0 -0.53173283
41 1 Dmrta2 -0.1968723 1.539823e-02 0 -0.28567311
42 1 Eci2 -0.1959389 1.625165e-02 0 -0.16442599
43 1 mt.Nd2 -0.1957754 1.633172e-02 0 -0.22039650
44 1 Rhbdl3 -0.1944022 1.748583e-02 0 -0.25720862
45 1 Ssr2 -0.1936495 1.811995e-02 0 -0.23702265
46 1 Ccnb1 -0.1931041 1.868251e-02 0 -0.80824955
47 1 Nfix -0.1921514 1.954910e-02 0 -0.17028655
48 1 Ppp1cb -0.1918527 1.983731e-02 0 -0.27439314
49 1 Rnf5 -0.1918121 1.983731e-02 0 -0.27232424
50 1 Eomes -0.1913548 2.033188e-02 0 -1.50008613
51 1 Laptm4a -0.1897758 2.218633e-02 0 -0.17299330
52 1 Gdpd1 -0.1887891 2.340841e-02 0 -0.23825994
53 1 Timp2 -0.1885776 2.366913e-02 0 -0.31062215
54 1 Tmem59 -0.1880719 2.426355e-02 0 -0.27392623
55 1 Cenpf -0.1864043 2.619452e-02 0 -0.41650568
56 1 Tmem127 -0.1862853 2.619452e-02 0 -0.68982733
57 1 Arxes2 -0.1862756 2.619452e-02 0 -0.68939246
58 1 Lzts1 -0.1859740 2.664017e-02 0 -1.50408762
59 1 Jmjd6 -0.1853850 2.745645e-02 0 -0.30428514
60 1 Bckdha -0.1840007 2.910257e-02 0 -0.51569540
61 1 Slit2 -0.1830365 3.058326e-02 0 -0.70007048
62 1 Ddit4 -0.1830365 3.058326e-02 0 -0.23056730
63 1 Siah3 -0.1829564 3.058326e-02 0 -0.50950870
64 1 Asna1 -0.1828479 3.059255e-02 0 -0.24053934
65 1 Akap8l -0.1822234 3.140759e-02 0 -0.43417761
66 1 Os9 -0.1814048 3.229840e-02 0 -0.40610196
67 1 Odc1 -0.1814037 3.229840e-02 0 -0.94708523
68 1 Selenos -0.1799813 3.427183e-02 0 -0.19306172
69 1 Aamdc -0.1798102 3.448342e-02 0 -0.40172927
70 1 Agpat4 -0.1798102 3.448342e-02 0 -0.37770129
71 1 Nop53 -0.1796210 3.473608e-02 0 -0.23849178
72 1 Emc6 -0.1794437 3.496512e-02 0 -0.18767018
73 1 Mfng -0.1783335 3.681725e-02 0 -0.54482185
74 1 Zfp637 -0.1783185 3.681725e-02 0 -0.19956155
75 1 Fam168b -0.1779520 3.735993e-02 0 -0.22485811
76 1 AC154683.1 -0.1774342 3.837054e-02 0 -1.49632113
77 1 Bptf -0.1771338 3.872229e-02 0 -0.34544312
78 1 Jtb -0.1763457 4.028975e-02 0 -0.19863647
79 1 Psrc1 -0.1760624 4.091123e-02 0 -0.93641309
80 1 Ttc23 -0.1749525 4.342427e-02 0 -0.42880194
81 1 Reps1 -0.1746468 4.405682e-02 0 -1.20006014
82 1 Top1 -0.1745413 4.415475e-02 0 -0.23557563
83 1 Psd3 -0.1742261 4.487590e-02 0 -1.13958202
84 1 Cltc -0.1737510 4.566116e-02 0 -0.68818990
85 1 Ktn1 -0.1733267 4.666085e-02 0 -0.22152324
86 1 Wdr12 -0.1732132 4.688660e-02 0 -0.34963288
87 1 Pabpc1 -0.1729215 4.752748e-02 0 -0.16464519
88 1 X2610001J05Rik -0.1728352 4.767874e-02 0 -0.17472798
89 1 Lhx2 -0.1726654 4.797466e-02 0 -0.28162939
90 1 Foxp2 -0.1725622 4.817668e-02 0 -0.25513168
91 1 Srrm4 -0.1720733 4.928654e-02 0 -1.03877312
92 1 Eml5 -0.1718230 4.966763e-02 0 -0.32448358
93 1 Sh3rf1 -0.1714391 5.054485e-02 0 -0.39969855
94 1 Slc16a14 -0.1714257 5.054485e-02 0 -0.72548528
95 1 Rb1cc1 -0.1713383 5.062964e-02 0 -0.42499406
96 1 Lockd -0.1710020 5.145818e-02 0 -0.36446249
97 1 Txnrd1 -0.1707097 5.216199e-02 0 -0.21117500
98 1 Pfdn2 -0.1705995 5.224874e-02 0 -0.08400791
99 1 Rps27rt -0.1696927 5.489125e-02 0 -0.19354428
100 1 Mbd5 -0.1695000 5.520461e-02 0 -0.48897472
101 1 Itgb1 -0.1694991 5.520461e-02 0 -0.19584190
102 1 Ccnl2 -0.1692367 5.521501e-02 0 -0.09177134
103 1 Rmst -0.1682253 5.796607e-02 0 -1.27032788
104 1 Hnrnpa1 -0.1681509 5.811180e-02 0 -0.14576877
105 1 Ccdc12 -0.1677864 5.915468e-02 0 -0.16906794
106 1 Zfp157 -0.1673683 5.995028e-02 0 -0.52026271
107 1 Trip12 -0.1673291 5.995028e-02 0 -0.34943156
108 1 Laptm4b -0.1672823 5.995028e-02 0 -0.33170170
109 1 Akirin2 -0.1670714 6.045082e-02 0 -0.40527418
110 1 Tshr -0.1669968 6.055351e-02 0 -0.55592360
111 1 Eif2a -0.1667767 6.105751e-02 0 -0.20248082
112 1 Bfar -0.1663525 6.191719e-02 0 -0.36167688
113 1 Ap3s1 -0.1663194 6.192523e-02 0 -0.33114029
114 1 Dph1 -0.1659315 6.278121e-02 0 -1.48371426
115 1 Cfap36 -0.1658042 6.291256e-02 0 -0.27506880
116 1 Gpx8 -0.1647999 6.535431e-02 0 -0.32579681
117 1 Hif1a -0.1640060 6.789374e-02 0 -0.48187187
118 1 Aasdhppt -0.1636473 6.825505e-02 0 -0.28623795
119 1 Draxin -0.1634910 6.834541e-02 0 -0.42253273
120 1 Tmem33 -0.1634841 6.834541e-02 0 -0.23757017
121 1 H13 -0.1626389 7.044856e-02 0 -0.32771944
122 1 Fpgs -0.1621770 7.198537e-02 0 -0.74272924
123 1 Mdga1 -0.1610644 7.450494e-02 0 -1.10884549
124 1 Kdm6b -0.1609352 7.469519e-02 0 -0.46530168
125 1 Bach2 -0.1606601 7.572134e-02 0 -0.29476183
126 1 Ankrd37 -0.1606398 7.572134e-02 0 -0.56885622
127 1 Lig3 -0.1604600 7.620548e-02 0 -0.57277632
128 1 Lrp4 -0.1602753 7.633588e-02 0 -0.54255835
129 1 Ccz1 -0.1600856 7.704235e-02 0 -0.13292645
130 1 Slc2a13 -0.1599703 7.742686e-02 0 -0.50855381
131 1 Ptms -0.1597050 7.830579e-02 0 -0.29259682
132 1 Rab7 -0.1592093 7.995981e-02 0 -0.12293605
133 1 Lrrc51 -0.1589161 8.104420e-02 0 -1.47316169
134 1 Tnfrsf19 -0.1588692 8.113333e-02 0 -0.45311955
135 1 Serinc1 -0.1587851 8.126099e-02 0 -0.21441979
136 1 X1110004F10Rik -0.1587595 8.126099e-02 0 -0.10430969
137 1 Klhl24 -0.1586593 8.126226e-02 0 -0.38142234
138 1 Snrpa -0.1585852 8.131399e-02 0 -0.17180810
139 1 Tmed4 -0.1585087 8.141722e-02 0 -0.28734854
140 1 Syne2 -0.1581768 8.237897e-02 0 -0.23440549
141 1 Kcnrg -0.1578483 8.335872e-02 0 -1.49462152
142 1 Rnd2 -0.1578483 8.335872e-02 0 -1.48697089
143 1 Hmgn5 -0.1570710 8.645971e-02 0 -0.24680033
144 1 Mia2 -0.1568528 8.735149e-02 0 -0.26692785
145 1 Kif21a -0.1567768 8.759292e-02 0 -0.11360722
146 1 Cct2 -0.1566584 8.765398e-02 0 -0.13234402
147 1 Eef2k -0.1564831 8.812519e-02 0 -0.57994616
148 1 Ppm1b -0.1562277 8.912649e-02 0 -0.31158233
149 1 Cacnb4 -0.1560213 8.965318e-02 0 -0.59596871
150 1 Mex3a -0.1557274 9.097391e-02 0 -0.24904478
151 1 Paip2 -0.1554416 9.202663e-02 0 -0.13123212
152 1 Lsg1 -0.1553886 9.216399e-02 0 -0.24220200
153 1 Arhgef2 -0.1553111 9.236420e-02 0 -0.52227443
154 1 Hyal2 -0.1552934 9.236420e-02 0 -0.28606082
155 1 Samd8 -0.1552303 9.244166e-02 0 -1.04246472
156 1 Slc18b1 -0.1549973 9.350691e-02 0 -0.89119608
157 1 Clcn3 -0.1546560 9.501403e-02 0 -0.27388620
158 1 Igfbp2 -0.1545482 9.528203e-02 0 -0.17183487
159 1 Rps25 -0.1540559 9.709776e-02 0 -0.08285596
160 1 Tubb3 -0.1539727 9.730002e-02 0 -0.28710293
161 1 Trrap -0.1539668 9.730002e-02 0 -0.69086779
162 1 Rbm28 -0.1535993 9.900455e-02 0 -0.17512792
163 1 Igf1r -0.1532320 1.001737e-01 0 -0.18565244
164 1 Acsl4 -0.1524926 1.032971e-01 0 -1.47648044
165 1 Tmem178 -0.1522797 1.043592e-01 0 -0.42984756
166 1 Ndufa6 -0.1518572 1.062009e-01 0 -0.13794099
167 1 Alpk1 -0.1508881 1.105650e-01 0 -0.77110477
168 1 Wapl -0.1507023 1.113799e-01 0 -0.37155075
169 1 Usp22 -0.1503368 1.134450e-01 0 -0.33912281
170 1 Dnttip2 -0.1503071 1.134738e-01 0 -0.20322647
171 1 Lrp8 -0.1499898 1.146573e-01 0 -0.53557896
172 1 Masp1 -0.1497247 1.160696e-01 0 -0.32132151
173 1 Hilpda -0.1494661 1.160696e-01 0 -0.40070065
174 1 Rnf41 -0.1494661 1.160696e-01 0 -0.23944894
175 1 Pias1 -0.1493413 1.163868e-01 0 -0.28687435
176 1 Jakmip2 -0.1490263 1.179033e-01 0 -0.45703951
177 1 Crebbp -0.1483156 1.214410e-01 0 -0.21721242
178 1 Gm15545 -0.1476550 1.242196e-01 0 -1.49398047
179 1 Mboat2 -0.1476355 1.242196e-01 0 -0.24453534
180 1 Nle1 -0.1472637 1.260498e-01 0 -0.29531402
181 1 Mbtd1 -0.1470653 1.265774e-01 0 -0.22167452
182 1 Tmem35a -0.1469851 1.266466e-01 0 -1.50611416
183 1 Cebpz -0.1469835 1.266466e-01 0 -0.17629012
184 1 Emx1 -0.1468535 1.271638e-01 0 -0.20501463
185 1 Tsr3 -0.1467125 1.273525e-01 0 -0.28468483
186 1 Fezf2 -0.1462894 1.284581e-01 0 -0.25237380
187 1 Col4a3bp -0.1462746 1.284581e-01 0 -0.53977782
188 1 Ypel2 -0.1460369 1.293375e-01 0 -0.59908155
189 1 Zdhhc9 -0.1460369 1.293375e-01 0 -0.82703245
190 1 BC049730 -0.1458864 1.293375e-01 0 -0.86594762
191 1 Slc15a4 -0.1458146 1.293375e-01 0 -0.81315673
192 1 Mtus1 -0.1457745 1.293375e-01 0 -0.46501331
193 1 Slc30a6 -0.1457424 1.293375e-01 0 -0.46955821
194 1 mt.Nd5 -0.1455962 1.298816e-01 0 -0.26450106
195 1 Cdc40 -0.1455164 1.302707e-01 0 -0.28549454
196 1 Morf4l2 -0.1453907 1.306626e-01 0 -0.11739701
197 1 Slc35e2 -0.1452965 1.310604e-01 0 -0.79268238
198 1 Tmed9 -0.1452780 1.310604e-01 0 -0.06663226
199 1 Fbxo11 -0.1452515 1.310604e-01 0 -0.49404543
200 1 Ftl1.ps1 -0.1450887 1.319597e-01 0 -0.32582298
201 1 Tk1 0.5481229 4.762447e-19 0 1.23101921
202 1 Ung 0.5184538 5.470494e-17 0 0.79295818
203 1 Hells 0.5052264 3.338213e-16 0 0.67681838
204 1 Rrm2 0.5045323 3.338213e-16 0 0.90657877
205 1 Lig1 0.4999158 5.921905e-16 0 0.89100637
206 1 Prim1 0.4947631 1.170238e-15 0 0.66506406
207 1 Mcm3 0.4924806 1.478449e-15 0 0.72979998
208 1 Dscc1 0.4904379 1.823075e-15 0 1.75567703
209 1 Dhfr 0.4855447 3.574481e-15 0 0.85281521
210 1 Ccne2 0.4813898 6.257065e-15 0 1.50581190
211 1 Rmi2 0.4764947 1.232433e-14 0 1.21147155
212 1 Cdt1 0.4716972 2.389760e-14 0 0.87079957
213 1 Gmnn 0.4705496 2.647318e-14 0 0.79120719
214 1 E2f1 0.4691825 3.047224e-14 0 0.77782890
215 1 Mcm5 0.4661990 4.505093e-14 0 0.73973513
216 1 Exo1 0.4629547 6.935804e-14 0 1.31188184
217 1 Gins2 0.4586114 1.259294e-13 0 0.74222428
218 1 Pkmyt1 0.4525524 2.939510e-13 0 1.76480458
219 1 Rpa2 0.4483145 5.210920e-13 0 0.75795432
220 1 Chaf1b 0.4330415 4.482742e-12 0 0.83861798
221 1 Smc2 0.4298745 6.691337e-12 0 0.65332490
222 1 Mcm6 0.4255158 1.164964e-11 0 0.53880518
223 1 Rfc3 0.4252908 1.164964e-11 0 0.67977204
224 1 Fen1 0.4241740 1.306249e-11 0 0.79956735
225 1 Cdc6 0.4147952 4.555751e-11 0 1.30725721
226 1 Tipin 0.4128253 5.730175e-11 0 0.55333545
227 1 Rfc4 0.4055504 1.465941e-10 0 0.56606644
228 1 Orc6 0.4031162 1.889336e-10 0 0.51696150
229 1 Atad2 0.4027014 1.931419e-10 0 0.82256923
230 1 Rad51 0.4015230 2.185635e-10 0 1.05155473
231 1 Sorcs1 0.3998672 2.634664e-10 0 0.71056991
232 1 Cdc45 0.3994626 2.696508e-10 0 1.38985555
233 1 Pcna 0.3958584 4.192105e-10 0 0.62245412
234 1 Prim2 0.3926569 6.167546e-10 0 0.76923210
235 1 Gins1 0.3889994 9.068043e-10 0 0.75790737
236 1 Tyms 0.3889452 9.068043e-10 0 0.63069038
237 1 Rfc2 0.3888308 9.068043e-10 0 0.48689426
238 1 Pold1 0.3840099 1.592402e-09 0 0.85763653
239 1 Brca1 0.3809564 2.282924e-09 0 1.53371887
240 1 Nrm 0.3746952 4.855518e-09 0 0.71752912
241 1 Uhrf1 0.3741092 5.102867e-09 0 0.71774577
242 1 Tcf19 0.3726651 5.960484e-09 0 1.09393659
243 1 Clspn 0.3708249 7.305879e-09 0 1.21161664
244 1 Mcm4 0.3705882 7.363143e-09 0 0.69221047
245 1 Rad51ap1 0.3664869 1.183208e-08 0 1.51093976
246 1 Fignl1 0.3663395 1.183208e-08 0 0.78739338
247 1 Tubb2a 0.3584901 2.959921e-08 0 0.58301867
248 1 Rfc5 0.3580495 3.057987e-08 0 0.65123397
249 1 Dnmt1 0.3534086 5.073745e-08 0 0.64921891
250 1 Mms22l 0.3523348 5.644314e-08 0 0.47476249
251 1 Blm 0.3513156 6.239238e-08 0 1.09753554
252 1 Cadm2 0.3494327 7.619531e-08 0 0.43100882
253 1 Kbtbd11 0.3475093 9.340953e-08 0 0.53870228
254 1 Asf1b 0.3456599 1.097336e-07 0 1.12574407
255 1 Gins3 0.3437180 1.346525e-07 0 1.43953193
256 1 Dtl 0.3420028 1.609066e-07 0 0.63666799
257 1 Lrr1 0.3410244 1.768658e-07 0 1.34776091
258 1 Plk4 0.3375183 2.579469e-07 0 1.27616216
259 1 Cenph 0.3368739 2.729450e-07 0 0.72695469
260 1 Fbxo5 0.3365915 2.774533e-07 0 1.06334486
261 1 Ccne1 0.3364004 2.792425e-07 0 0.82221801
262 1 Grik1 0.3344476 3.417014e-07 0 0.72816303
263 1 Alad 0.3327220 4.074095e-07 0 0.48414721
264 1 Eepd1 0.3274962 7.106262e-07 0 0.77762316
265 1 Pole 0.3222971 1.225679e-06 0 1.03798408
266 1 Mcm2 0.3201911 1.512491e-06 0 0.37595352
267 1 Kntc1 0.3185664 1.771901e-06 0 1.10636461
268 1 Pold3 0.3184197 1.775550e-06 0 0.56141552
269 1 Pclaf 0.3180722 1.815112e-06 0 0.64644078
270 1 Csmd1 0.3179611 1.815112e-06 0 0.51261398
271 1 Dnajc9 0.3161577 2.165687e-06 0 0.43077793
272 1 Sdf2l1 0.3111449 3.575833e-06 0 0.55112559
273 1 Cenps 0.3110926 3.575833e-06 0 0.56140907
274 1 Rnaseh2a 0.3106096 3.712066e-06 0 0.43128750
275 1 Rad54l 0.3088625 4.388036e-06 0 0.90032432
276 1 Mastl 0.3086734 4.420005e-06 0 1.78749970
277 1 Rrm1 0.3076512 4.848783e-06 0 0.48997891
278 1 Cdk1 0.3053396 6.062574e-06 0 0.42998209
279 1 Tedc1 0.3015961 8.739604e-06 0 1.57988859
280 1 Polq 0.3005893 9.554950e-06 0 1.79941491
281 1 Syce2 0.2998356 1.018436e-05 0 0.57870336
282 1 Fanca 0.2995940 1.020068e-05 0 1.76252131
283 1 Mcm10 0.2995940 1.020068e-05 0 1.77431964
284 1 Cenpk 0.2970192 1.302457e-05 0 0.92684790
285 1 Atad5 0.2960161 1.422295e-05 0 0.66497600
286 1 Hspa5 0.2957557 1.443540e-05 0 0.34857351
287 1 Donson 0.2942344 1.658229e-05 0 0.70953315
288 1 Topbp1 0.2931980 1.815752e-05 0 0.56767034
289 1 Mcm7 0.2908473 2.258309e-05 0 0.47125498
290 1 Prc1 0.2885362 2.793528e-05 0 0.87174887
291 1 Mis18a 0.2874469 3.038777e-05 0 0.71322525
292 1 Cenpu 0.2864857 3.250784e-05 0 0.90962079
293 1 Pola2 0.2864550 3.250784e-05 0 0.57334202
294 1 Aunip 0.2864298 3.250784e-05 0 1.76517410
295 1 Mthfd2 0.2850154 3.650680e-05 0 0.54048861
296 1 Etv4 0.2850083 3.650680e-05 0 1.75903148
297 1 Mcm8 0.2831852 4.297835e-05 0 0.78050949
298 1 Top2a 0.2829825 4.339581e-05 0 0.82979097
299 1 Fxyd6 0.2813744 5.001967e-05 0 0.40426670
300 1 Nav2 0.2797307 5.727431e-05 0 0.66779549
301 1 Wdr76 0.2786202 6.294447e-05 0 0.71742684
302 1 Pgp 0.2772259 7.099889e-05 0 0.41317974
303 1 Alcam 0.2766013 7.455105e-05 0 0.39154940
304 1 Rad18 0.2764652 7.482670e-05 0 1.07430737
305 1 Eme1 0.2757315 7.936558e-05 0 0.95504349
306 1 Psmc3ip 0.2755943 7.959986e-05 0 0.45749056
307 1 Timeless 0.2754980 7.959986e-05 0 0.54988161
308 1 Wwox 0.2754176 7.959986e-05 0 0.32227988
309 1 Hspa14 0.2727729 9.972895e-05 0 0.40857579
310 1 Fam111a 0.2725486 1.001077e-04 0 1.76316774
311 1 Cenpi 0.2725486 1.001077e-04 0 1.83787774
312 1 Ticrr 0.2709664 1.137171e-04 0 1.09466338
313 1 Cltb 0.2659193 1.761443e-04 0 0.47464273
314 1 Vrk1 0.2657271 1.777642e-04 0 0.39919978
315 1 Esco2 0.2616524 2.528592e-04 0 1.13610777
316 1 Prkab1 0.2609828 2.639917e-04 0 0.69817315
317 1 Cenpn 0.2606012 2.708575e-04 0 0.60515605
318 1 Haus6 0.2601831 2.787937e-04 0 0.67359863
319 1 Gna14 0.2592081 2.989626e-04 0 1.24822818
320 1 Brip1 0.2592081 2.989626e-04 0 1.16674243
321 1 Nup93 0.2587342 3.092151e-04 0 0.53491483
322 1 Fam181b 0.2580633 3.230401e-04 0 0.35332726
323 1 Shisa9 0.2580595 3.230401e-04 0 1.73879040
324 1 Tex30 0.2578102 3.253080e-04 0 0.51878228
325 1 Rfc1 0.2562919 3.680646e-04 0 0.31382899
326 1 Ccnd1 0.2562135 3.680646e-04 0 0.49886167
327 1 Manf 0.2558539 3.769365e-04 0 0.30846644
328 1 Nsd2 0.2551691 3.960768e-04 0 0.36592805
329 1 Rgcc 0.2551131 3.960768e-04 0 0.35209128
330 1 Siva1 0.2545418 4.130557e-04 0 0.30396703
331 1 Lsm2 0.2532311 4.587805e-04 0 0.27714384
332 1 Nsl1 0.2524604 4.865060e-04 0 0.73228120
333 1 Tnfaip8 0.2515013 5.205927e-04 0 0.53773780
334 1 Tubb4b 0.2500445 5.847639e-04 0 0.32728177
335 1 St8sia1 0.2494842 6.088915e-04 0 0.74123396
336 1 Mtbp 0.2489993 6.299863e-04 0 0.74784551
337 1 Gins4 0.2486660 6.435753e-04 0 0.35407544
338 1 Hat1 0.2482886 6.567606e-04 0 0.39901499
339 1 Cand2 0.2482675 6.567606e-04 0 0.84060034
340 1 Dut 0.2480137 6.665157e-04 0 0.37622944
341 1 Tmem201 0.2472057 7.039173e-04 0 0.67399836
342 1 Rbbp7 0.2469684 7.134225e-04 0 0.25999405
343 1 Zscan22 0.2462672 7.503276e-04 0 0.86018446
344 1 Xbp1 0.2462103 7.503276e-04 0 0.49134064
345 1 Ywhah 0.2461228 7.510983e-04 0 0.32825814
346 1 Haus4 0.2458835 7.598680e-04 0 0.53385523
347 1 Usp51 0.2458340 7.598680e-04 0 1.19671799
348 1 Mrps26 0.2448680 8.180747e-04 0 0.40447865
349 1 Cyr61 0.2441632 8.543449e-04 0 0.17814705
350 1 Nrg1 0.2441222 8.543449e-04 0 0.27984683
351 1 Dek 0.2435911 8.871954e-04 0 0.34892341
352 1 Fstl5 0.2427873 9.365412e-04 0 0.33185528
353 1 Kif24 0.2424962 9.479911e-04 0 1.15680175
354 1 Nrg3 0.2421038 9.676553e-04 0 0.45766554
355 1 Flywch2 0.2411600 1.033238e-03 0 0.58361314
356 1 Chek1 0.2391718 1.200473e-03 0 0.91292776
357 1 Trim37 0.2379107 1.321544e-03 0 0.28132708
358 1 Chaf1a 0.2376088 1.346492e-03 0 0.68231148
359 1 Pdzph1 0.2374147 1.360093e-03 0 0.57366634
360 1 Haus8 0.2370510 1.392666e-03 0 0.49203394
361 1 Hmbs 0.2369100 1.400802e-03 0 0.45776455
362 1 Pcna.ps2 0.2367286 1.409097e-03 0 0.85437301
363 1 Etaa1 0.2367006 1.409097e-03 0 0.36956284
364 1 Tmem121 0.2362380 1.446582e-03 0 0.47909447
365 1 Cdca2 0.2359494 1.472437e-03 0 1.34225876
366 1 Irf2bpl 0.2356720 1.497428e-03 0 0.36188008
367 1 Pde4b 0.2349984 1.571644e-03 0 0.45709381
368 1 Mlf1 0.2346168 1.594202e-03 0 1.29851946
369 1 Mis18bp1 0.2346168 1.594202e-03 0 1.21482781
370 1 Spag5 0.2346168 1.594202e-03 0 1.34384480
371 1 Zmym1 0.2345570 1.594202e-03 0 0.89458503
372 1 Shmt1 0.2344105 1.600521e-03 0 0.52870919
373 1 Tssc4 0.2343779 1.600521e-03 0 0.32770961
374 1 Rhoc 0.2342239 1.611970e-03 0 0.36469101
375 1 Cdca7 0.2338301 1.654677e-03 0 0.28447965
376 1 Tfdp1 0.2335707 1.680510e-03 0 0.39952713
377 1 Ncapg2 0.2327668 1.778155e-03 0 1.11538303
378 1 Pradc1 0.2327289 1.778155e-03 0 0.53613567
379 1 Slbp 0.2314104 1.962668e-03 0 0.51848583
380 1 Hmga2 0.2300276 2.152345e-03 0 0.65705685
381 1 Bard1 0.2299802 2.152345e-03 0 1.76615471
382 1 Phlda1 0.2283316 2.423158e-03 0 0.55121094
383 1 E2f6 0.2280089 2.457285e-03 0 0.59038008
384 1 Cdk2 0.2279660 2.457285e-03 0 0.52067649
385 1 Tnc 0.2276578 2.504683e-03 0 0.56151444
386 1 Cks1b 0.2274528 2.532731e-03 0 0.27702256
387 1 Glrb 0.2272253 2.565546e-03 0 0.52831459
388 1 Trmt2a 0.2268055 2.637598e-03 0 0.46322401
389 1 Hjurp 0.2266443 2.645925e-03 0 0.74464188
390 1 Ect2 0.2257246 2.826640e-03 0 0.71038020
391 1 Sall3 0.2255011 2.862344e-03 0 0.28170195
392 1 Aars 0.2252039 2.914917e-03 0 0.47260875
393 1 Hmgb2 0.2249976 2.933452e-03 0 0.07133909
394 1 Htra2 0.2249440 2.933452e-03 0 0.61829587
395 1 Ube2t 0.2248532 2.940696e-03 0 0.93571480
396 1 Klhl29 0.2231737 3.316738e-03 0 0.77157230
397 1 Slf1 0.2231390 3.316738e-03 0 0.13283425
398 1 Msh6 0.2230983 3.316738e-03 0 0.49912847
399 1 Tsen15 0.2229020 3.351720e-03 0 0.23835610
400 1 Cep192 0.2226956 3.389717e-03 0 0.66700755
401 2 Tk1 -0.5481345 4.752571e-19 0 -1.23101921
402 2 Ung -0.5184663 5.458905e-17 0 -0.79295818
403 2 Hells -0.5052327 3.334608e-16 0 -0.67681838
404 2 Rrm2 -0.5045389 3.334608e-16 0 -0.90657877
405 2 Lig1 -0.4999139 5.923731e-16 0 -0.89100637
406 2 Prim1 -0.4947496 1.172798e-15 0 -0.66506406
407 2 Mcm3 -0.4924667 1.481750e-15 0 -0.72979998
408 2 Dscc1 -0.4904266 1.826358e-15 0 -1.75567703
409 2 Dhfr -0.4855568 3.567640e-15 0 -0.85281521
410 2 Ccne2 -0.4813782 6.268432e-15 0 -1.50581190
411 2 Rmi2 -0.4764904 1.233260e-14 0 -1.21147155
412 2 Cdt1 -0.4716974 2.389675e-14 0 -0.87079957
413 2 Gmnn -0.4705553 2.644993e-14 0 -0.79120719
414 2 E2f1 -0.4691944 3.041640e-14 0 -0.77782890
415 2 Mcm5 -0.4661965 4.506787e-14 0 -0.73973513
416 2 Exo1 -0.4629639 6.926220e-14 0 -1.31188184
417 2 Gins2 -0.4586213 1.257432e-13 0 -0.74222428
418 2 Pkmyt1 -0.4525684 2.932596e-13 0 -1.76480458
419 2 Rpa2 -0.4483032 5.219558e-13 0 -0.75795432
420 2 Chaf1b -0.4330365 4.485871e-12 0 -0.83861798
421 2 Smc2 -0.4298835 6.682888e-12 0 -0.65332490
422 2 Mcm6 -0.4255162 1.166768e-11 0 -0.53880518
423 2 Rfc3 -0.4252797 1.166768e-11 0 -0.67977204
424 2 Fen1 -0.4241640 1.308063e-11 0 -0.79956735
425 2 Cdc6 -0.4147942 4.556424e-11 0 -1.30725721
426 2 Tipin -0.4128119 5.740520e-11 0 -0.55333545
427 2 Rfc4 -0.4055386 1.468243e-10 0 -0.56606644
428 2 Orc6 -0.4031072 1.891601e-10 0 -0.51696150
429 2 Atad2 -0.4026975 1.932413e-10 0 -0.82256923
430 2 Rad51 -0.4015229 2.185669e-10 0 -1.05155473
431 2 Sorcs1 -0.3998704 2.633575e-10 0 -0.71056991
432 2 Cdc45 -0.3994418 2.703861e-10 0 -1.38985555
433 2 Pcna -0.3958588 4.191910e-10 0 -0.62245412
434 2 Prim2 -0.3926493 6.173534e-10 0 -0.76923210
435 2 Gins1 -0.3890007 9.079434e-10 0 -0.75790737
436 2 Tyms -0.3889389 9.079434e-10 0 -0.63069038
437 2 Rfc2 -0.3888210 9.079434e-10 0 -0.48689426
438 2 Pold1 -0.3840017 1.594052e-09 0 -0.85763653
439 2 Brca1 -0.3809559 2.283052e-09 0 -1.53371887
440 2 Nrm -0.3746927 4.857066e-09 0 -0.71752912
441 2 Uhrf1 -0.3741173 5.097731e-09 0 -0.71774577
442 2 Tcf19 -0.3726637 5.961525e-09 0 -1.09393659
443 2 Clspn -0.3708075 7.321364e-09 0 -1.21161664
444 2 Mcm4 -0.3706020 7.350728e-09 0 -0.69221047
445 2 Rad51ap1 -0.3664745 1.182065e-08 0 -1.51093976
446 2 Fignl1 -0.3663475 1.182065e-08 0 -0.78739338
447 2 Tubb2a -0.3585003 2.956364e-08 0 -0.58301867
448 2 Rfc5 -0.3580409 3.061082e-08 0 -0.65123397
449 2 Dnmt1 -0.3534185 5.067871e-08 0 -0.64921891
450 2 Mms22l -0.3523472 5.636179e-08 0 -0.47476249
451 2 Blm -0.3513021 6.248984e-08 0 -1.09753554
452 2 Cadm2 -0.3494273 7.624308e-08 0 -0.43100882
453 2 Kbtbd11 -0.3475166 9.333162e-08 0 -0.53870228
454 2 Asf1b -0.3456630 1.096947e-07 0 -1.12574407
455 2 Gins3 -0.3437142 1.347095e-07 0 -1.43953193
456 2 Dtl -0.3419938 1.610699e-07 0 -0.63666799
457 2 Lrr1 -0.3410120 1.771134e-07 0 -1.34776091
458 2 Plk4 -0.3375145 2.580565e-07 0 -1.27616216
459 2 Cenph -0.3368874 2.725359e-07 0 -0.72695469
460 2 Fbxo5 -0.3365765 2.779176e-07 0 -1.06334486
461 2 Ccne1 -0.3363932 2.794664e-07 0 -0.82221801
462 2 Grik1 -0.3344500 3.416098e-07 0 -0.72816303
463 2 Alad -0.3327345 4.068515e-07 0 -0.48414721
464 2 Eepd1 -0.3275144 7.092294e-07 0 -0.77762316
465 2 Pole -0.3223002 1.225272e-06 0 -1.03798408
466 2 Mcm2 -0.3201906 1.512578e-06 0 -0.37595352
467 2 Kntc1 -0.3185619 1.772754e-06 0 -1.10636461
468 2 Pold3 -0.3184306 1.773505e-06 0 -0.56141552
469 2 Pclaf -0.3180640 1.813334e-06 0 -0.64644078
470 2 Csmd1 -0.3179704 1.813334e-06 0 -0.51261398
471 2 Dnajc9 -0.3161624 2.164628e-06 0 -0.43077793
472 2 Sdf2l1 -0.3111584 3.574428e-06 0 -0.55112559
473 2 Cenps -0.3110964 3.574428e-06 0 -0.56140907
474 2 Rnaseh2a -0.3106038 3.714273e-06 0 -0.43128750
475 2 Rad54l -0.3088671 4.385964e-06 0 -0.90032432
476 2 Mastl -0.3086693 4.421875e-06 0 -1.78749970
477 2 Rrm1 -0.3076603 4.844291e-06 0 -0.48997891
478 2 Cdk1 -0.3053578 6.051432e-06 0 -0.42998209
479 2 Tedc1 -0.3016261 8.713351e-06 0 -1.57988859
480 2 Polq -0.3005773 9.566400e-06 0 -1.79941491
481 2 Syce2 -0.2998414 1.017840e-05 0 -0.57870336
482 2 Fanca -0.2995808 1.021407e-05 0 -1.76252131
483 2 Mcm10 -0.2995808 1.021407e-05 0 -1.77431964
484 2 Cenpk -0.2970270 1.301446e-05 0 -0.92684790
485 2 Atad5 -0.2960144 1.422540e-05 0 -0.66497600
486 2 Hspa5 -0.2957514 1.444147e-05 0 -0.34857351
487 2 Donson -0.2942376 1.657710e-05 0 -0.70953315
488 2 Topbp1 -0.2932021 1.815025e-05 0 -0.56767034
489 2 Mcm7 -0.2908434 2.259163e-05 0 -0.47125498
490 2 Prc1 -0.2885447 2.791246e-05 0 -0.87174887
491 2 Mis18a -0.2874603 3.034868e-05 0 -0.71322525
492 2 Cenpu -0.2864638 3.255471e-05 0 -0.90962079
493 2 Pola2 -0.2864380 3.255471e-05 0 -0.57334202
494 2 Aunip -0.2864147 3.255471e-05 0 -1.76517410
495 2 Etv4 -0.2850162 3.653865e-05 0 -1.75903148
496 2 Mthfd2 -0.2849991 3.653865e-05 0 -0.54048861
497 2 Mcm8 -0.2831930 4.294694e-05 0 -0.78050949
498 2 Top2a -0.2829765 4.342063e-05 0 -0.82979097
499 2 Fxyd6 -0.2813864 4.996331e-05 0 -0.40426670
500 2 Nav2 -0.2797154 5.735616e-05 0 -0.66779549
501 2 Wdr76 -0.2786260 6.291080e-05 0 -0.71742684
502 2 Pgp -0.2772129 7.108394e-05 0 -0.41317974
503 2 Alcam -0.2765884 7.464013e-05 0 -0.39154940
504 2 Rad18 -0.2764641 7.483439e-05 0 -1.07430737
505 2 Eme1 -0.2757416 7.929175e-05 0 -0.95504349
506 2 Psmc3ip -0.2756039 7.960615e-05 0 -0.45749056
507 2 Timeless -0.2754954 7.966689e-05 0 -0.54988161
508 2 Wwox -0.2754084 7.966689e-05 0 -0.32227988
509 2 Hspa14 -0.2727748 9.971178e-05 0 -0.40857579
510 2 Fam111a -0.2725442 1.001479e-04 0 -1.76316774
511 2 Cenpi -0.2725442 1.001479e-04 0 -1.83787774
512 2 Ticrr -0.2709964 1.134080e-04 0 -1.09466338
513 2 Cltb -0.2659064 1.763467e-04 0 -0.47464273
514 2 Vrk1 -0.2657318 1.776896e-04 0 -0.39919978
515 2 Esco2 -0.2616651 2.525769e-04 0 -1.13610777
516 2 Prkab1 -0.2609871 2.638929e-04 0 -0.69817315
517 2 Cenpn -0.2606049 2.707702e-04 0 -0.60515605
518 2 Haus6 -0.2601783 2.789102e-04 0 -0.67359863
519 2 Gna14 -0.2591830 2.996177e-04 0 -1.24822818
520 2 Brip1 -0.2591830 2.996177e-04 0 -1.16674243
521 2 Nup93 -0.2587405 3.090453e-04 0 -0.53491483
522 2 Shisa9 -0.2580660 3.231057e-04 0 -1.73879040
523 2 Fam181b -0.2580571 3.231057e-04 0 -0.35332726
524 2 Tex30 -0.2578000 3.255957e-04 0 -0.51878228
525 2 Rfc1 -0.2562782 3.679706e-04 0 -0.31382899
526 2 Ccnd1 -0.2562164 3.679706e-04 0 -0.49886167
527 2 Manf -0.2558507 3.770416e-04 0 -0.30846644
528 2 Nsd2 -0.2551829 3.961463e-04 0 -0.36592805
529 2 Rgcc -0.2551111 3.961463e-04 0 -0.35209128
530 2 Siva1 -0.2545297 4.134846e-04 0 -0.30396703
531 2 Lsm2 -0.2532381 4.585073e-04 0 -0.27714384
532 2 Nsl1 -0.2524423 4.872552e-04 0 -0.73228120
533 2 Tnfaip8 -0.2515080 5.202976e-04 0 -0.53773780
534 2 Tubb4b -0.2500482 5.845826e-04 0 -0.32728177
535 2 St8sia1 -0.2494831 6.089485e-04 0 -0.74123396
536 2 Mtbp -0.2490175 6.290258e-04 0 -0.74784551
537 2 Gins4 -0.2486622 6.437783e-04 0 -0.35407544
538 2 Hat1 -0.2482794 6.567812e-04 0 -0.39901499
539 2 Cand2 -0.2482671 6.567812e-04 0 -0.84060034
540 2 Dut -0.2480184 6.662547e-04 0 -0.37622944
541 2 Tmem201 -0.2472088 7.037353e-04 0 -0.67399836
542 2 Rbbp7 -0.2469797 7.127525e-04 0 -0.25999405
543 2 Zscan22 -0.2462507 7.508874e-04 0 -0.86018446
544 2 Xbp1 -0.2462013 7.508874e-04 0 -0.49134064
545 2 Ywhah -0.2461255 7.509325e-04 0 -0.32825814
546 2 Haus4 -0.2458945 7.607330e-04 0 -0.53385523
547 2 Usp51 -0.2458027 7.618395e-04 0 -1.19671799
548 2 Mrps26 -0.2448711 8.178595e-04 0 -0.40447865
549 2 Cyr61 -0.2441738 8.535357e-04 0 -0.17814705
550 2 Nrg1 -0.2441337 8.535357e-04 0 -0.27984683
551 2 Dek -0.2435837 8.877308e-04 0 -0.34892341
552 2 Fstl5 -0.2427972 9.357863e-04 0 -0.33185528
553 2 Kif24 -0.2425030 9.474571e-04 0 -1.15680175
554 2 Nrg3 -0.2421109 9.670970e-04 0 -0.45766554
555 2 Flywch2 -0.2411415 1.034796e-03 0 -0.58361314
556 2 Chek1 -0.2391568 1.201924e-03 0 -0.91292776
557 2 Trim37 -0.2379087 1.321762e-03 0 -0.28132708
558 2 Chaf1a -0.2376221 1.345055e-03 0 -0.68231148
559 2 Pdzph1 -0.2374145 1.360119e-03 0 -0.57366634
560 2 Haus8 -0.2370465 1.393171e-03 0 -0.49203394
561 2 Hmbs -0.2368959 1.402389e-03 0 -0.45776455
562 2 Pcna.ps2 -0.2367291 1.410749e-03 0 -0.85437301
563 2 Etaa1 -0.2366860 1.410749e-03 0 -0.36956284
564 2 Tmem121 -0.2362287 1.447658e-03 0 -0.47909447
565 2 Cdca2 -0.2359450 1.472955e-03 0 -1.34225876
566 2 Irf2bpl -0.2356631 1.498498e-03 0 -0.36188008
567 2 Pde4b -0.2350038 1.570973e-03 0 -0.45709381
568 2 Mlf1 -0.2346278 1.593471e-03 0 -1.29851946
569 2 Mis18bp1 -0.2346278 1.593471e-03 0 -1.21482781
570 2 Spag5 -0.2346278 1.593471e-03 0 -1.34384480
571 2 Zmym1 -0.2345503 1.595050e-03 0 -0.89458503
572 2 Shmt1 -0.2344091 1.600590e-03 0 -0.52870919
573 2 Tssc4 -0.2343774 1.600590e-03 0 -0.32770961
574 2 Rhoc -0.2342307 1.611104e-03 0 -0.36469101
575 2 Cdca7 -0.2338417 1.653156e-03 0 -0.28447965
576 2 Tfdp1 -0.2335739 1.680076e-03 0 -0.39952713
577 2 Ncapg2 -0.2327548 1.776999e-03 0 -1.11538303
578 2 Pradc1 -0.2327371 1.776999e-03 0 -0.53613567
579 2 Slbp -0.2314011 1.964092e-03 0 -0.51848583
580 2 Hmga2 -0.2300230 2.153792e-03 0 -0.65705685
581 2 Bard1 -0.2299716 2.153792e-03 0 -1.76615471
582 2 Phlda1 -0.2283186 2.425602e-03 0 -0.55121094
583 2 E2f6 -0.2280026 2.455185e-03 0 -0.59038008
584 2 Cdk2 -0.2279771 2.455185e-03 0 -0.52067649
585 2 Tnc -0.2276397 2.508196e-03 0 -0.56151444
586 2 Cks1b -0.2274410 2.535035e-03 0 -0.27702256
587 2 Glrb -0.2272191 2.566777e-03 0 -0.52831459
588 2 Trmt2a -0.2268075 2.637197e-03 0 -0.46322401
589 2 Hjurp -0.2266469 2.645398e-03 0 -0.74464188
590 2 Ect2 -0.2257472 2.821738e-03 0 -0.71038020
591 2 Sall3 -0.2254999 2.862601e-03 0 -0.28170195
592 2 Aars -0.2252047 2.914742e-03 0 -0.47260875
593 2 Hmgb2 -0.2249984 2.933925e-03 0 -0.07133909
594 2 Htra2 -0.2249419 2.933925e-03 0 -0.61829587
595 2 Ube2t -0.2248689 2.937173e-03 0 -0.93571480
596 2 Klhl29 -0.2231829 3.320246e-03 0 -0.77157230
597 2 Slf1 -0.2231241 3.320246e-03 0 -0.13283425
598 2 Msh6 -0.2230844 3.320246e-03 0 -0.49912847
599 2 Tsen15 -0.2228915 3.354395e-03 0 -0.23835610
600 2 Cep192 -0.2227014 3.388223e-03 0 -0.66700755
601 2 Neurog2 0.5831705 1.513990e-21 0 1.39130757
602 2 Pttg1 0.4033662 1.890949e-10 0 1.43150739
603 2 Gadd45g 0.3900987 8.335976e-10 0 1.47879552
604 2 Cenpa 0.3862762 1.224608e-09 0 1.29099095
605 2 Ccnb2 0.3567634 3.490893e-08 0 1.46159235
606 2 Elavl4 0.3468110 9.947233e-08 0 0.75589932
607 2 Hist1h2bc 0.3466351 9.980272e-08 0 0.86447991
608 2 Ascl1 0.2878236 2.960890e-05 0 1.23580955
609 2 Zc3h12c 0.2809180 5.172512e-05 0 0.71906028
610 2 Rcor2 0.2747655 8.380291e-05 0 0.68126225
611 2 Bsg 0.2711735 1.125159e-04 0 0.16704556
612 2 Chd7 0.2689165 1.357545e-04 0 0.45825134
613 2 Btg2 0.2612244 2.604819e-04 0 0.57453573
614 2 Dll1 0.2579554 3.235874e-04 0 1.48812048
615 2 Palld 0.2522486 4.919641e-04 0 0.39830033
616 2 Ube2c 0.2475209 6.900588e-04 0 0.41115299
617 2 Kdm7a 0.2447976 8.178595e-04 0 1.03349500
618 2 Tpr 0.2430861 9.192848e-04 0 0.23402062
619 2 Mt2 0.2426740 9.397476e-04 0 0.21444711
620 2 Hes6 0.2422195 9.640875e-04 0 0.44197418
621 2 Fgd4 0.2419872 9.713416e-04 0 0.50218344
622 2 Gpc4 0.2400295 1.126267e-03 0 0.31960198
623 2 Mir9.3hg 0.2365568 1.417750e-03 0 0.19384147
624 2 Hist3h2ba 0.2311144 1.998848e-03 0 0.34933545
625 2 Cenpe 0.2300522 2.153792e-03 0 1.45377818
626 2 H1f0 0.2288871 2.332162e-03 0 0.30932670
627 2 Knstrn 0.2281380 2.447995e-03 0 0.68360700
628 2 Atad2b 0.2266654 2.645398e-03 0 0.42532807
629 2 Igfbpl1 0.2250901 2.927116e-03 0 0.50257889
630 2 Jam3 0.2204014 3.797733e-03 0 0.41024029
631 2 Slc25a27 0.2169481 4.813378e-03 0 0.42497684
632 2 Smim13 0.2139058 5.764408e-03 0 0.60289476
633 2 Gng2 0.2137151 5.815854e-03 0 0.46536664
634 2 Kdm5b 0.2120960 6.427188e-03 0 0.36398690
635 2 Cdca3 0.2100817 7.215511e-03 0 0.68499462
636 2 Gja1 0.2085036 7.962702e-03 0 0.64915425
637 2 Usp3 0.2070938 8.526446e-03 0 0.31011816
638 2 Insm1 0.2063884 8.932343e-03 0 0.80644302
639 2 Rnf146 0.2019070 1.165956e-02 0 0.49655832
640 2 Prag1 0.2000067 1.308501e-02 0 0.53173283
641 2 Dmrta2 0.1968664 1.540434e-02 0 0.28567311
642 2 Eci2 0.1959468 1.624300e-02 0 0.16442599
643 2 mt.Nd2 0.1957873 1.631856e-02 0 0.22039650
644 2 Rhbdl3 0.1944032 1.748468e-02 0 0.25720862
645 2 Ssr2 0.1936514 1.811766e-02 0 0.23702265
646 2 Ccnb1 0.1931207 1.866173e-02 0 0.80824955
647 2 Nfix 0.1921382 1.954309e-02 0 0.17028655
648 2 Ppp1cb 0.1918466 1.983806e-02 0 0.27439314
649 2 Rnf5 0.1918116 1.983806e-02 0 0.27232424
650 2 Eomes 0.1913350 2.035845e-02 0 1.50008613
651 2 Laptm4a 0.1897594 2.221036e-02 0 0.17299330
652 2 Gdpd1 0.1887921 2.340382e-02 0 0.23825994
653 2 Timp2 0.1885731 2.367619e-02 0 0.31062215
654 2 Tmem59 0.1880633 2.427720e-02 0 0.27392623
655 2 Cenpf 0.1864141 2.620852e-02 0 0.41650568
656 2 Tmem127 0.1862794 2.620852e-02 0 0.68982733
657 2 Arxes2 0.1862673 2.620852e-02 0 0.68939246
658 2 Lzts1 0.1859711 2.664518e-02 0 1.50408762
659 2 Jmjd6 0.1853788 2.746733e-02 0 0.30428514
660 2 Bckdha 0.1839872 2.912772e-02 0 0.51569540
661 2 Slit2 0.1830418 3.056483e-02 0 0.70007048
662 2 Ddit4 0.1830287 3.056483e-02 0 0.23056730
663 2 Siah3 0.1829428 3.056483e-02 0 0.50950870
664 2 Asna1 0.1828525 3.056483e-02 0 0.24053934
665 2 Akap8l 0.1822160 3.142236e-02 0 0.43417761
666 2 Os9 0.1814018 3.232165e-02 0 0.40610196
667 2 Odc1 0.1813924 3.232165e-02 0 0.94708523
668 2 Selenos 0.1799740 3.428738e-02 0 0.19306172
669 2 Aamdc 0.1797952 3.446034e-02 0 0.40172927
670 2 Agpat4 0.1797952 3.446034e-02 0 0.37770129
671 2 Nop53 0.1796128 3.475395e-02 0 0.23849178
672 2 Emc6 0.1794405 3.497203e-02 0 0.18767018
673 2 Zfp637 0.1783292 3.682671e-02 0 0.19956155
674 2 Mfng 0.1783260 3.682671e-02 0 0.54482185
675 2 Fam168b 0.1779487 3.736772e-02 0 0.22485811
676 2 AC154683.1 0.1774403 3.835202e-02 0 1.49632113
677 2 Bptf 0.1771458 3.874950e-02 0 0.34544312
678 2 Jtb 0.1763424 4.029795e-02 0 0.19863647
679 2 Psrc1 0.1760528 4.093552e-02 0 0.93641309
680 2 Ttc23 0.1749617 4.339970e-02 0 0.42880194
681 2 Reps1 0.1746310 4.409934e-02 0 1.20006014
682 2 Top1 0.1745432 4.414974e-02 0 0.23557563
683 2 Psd3 0.1742178 4.488840e-02 0 1.13958202
684 2 Cltc 0.1737330 4.571130e-02 0 0.68818990
685 2 Ktn1 0.1733240 4.666851e-02 0 0.22152324
686 2 Wdr12 0.1732151 4.688129e-02 0 0.34963288
687 2 Pabpc1 0.1729144 4.754789e-02 0 0.16464519
688 2 X2610001J05Rik 0.1728402 4.766428e-02 0 0.17472798
689 2 Lhx2 0.1726749 4.794708e-02 0 0.28162939
690 2 Foxp2 0.1725655 4.816722e-02 0 0.25513168
691 2 Srrm4 0.1720562 4.928818e-02 0 1.03877312
692 2 Eml5 0.1718234 4.966616e-02 0 0.32448358
693 2 Sh3rf1 0.1714332 5.051673e-02 0 0.39969855
694 2 Slc16a14 0.1714196 5.051673e-02 0 0.72548528
695 2 Rb1cc1 0.1713363 5.063565e-02 0 0.42499406
696 2 Lockd 0.1709997 5.147271e-02 0 0.36446249
697 2 Txnrd1 0.1707174 5.213788e-02 0 0.21117500
698 2 Pfdn2 0.1705926 5.225422e-02 0 0.08400791
699 2 Rps27rt 0.1696975 5.487550e-02 0 0.19354428
700 2 Mbd5 0.1695074 5.518622e-02 0 0.48897472
701 2 Itgb1 0.1695047 5.518622e-02 0 0.19584190
702 2 Ccnl2 0.1692338 5.522438e-02 0 0.09177134
703 2 Rmst 0.1682377 5.792345e-02 0 1.27032788
704 2 Hnrnpa1 0.1681490 5.811857e-02 0 0.14576877
705 2 Ccdc12 0.1677730 5.920151e-02 0 0.16906794
706 2 Zfp157 0.1673699 5.989724e-02 0 0.52026271
707 2 Trip12 0.1673163 5.989724e-02 0 0.34943156
708 2 Laptm4b 0.1672896 5.989724e-02 0 0.33170170
709 2 Akirin2 0.1670726 6.044633e-02 0 0.40527418
710 2 Tshr 0.1669986 6.056937e-02 0 0.55592360
711 2 Eif2a 0.1667874 6.101892e-02 0 0.20248082
712 2 Bfar 0.1663484 6.190643e-02 0 0.36167688
713 2 Ap3s1 0.1663118 6.190643e-02 0 0.33114029
714 2 Dph1 0.1659134 6.284806e-02 0 1.48371426
715 2 Cfap36 0.1658016 6.292215e-02 0 0.27506880
716 2 Gpx8 0.1648038 6.531965e-02 0 0.32579681
717 2 Hif1a 0.1640067 6.786081e-02 0 0.48187187
718 2 Aasdhppt 0.1636368 6.827705e-02 0 0.28623795
719 2 Draxin 0.1635003 6.834423e-02 0 0.42253273
720 2 Tmem33 0.1634844 6.834423e-02 0 0.23757017
721 2 H13 0.1626499 7.040415e-02 0 0.32771944
722 2 Fpgs 0.1621757 7.199101e-02 0 0.74272924
723 2 Mdga1 0.1610562 7.453807e-02 0 1.10884549
724 2 Kdm6b 0.1609537 7.461636e-02 0 0.46530168
725 2 Bach2 0.1606667 7.571972e-02 0 0.29476183
726 2 Ankrd37 0.1606402 7.571972e-02 0 0.56885622
727 2 Lig3 0.1604519 7.623253e-02 0 0.57277632
728 2 Lrp4 0.1602715 7.635252e-02 0 0.54255835
729 2 Ccz1 0.1600780 7.707543e-02 0 0.13292645
730 2 Slc2a13 0.1599666 7.744285e-02 0 0.50855381
731 2 Ptms 0.1596970 7.829392e-02 0 0.29259682
732 2 Rab7 0.1592068 7.997150e-02 0 0.12293605
733 2 Lrrc51 0.1589303 8.097922e-02 0 1.47316169
734 2 Tnfrsf19 0.1588611 8.117062e-02 0 0.45311955
735 2 Serinc1 0.1587842 8.122104e-02 0 0.21441979
736 2 X1110004F10Rik 0.1587624 8.122104e-02 0 0.10430969
737 2 Klhl24 0.1586645 8.122104e-02 0 0.38142234
738 2 Snrpa 0.1586010 8.124152e-02 0 0.17180810
739 2 Tmed4 0.1585172 8.137816e-02 0 0.28734854
740 2 Syne2 0.1581705 8.240131e-02 0 0.23440549
741 2 Kcnrg 0.1578183 8.349924e-02 0 1.49462152
742 2 Rnd2 0.1578183 8.349924e-02 0 1.48697089
743 2 Hmgn5 0.1570720 8.651970e-02 0 0.24680033
744 2 Mia2 0.1568596 8.731838e-02 0 0.26692785
745 2 Kif21a 0.1567786 8.758423e-02 0 0.11360722
746 2 Cct2 0.1566585 8.765486e-02 0 0.13234402
747 2 Eef2k 0.1564710 8.818496e-02 0 0.57994616
748 2 Ppm1b 0.1562393 8.906899e-02 0 0.31158233
749 2 Cacnb4 0.1560135 8.967001e-02 0 0.59596871
750 2 Mex3a 0.1557236 9.099315e-02 0 0.24904478
751 2 Paip2 0.1554324 9.207324e-02 0 0.13123212
752 2 Lsg1 0.1553801 9.220718e-02 0 0.24220200
753 2 Hyal2 0.1553093 9.233458e-02 0 0.28606082
754 2 Arhgef2 0.1553032 9.233458e-02 0 0.52227443
755 2 Samd8 0.1552314 9.243597e-02 0 1.04246472
756 2 Slc18b1 0.1549956 9.351537e-02 0 0.89119608
757 2 Clcn3 0.1546511 9.503981e-02 0 0.27388620
758 2 Igfbp2 0.1545469 9.523666e-02 0 0.17183487
759 2 Rps25 0.1540116 9.721140e-02 0 0.08285596
760 2 Trrap 0.1539845 9.721140e-02 0 0.69086779
761 2 Tubb3 0.1539833 9.721140e-02 0 0.28710293
762 2 Rbm28 0.1536014 9.899314e-02 0 0.17512792
763 2 Igf1r 0.1532369 1.001473e-01 0 0.18565244
764 2 Acsl4 0.1524843 1.033439e-01 0 1.47648044
765 2 Tmem178 0.1522769 1.043748e-01 0 0.42984756
766 2 Ndufa6 0.1518733 1.061080e-01 0 0.13794099
767 2 Alpk1 0.1508835 1.104910e-01 0 0.77110477
768 2 Wapl 0.1507020 1.113812e-01 0 0.37155075
769 2 Usp22 0.1503240 1.135232e-01 0 0.33912281
770 2 Dnttip2 0.1502964 1.135389e-01 0 0.20322647
771 2 Lrp8 0.1500065 1.145543e-01 0 0.53557896
772 2 Masp1 0.1497192 1.161822e-01 0 0.32132151
773 2 Hilpda 0.1494678 1.162472e-01 0 0.40070065
774 2 Rnf41 0.1494678 1.162472e-01 0 0.23944894
775 2 Pias1 0.1493379 1.164078e-01 0 0.28687435
776 2 Jakmip2 0.1490277 1.178946e-01 0 0.45703951
777 2 Crebbp 0.1483029 1.214373e-01 0 0.21721242
778 2 Gm15545 0.1476591 1.241770e-01 0 1.49398047
779 2 Mboat2 0.1476419 1.241770e-01 0 0.24453534
780 2 Nle1 0.1472636 1.260502e-01 0 0.29531402
781 2 Mbtd1 0.1470658 1.265740e-01 0 0.22167452
782 2 Tmem35a 0.1469877 1.266961e-01 0 1.50611416
783 2 Cebpz 0.1469761 1.266961e-01 0 0.17629012
784 2 Emx1 0.1468458 1.271813e-01 0 0.20501463
785 2 Tsr3 0.1467142 1.274341e-01 0 0.28468483
786 2 Fezf2 0.1463003 1.285268e-01 0 0.25237380
787 2 Col4a3bp 0.1462571 1.285268e-01 0 0.53977782
788 2 Ypel2 0.1460458 1.293656e-01 0 0.59908155
789 2 Zdhhc9 0.1460458 1.293656e-01 0 0.82703245
790 2 BC049730 0.1458932 1.293656e-01 0 0.86594762
791 2 Slc15a4 0.1458330 1.293656e-01 0 0.81315673
792 2 Mtus1 0.1457899 1.293656e-01 0 0.46501331
793 2 Slc30a6 0.1457487 1.293656e-01 0 0.46955821
794 2 mt.Nd5 0.1456056 1.298175e-01 0 0.26450106
795 2 Cdc40 0.1455259 1.302056e-01 0 0.28549454
796 2 Morf4l2 0.1453975 1.306164e-01 0 0.11739701
797 2 Slc35e2 0.1452838 1.310349e-01 0 0.79268238
798 2 Tmed9 0.1452656 1.310349e-01 0 0.06663226
799 2 Fbxo11 0.1452456 1.310349e-01 0 0.49404543
800 2 Ftl1.ps1 0.1450878 1.319654e-01 0 0.32582298Cluster 432 e13.5
OriginalCluster CellNumber COTANClusterNumber Accuracy
1 Cl525E15.0 826 3 0.786585365853659
2 Cl511E15.0 540 2 0.916666666666667
3 Cl184E15.0 322 2 0.734375
4 Cl432E13.5 536 2 <NA>e13.5 <- readRDS(paste0(inDir,"e13.5_ForebrainDorsal.cotan.RDS"))
cells <- getClusterizationData(e13.5,clName = "original.clusters")[[1]][getClusterizationData(e13.5,clName = "original.clusters")[[1]] == "432"]
cells <-names(cells)
cl432 <- automaticCOTANObjectCreation(raw = getRawData(e13.5)[,cells],
GEO = "Loom",
sequencingMethod = "10X",
sampleCondition = "cl432",
cores = 10,saveObj = T,
outDir = "Data/MouseCortexFromLoom/NotCTSingleClusters/",
calcCoex = T)cl432GDI <- calculateGDI(cl432)
subsetGDIcl432 <- cl432GDI[cl432GDI$sum.raw.norm > 5,]
top.GDI.genes <- rownames(subsetGDIcl432[order(subsetGDIcl432$GDI,decreasing = T),])[1:25]
GDIPlot(cl432,genes = list("topGDI"=top.GDI.genes),GDIIn = cl432GDI)
list.cl.CT <- cellsUniformClustering(cl432, GDIThreshold = 1.43, cores = 10L,
saveObj = TRUE, outDir = outDir)
cl432 <- addClusterization(cl432, clName = "split",
clusters = list.cl.CT$clusters,
coexDF = list.cl.CT$coex, override = TRUE)
table(list.cl.CT$clusters)c(mergedClusters, mergedCoexDF) %<-%
mergeUniformCellsClusters(cl432, clusters = list.cl.CT$clusters,
GDIThreshold = 1.43, batchSize = 4L, cores = 10L,
saveObj = TRUE, outDir = outDir)
cl432 <- addClusterization(cl432, clName = "merge",
clusters = mergedClusters,
coexDF = mergedCoexDF,
override = TRUE)
saveRDS(cl432,paste0(outDir,"cl432.cotan.RDS"))
table(str_split(names(mergedClusters),pattern = "_",simplify = T)[,1],mergedClusters)data <- getNormalizedData(cl432)
data <- data[!rowSums(as.matrix(data)) < 1,]
data <- log(data*10000+1)
row_stdev <- apply(data, 1, sd, na.rm=TRUE)
row_stdev <- row_stdev[order(row_stdev,decreasing = T)]
genes.to.keep <- c(names(row_stdev[1:100]),top.GDI.genes)
data.small <- data[rownames(data) %in% genes.to.keep,]
#data <- t(as.matrix(data))
data.small <- t(as.matrix(data.small))
COTAN_Cl.code <- getClusterizationData(cl432)[[1]]
#COTAN_Cl.code[COTAN_Cl.code == "A549"] <- 0
#COTAN_Cl.code[COTAN_Cl.code == "CCL-185-IG"] <- 1
COTAN_Cl.code <- as.numeric(COTAN_Cl.code)-1
data.small <- cbind(data.small,COTAN_Cl.code)
data.small <- as.data.frame(data.small)
# Split the data into training and test set
set.seed(123)
training.samples <- data.small[,"COTAN_Cl.code"] %>%
createDataPartition(p = 0.8, list = FALSE)
train.data <- data.small[training.samples, ]
test.data <- data.small[-training.samples, ]
head(train.data) Slc8a1 Csrp2 Rpl22l1 Sec61g Pgk1
10X14_4_A_1:AAGAACGAGGTAAAx 0.000000 0.000000 10.423023 0.000000 0.000000
10X12_3_A_1:CAAGCATGAATCGCx 9.076224 9.076224 0.000000 0.000000 0.000000
10X12_3_A_1:GTGATCGACCAATGx 0.000000 9.411567 0.000000 9.411567 9.411567
10X12_3_A_1:CTGGATGAACAGCTx 0.000000 0.000000 0.000000 0.000000 10.748672
10X14_4_A_1:ATTCAAGATCCCACx 0.000000 0.000000 0.000000 0.000000 0.000000
10X12_3_A_1:CGATCCACCCGAATx 0.000000 9.132491 9.132491 9.132491 9.132491
Gm10076 Rpl36al Mfap4 Ier2 Ptprk
10X14_4_A_1:AAGAACGAGGTAAAx 9.729905 0.00000 9.729905 9.729905 10.423023
10X12_3_A_1:CAAGCATGAATCGCx 9.769314 0.00000 9.076224 0.000000 9.076224
10X12_3_A_1:GTGATCGACCAATGx 10.510124 0.00000 0.000000 0.000000 10.104673
10X12_3_A_1:CTGGATGAACAGCTx 10.343218 0.00000 9.650103 0.000000 9.650103
10X14_4_A_1:ATTCAAGATCCCACx 0.000000 0.00000 9.866303 9.866303 10.271751
10X12_3_A_1:CGATCCACCCGAATx 10.518705 10.23103 0.000000 0.000000 0.000000
Cadps Uba52 Pantr1 Mir9.3hg Tmem108
10X14_4_A_1:AAGAACGAGGTAAAx 9.729905 0.00000 11.521615 0.000000 10.423023
10X12_3_A_1:CAAGCATGAATCGCx 9.076224 10.68557 9.076224 0.000000 10.685571
10X12_3_A_1:GTGATCGACCAATGx 0.000000 11.60872 0.000000 9.411567 0.000000
10X12_3_A_1:CTGGATGAACAGCTx 0.000000 11.59596 10.748672 9.650103 0.000000
10X14_4_A_1:ATTCAAGATCCCACx 10.559424 0.00000 9.173208 9.866303 9.866303
10X12_3_A_1:CGATCCACCCGAATx 9.132491 11.21184 0.000000 0.000000 9.825584
Klhl29 Dusp14 Adgrb3 Alcam Nell2
10X14_4_A_1:AAGAACGAGGTAAAx 0.000000 9.729905 0.000000 0.000000 0.000000
10X12_3_A_1:CAAGCATGAATCGCx 9.076224 0.000000 9.076224 9.769314 9.769314
10X12_3_A_1:GTGATCGACCAATGx 10.104673 9.411567 0.000000 0.000000 9.411567
10X12_3_A_1:CTGGATGAACAGCTx 0.000000 0.000000 0.000000 0.000000 0.000000
10X14_4_A_1:ATTCAAGATCCCACx 9.866303 10.271751 9.173208 9.866303 9.866303
10X12_3_A_1:CGATCCACCCGAATx 0.000000 9.825584 9.132491 9.825584 0.000000
Fabp7 Ptn Rasgef1b Nckap5 Nfasc
10X14_4_A_1:AAGAACGAGGTAAAx 0.000000 10.423023 0.000000 0.000000 9.729905
10X12_3_A_1:CAAGCATGAATCGCx 0.000000 0.000000 0.000000 0.000000 9.769314
10X12_3_A_1:GTGATCGACCAATGx 10.104673 9.411567 10.104673 0.000000 0.000000
10X12_3_A_1:CTGGATGAACAGCTx 0.000000 9.650103 0.000000 10.343218 9.650103
10X14_4_A_1:ATTCAAGATCCCACx 0.000000 0.000000 0.000000 0.000000 9.866303
10X12_3_A_1:CGATCCACCCGAATx 9.132491 0.000000 9.132491 9.825584 0.000000
Frmd4a Nkain2 Tcf12 Ppp1r14a Stmn2
10X14_4_A_1:AAGAACGAGGTAAAx 0.000000 9.729905 9.729905 0.000000 0.00000
10X12_3_A_1:CAAGCATGAATCGCx 9.076224 0.000000 0.000000 9.076224 10.68557
10X12_3_A_1:GTGATCGACCAATGx 0.000000 0.000000 0.000000 0.000000 0.00000
10X12_3_A_1:CTGGATGAACAGCTx 9.650103 0.000000 9.650103 0.000000 0.00000
10X14_4_A_1:ATTCAAGATCCCACx 9.173208 9.173208 0.000000 0.000000 0.00000
10X12_3_A_1:CGATCCACCCGAATx 0.000000 9.132491 0.000000 0.000000 0.00000
Cadm1 Msmo1 Dpysl5 Sema6d Ina
10X14_4_A_1:AAGAACGAGGTAAAx 9.729905 9.729905 9.729905 0.000000 0.000000
10X12_3_A_1:CAAGCATGAATCGCx 10.685571 0.000000 0.000000 0.000000 9.076224
10X12_3_A_1:GTGATCGACCAATGx 0.000000 0.000000 9.411567 9.411567 0.000000
10X12_3_A_1:CTGGATGAACAGCTx 10.748672 0.000000 10.343218 9.650103 0.000000
10X14_4_A_1:ATTCAAGATCCCACx 9.866303 10.559424 0.000000 9.173208 9.173208
10X12_3_A_1:CGATCCACCCGAATx 0.000000 10.518705 9.825584 10.231032 0.000000
Pak7 Unc5d Sstr2 Aff2 Epha4
10X14_4_A_1:AAGAACGAGGTAAAx 10.423023 11.521615 10.423023 0.000000 0.000000
10X12_3_A_1:CAAGCATGAATCGCx 0.000000 10.462433 0.000000 10.462433 9.076224
10X12_3_A_1:GTGATCGACCAATGx 10.104673 0.000000 9.411567 9.411567 10.104673
10X12_3_A_1:CTGGATGAACAGCTx 0.000000 9.650103 9.650103 0.000000 10.343218
10X14_4_A_1:ATTCAAGATCCCACx 0.000000 10.964881 9.173208 9.866303 10.964881
10X12_3_A_1:CGATCCACCCGAATx 9.132491 0.000000 0.000000 0.000000 9.132491
Zfpm2 Bhlhe22 Kcnq3 Nrp1 Satb2 Cdh13
10X14_4_A_1:AAGAACGAGGTAAAx 0 0.000000 0.000000 0.000000 0.000000 0.000000
10X12_3_A_1:CAAGCATGAATCGCx 0 9.076224 9.076224 9.076224 9.076224 0.000000
10X12_3_A_1:GTGATCGACCAATGx 0 0.000000 9.411567 0.000000 0.000000 0.000000
10X12_3_A_1:CTGGATGAACAGCTx 0 0.000000 0.000000 9.650103 0.000000 0.000000
10X14_4_A_1:ATTCAAGATCCCACx 0 9.173208 0.000000 0.000000 9.173208 0.000000
10X12_3_A_1:CGATCCACCCGAATx 0 9.132491 9.132491 0.000000 0.000000 9.825584
Mpped2 Phactr1 Nol4 Cnr1 Runx1t1
10X14_4_A_1:AAGAACGAGGTAAAx 0.00000 11.116155 0.000000 0.00000 0.000000
10X12_3_A_1:CAAGCATGAATCGCx 10.17476 9.769314 9.769314 0.00000 9.769314
10X12_3_A_1:GTGATCGACCAATGx 0.00000 9.411567 0.000000 0.00000 0.000000
10X12_3_A_1:CTGGATGAACAGCTx 0.00000 0.000000 9.650103 0.00000 0.000000
10X14_4_A_1:ATTCAAGATCCCACx 0.00000 9.173208 9.866303 0.00000 0.000000
10X12_3_A_1:CGATCCACCCGAATx 0.00000 9.132491 9.825584 10.23103 0.000000
Grik2 Mir124.2hg Tbr1 B3galt1 Kcnb2
10X14_4_A_1:AAGAACGAGGTAAAx 9.729905 9.729905 0.000000 0.000000 9.729905
10X12_3_A_1:CAAGCATGAATCGCx 9.076224 0.000000 9.076224 9.076224 0.000000
10X12_3_A_1:GTGATCGACCAATGx 0.000000 9.411567 9.411567 0.000000 9.411567
10X12_3_A_1:CTGGATGAACAGCTx 0.000000 11.036349 0.000000 0.000000 11.036349
10X14_4_A_1:ATTCAAGATCCCACx 9.173208 0.000000 9.173208 0.000000 0.000000
10X12_3_A_1:CGATCCACCCGAATx 9.132491 9.132491 9.132491 9.132491 9.132491
Ly6h Negr1 Smarcd3 Ppm1e Lmo4
10X14_4_A_1:AAGAACGAGGTAAAx 0.000000 10.42302 9.729905 9.729905 9.729905
10X12_3_A_1:CAAGCATGAATCGCx 0.000000 0.00000 0.000000 10.462433 9.076224
10X12_3_A_1:GTGATCGACCAATGx 9.411567 0.00000 0.000000 0.000000 0.000000
10X12_3_A_1:CTGGATGAACAGCTx 0.000000 11.44181 0.000000 10.343218 9.650103
10X14_4_A_1:ATTCAAGATCCCACx 0.000000 0.00000 9.173208 10.271751 0.000000
10X12_3_A_1:CGATCCACCCGAATx 0.000000 0.00000 9.825584 9.825584 0.000000
Dab1 Serpini1 Pcdh7 Robo2 Nrxn1
10X14_4_A_1:AAGAACGAGGTAAAx 9.729905 10.423023 0.00000 11.339295 0.00000
10X12_3_A_1:CAAGCATGAATCGCx 0.000000 9.769314 0.00000 10.867888 0.00000
10X12_3_A_1:GTGATCGACCAATGx 0.000000 0.000000 0.00000 9.411567 0.00000
10X12_3_A_1:CTGGATGAACAGCTx 0.000000 0.000000 0.00000 11.036349 0.00000
10X14_4_A_1:ATTCAAGATCCCACx 10.964881 0.000000 0.00000 10.782562 10.27175
10X12_3_A_1:CGATCCACCCGAATx 10.231032 9.825584 10.23103 11.078309 0.00000
Hecw1 Stmn4 Galnt17 Acot7 Parp6
10X14_4_A_1:AAGAACGAGGTAAAx 0.000000 0.00000 0.000000 0.000000 0.000000
10X12_3_A_1:CAAGCATGAATCGCx 9.076224 10.46243 0.000000 0.000000 9.076224
10X12_3_A_1:GTGATCGACCAATGx 9.411567 0.00000 0.000000 10.104673 9.411567
10X12_3_A_1:CTGGATGAACAGCTx 0.000000 0.00000 0.000000 0.000000 9.650103
10X14_4_A_1:ATTCAAGATCCCACx 9.866303 0.00000 0.000000 0.000000 10.271751
10X12_3_A_1:CGATCCACCCGAATx 9.132491 0.00000 9.132491 9.132491 9.825584
Tmem176b Nrn1 Pcdh9 Cdh4 Nav3
10X14_4_A_1:AAGAACGAGGTAAAx 0.000000 9.729905 0.000000 0.000000 9.729905
10X12_3_A_1:CAAGCATGAATCGCx 0.000000 9.076224 11.155566 9.076224 9.769314
10X12_3_A_1:GTGATCGACCAATGx 10.104673 0.000000 9.411567 0.000000 0.000000
10X12_3_A_1:CTGGATGAACAGCTx 10.343218 9.650103 0.000000 0.000000 0.000000
10X14_4_A_1:ATTCAAGATCCCACx 0.000000 9.173208 0.000000 10.271751 9.866303
10X12_3_A_1:CGATCCACCCGAATx 9.132491 9.825584 0.000000 0.000000 0.000000
Nrg1 Ppfia2 Robo1 Cdh8 Lrpap1
10X14_4_A_1:AAGAACGAGGTAAAx 11.116155 0.000000 0.000000 11.116155 0.000000
10X12_3_A_1:CAAGCATGAATCGCx 9.769314 9.769314 0.000000 9.769314 9.076224
10X12_3_A_1:GTGATCGACCAATGx 9.411567 10.104673 0.000000 9.411567 9.411567
10X12_3_A_1:CTGGATGAACAGCTx 0.000000 0.000000 0.000000 9.650103 0.000000
10X14_4_A_1:ATTCAAGATCCCACx 10.559424 10.559424 0.000000 9.866303 10.271751
10X12_3_A_1:CGATCCACCCGAATx 0.000000 0.000000 9.825584 0.000000 0.000000
X2010107E04Rik Ssbp3 Srsf4 Mtf2
10X14_4_A_1:AAGAACGAGGTAAAx 0.00000 0.000000 9.729905 9.729905
10X12_3_A_1:CAAGCATGAATCGCx 10.46243 9.769314 9.076224 10.174760
10X12_3_A_1:GTGATCGACCAATGx 0.00000 9.411567 9.411567 0.000000
10X12_3_A_1:CTGGATGAACAGCTx 0.00000 0.000000 9.650103 9.650103
10X14_4_A_1:ATTCAAGATCCCACx 0.00000 0.000000 0.000000 0.000000
10X12_3_A_1:CGATCCACCCGAATx 0.00000 10.231032 0.000000 0.000000
Gtf2a2 Canx Phf6 Higd1a Dctpp1
10X14_4_A_1:AAGAACGAGGTAAAx 0.000000 0.000000 0.000000 0.000000 0.000000
10X12_3_A_1:CAAGCATGAATCGCx 0.000000 9.769314 0.000000 9.076224 9.076224
10X12_3_A_1:GTGATCGACCAATGx 0.000000 9.411567 9.411567 0.000000 10.510124
10X12_3_A_1:CTGGATGAACAGCTx 0.000000 9.650103 9.650103 9.650103 0.000000
10X14_4_A_1:ATTCAAGATCCCACx 9.173208 9.866303 9.173208 0.000000 0.000000
10X12_3_A_1:CGATCCACCCGAATx 9.825584 10.231032 10.924161 9.825584 9.132491
Srek1 Mdk Prdx6 Jun Tspan14
10X14_4_A_1:AAGAACGAGGTAAAx 0.000000 0.00000 0.000000 0.000000 9.729905
10X12_3_A_1:CAAGCATGAATCGCx 9.076224 0.00000 0.000000 9.769314 0.000000
10X12_3_A_1:GTGATCGACCAATGx 0.000000 0.00000 10.104673 11.203258 10.510124
10X12_3_A_1:CTGGATGAACAGCTx 9.650103 10.74867 9.650103 0.000000 0.000000
10X14_4_A_1:ATTCAAGATCCCACx 10.782562 0.00000 0.000000 9.173208 0.000000
10X12_3_A_1:CGATCCACCCGAATx 0.000000 0.00000 0.000000 9.825584 9.132491
Prkar1a Phf21a Mrps21 Ubc Fam114a2
10X14_4_A_1:AAGAACGAGGTAAAx 0.000000 9.729905 9.729905 0.000000 0.000000
10X12_3_A_1:CAAGCATGAATCGCx 9.769314 0.000000 0.000000 10.174760 9.076224
10X12_3_A_1:GTGATCGACCAATGx 0.000000 0.000000 0.000000 0.000000 9.411567
10X12_3_A_1:CTGGATGAACAGCTx 9.650103 9.650103 0.000000 0.000000 0.000000
10X14_4_A_1:ATTCAAGATCCCACx 0.000000 9.173208 9.173208 0.000000 9.866303
10X12_3_A_1:CGATCCACCCGAATx 9.132491 9.825584 9.825584 9.132491 0.000000
Large1 Gmcl1 Gpatch8 Csnk2a1 Xist
10X14_4_A_1:AAGAACGAGGTAAAx 0.000000 10.423023 0.000000 0.000000 0.00000
10X12_3_A_1:CAAGCATGAATCGCx 0.000000 0.000000 9.076224 0.000000 11.02204
10X12_3_A_1:GTGATCGACCAATGx 10.104673 10.510124 0.000000 9.411567 0.00000
10X12_3_A_1:CTGGATGAACAGCTx 0.000000 9.650103 0.000000 0.000000 11.44181
10X14_4_A_1:ATTCAAGATCCCACx 0.000000 9.173208 9.866303 9.173208 10.55942
10X12_3_A_1:CGATCCACCCGAATx 9.825584 0.000000 9.132491 9.132491 0.00000
Fdps Phip Sqle Zbtb20 Fnbp1l
10X14_4_A_1:AAGAACGAGGTAAAx 0.000000 0.000000 9.729905 0.000000 9.729905
10X12_3_A_1:CAAGCATGAATCGCx 10.174760 9.076224 9.769314 0.000000 0.000000
10X12_3_A_1:GTGATCGACCAATGx 9.411567 9.411567 9.411567 10.104673 9.411567
10X12_3_A_1:CTGGATGAACAGCTx 0.000000 9.650103 0.000000 9.650103 9.650103
10X14_4_A_1:ATTCAAGATCCCACx 0.000000 9.173208 9.173208 0.000000 9.173208
10X12_3_A_1:CGATCCACCCGAATx 10.518705 9.132491 9.132491 0.000000 9.132491
Tubb2a Ncam1 Dclk1 Klc1 COTAN_Cl.code
10X14_4_A_1:AAGAACGAGGTAAAx 0.000000 0.000000 9.729905 0.000000 0
10X12_3_A_1:CAAGCATGAATCGCx 0.000000 10.174760 9.769314 0.000000 1
10X12_3_A_1:GTGATCGACCAATGx 0.000000 10.510124 0.000000 0.000000 1
10X12_3_A_1:CTGGATGAACAGCTx 0.000000 0.000000 0.000000 0.000000 1
10X14_4_A_1:ATTCAAGATCCCACx 9.866303 9.866303 9.866303 9.173208 0
10X12_3_A_1:CGATCCACCCGAATx 0.000000 0.000000 9.132491 0.000000 1# Fit the model
model <- glm( COTAN_Cl.code ~., data = train.data, family = binomial,control = list(maxit = 50))
# Summarize the model
summary(model)
Call:
glm(formula = COTAN_Cl.code ~ ., family = binomial, data = train.data,
control = list(maxit = 50))
Coefficients:
Estimate Std. Error z value Pr(>|z|)
(Intercept) -5.161e+01 3.060e+06 0 1
Slc8a1 7.693e-01 1.171e+05 0 1
Csrp2 1.426e+00 7.682e+04 0 1
Rpl22l1 -2.862e-01 1.063e+05 0 1
Sec61g 1.296e+00 8.025e+04 0 1
Pgk1 1.829e+00 1.253e+05 0 1
Gm10076 9.697e-01 1.833e+05 0 1
Rpl36al 1.583e+00 1.728e+05 0 1
Mfap4 5.115e-01 1.249e+05 0 1
Ier2 7.954e-02 1.269e+05 0 1
Ptprk 1.319e+00 1.251e+05 0 1
Cadps 8.187e-01 9.443e+04 0 1
Uba52 7.255e+00 9.522e+04 0 1
Pantr1 1.752e+00 8.892e+04 0 1
Mir9.3hg -4.958e-01 9.292e+04 0 1
Tmem108 -7.053e-01 9.884e+04 0 1
Klhl29 -1.855e-01 9.946e+04 0 1
Dusp14 -1.196e+00 1.034e+05 0 1
Adgrb3 1.743e-01 1.773e+05 0 1
Alcam -5.075e-01 1.555e+05 0 1
Nell2 4.394e-01 1.578e+05 0 1
Fabp7 1.186e+00 1.018e+05 0 1
Ptn 9.612e-01 1.517e+05 0 1
Rasgef1b -7.001e-01 1.122e+05 0 1
Nckap5 -1.163e+00 1.047e+05 0 1
Nfasc 8.546e-01 6.054e+04 0 1
Frmd4a -6.578e-01 1.720e+05 0 1
Nkain2 4.318e-01 1.652e+05 0 1
Tcf12 7.042e-01 1.195e+05 0 1
Ppp1r14a -2.636e-01 1.283e+05 0 1
Stmn2 9.936e-01 8.753e+04 0 1
Cadm1 1.011e+00 8.722e+04 0 1
Msmo1 -1.956e-01 1.085e+05 0 1
Dpysl5 -5.631e-01 8.174e+04 0 1
Sema6d 1.209e+00 1.182e+05 0 1
Ina -1.725e-01 1.004e+05 0 1
Pak7 1.784e-02 7.803e+04 0 1
Unc5d -9.328e-01 1.065e+05 0 1
Sstr2 -1.249e+00 9.338e+04 0 1
Aff2 -5.563e-01 5.025e+04 0 1
Epha4 9.871e-01 1.085e+05 0 1
Zfpm2 3.716e+00 6.581e+04 0 1
Bhlhe22 -4.104e-02 9.431e+04 0 1
Kcnq3 8.499e-01 5.114e+04 0 1
Nrp1 -6.156e-01 2.355e+05 0 1
Satb2 3.264e-01 1.145e+05 0 1
Cdh13 1.995e+00 2.566e+05 0 1
Mpped2 1.031e-01 2.213e+05 0 1
Phactr1 -2.101e-01 1.566e+05 0 1
Nol4 -2.159e-01 1.206e+05 0 1
Cnr1 -1.690e+00 1.296e+05 0 1
Runx1t1 -1.049e+00 1.793e+05 0 1
Grik2 7.952e-01 9.668e+04 0 1
Mir124.2hg 3.016e-01 8.916e+04 0 1
Tbr1 3.688e-01 7.522e+04 0 1
B3galt1 -5.395e-01 8.938e+04 0 1
Kcnb2 6.570e-01 1.125e+05 0 1
Ly6h 9.767e-01 1.810e+05 0 1
Negr1 1.996e+00 1.346e+05 0 1
Smarcd3 5.877e-01 6.313e+04 0 1
Ppm1e -3.702e-04 1.134e+05 0 1
Lmo4 3.436e-01 1.531e+05 0 1
Dab1 -7.583e-01 9.049e+04 0 1
Serpini1 -8.662e-01 7.453e+04 0 1
Pcdh7 -1.879e+00 9.777e+04 0 1
Robo2 -3.806e+00 1.643e+05 0 1
Nrxn1 8.571e-01 7.508e+04 0 1
Hecw1 4.333e-01 1.495e+05 0 1
Stmn4 -1.913e+00 1.210e+05 0 1
Galnt17 2.192e+00 1.638e+05 0 1
Acot7 1.937e+00 1.024e+05 0 1
Parp6 5.778e-01 1.053e+05 0 1
Tmem176b -4.505e-01 7.658e+04 0 1
Nrn1 1.895e+00 7.471e+04 0 1
Pcdh9 6.794e-01 9.677e+04 0 1
Cdh4 6.568e-01 1.501e+05 0 1
Nav3 -7.964e-01 8.285e+04 0 1
Nrg1 -5.768e-01 1.066e+05 0 1
Ppfia2 -1.026e+00 1.075e+05 0 1
Robo1 3.440e-01 4.997e+04 0 1
Cdh8 3.917e-02 1.486e+05 0 1
Lrpap1 -2.107e-01 9.521e+04 0 1
X2010107E04Rik -1.419e-01 1.283e+05 0 1
Ssbp3 6.578e-01 8.910e+04 0 1
Srsf4 5.215e-01 7.464e+04 0 1
Mtf2 4.725e-01 8.384e+04 0 1
Gtf2a2 -1.462e+00 8.082e+04 0 1
Canx -1.029e+00 8.597e+04 0 1
Phf6 -1.989e-01 1.017e+05 0 1
Higd1a -5.775e-01 9.319e+04 0 1
Dctpp1 -4.058e-01 7.024e+04 0 1
Srek1 3.479e-01 6.937e+04 0 1
Mdk -2.930e-01 7.334e+04 0 1
Prdx6 6.210e-02 8.068e+04 0 1
Jun -6.216e-01 5.076e+04 0 1
Tspan14 6.353e-01 9.293e+04 0 1
Prkar1a 3.660e-01 1.070e+05 0 1
Phf21a 5.023e-01 1.530e+05 0 1
Mrps21 -1.200e+00 1.308e+05 0 1
Ubc 1.663e-01 8.846e+04 0 1
Fam114a2 3.522e-01 4.596e+04 0 1
Large1 -3.051e-01 1.731e+05 0 1
Gmcl1 -1.071e+00 1.252e+05 0 1
Gpatch8 1.671e-01 7.485e+04 0 1
Csnk2a1 -1.901e+00 1.483e+05 0 1
Xist 9.840e-01 6.415e+04 0 1
Fdps 1.136e+00 9.151e+04 0 1
Phip 2.852e-01 1.443e+05 0 1
Sqle -4.126e-01 8.765e+04 0 1
Zbtb20 3.140e-01 1.013e+05 0 1
Fnbp1l 7.334e-01 9.184e+04 0 1
Tubb2a -1.487e-01 9.100e+04 0 1
Ncam1 -1.924e-01 1.362e+05 0 1
Dclk1 -1.084e+00 7.479e+04 0 1
Klc1 -1.020e-01 7.647e+04 0 1
(Dispersion parameter for binomial family taken to be 1)
Null deviance: 5.9080e+02 on 428 degrees of freedom
Residual deviance: 2.4052e-10 on 314 degrees of freedom
AIC: 230
Number of Fisher Scoring iterations: 29# Make predictions
probabilities <- model %>% predict(test.data, type = "response")
predicted.classes <- ifelse(probabilities > 0.5, "1", "0")
# Model accuracy
accuracy <- mean(predicted.classes == test.data$COTAN_Cl.code)
result.df[nrow(result.df),"Accuracy"] <- accuracy
accuracy[1] 0.8878505So also in this case a logistic regression confirm the difference in cell population detected by COTAN.
cl432ClsMarkers <- findClustersMarkers(cl432,n = 200, adjustmentMethod = "BH")
cl432ClsMarkers CL Gene DEA adjPVal IsMarker logFoldCh
1 1 Uba52 -0.8106586 1.621708e-74 0 -1.53792300
2 1 Pgk1 -0.5238207 4.456029e-30 0 -1.25344098
3 1 Sec61g -0.4973970 4.322781e-27 0 -0.94392234
4 1 Erh -0.4763866 8.139496e-25 0 -0.66616044
5 1 Atp5l -0.4636196 1.667637e-23 0 -0.72958798
6 1 Gm10076 -0.4404727 3.985478e-21 0 -0.64435861
7 1 Gm10260 -0.4297397 4.276949e-20 0 -0.55876061
8 1 Stmn1 -0.3970492 5.657414e-17 0 -0.62877743
9 1 Rpl36al -0.3734641 6.959301e-15 0 -0.60240089
10 1 Nme2 -0.3595564 9.986587e-14 0 -1.48759648
11 1 Raly -0.3384064 4.257980e-12 0 -1.02907857
12 1 Rpl27a -0.3273853 2.917431e-11 0 -0.39318812
13 1 Hnrnpa1 -0.3204800 8.642931e-11 0 -0.42371612
14 1 Rpl15 -0.3142968 2.373219e-10 0 -0.60150822
15 1 Glo1 -0.3060652 9.036242e-10 0 -0.50825182
16 1 Ppia -0.2990938 2.575683e-09 0 -0.61119720
17 1 Gstp1 -0.2987705 2.586162e-09 0 -0.67817495
18 1 Gm9844 -0.2873804 1.405859e-08 0 -0.72485194
19 1 Gnb2 -0.2863104 1.596675e-08 0 -0.89089883
20 1 Gps1 -0.2841718 2.144394e-08 0 -1.02113299
21 1 Fdps -0.2786077 4.870749e-08 0 -0.35290526
22 1 mt.Co1 -0.2701456 1.621212e-07 0 -0.45083061
23 1 Pcdh9 -0.2600888 6.783712e-07 0 -0.33568931
24 1 Eno1 -0.2521273 1.953908e-06 0 -0.34261648
25 1 Tomm20 -0.2464009 4.161634e-06 0 -0.38429325
26 1 Fopnl -0.2445309 5.059678e-06 0 -0.54335800
27 1 Bloc1s1 -0.2445235 5.059678e-06 0 -0.68382633
28 1 Nme1 -0.2368368 1.294655e-05 0 -0.31943344
29 1 Mea1 -0.2358888 1.427839e-05 0 -1.22670712
30 1 Polr2k -0.2314427 2.413075e-05 0 -0.74896109
31 1 Tpm3.rs7 -0.2256287 4.917877e-05 0 -0.38346143
32 1 Lsm7 -0.2247260 5.376587e-05 0 -0.29980444
33 1 Rwdd1 -0.2236509 5.872473e-05 0 -0.25680432
34 1 Ppp1cc -0.2216835 7.169717e-05 0 -0.42313946
35 1 Tln1 -0.2176354 1.150343e-04 0 -0.60121336
36 1 Cap1 -0.2167206 1.240952e-04 0 -0.28472756
37 1 Lamtor3 -0.2166690 1.240952e-04 0 -0.43463703
38 1 Btf3 -0.2147496 1.528275e-04 0 -0.27400311
39 1 Ndufs5 -0.2128721 1.842585e-04 0 -0.48320512
40 1 Tarbp2 -0.2123358 1.926960e-04 0 -0.98975553
41 1 Ifitm2 -0.2075714 3.124845e-04 0 -0.93419770
42 1 Btg1 -0.2074439 3.124845e-04 0 -0.48968203
43 1 Atp5g2 -0.2050227 4.059691e-04 0 -1.00411870
44 1 Ubb -0.2041784 4.397309e-04 0 -0.73394166
45 1 Pop4 -0.2030165 4.858863e-04 0 -0.31795136
46 1 Mrps33 -0.2024224 5.115751e-04 0 -0.31275401
47 1 Xist -0.2015720 5.428791e-04 0 -0.20099999
48 1 Zfpm2 -0.2013996 5.428791e-04 0 -0.48028351
49 1 Serf2 -0.1979161 7.529353e-04 0 -0.33563043
50 1 Serpini1 -0.1971836 7.943739e-04 0 -0.20380776
51 1 Mrps36 -0.1953705 9.081659e-04 0 -0.77800701
52 1 Sap18 -0.1946831 9.667589e-04 0 -0.25178663
53 1 Psap -0.1940358 1.024567e-03 0 -0.25725676
54 1 Ube2s -0.1919582 1.251923e-03 0 -0.61258722
55 1 Cntnap2 -0.1901799 1.479238e-03 0 -0.27548961
56 1 mt.Nd5 -0.1870497 1.990702e-03 0 -0.37227982
57 1 Naa10 -0.1863570 2.070267e-03 0 -0.60095155
58 1 Gpx4 -0.1857669 2.178201e-03 0 -0.20008708
59 1 Stmn2 -0.1841842 2.487140e-03 0 -0.28112428
60 1 Rnf114 -0.1828209 2.825226e-03 0 -0.24970003
61 1 Rbm3 -0.1815005 3.114980e-03 0 -0.34334621
62 1 Mrpl23 -0.1774233 4.525958e-03 0 -0.33564600
63 1 Kpna2 -0.1765228 4.858883e-03 0 -0.63216478
64 1 Mettl2 -0.1754189 5.322398e-03 0 -0.33267933
65 1 Grcc10 -0.1746312 5.649315e-03 0 -0.93197938
66 1 Ap3s1 -0.1737918 6.027032e-03 0 -0.20527616
67 1 Psenen -0.1731937 6.217071e-03 0 -0.25801194
68 1 Dstn -0.1729203 6.217071e-03 0 -0.27449226
69 1 X4833439L19Rik -0.1727385 6.217071e-03 0 -0.22690981
70 1 Ndn -0.1726871 6.217071e-03 0 -0.21869226
71 1 Lrfn5 -0.1699586 7.843473e-03 0 -0.47692581
72 1 Trmt112 -0.1689513 8.504892e-03 0 -0.22881986
73 1 Exosc9 -0.1686363 8.697021e-03 0 -0.35186517
74 1 Apopt1 -0.1682036 8.924860e-03 0 -0.26016106
75 1 Gpx1 -0.1674662 9.501605e-03 0 -0.17772780
76 1 Polr2l -0.1668766 9.897726e-03 0 -0.38342945
77 1 Rtl8a -0.1664545 1.014883e-02 0 -0.43148510
78 1 Lhx9 -0.1655502 1.097174e-02 0 -0.39696671
79 1 Ube2d3 -0.1647669 1.172338e-02 0 -0.11304321
80 1 Gadd45g -0.1635794 1.291070e-02 0 -0.19430562
81 1 Gm10320 -0.1634505 1.297320e-02 0 -1.48259469
82 1 Fam171b -0.1633075 1.305369e-02 0 -0.26127670
83 1 Cdca4 -0.1630273 1.330377e-02 0 -0.39779613
84 1 Hnrnpl -0.1614933 1.511836e-02 0 -0.24555980
85 1 Prkag2 -0.1598483 1.721999e-02 0 -0.31107620
86 1 Rpl35 -0.1576980 1.984815e-02 0 -0.35494978
87 1 Kansl2 -0.1569664 2.092858e-02 0 -0.30446483
88 1 Akr1b3 -0.1564546 2.177240e-02 0 -0.95812276
89 1 Wtap -0.1550175 2.362290e-02 0 -0.24636895
90 1 Tmem50a -0.1546376 2.415018e-02 0 -0.20486681
91 1 Btbd9 -0.1544588 2.416976e-02 0 -0.16390100
92 1 Churc1 -0.1542854 2.439997e-02 0 -0.59272102
93 1 Stx7 -0.1539896 2.490030e-02 0 -0.15631767
94 1 Tenm1 -0.1538699 2.493781e-02 0 -0.58258836
95 1 Tma7 -0.1530726 2.587660e-02 0 -0.17778596
96 1 Ncam2 -0.1529851 2.587660e-02 0 -0.55049454
97 1 Taf13 -0.1514154 2.900826e-02 0 -0.20711175
98 1 Cd81 -0.1507704 3.035059e-02 0 -0.14194102
99 1 Rpl29 -0.1498042 3.281749e-02 0 -0.81233384
100 1 Ly6h -0.1495588 3.313048e-02 0 -0.31738241
101 1 Pts -0.1495101 3.313048e-02 0 -0.33479576
102 1 Emc8 -0.1490463 3.411955e-02 0 -1.53338622
103 1 Ntan1 -0.1487829 3.454074e-02 0 -0.14776099
104 1 Ift46 -0.1486239 3.467576e-02 0 -0.19087506
105 1 Rhob -0.1486181 3.467576e-02 0 -0.24365623
106 1 Pabpc1 -0.1473347 3.781523e-02 0 -0.12731174
107 1 Rpn1 -0.1473172 3.781523e-02 0 -0.29685829
108 1 Cd164 -0.1470407 3.806987e-02 0 -0.95510002
109 1 Ndufs3 -0.1469968 3.806987e-02 0 -0.19286496
110 1 Faap20 -0.1457849 4.079903e-02 0 -0.40722095
111 1 Rpp25l -0.1455277 4.090874e-02 0 -0.20533516
112 1 Ctps -0.1453366 4.137977e-02 0 -0.20157322
113 1 Gstm7 -0.1441713 4.459168e-02 0 -0.27771035
114 1 Rwdd3 -0.1440951 4.467529e-02 0 -0.19818151
115 1 Uqcrc1 -0.1423990 5.007439e-02 0 -0.17200440
116 1 Fdxacb1 -0.1422882 5.009805e-02 0 -0.76452548
117 1 X1300002E11Rik -0.1422882 5.009805e-02 0 -0.96681879
118 1 Gdi1 -0.1416844 5.219774e-02 0 -0.12858017
119 1 Sms -0.1415853 5.240009e-02 0 -0.16537841
120 1 Rgs17 -0.1402212 5.759560e-02 0 -0.60867803
121 1 Insig1 -0.1397145 5.951638e-02 0 -0.24820691
122 1 Nop16 -0.1390305 6.187597e-02 0 -0.36967027
123 1 Lrrn2 -0.1388253 6.231933e-02 0 -0.59551504
124 1 Marcks -0.1387912 6.231933e-02 0 -0.16704611
125 1 Supt4a -0.1385152 6.346419e-02 0 -0.10278269
126 1 Tusc2 -0.1380959 6.511624e-02 0 -0.30700412
127 1 Gm17231 -0.1377187 6.658470e-02 0 -0.48697134
128 1 Gapdh -0.1372482 6.859523e-02 0 -0.24637523
129 1 Hmga1 -0.1370103 6.963649e-02 0 -0.88024187
130 1 Rprm -0.1361143 7.391134e-02 0 -0.17727408
131 1 Ebf1 -0.1357991 7.491177e-02 0 -0.84978663
132 1 Dad1 -0.1354080 7.638830e-02 0 -0.09449466
133 1 Zbed4 -0.1351557 7.711751e-02 0 -0.36013105
134 1 Cdk16 -0.1351448 7.711751e-02 0 -0.24855976
135 1 Snrpe -0.1345307 7.942293e-02 0 -0.15794122
136 1 Smim7 -0.1344885 7.942293e-02 0 -0.16480519
137 1 Aldh1a7 -0.1341285 8.110384e-02 0 -1.51622445
138 1 Acp1 -0.1336584 8.329023e-02 0 -0.35086645
139 1 Gipc1 -0.1330803 8.675737e-02 0 -0.15192410
140 1 Eef1akmt2 -0.1327564 8.833701e-02 0 -0.11416905
141 1 Cacna2d3 -0.1325698 8.914832e-02 0 -0.63717391
142 1 Rbmxl1 -0.1325473 8.914832e-02 0 -0.18170969
143 1 Gm44790 -0.1321926 9.032299e-02 0 -0.52945025
144 1 Rtn4r -0.1321600 9.032299e-02 0 -1.14607846
145 1 Golga7 -0.1321165 9.032299e-02 0 -0.13871035
146 1 Arf2 -0.1317252 9.207863e-02 0 -0.21418581
147 1 Tnpo3 -0.1312512 9.442935e-02 0 -0.18232415
148 1 Tspan13 -0.1312214 9.442935e-02 0 -0.12403069
149 1 Pcbp2 -0.1308196 9.663177e-02 0 -0.06080126
150 1 Mrpl42 -0.1302949 9.871472e-02 0 -0.11762894
151 1 Rnf11 -0.1300110 9.957040e-02 0 -0.16489141
152 1 Coro1a -0.1297707 1.009205e-01 0 -0.21200976
153 1 Asnsd1 -0.1296167 1.009205e-01 0 -0.59351386
154 1 Zmynd19 -0.1295814 1.009205e-01 0 -0.61218867
155 1 Ndufaf1 -0.1294409 1.016811e-01 0 -0.41922942
156 1 Copz1 -0.1292181 1.027647e-01 0 -0.06069248
157 1 Kcnq5 -0.1289435 1.045958e-01 0 -0.21905449
158 1 Lipa -0.1288125 1.049142e-01 0 -1.48389373
159 1 Lgals1 -0.1287626 1.049142e-01 0 -0.77507374
160 1 Cycs -0.1283205 1.066272e-01 0 -0.19111465
161 1 Nap1l5 -0.1280920 1.078207e-01 0 -0.74166992
162 1 Ndel1 -0.1279612 1.082311e-01 0 -0.21950820
163 1 Emc4 -0.1277823 1.090392e-01 0 -0.18197192
164 1 Ankrd40 -0.1275914 1.095144e-01 0 -1.04874102
165 1 Cetn3 -0.1275658 1.095144e-01 0 -0.12402363
166 1 Ddt -0.1274910 1.098060e-01 0 -0.21534417
167 1 Ube2d1 -0.1274394 1.099072e-01 0 -0.05989198
168 1 Lztr1 -0.1267043 1.154370e-01 0 -0.35554758
169 1 Hdhd3 -0.1261863 1.187789e-01 0 -1.03765416
170 1 Prmt2 -0.1260355 1.195789e-01 0 -0.15842919
171 1 Gng2 -0.1257934 1.203993e-01 0 -0.05703520
172 1 Ccdc71 -0.1257889 1.203993e-01 0 -0.29402403
173 1 Sult4a1 -0.1256195 1.211950e-01 0 -0.19724735
174 1 Dazap1 -0.1253577 1.218730e-01 0 -0.07491903
175 1 Pagr1b -0.1251951 1.226600e-01 0 -0.09772905
176 1 Med29 -0.1250112 1.231010e-01 0 -0.31959522
177 1 H2afz -0.1249504 1.231010e-01 0 -0.13517372
178 1 Pgrmc1 -0.1249224 1.231010e-01 0 -0.12353972
179 1 F13a1 -0.1247344 1.238026e-01 0 -1.52270746
180 1 Rpl35a -0.1246453 1.242499e-01 0 -0.22888981
181 1 Jagn1 -0.1246119 1.242499e-01 0 -0.16362032
182 1 Ugp2 -0.1243514 1.263105e-01 0 -0.26457037
183 1 Slit1 -0.1242172 1.265399e-01 0 -1.24170259
184 1 Akr1e1 -0.1241699 1.266415e-01 0 -0.26869253
185 1 Zbtb18 -0.1241108 1.268546e-01 0 -0.02494936
186 1 Skp1a -0.1236131 1.292788e-01 0 -0.08361736
187 1 Alg8 -0.1233992 1.298407e-01 0 -0.29004950
188 1 X4933404O12Rik -0.1232871 1.302624e-01 0 -1.53093894
189 1 Gm48551 -0.1232842 1.302624e-01 0 -0.65149996
190 1 Rwdd4a -0.1230208 1.314840e-01 0 -0.16272864
191 1 Gcat -0.1227368 1.335001e-01 0 -0.90784266
192 1 Psmg3 -0.1224230 1.358870e-01 0 -1.45761797
193 1 Gm16973 -0.1224230 1.358870e-01 0 -1.52662646
194 1 Trib1 -0.1220789 1.375852e-01 0 -1.12151004
195 1 Rrp7a -0.1220364 1.376667e-01 0 -0.27596938
196 1 Gpi1 -0.1214913 1.414366e-01 0 -0.13377824
197 1 Psma3 -0.1213696 1.416416e-01 0 -0.03872378
198 1 Gm36198 -0.1213099 1.419073e-01 0 -1.12334271
199 1 Cyb5a -0.1212517 1.421581e-01 0 -0.14287255
200 1 Txndc9 -0.1211333 1.430268e-01 0 -0.03272968
201 1 Gm11808 0.3484559 7.691635e-13 0 0.49651641
202 1 Traf5 0.3460910 1.102236e-12 0 0.61862023
203 1 Grm8 0.3222584 6.750370e-11 0 0.36130888
204 1 Gm12166 0.3031504 1.390566e-09 0 0.70766903
205 1 Akap9 0.2963933 3.634612e-09 0 0.30684159
206 1 Pdzrn3 0.2936841 5.383420e-09 0 0.58043775
207 1 Csnk2a1 0.2760060 6.976655e-08 0 0.36399007
208 1 Rpl10.ps3 0.2547755 1.393615e-06 0 0.40532835
209 1 Txlng 0.2416229 7.259525e-06 0 0.65886271
210 1 Rps27rt 0.2371948 1.268722e-05 0 0.34513991
211 1 Hbb.bs 0.2344874 1.670480e-05 0 0.38981282
212 1 Rpl13a.ps1 0.2243530 5.504190e-05 0 0.52788210
213 1 Mrps28 0.2230924 6.156462e-05 0 0.27976541
214 1 Tuba1a 0.2146050 1.528275e-04 0 0.50226547
215 1 Rab39 0.2108862 2.244275e-04 0 0.44863682
216 1 Vmp1 0.2086942 2.847840e-04 0 0.27843562
217 1 Selenos 0.2078679 3.079542e-04 0 0.31692245
218 1 Nrg1 0.2031470 4.858863e-04 0 0.24385197
219 1 Aurkaip1 0.2016231 5.428791e-04 0 0.22703384
220 1 Gm11361 0.2013583 5.428791e-04 0 0.41707948
221 1 Pnn 0.2011177 5.496875e-04 0 0.25610844
222 1 Fez1 0.2000549 6.103992e-04 0 0.15608070
223 1 Gtf2a2 0.1980148 7.529353e-04 0 0.20731297
224 1 Kalrn 0.1977169 7.591726e-04 0 0.25084516
225 1 Cox7a2l 0.1960664 8.863459e-04 0 0.13539672
226 1 Gm2000 0.1957360 9.069722e-04 0 0.35095049
227 1 Rps29 0.1955730 9.081659e-04 0 0.26074972
228 1 Nutf2.ps1 0.1954743 9.081659e-04 0 0.34815392
229 1 Morf4l1 0.1935647 1.065207e-03 0 0.28841746
230 1 Srpk1 0.1915643 1.290557e-03 0 0.27646069
231 1 Gm10131 0.1888895 1.677258e-03 0 0.25190947
232 1 Gtpbp4 0.1883130 1.762401e-03 0 0.26483373
233 1 Rdh5 0.1867587 2.029449e-03 0 0.35676065
234 1 Nedd4l 0.1864298 2.070267e-03 0 0.17374290
235 1 Ndufb4 0.1846130 2.430047e-03 0 0.20375478
236 1 Smc3 0.1842032 2.487140e-03 0 0.17446696
237 1 Nsg2 0.1827488 2.825226e-03 0 0.15724921
238 1 Gm10282 0.1823049 2.927000e-03 0 0.44216637
239 1 Eif3m 0.1819904 2.992458e-03 0 0.15506031
240 1 Rsf1 0.1801963 3.522809e-03 0 0.21615777
241 1 Nop58 0.1795542 3.723095e-03 0 0.23662780
242 1 Evi5l 0.1778623 4.373030e-03 0 0.39856473
243 1 Prex1 0.1767249 4.807246e-03 0 0.21728572
244 1 Pcm1 0.1758301 5.157203e-03 0 0.21233798
245 1 Cbx3 0.1753131 5.329132e-03 0 0.23293264
246 1 Ankrd12 0.1741340 5.879860e-03 0 0.26085483
247 1 Rtf1 0.1734383 6.184841e-03 0 0.18667602
248 1 Bend5 0.1732811 6.217071e-03 0 0.39412137
249 1 Zfp131 0.1728544 6.217071e-03 0 0.32729559
250 1 Ppp4r2 0.1728279 6.217071e-03 0 0.38181828
251 1 Rsrc2 0.1727728 6.217071e-03 0 0.16424777
252 1 Fam98b 0.1721118 6.522381e-03 0 0.33362966
253 1 Robo2 0.1714409 6.905846e-03 0 0.17950207
254 1 Tnrc18 0.1711932 7.016900e-03 0 0.23993018
255 1 Tmed2 0.1692618 8.320781e-03 0 0.14006620
256 1 Hba.a1 0.1682890 8.920983e-03 0 0.31612082
257 1 Zfp326 0.1672114 9.660837e-03 0 0.20378968
258 1 Rufy1 0.1667597 9.933330e-03 0 0.51521168
259 1 Rsbn1 0.1641105 1.237573e-02 0 0.24213388
260 1 Setd7 0.1621521 1.432645e-02 0 0.36853389
261 1 Ubxn4 0.1604211 1.656725e-02 0 0.17550433
262 1 Strn3 0.1600254 1.705995e-02 0 0.29537780
263 1 Ly6g6e 0.1592500 1.806167e-02 0 0.61922904
264 1 Mtdh 0.1591180 1.815719e-02 0 0.19389366
265 1 Adamtsl3 0.1586308 1.885146e-02 0 0.20107630
266 1 Dusp14 0.1584301 1.904970e-02 0 0.13102267
267 1 Pttg1 0.1583690 1.904970e-02 0 0.55526647
268 1 Pibf1 0.1581988 1.921884e-02 0 0.41003624
269 1 Appl1 0.1577189 1.984815e-02 0 0.29426390
270 1 H2afy 0.1574882 2.009731e-02 0 0.16285027
271 1 Calm3 0.1562708 2.199430e-02 0 0.16070424
272 1 Ino80b 0.1559814 2.242948e-02 0 0.34168188
273 1 Bod1l 0.1553064 2.362290e-02 0 0.18358382
274 1 Iws1 0.1552566 2.362290e-02 0 0.27071531
275 1 Kif1a 0.1551482 2.362290e-02 0 0.22522502
276 1 Alcam 0.1550095 2.362290e-02 0 0.16601032
277 1 Sept6 0.1549856 2.362290e-02 0 0.58960723
278 1 Zfp692 0.1546016 2.415018e-02 0 0.37221216
279 1 Rock1 0.1545226 2.416976e-02 0 0.28766305
280 1 Eif2b4 0.1538415 2.493781e-02 0 0.27560319
281 1 Fnbp1l 0.1536705 2.517196e-02 0 0.17377379
282 1 Ktn1 0.1534778 2.545738e-02 0 0.17307918
283 1 Tcea1 0.1533702 2.555425e-02 0 0.33471381
284 1 Zfp397 0.1532373 2.570944e-02 0 0.25674657
285 1 Cdk5rap2 0.1529732 2.587660e-02 0 0.45056901
286 1 Kdm2a 0.1526865 2.638960e-02 0 0.21137933
287 1 Smg1 0.1521638 2.747340e-02 0 0.27114108
288 1 Rabgap1 0.1517848 2.824278e-02 0 0.21136886
289 1 Tmem267 0.1510929 2.967221e-02 0 0.31464961
290 1 Gm43518 0.1496645 3.303897e-02 0 0.45701413
291 1 Kdm5b 0.1492795 3.361768e-02 0 0.16632349
292 1 Tpm3 0.1489575 3.420303e-02 0 0.20175765
293 1 Dcaf5 0.1484868 3.489011e-02 0 0.36801821
294 1 Kcnd2 0.1476244 3.736397e-02 0 0.33926994
295 1 Lrch2 0.1473071 3.781523e-02 0 0.24954469
296 1 Ncl 0.1471834 3.802584e-02 0 0.12797966
297 1 Gm3550 0.1470355 3.806987e-02 0 0.21855095
298 1 Abl2 0.1465309 3.937628e-02 0 0.29724249
299 1 Dync1h1 0.1464838 3.937628e-02 0 0.20306988
300 1 Ik 0.1462807 3.986552e-02 0 0.18514602
301 1 Rpl9.ps6 0.1461052 4.026736e-02 0 0.22611091
302 1 Zfand2b 0.1458493 4.079903e-02 0 0.32873114
303 1 Atrx 0.1457394 4.079903e-02 0 0.13942252
304 1 Gfm2 0.1456779 4.079903e-02 0 0.40499451
305 1 Serbp1 0.1456699 4.079903e-02 0 0.14969501
306 1 Gm9008 0.1455408 4.090874e-02 0 1.76164484
307 1 CT025619.1 0.1449154 4.267056e-02 0 0.19392534
308 1 Zc3h18 0.1447141 4.319791e-02 0 0.37215313
309 1 A330084C13Rik 0.1443574 4.430262e-02 0 0.56562469
310 1 Mycbp2 0.1441810 4.459168e-02 0 0.16615709
311 1 Scaf11 0.1439549 4.499877e-02 0 0.20986198
312 1 Nuak1 0.1435553 4.631266e-02 0 0.17576114
313 1 Cul1 0.1434988 4.632527e-02 0 0.15170703
314 1 Zfand5 0.1434020 4.649383e-02 0 0.13026238
315 1 Mrps5 0.1431078 4.743323e-02 0 0.15458456
316 1 Nrp1 0.1420521 5.086195e-02 0 0.06606303
317 1 Ddx5 0.1408348 5.548305e-02 0 0.21826847
318 1 Fat3 0.1403539 5.739234e-02 0 0.19218385
319 1 Zcchc11 0.1403161 5.739234e-02 0 0.25537927
320 1 Vgll4 0.1401097 5.787786e-02 0 0.13805112
321 1 L3mbtl3 0.1395875 5.988395e-02 0 0.34384398
322 1 Cep85l 0.1391752 6.166041e-02 0 0.26278821
323 1 Lrch3 0.1390308 6.187597e-02 0 0.34368877
324 1 Ddx24 0.1388622 6.231933e-02 0 0.12106951
325 1 Chd7 0.1383650 6.397851e-02 0 0.23358757
326 1 Ftl1.ps1 0.1379283 6.573575e-02 0 0.21973182
327 1 Pde4d 0.1376638 6.661487e-02 0 0.03943154
328 1 Gm45736 0.1366509 7.137961e-02 0 0.30265555
329 1 Zfr 0.1361690 7.387710e-02 0 0.22322110
330 1 Gm13402 0.1360212 7.417222e-02 0 1.78501126
331 1 Cdh4 0.1358588 7.484470e-02 0 0.24472568
332 1 Eml4 0.1355148 7.632325e-02 0 0.26994997
333 1 Ptov1 0.1354443 7.638830e-02 0 0.15583284
334 1 Map3k3 0.1352940 7.678851e-02 0 0.32635471
335 1 Ddx3y 0.1348404 7.869394e-02 0 0.24123454
336 1 Klf13 0.1347567 7.891962e-02 0 0.19762500
337 1 Golgb1 0.1346709 7.916026e-02 0 0.16523988
338 1 Bcor 0.1345941 7.934645e-02 0 0.18264437
339 1 Pde9a 0.1344332 7.947821e-02 0 0.27008760
340 1 Nop56 0.1336623 8.329023e-02 0 0.16798515
341 1 Gm26848 0.1336498 8.329023e-02 0 0.52469205
342 1 Chd2 0.1328581 8.795434e-02 0 0.32331614
343 1 Slc38a10 0.1322315 9.032299e-02 0 0.24505316
344 1 Lias 0.1321528 9.032299e-02 0 0.25865768
345 1 Ccdc191 0.1321080 9.032299e-02 0 0.44177446
346 1 Srrm4 0.1319044 9.143870e-02 0 0.14104522
347 1 Hmgb1 0.1318126 9.177330e-02 0 0.22391249
348 1 Aff2 0.1314396 9.380595e-02 0 0.16314267
349 1 Tor2a 0.1312504 9.442935e-02 0 0.23475385
350 1 Oxnad1 0.1310417 9.542021e-02 0 0.35324940
351 1 Vps13a 0.1307438 9.663177e-02 0 0.48735806
352 1 Opa1 0.1307054 9.663177e-02 0 0.34119936
353 1 Apip 0.1307031 9.663177e-02 0 0.30031728
354 1 Usp3 0.1306567 9.665538e-02 0 0.14793247
355 1 Leo1 0.1305854 9.686486e-02 0 0.30054292
356 1 Clasp1 0.1301527 9.932987e-02 0 0.11674027
357 1 Prrc2c 0.1301279 9.932987e-02 0 0.17458086
358 1 Iqgap2 0.1300294 9.957040e-02 0 0.39929966
359 1 Znrf3 0.1297207 1.009205e-01 0 0.58115486
360 1 Epm2aip1 0.1297036 1.009205e-01 0 0.34196457
361 1 Lrrc7 0.1295886 1.009205e-01 0 0.14819548
362 1 Jak1 0.1292634 1.027347e-01 0 0.30284988
363 1 Ccdc186 0.1288669 1.048750e-01 0 0.13494288
364 1 Sltm 0.1287386 1.049142e-01 0 0.13242058
365 1 Rybp 0.1286916 1.049623e-01 0 0.36975968
366 1 Gdpd5 0.1283864 1.066272e-01 0 0.31617136
367 1 Igsf3 0.1283846 1.066272e-01 0 0.19494614
368 1 Hdac4 0.1283498 1.066272e-01 0 0.44260801
369 1 C530008M17Rik 0.1281383 1.077726e-01 0 0.24586000
370 1 Agpat4 0.1279918 1.082311e-01 0 0.24201463
371 1 Nek3 0.1278735 1.086200e-01 0 0.46543654
372 1 Ccdc85c 0.1276971 1.092591e-01 0 0.86417579
373 1 Rhbdl3 0.1276760 1.092591e-01 0 0.43639431
374 1 Baz1b 0.1273824 1.100538e-01 0 0.20240472
375 1 Frmd4a 0.1264058 1.176893e-01 0 0.23490660
376 1 Pelp1 0.1263596 1.177511e-01 0 0.25685839
377 1 Ezh2 0.1261647 1.187789e-01 0 0.11801844
378 1 Ngef 0.1258210 1.203993e-01 0 1.69694386
379 1 BC055324 0.1258210 1.203993e-01 0 1.66490323
380 1 Bcl9 0.1256579 1.211950e-01 0 0.22112673
381 1 Unc5d 0.1255533 1.211950e-01 0 0.12876094
382 1 Bbx 0.1255469 1.211950e-01 0 0.18950593
383 1 Synrg 0.1254709 1.215360e-01 0 0.19347041
384 1 Hnrnph3 0.1254295 1.215670e-01 0 0.15967412
385 1 Il10 0.1252627 1.223894e-01 0 0.25691673
386 1 Gm10184 0.1250609 1.231010e-01 0 1.23840587
387 1 Unkl 0.1250609 1.231010e-01 0 1.16904644
388 1 Ywhae 0.1249717 1.231010e-01 0 0.10178118
389 1 Ccdc34 0.1247871 1.236635e-01 0 0.09210400
390 1 Plekha5 0.1247865 1.236635e-01 0 0.23105713
391 1 Ppfia2 0.1242970 1.263882e-01 0 0.19928589
392 1 Dnm3 0.1242700 1.263882e-01 0 0.68369775
393 1 Diablo 0.1239599 1.279252e-01 0 0.20538381
394 1 Eno1b 0.1238235 1.285838e-01 0 0.34441883
395 1 Nt5m 0.1238176 1.285838e-01 0 0.30888221
396 1 Odf2l 0.1237296 1.290743e-01 0 0.32395824
397 1 Brd3 0.1236466 1.292788e-01 0 0.12744106
398 1 Wnk3 0.1236006 1.292788e-01 0 0.30950183
399 1 Ccar1 0.1234892 1.298407e-01 0 0.09869740
400 1 Epg5 0.1234448 1.298407e-01 0 0.59491318
401 2 Gm11808 -0.3484518 7.697548e-13 0 -0.49651641
402 2 Traf5 -0.3460862 1.103237e-12 0 -0.61862023
403 2 Grm8 -0.3222594 6.749210e-11 0 -0.36130888
404 2 Gm12166 -0.3031474 1.391247e-09 0 -0.70766903
405 2 Akap9 -0.2964012 3.629973e-09 0 -0.30684159
406 2 Pdzrn3 -0.2936781 5.388553e-09 0 -0.58043775
407 2 Csnk2a1 -0.2760001 6.982889e-08 0 -0.36399007
408 2 Rpl10.ps3 -0.2547703 1.394645e-06 0 -0.40532835
409 2 Txlng -0.2416189 7.263440e-06 0 -0.65886271
410 2 Rps27rt -0.2371900 1.269524e-05 0 -0.34513991
411 2 Hbb.bs -0.2344950 1.668837e-05 0 -0.38981282
412 2 Rpl13a.ps1 -0.2243523 5.504692e-05 0 -0.52788210
413 2 Mrps28 -0.2230893 6.158832e-05 0 -0.27976541
414 2 Tuba1a -0.2146021 1.528810e-04 0 -0.50226547
415 2 Rab39 -0.2108843 2.244774e-04 0 -0.44863682
416 2 Vmp1 -0.2086986 2.846360e-04 0 -0.27843562
417 2 Selenos -0.2078726 3.077870e-04 0 -0.31692245
418 2 Nrg1 -0.2031443 4.858960e-04 0 -0.24385197
419 2 Aurkaip1 -0.2016202 5.428977e-04 0 -0.22703384
420 2 Gm11361 -0.2013580 5.428977e-04 0 -0.41707948
421 2 Pnn -0.2011202 5.495292e-04 0 -0.25610844
422 2 Fez1 -0.2000574 6.102337e-04 0 -0.15608070
423 2 Gtf2a2 -0.1980178 7.533692e-04 0 -0.20731297
424 2 Kalrn -0.1977204 7.588850e-04 0 -0.25084516
425 2 Cox7a2l -0.1960558 8.873832e-04 0 -0.13539672
426 2 Gm2000 -0.1957453 9.060456e-04 0 -0.35095049
427 2 Rps29 -0.1955583 9.080899e-04 0 -0.26074972
428 2 Nutf2.ps1 -0.1954740 9.080899e-04 0 -0.34815392
429 2 Morf4l1 -0.1935622 1.065489e-03 0 -0.28841746
430 2 Srpk1 -0.1915667 1.290231e-03 0 -0.27646069
431 2 Gm10131 -0.1888901 1.677144e-03 0 -0.25190947
432 2 Gtpbp4 -0.1883153 1.761979e-03 0 -0.26483373
433 2 Rdh5 -0.1867627 2.028606e-03 0 -0.35676065
434 2 Nedd4l -0.1864228 2.067776e-03 0 -0.17374290
435 2 Ndufb4 -0.1846059 2.431827e-03 0 -0.20375478
436 2 Smc3 -0.1842010 2.488602e-03 0 -0.17446696
437 2 Nsg2 -0.1827508 2.824646e-03 0 -0.15724921
438 2 Gm10282 -0.1823008 2.928218e-03 0 -0.44216637
439 2 Eif3m -0.1819981 2.990112e-03 0 -0.15506031
440 2 Rsf1 -0.1801900 3.525046e-03 0 -0.21615777
441 2 Nop58 -0.1795474 3.725645e-03 0 -0.23662780
442 2 Evi5l -0.1778636 4.372422e-03 0 -0.39856473
443 2 Prex1 -0.1767190 4.810053e-03 0 -0.21728572
444 2 Pcm1 -0.1758333 5.155561e-03 0 -0.21233798
445 2 Cbx3 -0.1753203 5.325344e-03 0 -0.23293264
446 2 Ankrd12 -0.1741269 5.883987e-03 0 -0.26085483
447 2 Rtf1 -0.1734301 6.189829e-03 0 -0.18667602
448 2 Bend5 -0.1732906 6.214230e-03 0 -0.39412137
449 2 Zfp131 -0.1728609 6.214230e-03 0 -0.32729559
450 2 Ppp4r2 -0.1728226 6.214230e-03 0 -0.38181828
451 2 Rsrc2 -0.1727732 6.214230e-03 0 -0.16424777
452 2 Fam98b -0.1721113 6.522691e-03 0 -0.33362966
453 2 Robo2 -0.1714317 6.911986e-03 0 -0.17950207
454 2 Tnrc18 -0.1711863 7.021606e-03 0 -0.23993018
455 2 Tmed2 -0.1692572 8.324481e-03 0 -0.14006620
456 2 Hba.a1 -0.1682859 8.923616e-03 0 -0.31612082
457 2 Zfp326 -0.1672118 9.660406e-03 0 -0.20378968
458 2 Rufy1 -0.1667701 9.923580e-03 0 -0.51521168
459 2 Rsbn1 -0.1641050 1.238200e-02 0 -0.24213388
460 2 Setd7 -0.1621581 1.431852e-02 0 -0.36853389
461 2 Ubxn4 -0.1604206 1.656794e-02 0 -0.17550433
462 2 Strn3 -0.1600201 1.706826e-02 0 -0.29537780
463 2 Ly6g6e -0.1592551 1.805340e-02 0 -0.61922904
464 2 Mtdh -0.1591228 1.814915e-02 0 -0.19389366
465 2 Adamtsl3 -0.1586315 1.885016e-02 0 -0.20107630
466 2 Dusp14 -0.1584262 1.903247e-02 0 -0.13102267
467 2 Pttg1 -0.1583790 1.903247e-02 0 -0.55526647
468 2 Pibf1 -0.1582008 1.921533e-02 0 -0.41003624
469 2 Appl1 -0.1577168 1.981484e-02 0 -0.29426390
470 2 H2afy -0.1574831 2.010660e-02 0 -0.16285027
471 2 Calm3 -0.1562729 2.199016e-02 0 -0.16070424
472 2 Ino80b -0.1559776 2.243697e-02 0 -0.34168188
473 2 Bod1l -0.1553121 2.363774e-02 0 -0.18358382
474 2 Iws1 -0.1552531 2.363774e-02 0 -0.27071531
475 2 Kif1a -0.1551444 2.364238e-02 0 -0.22522502
476 2 Alcam -0.1550037 2.364238e-02 0 -0.16601032
477 2 Sept6 -0.1549763 2.364238e-02 0 -0.58960723
478 2 Zfp692 -0.1546065 2.413978e-02 0 -0.37221216
479 2 Rock1 -0.1545208 2.417674e-02 0 -0.28766305
480 2 Eif2b4 -0.1538404 2.494024e-02 0 -0.27560319
481 2 Fnbp1l -0.1536734 2.516567e-02 0 -0.17377379
482 2 Ktn1 -0.1534807 2.545074e-02 0 -0.17307918
483 2 Tcea1 -0.1533759 2.554144e-02 0 -0.33471381
484 2 Zfp397 -0.1532392 2.570503e-02 0 -0.25674657
485 2 Cdk5rap2 -0.1529680 2.588837e-02 0 -0.45056901
486 2 Kdm2a -0.1526938 2.637271e-02 0 -0.21137933
487 2 Smg1 -0.1521631 2.747503e-02 0 -0.27114108
488 2 Rabgap1 -0.1517827 2.824798e-02 0 -0.21136886
489 2 Tmem267 -0.1510996 2.965487e-02 0 -0.31464961
490 2 Gm43518 -0.1496620 3.304610e-02 0 -0.45701413
491 2 Kdm5b -0.1492767 3.362564e-02 0 -0.16632349
492 2 Tpm3 -0.1489532 3.421561e-02 0 -0.20175765
493 2 Dcaf5 -0.1484826 3.490277e-02 0 -0.36801821
494 2 Kcnd2 -0.1476345 3.733185e-02 0 -0.33926994
495 2 Lrch2 -0.1472992 3.784038e-02 0 -0.24954469
496 2 Ncl -0.1471858 3.801824e-02 0 -0.12797966
497 2 Gm3550 -0.1470382 3.807706e-02 0 -0.21855095
498 2 Abl2 -0.1465348 3.939639e-02 0 -0.29724249
499 2 Dync1h1 -0.1464765 3.940062e-02 0 -0.20306988
500 2 Ik -0.1462855 3.984947e-02 0 -0.18514602
501 2 Rpl9.ps6 -0.1461088 4.025505e-02 0 -0.22611091
502 2 Zfand2b -0.1458378 4.081354e-02 0 -0.32873114
503 2 Atrx -0.1457391 4.081354e-02 0 -0.13942252
504 2 Gfm2 -0.1456801 4.081354e-02 0 -0.40499451
505 2 Serbp1 -0.1456656 4.081354e-02 0 -0.14969501
506 2 Gm9008 -0.1455257 4.091578e-02 0 -1.76164484
507 2 CT025619.1 -0.1449230 4.264367e-02 0 -0.19392534
508 2 Zc3h18 -0.1447176 4.318529e-02 0 -0.37215313
509 2 A330084C13Rik -0.1443521 4.432214e-02 0 -0.56562469
510 2 Mycbp2 -0.1441840 4.457820e-02 0 -0.16615709
511 2 Scaf11 -0.1439583 4.498619e-02 0 -0.20986198
512 2 Nuak1 -0.1435589 4.629872e-02 0 -0.17576114
513 2 Cul1 -0.1434946 4.634138e-02 0 -0.15170703
514 2 Zfand5 -0.1434052 4.648139e-02 0 -0.13026238
515 2 Mrps5 -0.1431042 4.744731e-02 0 -0.15458456
516 2 Nrp1 -0.1420546 5.085142e-02 0 -0.06606303
517 2 Ddx5 -0.1408325 5.549341e-02 0 -0.21826847
518 2 Fat3 -0.1403519 5.739409e-02 0 -0.19218385
519 2 Zcchc11 -0.1403158 5.739409e-02 0 -0.25537927
520 2 Vgll4 -0.1401099 5.787694e-02 0 -0.13805112
521 2 L3mbtl3 -0.1395909 5.986721e-02 0 -0.34384398
522 2 Cep85l -0.1391772 6.165036e-02 0 -0.26278821
523 2 Lrch3 -0.1390245 6.191587e-02 0 -0.34368877
524 2 Ddx24 -0.1388620 6.233519e-02 0 -0.12106951
525 2 Chd7 -0.1383698 6.395383e-02 0 -0.23358757
526 2 Ftl1.ps1 -0.1379344 6.570340e-02 0 -0.21973182
527 2 Pde4d -0.1376713 6.657474e-02 0 -0.03943154
528 2 Gm45736 -0.1366498 7.138544e-02 0 -0.30265555
529 2 Zfr -0.1361699 7.387152e-02 0 -0.22322110
530 2 Gm13402 -0.1360180 7.419125e-02 0 -1.78501126
531 2 Cdh4 -0.1358559 7.486189e-02 0 -0.24472568
532 2 Eml4 -0.1355109 7.634653e-02 0 -0.26994997
533 2 Ptov1 -0.1354485 7.638457e-02 0 -0.15583284
534 2 Map3k3 -0.1352972 7.676939e-02 0 -0.32635471
535 2 Ddx3y -0.1348408 7.869134e-02 0 -0.24123454
536 2 Klf13 -0.1347597 7.890145e-02 0 -0.19762500
537 2 Golgb1 -0.1346720 7.915368e-02 0 -0.16523988
538 2 Bcor -0.1345897 7.937393e-02 0 -0.18264437
539 2 Pde9a -0.1344377 7.945022e-02 0 -0.27008760
540 2 Nop56 -0.1336573 8.338971e-02 0 -0.16798515
541 2 Gm26848 -0.1336345 8.338971e-02 0 -0.52469205
542 2 Chd2 -0.1328623 8.792534e-02 0 -0.32331614
543 2 Slc38a10 -0.1322398 9.040119e-02 0 -0.24505316
544 2 Lias -0.1321459 9.040119e-02 0 -0.25865768
545 2 Ccdc191 -0.1320968 9.040119e-02 0 -0.44177446
546 2 Srrm4 -0.1319095 9.140254e-02 0 -0.14104522
547 2 Hmgb1 -0.1318259 9.167927e-02 0 -0.22391249
548 2 Aff2 -0.1314429 9.378199e-02 0 -0.16314267
549 2 Tor2a -0.1312494 9.444128e-02 0 -0.23475385
550 2 Oxnad1 -0.1310548 9.532378e-02 0 -0.35324940
551 2 Vps13a -0.1307479 9.665266e-02 0 -0.48735806
552 2 Apip -0.1307026 9.665266e-02 0 -0.30031728
553 2 Opa1 -0.1307003 9.665266e-02 0 -0.34119936
554 2 Usp3 -0.1306555 9.666486e-02 0 -0.14793247
555 2 Leo1 -0.1305852 9.686614e-02 0 -0.30054292
556 2 Clasp1 -0.1301519 9.933613e-02 0 -0.11674027
557 2 Prrc2c -0.1301271 9.933613e-02 0 -0.17458086
558 2 Iqgap2 -0.1300260 9.959059e-02 0 -0.39929966
559 2 Epm2aip1 -0.1297069 1.009396e-01 0 -0.34196457
560 2 Znrf3 -0.1297048 1.009396e-01 0 -0.58115486
561 2 Lrrc7 -0.1295880 1.010264e-01 0 -0.14819548
562 2 Jak1 -0.1292660 1.027148e-01 0 -0.30284988
563 2 Ccdc186 -0.1288590 1.049197e-01 0 -0.13494288
564 2 Sltm -0.1287321 1.049657e-01 0 -0.13242058
565 2 Rybp -0.1286835 1.050266e-01 0 -0.36975968
566 2 Gdpd5 -0.1283845 1.066594e-01 0 -0.31617136
567 2 Igsf3 -0.1283813 1.066594e-01 0 -0.19494614
568 2 Hdac4 -0.1283448 1.066594e-01 0 -0.44260801
569 2 C530008M17Rik -0.1281322 1.077066e-01 0 -0.24586000
570 2 Agpat4 -0.1279906 1.082208e-01 0 -0.24201463
571 2 Nek3 -0.1278641 1.086972e-01 0 -0.46543654
572 2 Ccdc85c -0.1276868 1.091727e-01 0 -0.86417579
573 2 Rhbdl3 -0.1276866 1.091727e-01 0 -0.43639431
574 2 Baz1b -0.1273785 1.100857e-01 0 -0.20240472
575 2 Frmd4a -0.1264096 1.176558e-01 0 -0.23490660
576 2 Pelp1 -0.1263606 1.177427e-01 0 -0.25685839
577 2 Ezh2 -0.1261583 1.188359e-01 0 -0.11801844
578 2 Ngef -0.1258276 1.203146e-01 0 -1.69694386
579 2 BC055324 -0.1258276 1.203146e-01 0 -1.66490323
580 2 Bcl9 -0.1256521 1.212058e-01 0 -0.22112673
581 2 Unc5d -0.1255478 1.212058e-01 0 -0.12876094
582 2 Bbx -0.1255457 1.212058e-01 0 -0.18950593
583 2 Synrg -0.1254746 1.215027e-01 0 -0.19347041
584 2 Hnrnph3 -0.1254333 1.215329e-01 0 -0.15967412
585 2 Il10 -0.1252729 1.222976e-01 0 -0.25691673
586 2 Gm10184 -0.1250318 1.230558e-01 0 -1.23840587
587 2 Unkl -0.1250318 1.230558e-01 0 -1.16904644
588 2 Ywhae -0.1249512 1.230558e-01 0 -0.10178118
589 2 Ccdc34 -0.1247844 1.237110e-01 0 -0.09210400
590 2 Plekha5 -0.1247813 1.237110e-01 0 -0.23105713
591 2 Ppfia2 -0.1242922 1.264621e-01 0 -0.19928589
592 2 Dnm3 -0.1242606 1.264621e-01 0 -0.68369775
593 2 Diablo -0.1239611 1.279141e-01 0 -0.20538381
594 2 Nt5m -0.1238218 1.285887e-01 0 -0.30888221
595 2 Eno1b -0.1238171 1.285887e-01 0 -0.34441883
596 2 Odf2l -0.1237346 1.290265e-01 0 -0.32395824
597 2 Brd3 -0.1236467 1.292792e-01 0 -0.12744106
598 2 Wnk3 -0.1236005 1.292792e-01 0 -0.30950183
599 2 Ccar1 -0.1234960 1.297591e-01 0 -0.09869740
600 2 Epg5 -0.1234494 1.297591e-01 0 -0.59491318
601 2 Uba52 0.8106578 1.622319e-74 0 1.53792300
602 2 Pgk1 0.5238239 4.452013e-30 0 1.25344098
603 2 Sec61g 0.4973904 4.330414e-27 0 0.94392234
604 2 Erh 0.4763877 8.137141e-25 0 0.66616044
605 2 Atp5l 0.4636140 1.669979e-23 0 0.72958798
606 2 Gm10076 0.4404746 3.983630e-21 0 0.64435861
607 2 Gm10260 0.4297455 4.271154e-20 0 0.55876061
608 2 Stmn1 0.3970580 5.646794e-17 0 0.62877743
609 2 Rpl36al 0.3734641 6.959234e-15 0 0.60240089
610 2 Nme2 0.3595523 9.994733e-14 0 1.48759648
611 2 Raly 0.3384072 4.257342e-12 0 1.02907857
612 2 Rpl27a 0.3273849 2.917626e-11 0 0.39318812
613 2 Hnrnpa1 0.3204802 8.642714e-11 0 0.42371612
614 2 Rpl15 0.3143006 2.371646e-10 0 0.60150822
615 2 Glo1 0.3060682 9.031637e-10 0 0.50825182
616 2 Ppia 0.2990919 2.576494e-09 0 0.61119720
617 2 Gstp1 0.2987705 2.586181e-09 0 0.67817495
618 2 Gm9844 0.2873811 1.405713e-08 0 0.72485194
619 2 Gnb2 0.2863184 1.594659e-08 0 0.89089883
620 2 Gps1 0.2841683 2.145561e-08 0 1.02113299
621 2 Fdps 0.2786061 4.871945e-08 0 0.35290526
622 2 mt.Co1 0.2701407 1.622385e-07 0 0.45083061
623 2 Pcdh9 0.2600918 6.780802e-07 0 0.33568931
624 2 Eno1 0.2521340 1.952078e-06 0 0.34261648
625 2 Tomm20 0.2464028 4.160546e-06 0 0.38429325
626 2 Fopnl 0.2445296 5.066179e-06 0 0.54335800
627 2 Bloc1s1 0.2445140 5.066179e-06 0 0.68382633
628 2 Nme1 0.2368440 1.293442e-05 0 0.31943344
629 2 Mea1 0.2358807 1.429343e-05 0 1.22670712
630 2 Polr2k 0.2314505 2.410659e-05 0 0.74896109
631 2 Tpm3.rs7 0.2256353 4.913834e-05 0 0.38346143
632 2 Lsm7 0.2247241 5.377900e-05 0 0.29980444
633 2 Rwdd1 0.2236545 5.869821e-05 0 0.25680432
634 2 Ppp1cc 0.2216787 7.173969e-05 0 0.42313946
635 2 Tln1 0.2176258 1.151688e-04 0 0.60121336
636 2 Cap1 0.2167225 1.241571e-04 0 0.28472756
637 2 Lamtor3 0.2166648 1.241571e-04 0 0.43463703
638 2 Btf3 0.2147536 1.528810e-04 0 0.27400311
639 2 Ndufs5 0.2128700 1.843052e-04 0 0.48320512
640 2 Tarbp2 0.2123420 1.925531e-04 0 0.98975553
641 2 Ifitm2 0.2075667 3.122521e-04 0 0.93419770
642 2 Btg1 0.2074504 3.122521e-04 0 0.48968203
643 2 Atp5g2 0.2050316 4.055558e-04 0 1.00411870
644 2 Ubb 0.2041761 4.398443e-04 0 0.73394166
645 2 Pop4 0.2030163 4.858960e-04 0 0.31795136
646 2 Mrps33 0.2024270 5.113065e-04 0 0.31275401
647 2 Xist 0.2015710 5.428977e-04 0 0.20099999
648 2 Zfpm2 0.2014001 5.428977e-04 0 0.48028351
649 2 Serf2 0.1979109 7.533692e-04 0 0.33563043
650 2 Serpini1 0.1971857 7.941919e-04 0 0.20380776
651 2 Mrps36 0.1953713 9.080899e-04 0 0.77800701
652 2 Sap18 0.1946847 9.665871e-04 0 0.25178663
653 2 Psap 0.1940357 1.024577e-03 0 0.25725676
654 2 Ube2s 0.1919584 1.251890e-03 0 0.61258722
655 2 Cntnap2 0.1901810 1.479072e-03 0 0.27548961
656 2 mt.Nd5 0.1870468 1.991312e-03 0 0.37227982
657 2 Naa10 0.1863685 2.067776e-03 0 0.60095155
658 2 Gpx4 0.1857663 2.178322e-03 0 0.20008708
659 2 Stmn2 0.1841786 2.488602e-03 0 0.28112428
660 2 Rnf114 0.1828246 2.824646e-03 0 0.24970003
661 2 Rbm3 0.1815099 3.111986e-03 0 0.34334621
662 2 Mrpl23 0.1774163 4.529131e-03 0 0.33564600
663 2 Kpna2 0.1765308 4.855019e-03 0 0.63216478
664 2 Mettl2 0.1754197 5.321950e-03 0 0.33267933
665 2 Grcc10 0.1746264 5.652006e-03 0 0.93197938
666 2 Ap3s1 0.1737990 6.022744e-03 0 0.20527616
667 2 Psenen 0.1731957 6.214230e-03 0 0.25801194
668 2 Dstn 0.1729236 6.214230e-03 0 0.27449226
669 2 X4833439L19Rik 0.1727312 6.214230e-03 0 0.22690981
670 2 Ndn 0.1726918 6.214230e-03 0 0.21869226
671 2 Lrfn5 0.1699571 7.844594e-03 0 0.47692581
672 2 Trmt112 0.1689505 8.505539e-03 0 0.22881986
673 2 Exosc9 0.1686346 8.698411e-03 0 0.35186517
674 2 Apopt1 0.1682024 8.925929e-03 0 0.26016106
675 2 Gpx1 0.1674659 9.501882e-03 0 0.17772780
676 2 Polr2l 0.1668801 9.894426e-03 0 0.38342945
677 2 Rtl8a 0.1664593 1.014425e-02 0 0.43148510
678 2 Lhx9 0.1655589 1.096274e-02 0 0.39696671
679 2 Ube2d3 0.1647657 1.172467e-02 0 0.11304321
680 2 Gadd45g 0.1635806 1.290916e-02 0 0.19430562
681 2 Gm10320 0.1634424 1.298299e-02 0 1.48259469
682 2 Fam171b 0.1633003 1.306246e-02 0 0.26127670
683 2 Cdca4 0.1630280 1.330295e-02 0 0.39779613
684 2 Hnrnpl 0.1614943 1.511702e-02 0 0.24555980
685 2 Prkag2 0.1598511 1.721559e-02 0 0.31107620
686 2 Rpl35 0.1577167 1.981484e-02 0 0.35494978
687 2 Kansl2 0.1569738 2.091460e-02 0 0.30446483
688 2 Akr1b3 0.1564470 2.178729e-02 0 0.95812276
689 2 Wtap 0.1550206 2.364238e-02 0 0.24636895
690 2 Tmem50a 0.1546371 2.413978e-02 0 0.20486681
691 2 Btbd9 0.1544556 2.417674e-02 0 0.16390100
692 2 Churc1 0.1542868 2.439696e-02 0 0.59272102
693 2 Stx7 0.1539892 2.490119e-02 0 0.15631767
694 2 Tenm1 0.1538810 2.494024e-02 0 0.58258836
695 2 Tma7 0.1530701 2.588837e-02 0 0.17778596
696 2 Ncam2 0.1529851 2.588837e-02 0 0.55049454
697 2 Taf13 0.1514087 2.902505e-02 0 0.20711175
698 2 Cd81 0.1507769 3.033349e-02 0 0.14194102
699 2 Rpl29 0.1498115 3.279706e-02 0 0.81233384
700 2 Ly6h 0.1495575 3.313462e-02 0 0.31738241
701 2 Pts 0.1495086 3.313462e-02 0 0.33479576
702 2 Emc8 0.1490372 3.414610e-02 0 1.53338622
703 2 Ntan1 0.1487883 3.452461e-02 0 0.14776099
704 2 Ift46 0.1486298 3.468291e-02 0 0.19087506
705 2 Rhob 0.1486157 3.468291e-02 0 0.24365623
706 2 Pabpc1 0.1473271 3.784038e-02 0 0.12731174
707 2 Rpn1 0.1473114 3.784038e-02 0 0.29685829
708 2 Cd164 0.1470494 3.807706e-02 0 0.95510002
709 2 Ndufs3 0.1469945 3.807706e-02 0 0.19286496
710 2 Faap20 0.1457802 4.081354e-02 0 0.40722095
711 2 Rpp25l 0.1455308 4.091578e-02 0 0.20533516
712 2 Ctps 0.1453310 4.139907e-02 0 0.20157322
713 2 Gstm7 0.1441749 4.457820e-02 0 0.27771035
714 2 Rwdd3 0.1441006 4.465475e-02 0 0.19818151
715 2 Uqcrc1 0.1423919 5.010399e-02 0 0.17200440
716 2 Fdxacb1 0.1422729 5.016131e-02 0 0.76452548
717 2 X1300002E11Rik 0.1422729 5.016131e-02 0 0.96681879
718 2 Gdi1 0.1416790 5.222127e-02 0 0.12858017
719 2 Sms 0.1415829 5.241051e-02 0 0.16537841
720 2 Rgs17 0.1402121 5.763811e-02 0 0.60867803
721 2 Insig1 0.1397114 5.953162e-02 0 0.24820691
722 2 Nop16 0.1390225 6.191587e-02 0 0.36967027
723 2 Lrrn2 0.1388287 6.233519e-02 0 0.59551504
724 2 Marcks 0.1387880 6.233519e-02 0 0.16704611
725 2 Supt4a 0.1385178 6.345086e-02 0 0.10278269
726 2 Tusc2 0.1380995 6.509740e-02 0 0.30700412
727 2 Gm17231 0.1377162 6.657474e-02 0 0.48697134
728 2 Gapdh 0.1372508 6.858074e-02 0 0.24637523
729 2 Hmga1 0.1370253 6.955328e-02 0 0.88024187
730 2 Rprm 0.1361056 7.396247e-02 0 0.17727408
731 2 Ebf1 0.1357785 7.503423e-02 0 0.84978663
732 2 Dad1 0.1354086 7.638457e-02 0 0.09449466
733 2 Zbed4 0.1351606 7.713798e-02 0 0.36013105
734 2 Cdk16 0.1351414 7.713798e-02 0 0.24855976
735 2 Snrpe 0.1345382 7.940378e-02 0 0.15794122
736 2 Smim7 0.1344905 7.941072e-02 0 0.16480519
737 2 Aldh1a7 0.1341357 8.105790e-02 0 1.51622445
738 2 Acp1 0.1336555 8.338971e-02 0 0.35086645
739 2 Gipc1 0.1330729 8.680719e-02 0 0.15192410
740 2 Eef1akmt2 0.1327587 8.832132e-02 0 0.11416905
741 2 Cacna2d3 0.1325827 8.917601e-02 0 0.63717391
742 2 Rbmxl1 0.1325433 8.917601e-02 0 0.18170969
743 2 Gm44790 0.1321837 9.040119e-02 0 0.52945025
744 2 Rtn4r 0.1321604 9.040119e-02 0 1.14607846
745 2 Golga7 0.1321158 9.040119e-02 0 0.13871035
746 2 Arf2 0.1317292 9.204989e-02 0 0.21418581
747 2 Tnpo3 0.1312581 9.444128e-02 0 0.18232415
748 2 Tspan13 0.1312197 9.444128e-02 0 0.12403069
749 2 Pcbp2 0.1308219 9.665266e-02 0 0.06080126
750 2 Mrpl42 0.1302880 9.876728e-02 0 0.11762894
751 2 Rnf11 0.1300084 9.959059e-02 0 0.16489141
752 2 Coro1a 0.1297722 1.009396e-01 0 0.21200976
753 2 Asnsd1 0.1296320 1.010264e-01 0 0.59351386
754 2 Zmynd19 0.1295676 1.010264e-01 0 0.61218867
755 2 Ndufaf1 0.1294306 1.017604e-01 0 0.41922942
756 2 Copz1 0.1292179 1.027661e-01 0 0.06069248
757 2 Kcnq5 0.1289381 1.046382e-01 0 0.21905449
758 2 Lipa 0.1288200 1.049197e-01 0 1.48389373
759 2 Lgals1 0.1287713 1.049657e-01 0 0.77507374
760 2 Cycs 0.1283165 1.066594e-01 0 0.19111465
761 2 Nap1l5 0.1281061 1.077066e-01 0 0.74166992
762 2 Ndel1 0.1279625 1.082208e-01 0 0.21950820
763 2 Emc4 0.1277865 1.090053e-01 0 0.18197192
764 2 Ankrd40 0.1275889 1.095669e-01 0 1.04874102
765 2 Cetn3 0.1275594 1.095669e-01 0 0.12402363
766 2 Ddt 0.1274969 1.097573e-01 0 0.21534417
767 2 Ube2d1 0.1274425 1.098818e-01 0 0.05989198
768 2 Lztr1 0.1267036 1.154428e-01 0 0.35554758
769 2 Hdhd3 0.1262039 1.187774e-01 0 1.03765416
770 2 Prmt2 0.1260393 1.195454e-01 0 0.15842919
771 2 Gng2 0.1257989 1.203146e-01 0 0.05703520
772 2 Ccdc71 0.1257984 1.203146e-01 0 0.29402403
773 2 Sult4a1 0.1256188 1.212058e-01 0 0.19724735
774 2 Dazap1 0.1253540 1.219067e-01 0 0.07491903
775 2 Pagr1b 0.1251957 1.226547e-01 0 0.09772905
776 2 Med29 0.1250203 1.230558e-01 0 0.31959522
777 2 H2afz 0.1249464 1.230558e-01 0 0.13517372
778 2 Pgrmc1 0.1249274 1.230558e-01 0 0.12353972
779 2 F13a1 0.1247282 1.238593e-01 0 1.52270746
780 2 Rpl35a 0.1246474 1.242606e-01 0 0.22888981
781 2 Jagn1 0.1246057 1.243068e-01 0 0.16362032
782 2 Ugp2 0.1243442 1.263772e-01 0 0.26457037
783 2 Slit1 0.1242256 1.264621e-01 0 1.24170259
784 2 Akr1e1 0.1241721 1.266214e-01 0 0.26869253
785 2 Zbtb18 0.1241083 1.268779e-01 0 0.02494936
786 2 Skp1a 0.1236075 1.292792e-01 0 0.08361736
787 2 Alg8 0.1234078 1.297591e-01 0 0.29004950
788 2 X4933404O12Rik 0.1232963 1.302453e-01 0 1.53093894
789 2 Gm48551 0.1232860 1.302453e-01 0 0.65149996
790 2 Rwdd4a 0.1230171 1.315205e-01 0 0.16272864
791 2 Gcat 0.1227221 1.336424e-01 0 0.90784266
792 2 Psmg3 0.1224162 1.359546e-01 0 1.45761797
793 2 Gm16973 0.1224162 1.359546e-01 0 1.52662646
794 2 Trib1 0.1220832 1.375425e-01 0 1.12151004
795 2 Rrp7a 0.1220344 1.376864e-01 0 0.27596938
796 2 Gpi1 0.1214876 1.413714e-01 0 0.13377824
797 2 Psma3 0.1213763 1.415736e-01 0 0.03872378
798 2 Gm36198 0.1213158 1.418467e-01 0 1.12334271
799 2 Cyb5a 0.1212564 1.421096e-01 0 0.14287255
800 2 Txndc9 0.1211408 1.429497e-01 0 0.03272968Cluster 510 e15.0
OriginalCluster CellNumber COTANClusterNumber Accuracy
1 Cl525E15.0 826 3 0.786585365853659
2 Cl511E15.0 540 2 0.916666666666667
3 Cl184E15.0 322 2 0.734375
4 Cl432E13.5 536 2 0.88785046728972
5 Cl510E15.0 402 2 <NA>cells <- getClusterizationData(e15.0,clName = "CL_original.clusters")[[1]][getClusterizationData(e15.0,clName = "CL_original.clusters")[[1]] == "510"]
cells <-names(cells)
cl510e15.0 <- automaticCOTANObjectCreation(raw = getRawData(e15.0)[,cells],
GEO = "Loom",
sequencingMethod = "10X",
sampleCondition = "cl510e15.0",
cores = 10,saveObj = T,
outDir = "Data/MouseCortexFromLoom/NotCTSingleClusters/",
calcCoex = T)cl510e15.0GDI <- calculateGDI(cl510e15.0)
subsetGDIcl510e15.0 <- cl510e15.0GDI[cl510e15.0GDI$sum.raw.norm > 5,]
top.GDI.genes <- rownames(subsetGDIcl510e15.0[order(subsetGDIcl510e15.0$GDI,decreasing = T),])[1:25]
GDIPlot(cl510e15.0,genes = list("topGDI"=top.GDI.genes),GDIIn = cl510e15.0GDI)
list.cl.CT <- cellsUniformClustering(cl510e15.0, GDIThreshold = 1.43, cores = 10L,
saveObj = TRUE, outDir = outDir)
cl510e15.0 <- addClusterization(cl510e15.0, clName = "split",
clusters = list.cl.CT$clusters,
coexDF = list.cl.CT$coex, override = TRUE)
table(list.cl.CT$clusters)c(mergedClusters, mergedCoexDF) %<-%
mergeUniformCellsClusters(cl510e15.0, clusters = list.cl.CT$clusters,
GDIThreshold = 1.43, batchSize = 4L, cores = 10L,
saveObj = TRUE, outDir = outDir)
cl510e15.0 <- addClusterization(cl510e15.0, clName = "merge",
clusters = mergedClusters,
coexDF = mergedCoexDF,
override = TRUE)
saveRDS(cl510e15.0,paste0(outDir,"cl510e15.0.cotan.RDS"))
table(str_split(names(mergedClusters),pattern = "_",simplify = T)[,1],mergedClusters)data <- getNormalizedData(cl510e15.0)
data <- data[!rowSums(as.matrix(data)) < 1,]
data <- log(data*10000+1)
row_stdev <- apply(data, 1, sd, na.rm=TRUE)
row_stdev <- row_stdev[order(row_stdev,decreasing = T)]
genes.to.keep <- c(names(row_stdev[1:100]),top.GDI.genes)
data.small <- data[rownames(data) %in% genes.to.keep,]
#data <- t(as.matrix(data))
data.small <- t(as.matrix(data.small))
COTAN_Cl.code <- getClusterizationData(cl510e15.0)[[1]]
#COTAN_Cl.code[COTAN_Cl.code == "A549"] <- 0
#COTAN_Cl.code[COTAN_Cl.code == "CCL-185-IG"] <- 1
COTAN_Cl.code <- as.numeric(COTAN_Cl.code)-1
data.small <- cbind(data.small,COTAN_Cl.code)
data.small <- as.data.frame(data.small)
# Split the data into training and test set
set.seed(123)
training.samples <- data.small[,"COTAN_Cl.code"] %>%
createDataPartition(p = 0.8, list = FALSE)
train.data <- data.small[training.samples, ]
test.data <- data.small[-training.samples, ]
head(train.data) Add2 Cdh11 Flrt2 Gtdc1 Dock4 Ldb2
10X74_4_A_1:GTCCCATGGTATCGx 0.000000 9.032079 0 0.000000 0.000000 0.00000
10X74_4_A_1:CAATTCACCAATCGx 0.000000 0.000000 0 0.000000 9.137791 11.21714
10X74_4_A_1:CGCGAGACCTCAAGx 0.000000 10.178981 0 0.000000 0.000000 10.87211
10X64_3_A_1:AATGGAGATAAGGAx 0.000000 0.000000 0 0.000000 9.626479 10.31959
10X64_3_A_1:TATACGCTAGCTCAx 9.323881 0.000000 0 9.323881 0.000000 10.42243
10X64_3_A_1:GAGCATACTTGTCTx 9.162964 0.000000 0 0.000000 0.000000 10.26151
Lpl Cadps Slc35f1 Frmd5 Dlgap1
10X74_4_A_1:GTCCCATGGTATCGx 0.00000 9.725166 0.000000 0.000000 10.418284
10X74_4_A_1:CAATTCACCAATCGx 0.00000 9.137791 0.000000 9.137791 9.137791
10X74_4_A_1:CGCGAGACCTCAAGx 0.00000 0.000000 0.000000 10.178981 0.000000
10X64_3_A_1:AATGGAGATAAGGAx 0.00000 0.000000 8.933398 9.626479 8.933398
10X64_3_A_1:TATACGCTAGCTCAx 0.00000 0.000000 9.323881 9.323881 9.323881
10X64_3_A_1:GAGCATACTTGTCTx 10.54918 0.000000 9.162964 9.856059 0.000000
Elmod1 Nin Kcnn2 Foxp1 Alcam
10X74_4_A_1:GTCCCATGGTATCGx 10.418284 0.000000 0.000000 10.13061 0.000000
10X74_4_A_1:CAATTCACCAATCGx 9.137791 10.236331 9.137791 0.00000 9.137791
10X74_4_A_1:CGCGAGACCTCAAGx 0.000000 0.000000 11.277568 0.00000 0.000000
10X64_3_A_1:AATGGAGATAAGGAx 8.933398 9.626479 10.031922 0.00000 10.031922
10X64_3_A_1:TATACGCTAGCTCAx 10.422434 0.000000 0.000000 10.42243 0.000000
10X64_3_A_1:GAGCATACTTGTCTx 0.000000 0.000000 10.549180 10.26151 9.856059
Plppr1 Gria1 Ncam2 Cadm2 Rnd2
10X74_4_A_1:GTCCCATGGTATCGx 9.725166 0.000000 0.00000 0.000000 0.000000
10X74_4_A_1:CAATTCACCAATCGx 10.236331 9.137791 0.00000 0.000000 0.000000
10X74_4_A_1:CGCGAGACCTCAAGx 10.178981 0.000000 0.00000 0.000000 0.000000
10X64_3_A_1:AATGGAGATAAGGAx 0.000000 10.319593 0.00000 0.000000 9.626479
10X64_3_A_1:TATACGCTAGCTCAx 9.323881 0.000000 10.01698 0.000000 0.000000
10X64_3_A_1:GAGCATACTTGTCTx 9.162964 0.000000 0.00000 9.162964 0.000000
Tenm3 Sorbs2 Cotl1 Grip1 Slit3
10X74_4_A_1:GTCCCATGGTATCGx 0.000000 9.032079 9.725166 9.032079 10.641421
10X74_4_A_1:CAATTCACCAATCGx 0.000000 0.000000 10.929461 0.000000 0.000000
10X74_4_A_1:CGCGAGACCTCAAGx 0.000000 0.000000 10.872110 0.000000 10.178981
10X64_3_A_1:AATGGAGATAAGGAx 8.933398 10.031922 11.130505 9.626479 8.933398
10X64_3_A_1:TATACGCTAGCTCAx 10.016984 0.000000 9.323881 10.422434 10.422434
10X64_3_A_1:GAGCATACTTGTCTx 10.549180 0.000000 9.856059 0.000000 0.000000
Pak7 Sobp Zfpm2 Tmem178 Bhlhe22
10X74_4_A_1:GTCCCATGGTATCGx 0.000000 9.032079 9.032079 9.725166 0.000000
10X74_4_A_1:CAATTCACCAATCGx 9.830884 0.000000 0.000000 0.000000 9.830884
10X74_4_A_1:CGCGAGACCTCAAGx 0.000000 0.000000 10.178981 10.178981 10.178981
10X64_3_A_1:AATGGAGATAAGGAx 0.000000 0.000000 9.626479 0.000000 0.000000
10X64_3_A_1:TATACGCTAGCTCAx 0.000000 0.000000 0.000000 10.016984 0.000000
10X64_3_A_1:GAGCATACTTGTCTx 0.000000 9.162964 0.000000 9.856059 10.549180
Epha3 Adgrl3 Kcnq3 Nrp1
10X74_4_A_1:GTCCCATGGTATCGx 10.82374 9.032079 0.000000 11.42987
10X74_4_A_1:CAATTCACCAATCGx 0.00000 0.000000 9.830884 0.00000
10X74_4_A_1:CGCGAGACCTCAAGx 0.00000 0.000000 10.178981 11.27757
10X64_3_A_1:AATGGAGATAAGGAx 0.00000 0.000000 10.725047 0.00000
10X64_3_A_1:TATACGCTAGCTCAx 10.42243 10.016984 9.323881 0.00000
10X64_3_A_1:GAGCATACTTGTCTx 0.00000 0.000000 0.000000 0.00000
X3110039M20Rik Cnih3 Dync1i1 Spock1 Gpr85
10X74_4_A_1:GTCCCATGGTATCGx 0.000000 10.130612 9.032079 10.41828 9.032079
10X74_4_A_1:CAATTCACCAATCGx 0.000000 0.000000 9.830884 0.00000 9.137791
10X74_4_A_1:CGCGAGACCTCAAGx 0.000000 0.000000 0.000000 0.00000 0.000000
10X64_3_A_1:AATGGAGATAAGGAx 0.000000 0.000000 9.626479 0.00000 8.933398
10X64_3_A_1:TATACGCTAGCTCAx 9.323881 9.323881 0.000000 10.01698 0.000000
10X64_3_A_1:GAGCATACTTGTCTx 0.000000 0.000000 0.000000 0.00000 9.856059
Kcnq5 Sh3gl2 Lrrtm4 Gm17750 Mir124.2hg
10X74_4_A_1:GTCCCATGGTATCGx 0.000000 0.000000 9.032079 0.000000 0.000000
10X74_4_A_1:CAATTCACCAATCGx 10.747143 0.000000 0.000000 9.137791 0.000000
10X74_4_A_1:CGCGAGACCTCAAGx 0.000000 10.178981 10.178981 0.000000 0.000000
10X64_3_A_1:AATGGAGATAAGGAx 0.000000 8.933398 0.000000 0.000000 8.933398
10X64_3_A_1:TATACGCTAGCTCAx 0.000000 9.323881 9.323881 0.000000 9.323881
10X64_3_A_1:GAGCATACTTGTCTx 9.162964 0.000000 0.000000 0.000000 9.162964
Tox Tbr1 Fat3 Kcnh7 Chl1
10X74_4_A_1:GTCCCATGGTATCGx 0.000000 0.000000 0.000000 10.41828 0.000000
10X74_4_A_1:CAATTCACCAATCGx 10.236331 0.000000 9.137791 0.00000 0.000000
10X74_4_A_1:CGCGAGACCTCAAGx 0.000000 10.178981 0.000000 0.00000 0.000000
10X64_3_A_1:AATGGAGATAAGGAx 8.933398 9.626479 0.000000 10.03192 10.031922
10X64_3_A_1:TATACGCTAGCTCAx 0.000000 0.000000 0.000000 10.01698 0.000000
10X64_3_A_1:GAGCATACTTGTCTx 0.000000 9.162964 10.261507 0.00000 9.856059
Cd47 Ntm Ntng2 Ryr3 Neto2
10X74_4_A_1:GTCCCATGGTATCGx 10.130612 10.64142 9.032079 10.130612 0.000000
10X74_4_A_1:CAATTCACCAATCGx 9.137791 11.33492 0.000000 0.000000 9.830884
10X74_4_A_1:CGCGAGACCTCAAGx 0.000000 10.17898 0.000000 10.178981 0.000000
10X64_3_A_1:AATGGAGATAAGGAx 9.626479 0.00000 0.000000 0.000000 10.031922
10X64_3_A_1:TATACGCTAGCTCAx 0.000000 10.42243 10.933248 0.000000 10.422434
10X64_3_A_1:GAGCATACTTGTCTx 9.162964 11.56076 10.549180 9.162964 0.000000
Ap1s2 Mdga2 Lmo4 Masp1 Snca
10X74_4_A_1:GTCCCATGGTATCGx 9.032079 0.000000 11.596918 0.000000 9.032079
10X74_4_A_1:CAATTCACCAATCGx 0.000000 9.137791 9.137791 9.137791 0.000000
10X74_4_A_1:CGCGAGACCTCAAGx 10.178981 0.000000 0.000000 0.000000 0.000000
10X64_3_A_1:AATGGAGATAAGGAx 10.031922 0.000000 8.933398 8.933398 8.933398
10X64_3_A_1:TATACGCTAGCTCAx 10.016984 9.323881 9.323881 9.323881 10.422434
10X64_3_A_1:GAGCATACTTGTCTx 0.000000 9.162964 9.856059 9.162964 0.000000
Crym Jakmip1 Galnt17 Enox1 Atrnl1
10X74_4_A_1:GTCCCATGGTATCGx 9.725166 0.000000 9.032079 9.032079 0.000000
10X74_4_A_1:CAATTCACCAATCGx 0.000000 9.137791 0.000000 0.000000 9.137791
10X74_4_A_1:CGCGAGACCTCAAGx 0.000000 10.178981 0.000000 11.277568 10.178981
10X64_3_A_1:AATGGAGATAAGGAx 0.000000 0.000000 0.000000 8.933398 0.000000
10X64_3_A_1:TATACGCTAGCTCAx 0.000000 0.000000 0.000000 0.000000 0.000000
10X64_3_A_1:GAGCATACTTGTCTx 0.000000 9.856059 9.162964 0.000000 0.000000
Tmem178b Kif21a Cntn2 Dgki Trim2
10X74_4_A_1:GTCCCATGGTATCGx 10.130612 0.000000 9.725166 0.000000 0.000000
10X74_4_A_1:CAATTCACCAATCGx 0.000000 0.000000 9.137791 9.137791 9.137791
10X74_4_A_1:CGCGAGACCTCAAGx 10.178981 0.000000 0.000000 0.000000 10.178981
10X64_3_A_1:AATGGAGATAAGGAx 8.933398 8.933398 8.933398 8.933398 0.000000
10X64_3_A_1:TATACGCTAGCTCAx 10.422434 0.000000 10.016984 0.000000 10.016984
10X64_3_A_1:GAGCATACTTGTCTx 9.162964 9.162964 10.549180 0.000000 0.000000
Neo1 Nrg1 Pcsk2 Cacna1e Cacna2d1
10X74_4_A_1:GTCCCATGGTATCGx 9.725166 0.000000 10.82374 9.032079 0.000000
10X74_4_A_1:CAATTCACCAATCGx 0.000000 0.000000 0.00000 0.000000 9.137791
10X74_4_A_1:CGCGAGACCTCAAGx 10.178981 0.000000 0.00000 10.178981 0.000000
10X64_3_A_1:AATGGAGATAAGGAx 0.000000 8.933398 0.00000 0.000000 10.031922
10X64_3_A_1:TATACGCTAGCTCAx 9.323881 0.000000 0.00000 0.000000 9.323881
10X64_3_A_1:GAGCATACTTGTCTx 0.000000 0.000000 0.00000 0.000000 0.000000
Rpl26 Rpl5 Hsp90b1 Sae1 Srsf1
10X74_4_A_1:GTCCCATGGTATCGx 11.740018 10.41828 0.000000 0.000000 9.725166
10X74_4_A_1:CAATTCACCAATCGx 10.236331 11.08361 9.137791 9.830884 0.000000
10X74_4_A_1:CGCGAGACCTCAAGx 10.178981 10.17898 10.178981 0.000000 0.000000
10X64_3_A_1:AATGGAGATAAGGAx 0.000000 10.03192 0.000000 0.000000 8.933398
10X64_3_A_1:TATACGCTAGCTCAx 0.000000 10.42243 10.016984 9.323881 9.323881
10X64_3_A_1:GAGCATACTTGTCTx 9.162964 10.54918 0.000000 9.162964 0.000000
Ehmt1 Wdr33 Hmgb3 Ssrp1 Rps17
10X74_4_A_1:GTCCCATGGTATCGx 0.000000 9.032079 0.000000 0.000000 11.59692
10X74_4_A_1:CAATTCACCAATCGx 9.137791 0.000000 9.137791 9.137791 11.33492
10X74_4_A_1:CGCGAGACCTCAAGx 0.000000 0.000000 0.000000 0.000000 0.00000
10X64_3_A_1:AATGGAGATAAGGAx 8.933398 0.000000 10.319593 8.933398 11.70586
10X64_3_A_1:TATACGCTAGCTCAx 0.000000 10.016984 0.000000 9.323881 10.93325
10X64_3_A_1:GAGCATACTTGTCTx 0.000000 0.000000 0.000000 9.162964 11.46546
Rpl13a Rps12 Hmgn1 Rps26 Selenos
10X74_4_A_1:GTCCCATGGTATCGx 10.82374 11.11142 10.13061 11.74002 9.725166
10X74_4_A_1:CAATTCACCAATCGx 10.92946 11.08361 12.27318 11.62260 10.236331
10X74_4_A_1:CGCGAGACCTCAAGx 0.00000 11.27757 10.87211 10.17898 0.000000
10X64_3_A_1:AATGGAGATAAGGAx 11.41818 11.13051 10.54273 11.33117 9.626479
10X64_3_A_1:TATACGCTAGCTCAx 11.26972 11.26972 10.71011 11.11557 10.016984
10X64_3_A_1:GAGCATACTTGTCTx 11.24231 10.26151 10.77232 11.36010 0.000000
Tspan5 Rps25 Rps28 Pomp Thoc2
10X74_4_A_1:GTCCCATGGTATCGx 0.000000 10.82374 10.641421 10.64142 9.032079
10X74_4_A_1:CAATTCACCAATCGx 9.830884 11.33492 9.830884 10.74714 0.000000
10X74_4_A_1:CGCGAGACCTCAAGx 0.000000 10.17898 10.178981 0.00000 0.000000
10X64_3_A_1:AATGGAGATAAGGAx 9.626479 11.23586 10.879195 10.72505 0.000000
10X64_3_A_1:TATACGCTAGCTCAx 0.000000 10.42243 11.403245 10.42243 0.000000
10X64_3_A_1:GAGCATACTTGTCTx 0.000000 11.36010 10.772318 10.54918 9.162964
Phf21a Sptan1 Phf20 Maged2 Taok3
10X74_4_A_1:GTCCCATGGTATCGx 9.725166 0.000000 9.725166 10.641421 10.130612
10X74_4_A_1:CAATTCACCAATCGx 0.000000 0.000000 0.000000 0.000000 0.000000
10X74_4_A_1:CGCGAGACCTCAAGx 0.000000 0.000000 0.000000 10.178981 10.178981
10X64_3_A_1:AATGGAGATAAGGAx 8.933398 10.031922 8.933398 0.000000 8.933398
10X64_3_A_1:TATACGCTAGCTCAx 0.000000 9.323881 0.000000 0.000000 0.000000
10X64_3_A_1:GAGCATACTTGTCTx 0.000000 9.856059 0.000000 9.856059 0.000000
Atp5e Rpl35a Pcm1 Cep170 Tmem57
10X74_4_A_1:GTCCCATGGTATCGx 10.64142 10.418284 0.000000 9.725166 10.130612
10X74_4_A_1:CAATTCACCAATCGx 10.92946 9.830884 0.000000 9.137791 9.137791
10X74_4_A_1:CGCGAGACCTCAAGx 0.00000 0.000000 10.178981 0.000000 10.872110
10X64_3_A_1:AATGGAGATAAGGAx 10.54273 9.626479 8.933398 0.000000 8.933398
10X64_3_A_1:TATACGCTAGCTCAx 10.42243 0.000000 0.000000 9.323881 9.323881
10X64_3_A_1:GAGCATACTTGTCTx 10.54918 0.000000 10.261507 9.162964 0.000000
Foxn3 Xist Hmgcs1 Eif1b Smarcc2
10X74_4_A_1:GTCCCATGGTATCGx 10.641421 11.22920 0.000000 9.725166 0.000000
10X74_4_A_1:CAATTCACCAATCGx 0.000000 10.74714 9.137791 9.830884 0.000000
10X74_4_A_1:CGCGAGACCTCAAGx 0.000000 0.00000 0.000000 10.178981 10.178981
10X64_3_A_1:AATGGAGATAAGGAx 9.626479 10.87919 10.319593 9.626479 8.933398
10X64_3_A_1:TATACGCTAGCTCAx 10.016984 10.42243 0.000000 10.016984 0.000000
10X64_3_A_1:GAGCATACTTGTCTx 9.162964 0.00000 10.261507 9.162964 0.000000
Ndn Plcb1 Clasp2 Tnrc6c Mapk3
10X74_4_A_1:GTCCCATGGTATCGx 9.725166 9.032079 9.725166 9.725166 10.13061
10X74_4_A_1:CAATTCACCAATCGx 9.137791 10.236331 0.000000 9.137791 0.00000
10X74_4_A_1:CGCGAGACCTCAAGx 0.000000 10.178981 0.000000 0.000000 10.87211
10X64_3_A_1:AATGGAGATAAGGAx 11.012724 0.000000 9.626479 0.000000 0.00000
10X64_3_A_1:TATACGCTAGCTCAx 10.016984 9.323881 10.710109 0.000000 10.01698
10X64_3_A_1:GAGCATACTTGTCTx 0.000000 0.000000 9.162964 0.000000 0.00000
Dync1h1 Ndfip1 COTAN_Cl.code
10X74_4_A_1:GTCCCATGGTATCGx 9.725166 9.032079 1
10X74_4_A_1:CAATTCACCAATCGx 0.000000 9.830884 1
10X74_4_A_1:CGCGAGACCTCAAGx 0.000000 0.000000 1
10X64_3_A_1:AATGGAGATAAGGAx 0.000000 0.000000 0
10X64_3_A_1:TATACGCTAGCTCAx 0.000000 0.000000 1
10X64_3_A_1:GAGCATACTTGTCTx 0.000000 0.000000 0# Fit the model
model <- glm( COTAN_Cl.code ~., data = train.data, family = binomial,control = list(maxit = 50))
# Summarize the model
summary(model)
Call:
glm(formula = COTAN_Cl.code ~ ., family = binomial, data = train.data,
control = list(maxit = 50))
Coefficients:
Estimate Std. Error z value Pr(>|z|)
(Intercept) 1.648e+01 2.538e+06 0 1
Add2 3.406e-01 6.709e+04 0 1
Cdh11 4.435e-01 8.331e+04 0 1
Flrt2 -1.368e+00 6.504e+04 0 1
Gtdc1 5.586e-01 7.498e+04 0 1
Dock4 -7.226e-01 5.558e+04 0 1
Ldb2 -1.161e+00 9.863e+04 0 1
Lpl -1.816e+00 7.031e+04 0 1
Cadps -1.277e-01 7.767e+04 0 1
Slc35f1 9.495e-01 1.162e+05 0 1
Frmd5 5.888e-02 6.500e+04 0 1
Dlgap1 5.982e-01 9.289e+04 0 1
Elmod1 -1.618e+00 9.177e+04 0 1
Nin 3.962e-01 5.751e+04 0 1
Kcnn2 3.354e-01 5.583e+04 0 1
Foxp1 1.078e-01 5.648e+04 0 1
Alcam -7.891e-01 7.024e+04 0 1
Plppr1 9.337e-01 9.847e+04 0 1
Gria1 -6.976e-01 1.222e+05 0 1
Ncam2 3.917e-01 1.416e+05 0 1
Cadm2 -7.945e-01 5.926e+04 0 1
Rnd2 -6.843e-01 1.052e+05 0 1
Tenm3 1.531e+00 7.112e+04 0 1
Sorbs2 5.778e-01 7.114e+04 0 1
Cotl1 -8.660e-01 1.551e+05 0 1
Grip1 1.188e+00 6.948e+04 0 1
Slit3 -2.722e-01 8.231e+04 0 1
Pak7 -6.810e-01 8.440e+04 0 1
Sobp -1.553e+00 1.008e+05 0 1
Zfpm2 -5.977e-01 1.242e+05 0 1
Tmem178 6.956e-01 7.115e+04 0 1
Bhlhe22 7.112e-01 9.282e+04 0 1
Epha3 -1.113e+00 6.664e+04 0 1
Adgrl3 6.038e-01 9.405e+04 0 1
Kcnq3 5.476e-01 1.043e+05 0 1
Nrp1 5.709e-01 8.500e+04 0 1
X3110039M20Rik 7.328e-01 9.668e+04 0 1
Cnih3 4.598e-01 9.917e+04 0 1
Dync1i1 8.848e-02 1.291e+05 0 1
Spock1 1.589e+00 1.089e+05 0 1
Gpr85 1.843e+00 9.086e+04 0 1
Kcnq5 -6.448e-01 6.210e+04 0 1
Sh3gl2 -5.639e-01 6.462e+04 0 1
Lrrtm4 -3.230e-01 8.841e+04 0 1
Gm17750 9.768e-01 1.322e+05 0 1
Mir124.2hg 5.690e-01 5.385e+04 0 1
Tox 1.579e+00 7.139e+04 0 1
Tbr1 -2.199e+00 9.993e+04 0 1
Fat3 -2.329e+00 7.544e+04 0 1
Kcnh7 -1.442e+00 8.955e+04 0 1
Chl1 -8.474e-01 6.276e+04 0 1
Cd47 2.609e-01 1.189e+05 0 1
Ntm 1.697e+00 1.032e+05 0 1
Ntng2 1.210e+00 9.358e+04 0 1
Ryr3 7.297e-01 7.496e+04 0 1
Neto2 -1.247e-01 8.568e+04 0 1
Ap1s2 -8.177e-01 7.710e+04 0 1
Mdga2 -3.161e-01 7.195e+04 0 1
Lmo4 9.815e-01 4.587e+04 0 1
Masp1 1.236e+00 9.610e+04 0 1
Snca 8.278e-01 1.062e+05 0 1
Crym -3.996e-01 8.715e+04 0 1
Jakmip1 1.617e+00 1.182e+05 0 1
Galnt17 -1.636e+00 8.228e+04 0 1
Enox1 -6.653e-02 1.498e+05 0 1
Atrnl1 5.075e-01 6.420e+04 0 1
Tmem178b -1.211e+00 6.437e+04 0 1
Kif21a -1.183e+00 8.275e+04 0 1
Cntn2 -6.145e-01 9.840e+04 0 1
Dgki 8.343e-01 6.970e+04 0 1
Trim2 2.193e-01 1.035e+05 0 1
Neo1 4.175e-01 9.042e+04 0 1
Nrg1 9.990e-01 8.920e+04 0 1
Pcsk2 1.356e+00 1.130e+05 0 1
Cacna1e -3.779e-01 9.071e+04 0 1
Cacna2d1 7.626e-01 9.022e+04 0 1
Rpl26 3.607e+00 1.616e+05 0 1
Rpl5 4.595e-01 1.501e+05 0 1
Hsp90b1 9.838e-02 7.218e+04 0 1
Sae1 8.304e-01 9.806e+04 0 1
Srsf1 8.954e-01 7.093e+04 0 1
Ehmt1 -5.895e-01 8.763e+04 0 1
Wdr33 -4.389e-02 6.339e+04 0 1
Hmgb3 -1.176e+00 9.332e+04 0 1
Ssrp1 -5.582e-01 9.471e+04 0 1
Rps17 4.539e+00 3.189e+05 0 1
Rpl13a -4.667e+00 4.786e+05 0 1
Rps12 -1.058e+00 2.749e+05 0 1
Hmgn1 1.426e+00 2.199e+05 0 1
Rps26 6.857e-01 4.161e+05 0 1
Selenos 6.071e-01 8.616e+04 0 1
Tspan5 1.076e+00 6.674e+04 0 1
Rps25 -1.283e+00 2.143e+05 0 1
Rps28 -2.860e+00 1.809e+05 0 1
Pomp -4.704e-01 1.433e+05 0 1
Thoc2 -8.902e-01 7.183e+04 0 1
Phf21a 1.319e+00 6.287e+04 0 1
Sptan1 -4.865e-01 7.307e+04 0 1
Phf20 -4.587e-01 7.967e+04 0 1
Maged2 -2.851e-01 6.644e+04 0 1
Taok3 -6.431e-01 5.279e+04 0 1
Atp5e -1.980e+00 1.947e+05 0 1
Rpl35a 3.354e+00 1.172e+05 0 1
Pcm1 2.279e-01 4.695e+04 0 1
Cep170 -8.238e-01 1.058e+05 0 1
Tmem57 2.726e-01 1.193e+05 0 1
Foxn3 7.669e-02 7.168e+04 0 1
Xist -6.332e-01 7.549e+04 0 1
Hmgcs1 -1.033e+00 7.508e+04 0 1
Eif1b -1.129e+00 6.464e+04 0 1
Smarcc2 1.391e+00 8.941e+04 0 1
Ndn -8.821e-01 6.755e+04 0 1
Plcb1 -2.334e-01 6.322e+04 0 1
Clasp2 7.266e-01 1.107e+05 0 1
Tnrc6c 4.524e-01 9.929e+04 0 1
Mapk3 -2.477e-01 9.378e+04 0 1
Dync1h1 3.548e-01 7.543e+04 0 1
Ndfip1 9.539e-01 7.695e+04 0 1
(Dispersion parameter for binomial family taken to be 1)
Null deviance: 4.4189e+02 on 321 degrees of freedom
Residual deviance: 3.7099e-10 on 204 degrees of freedom
AIC: 236
Number of Fisher Scoring iterations: 28# Make predictions
probabilities <- model %>% predict(test.data, type = "response")
predicted.classes <- ifelse(probabilities > 0.5, "1", "0")
# Model accuracy
accuracy <- mean(predicted.classes == test.data$COTAN_Cl.code)
result.df[nrow(result.df),"Accuracy"] <- accuracy
accuracy[1] 0.825So also in this case a logistic regression confirm the difference in cell population detected by COTAN.
cl510e15.0ClsMarkers <- findClustersMarkers(cl510e15.0,n = 200,adjustmentMethod = "BH")
cl510e15.0ClsMarkers CL Gene DEA adjPVal IsMarker logFoldCh
1 1 Rpl26 -0.7828372 2.011317e-51 0 -1.57515134
2 1 Rpl35a -0.6930519 4.191530e-40 0 -1.24898088
3 1 Uba52 -0.5225985 4.522799e-22 0 -0.94946200
4 1 Nrp1 -0.4696725 1.446485e-17 0 -1.10517320
5 1 Hcn1 -0.3625100 6.476616e-10 0 -1.08301395
6 1 Pantr1 -0.3607812 7.320065e-10 0 -0.80322987
7 1 Gstp1 -0.3518125 2.167905e-09 0 -0.62139975
8 1 Btg1 -0.3459701 4.544828e-09 0 -0.62262518
9 1 Fgfr2 -0.3257636 5.790833e-08 0 -0.73656272
10 1 Gm48091 -0.3208919 9.683038e-08 0 -0.80366280
11 1 Pcdh8 -0.3189523 1.176346e-07 0 -0.65834688
12 1 Nr4a2 -0.3125880 2.406869e-07 0 -1.55914852
13 1 Ryr3 -0.2861349 5.715567e-06 0 -0.38400773
14 1 Glo1 -0.2772202 1.475510e-05 0 -0.32896127
15 1 Shisa9 -0.2756852 1.685852e-05 0 -1.29465903
16 1 Fos -0.2713397 2.649096e-05 0 -0.81491072
17 1 Cd200 -0.2702092 2.791450e-05 0 -0.41826689
18 1 Msra -0.2698640 2.791450e-05 0 -0.37642731
19 1 Xist -0.2645742 4.685246e-05 0 -0.21820655
20 1 Wasf1 -0.2640100 4.823870e-05 0 -0.35028819
21 1 Crym -0.2587839 8.173607e-05 0 -0.50575693
22 1 Gabra2 -0.2577884 8.637252e-05 0 -0.55195273
23 1 Btbd9 -0.2530640 1.244468e-04 0 -0.21456202
24 1 Unc5d -0.2472700 2.139872e-04 0 -0.99447339
25 1 Ssbp2 -0.2449376 2.564976e-04 0 -0.43966196
26 1 Zfp608 -0.2419568 3.251422e-04 0 -0.49937452
27 1 Erh -0.2413687 3.378497e-04 0 -0.34071185
28 1 Raly -0.2408558 3.485106e-04 0 -0.48469271
29 1 Slc16a2 -0.2403499 3.593711e-04 0 -0.32388771
30 1 Stmn4 -0.2401442 3.596777e-04 0 -0.30591176
31 1 Dlg2 -0.2396385 3.626002e-04 0 -0.33412509
32 1 Klhl24 -0.2394935 3.626002e-04 0 -0.26915813
33 1 Sla -0.2355136 5.266787e-04 0 -0.40947014
34 1 St6galnac5 -0.2353702 5.266787e-04 0 -0.79039470
35 1 Fgf13 -0.2347569 5.310035e-04 0 -0.29957368
36 1 Dlgap2 -0.2340580 5.592429e-04 0 -0.58420474
37 1 Lamtor3 -0.2328010 6.119982e-04 0 -0.45660421
38 1 Ldb2 -0.2299657 7.805662e-04 0 -0.18277773
39 1 Rgs7bp -0.2289057 8.382196e-04 0 -0.46136373
40 1 Cdk14 -0.2275515 9.262468e-04 0 -0.60195604
41 1 Rgs4 -0.2270250 9.598547e-04 0 -1.05661205
42 1 Mycl -0.2262799 1.003577e-03 0 -0.25517353
43 1 Pigt -0.2239292 1.216417e-03 0 -0.38317223
44 1 Tnnt1 -0.2232951 1.265235e-03 0 -1.51510847
45 1 Sh3rf3 -0.2223092 1.360169e-03 0 -0.71212302
46 1 Fam131c -0.2195790 1.708244e-03 0 -0.50043032
47 1 Gm17750 -0.2153237 2.362506e-03 0 -0.37451733
48 1 Zfp385b -0.2152096 2.362506e-03 0 -1.01914318
49 1 Spock1 -0.2150999 2.362506e-03 0 -0.27243287
50 1 Gm44790 -0.2138004 2.626331e-03 0 -0.46109281
51 1 Eml1 -0.2133412 2.705861e-03 0 -0.49580939
52 1 Ntrk3 -0.2113750 3.190837e-03 0 -0.29238439
53 1 Tmeff2 -0.2098536 3.572255e-03 0 -0.63366960
54 1 Lingo1 -0.2092392 3.690063e-03 0 -0.32363975
55 1 Rgs7 -0.2088403 3.781385e-03 0 -0.50748659
56 1 Ncdn -0.2085916 3.824173e-03 0 -0.33167474
57 1 Magi1 -0.2082854 3.846968e-03 0 -0.55544260
58 1 Cpq -0.2071260 4.215064e-03 0 -0.45147205
59 1 Ube2e3 -0.2068274 4.239927e-03 0 -0.18538121
60 1 Dync1i1 -0.2055262 4.702362e-03 0 -0.28001247
61 1 Elmod1 -0.2020201 6.091546e-03 0 -0.33924307
62 1 Gm40418 -0.2019637 6.091546e-03 0 -1.00196057
63 1 Stk25 -0.2015629 6.244668e-03 0 -0.25645309
64 1 Rnf150 -0.2012348 6.362192e-03 0 -0.39764524
65 1 Vav3 -0.2006221 6.580448e-03 0 -0.63535035
66 1 Nrp2 -0.2000322 6.856061e-03 0 -0.84879141
67 1 Glra2 -0.1995343 7.051469e-03 0 -0.31248709
68 1 Ntm -0.1994763 7.051469e-03 0 -0.11491730
69 1 Lyrm9 -0.1993835 7.051469e-03 0 -1.04917745
70 1 Chsy3 -0.1981976 7.464014e-03 0 -0.54723834
71 1 Afap1 -0.1978723 7.606681e-03 0 -0.72467466
72 1 Insm1 -0.1976870 7.661707e-03 0 -0.67474095
73 1 Jun -0.1971034 7.979780e-03 0 -0.39742424
74 1 Nrg1 -0.1966621 8.212237e-03 0 -0.36396237
75 1 Camk2b -0.1965394 8.229488e-03 0 -0.37424981
76 1 Pggt1b -0.1958995 8.542057e-03 0 -0.50473799
77 1 Klhdc4 -0.1955147 8.613471e-03 0 -0.61250522
78 1 Efna5 -0.1945192 9.211540e-03 0 -0.45203288
79 1 Dlgap1 -0.1942208 9.369765e-03 0 -0.42564188
80 1 Dynll2 -0.1916262 1.125377e-02 0 -0.16343170
81 1 Pgk1 -0.1912120 1.139226e-02 0 -0.36364730
82 1 Bloc1s1 -0.1912071 1.139226e-02 0 -0.33457090
83 1 Nr4a3 -0.1909022 1.159484e-02 0 -0.38224660
84 1 Hnrnpa1 -0.1906361 1.175860e-02 0 -0.22896156
85 1 Atp5l -0.1905543 1.175860e-02 0 -0.22804386
86 1 Ccnd2 -0.1891045 1.300531e-02 0 -0.25660314
87 1 Nr2f2 -0.1878990 1.391752e-02 0 -0.98414448
88 1 Zbtb16 -0.1878680 1.391752e-02 0 -0.79304337
89 1 Gm2164 -0.1875012 1.423682e-02 0 -0.85319962
90 1 Snrnp48 -0.1869760 1.447967e-02 0 -0.23402910
91 1 Prcp -0.1869589 1.447967e-02 0 -0.51523122
92 1 Csrnp3 -0.1860576 1.535810e-02 0 -0.27861526
93 1 Opcml -0.1844872 1.695596e-02 0 -0.37422735
94 1 Kcnk10 -0.1844542 1.695596e-02 0 -0.29067023
95 1 Chp1 -0.1844447 1.695596e-02 0 -0.26331136
96 1 Asnsd1 -0.1844084 1.695596e-02 0 -0.45835879
97 1 Psd -0.1840836 1.707599e-02 0 -0.49864314
98 1 Igfbp3 -0.1836744 1.721283e-02 0 -0.49410243
99 1 Ptprr -0.1835620 1.724581e-02 0 -0.84088273
100 1 Epha6 -0.1834079 1.724581e-02 0 -1.26382484
101 1 Gm30382 -0.1832747 1.724581e-02 0 -0.62577434
102 1 Cntn1 -0.1826731 1.797432e-02 0 -0.38961775
103 1 Mief1 -0.1818800 1.901371e-02 0 -0.41984198
104 1 Frmd4b -0.1814745 1.951188e-02 0 -0.16555279
105 1 Snx10 -0.1813731 1.955473e-02 0 -0.31792690
106 1 Asic2 -0.1804126 2.071510e-02 0 -0.25466896
107 1 Tsnax -0.1798048 2.159122e-02 0 -0.16361773
108 1 Ckmt1 -0.1783983 2.379440e-02 0 -0.36194957
109 1 Gps1 -0.1779668 2.419508e-02 0 -0.48103220
110 1 Mast2 -0.1767480 2.618504e-02 0 -0.22886266
111 1 B3galt2 -0.1758061 2.762310e-02 0 -0.37387360
112 1 Glp1r -0.1749936 2.876891e-02 0 -1.29813641
113 1 Rgs6 -0.1738753 3.081771e-02 0 -0.27342864
114 1 Cnih3 -0.1737084 3.095944e-02 0 -0.19392913
115 1 Dpysl4 -0.1735207 3.095944e-02 0 -0.34080199
116 1 Lix1 -0.1734329 3.095944e-02 0 -0.24379550
117 1 Cacnb4 -0.1732409 3.121252e-02 0 -0.32715324
118 1 Cdh2 -0.1730778 3.144165e-02 0 -0.15879849
119 1 Pou3f2 -0.1727867 3.184569e-02 0 -1.28397209
120 1 Pak3 -0.1722478 3.265449e-02 0 -0.22725958
121 1 Tmem108 -0.1720824 3.290242e-02 0 -0.10052886
122 1 Adgrl3 -0.1714752 3.414042e-02 0 -0.23838521
123 1 Pak7 -0.1709451 3.496912e-02 0 -0.21089453
124 1 Fut9 -0.1702284 3.669697e-02 0 -0.26154758
125 1 Trim36 -0.1699043 3.724013e-02 0 -0.67610277
126 1 Rtl8a -0.1695151 3.814557e-02 0 -0.21199428
127 1 Kcnmb4 -0.1692925 3.859813e-02 0 -0.34607968
128 1 Lmo7 -0.1686382 3.977234e-02 0 -0.35459204
129 1 Rpgr -0.1686382 3.977234e-02 0 -0.37719879
130 1 Bcl6b -0.1684958 4.001042e-02 0 -0.55285610
131 1 Sdhc -0.1678811 4.147618e-02 0 -0.15411969
132 1 Snap25 -0.1677466 4.170156e-02 0 -0.25946972
133 1 Gm9885 -0.1672299 4.310664e-02 0 -0.40777547
134 1 Rint1 -0.1667188 4.434647e-02 0 -0.31311835
135 1 Sept6 -0.1664469 4.503242e-02 0 -0.28471311
136 1 Oma1 -0.1660209 4.604271e-02 0 -0.66865123
137 1 Slc35f1 -0.1658674 4.635754e-02 0 -0.24250790
138 1 Fosl2 -0.1654211 4.739498e-02 0 -0.47513449
139 1 Clpb -0.1642537 5.075223e-02 0 -0.35225590
140 1 Gm10260 -0.1639260 5.173832e-02 0 -0.23336764
141 1 Mea1 -0.1632038 5.380129e-02 0 -0.73359774
142 1 Cdh8 -0.1625672 5.564624e-02 0 -0.58109438
143 1 Pou3f3 -0.1625571 5.564624e-02 0 -0.52217593
144 1 C030034I22Rik -0.1622279 5.656407e-02 0 -0.56113965
145 1 Crtc1 -0.1620476 5.677546e-02 0 -0.32146464
146 1 Ctnnd2 -0.1612790 5.946096e-02 0 -0.17132854
147 1 Commd1 -0.1609966 6.041451e-02 0 -0.23330268
148 1 Dusp8 -0.1609135 6.046665e-02 0 -0.23123799
149 1 Nol4 -0.1608187 6.046665e-02 0 -0.15319369
150 1 Dap -0.1606727 6.074169e-02 0 -0.23228463
151 1 Cdk19 -0.1606443 6.074169e-02 0 -0.32241950
152 1 Zfp277 -0.1602165 6.234689e-02 0 -0.18222792
153 1 Fam135b -0.1601354 6.246332e-02 0 -0.49787642
154 1 Diaph3 -0.1597107 6.409686e-02 0 -0.69315519
155 1 Cep57l1 -0.1592159 6.584269e-02 0 -0.50764025
156 1 Snx21 -0.1589904 6.663172e-02 0 -0.43319094
157 1 Ntrk2 -0.1584678 6.882997e-02 0 -0.24868556
158 1 Ahcyl2 -0.1579957 7.073713e-02 0 -0.39857716
159 1 Mtus1 -0.1579422 7.073713e-02 0 -0.32594782
160 1 D130020L05Rik -0.1573145 7.314570e-02 0 -1.54913697
161 1 Magee2 -0.1572268 7.314570e-02 0 -0.47897240
162 1 Paxx -0.1570792 7.355087e-02 0 -0.15289852
163 1 Dhfr -0.1569798 7.378742e-02 0 -0.95228582
164 1 Zfp704 -0.1567213 7.430428e-02 0 -0.25996609
165 1 Gm30054 -0.1563446 7.597411e-02 0 -1.02783611
166 1 Snhg10 -0.1562388 7.611329e-02 0 -0.78649630
167 1 Gtf2h3 -0.1561812 7.611329e-02 0 -0.34844018
168 1 Shtn1 -0.1561629 7.611329e-02 0 -0.14371495
169 1 Hax1 -0.1556525 7.825902e-02 0 -0.19926078
170 1 Stxbp5l -0.1554698 7.896308e-02 0 -0.71053653
171 1 X4933404O12Rik -0.1554074 7.902454e-02 0 -0.60493265
172 1 Igsf3 -0.1552286 7.944085e-02 0 -0.26474386
173 1 Rell2 -0.1551654 7.950903e-02 0 -0.27945422
174 1 Tfdp1 -0.1550337 7.994944e-02 0 -0.20307052
175 1 Tamm41 -0.1545774 8.174804e-02 0 -0.39566047
176 1 Crlf1 -0.1544599 8.174804e-02 0 -0.64715042
177 1 Fut8 -0.1544555 8.174804e-02 0 -0.43124548
178 1 Gm21949 -0.1540545 8.331436e-02 0 -0.53590643
179 1 Zkscan3 -0.1539431 8.350519e-02 0 -0.24397057
180 1 Nr4a1 -0.1536578 8.446986e-02 0 -0.71999816
181 1 Spast -0.1536260 8.446986e-02 0 -0.22873782
182 1 Itpa -0.1525271 8.861084e-02 0 -0.13673904
183 1 Gm38948 -0.1513361 9.502504e-02 0 -0.37127192
184 1 Rusc2 -0.1510752 9.622233e-02 0 -0.25936942
185 1 Ypel1 -0.1510476 9.622233e-02 0 -0.17766308
186 1 Gpr137c -0.1510053 9.622233e-02 0 -0.23583596
187 1 Tcf4 -0.1503701 9.911297e-02 0 -0.32236888
188 1 Rgl1 -0.1503151 9.916711e-02 0 -0.56341013
189 1 Eif4b -0.1501534 9.963563e-02 0 -0.15901624
190 1 Dhrs13 -0.1494282 1.029138e-01 0 -0.23594266
191 1 Sik1 -0.1492590 1.034034e-01 0 -0.63223288
192 1 Pou3f1 -0.1491083 1.034034e-01 0 -0.54571045
193 1 Rangap1 -0.1490887 1.034034e-01 0 -0.19146620
194 1 Gm29478 -0.1490737 1.034034e-01 0 -1.59813122
195 1 Dbpht2 -0.1490737 1.034034e-01 0 -1.58991377
196 1 Dmac2 -0.1487370 1.039219e-01 0 -0.47524745
197 1 Actr6 -0.1484514 1.045365e-01 0 -0.27628804
198 1 Nup43 -0.1483965 1.045365e-01 0 -0.36551302
199 1 Pja1 -0.1483256 1.045365e-01 0 -0.04782317
200 1 Nln -0.1482548 1.045365e-01 0 -0.56574871
201 1 Rnd2 0.4411526 2.278116e-15 0 0.71602945
202 1 Fat3 0.3920370 7.953201e-12 0 0.49746970
203 1 Akirin2 0.3578270 1.004909e-09 0 0.44708226
204 1 Tmem176b 0.3299727 3.776860e-08 0 0.52656169
205 1 Tpm3.rs7 0.3294885 3.776860e-08 0 0.49128964
206 1 Necab3 0.3225718 8.270157e-08 0 0.54255970
207 1 Alcam 0.3153783 1.771304e-07 0 0.43922226
208 1 Tbr1 0.2873029 5.225192e-06 0 0.34863308
209 1 Klhl29 0.2787360 1.295524e-05 0 0.50900417
210 1 Hmgb3 0.2699098 2.791450e-05 0 0.25803900
211 1 Airn 0.2668793 3.758144e-05 0 1.23149612
212 1 Eef1a2 0.2585800 8.173607e-05 0 0.88080996
213 1 Me1 0.2572081 8.928822e-05 0 0.63650782
214 1 Mgll 0.2564800 9.383370e-05 0 0.45332306
215 1 Zfp804a 0.2538858 1.188432e-04 0 0.46575236
216 1 Slc35f4 0.2537466 1.188432e-04 0 0.80570310
217 1 Kcnh7 0.2523974 1.301585e-04 0 0.44733664
218 1 Glp2r 0.2471551 2.139872e-04 0 0.35983331
219 1 Btbd11 0.2465342 2.228146e-04 0 0.59427668
220 1 Tmem178 0.2445722 2.603409e-04 0 0.15104023
221 1 Kcnt2 0.2432026 2.928075e-04 0 0.45415418
222 1 Ccser1 0.2395868 3.626002e-04 0 0.21896740
223 1 Pcdh9 0.2349183 5.310035e-04 0 0.21511597
224 1 Nxph4 0.2348642 5.310035e-04 0 0.46231241
225 1 Pcbp1 0.2330561 6.067328e-04 0 0.24616696
226 1 Wnt7b 0.2320749 6.464241e-04 0 0.32823485
227 1 X4833418N02Rik 0.2290800 8.369810e-04 0 0.61793352
228 1 Ddah1 0.2279151 9.079579e-04 0 0.45550085
229 1 Vcan 0.2262567 1.003577e-03 0 0.46188461
230 1 Pttg1 0.2241669 1.206013e-03 0 0.81633983
231 1 Eif4a1 0.2232230 1.265235e-03 0 0.45728645
232 1 Lypd6 0.2201879 1.635603e-03 0 0.44198683
233 1 Slit1 0.2192018 1.746423e-03 0 0.42018111
234 1 Ngfr 0.2166520 2.179474e-03 0 0.48224168
235 1 Gadd45g 0.2159379 2.297375e-03 0 0.26941855
236 1 Dcc 0.2151425 2.362506e-03 0 0.30618565
237 1 Dact1 0.2106093 3.377829e-03 0 0.31138312
238 1 Nfia 0.2093243 3.690063e-03 0 0.20437947
239 1 Nhlh1 0.2083884 3.846968e-03 0 1.08318362
240 1 Rcor2 0.2070105 4.215064e-03 0 0.32594178
241 1 Cnr1 0.2048162 4.952106e-03 0 0.22114131
242 1 Nkd1 0.2036633 5.418059e-03 0 0.31376172
243 1 Fam69a 0.2025172 5.921902e-03 0 0.30172294
244 1 Epha3 0.2009170 6.476581e-03 0 0.21276778
245 1 Dscam 0.1990018 7.180153e-03 0 0.23084660
246 1 Ttc7 0.1989623 7.180153e-03 0 0.87499936
247 1 Aff2 0.1985532 7.368447e-03 0 0.27208450
248 1 Adamts18 0.1984406 7.375169e-03 0 0.32523533
249 1 Ncor1 0.1964277 8.239653e-03 0 0.25074715
250 1 Rab39 0.1955715 8.613471e-03 0 0.32821824
251 1 Sgcz 0.1955481 8.613471e-03 0 0.79823063
252 1 Lcorl 0.1951628 8.800384e-03 0 0.20412586
253 1 Higd1a 0.1931756 1.013621e-02 0 0.13053823
254 1 Sfxn1 0.1927318 1.043388e-02 0 0.23611785
255 1 Rab3c 0.1920901 1.091559e-02 0 0.22163251
256 1 Aff3 0.1913457 1.139226e-02 0 0.16007305
257 1 Lpp 0.1892065 1.300531e-02 0 0.36001600
258 1 Smap1 0.1890505 1.300531e-02 0 0.24879350
259 1 Epha4 0.1878986 1.391752e-02 0 0.18840904
260 1 Tmem50b 0.1878777 1.391752e-02 0 0.34579403
261 1 Tnks2 0.1873925 1.426565e-02 0 0.25954419
262 1 Vat1 0.1870031 1.447967e-02 0 0.34643001
263 1 Fabp7 0.1861153 1.535810e-02 0 0.30531366
264 1 Rbfox3 0.1858844 1.547126e-02 0 0.15332347
265 1 Neo1 0.1842369 1.704745e-02 0 0.17904854
266 1 Hbb.bt 0.1841828 1.704745e-02 0 0.61889653
267 1 Hypk 0.1838950 1.721283e-02 0 0.22945778
268 1 Stk40 0.1837853 1.721283e-02 0 0.44241082
269 1 Rdh5 0.1837015 1.721283e-02 0 0.28654515
270 1 Stk39 0.1834437 1.724581e-02 0 0.30722544
271 1 Vrk2 0.1833025 1.724581e-02 0 0.32600848
272 1 Sap30 0.1810603 1.989051e-02 0 0.16339897
273 1 Cox5b 0.1810087 1.989051e-02 0 0.14959702
274 1 X2010107E04Rik 0.1797066 2.163535e-02 0 0.13275819
275 1 Gm10320 0.1781667 2.396615e-02 0 1.60229359
276 1 Gm10131 0.1781618 2.396615e-02 0 0.23331333
277 1 Ppp1r14a 0.1774100 2.511080e-02 0 0.35167875
278 1 Snrpn 0.1767196 2.618504e-02 0 0.24864434
279 1 Eid1 0.1764497 2.658604e-02 0 0.14528985
280 1 Yeats4 0.1762184 2.691458e-02 0 0.07838677
281 1 Trappc6b 0.1756682 2.776742e-02 0 0.12186465
282 1 Mmp17 0.1755791 2.781028e-02 0 0.48650300
283 1 Crabp1 0.1753723 2.810277e-02 0 0.48025137
284 1 Arid4a 0.1746891 2.928622e-02 0 0.16133455
285 1 Cab39l 0.1743192 2.995935e-02 0 0.38340017
286 1 Nfe2l3 0.1736107 3.095944e-02 0 0.34784475
287 1 Cap1 0.1735905 3.095944e-02 0 0.17730278
288 1 Fat4 0.1734152 3.095944e-02 0 0.28882798
289 1 H2afy2 0.1727771 3.184569e-02 0 0.13380026
290 1 Sema7a 0.1726907 3.189800e-02 0 0.66007786
291 1 Fam96a 0.1722868 3.265449e-02 0 0.24011122
292 1 Gtf3a 0.1714577 3.414042e-02 0 0.28519266
293 1 Cops9 0.1710146 3.496912e-02 0 0.09429890
294 1 St18 0.1709555 3.496912e-02 0 0.35421704
295 1 Hbb.y 0.1700387 3.704241e-02 0 0.78926208
296 1 Ntf3 0.1692293 3.860317e-02 0 0.85374739
297 1 Lrfn5 0.1690169 3.903262e-02 0 0.12982170
298 1 Gm2000 0.1683222 4.034222e-02 0 0.19941445
299 1 Nkain3 0.1670052 4.362492e-02 0 0.18708833
300 1 Ndn 0.1661270 4.588663e-02 0 0.34670656
301 1 Hmg20b 0.1656506 4.688799e-02 0 0.34990372
302 1 Kctd8 0.1653842 4.739498e-02 0 0.29064360
303 1 Lhfp 0.1643023 5.075223e-02 0 0.26519087
304 1 Ier3ip1 0.1642683 5.075223e-02 0 0.18283423
305 1 Lhx9 0.1637637 5.212585e-02 0 0.49523456
306 1 Slc17a7 0.1634280 5.316759e-02 0 0.37078308
307 1 Pcbp4 0.1630110 5.432173e-02 0 0.09870609
308 1 Bcas3os1 0.1622079 5.656407e-02 0 1.73454326
309 1 Ppp1r1b 0.1621564 5.656407e-02 0 0.34779065
310 1 U2af1 0.1612813 5.946096e-02 0 0.08799859
311 1 Slc44a5 0.1608207 6.046665e-02 0 0.22134424
312 1 X9330111N05Rik 0.1594520 6.501513e-02 0 0.31883319
313 1 Rpl38 0.1579112 7.073713e-02 0 0.19817423
314 1 Alyref 0.1573450 7.314570e-02 0 0.34281340
315 1 Gfpt1 0.1572123 7.314570e-02 0 0.35153345
316 1 Mrpl22 0.1568935 7.395930e-02 0 0.22231450
317 1 A930004D18Rik 0.1567618 7.430428e-02 0 0.59244464
318 1 Ckap5 0.1560491 7.643820e-02 0 0.17254888
319 1 Ddx24 0.1553231 7.920465e-02 0 0.15608934
320 1 Hs3st5 0.1547861 8.102637e-02 0 0.72980921
321 1 Cxxc5 0.1545233 8.174804e-02 0 0.38901299
322 1 Rps27rt 0.1543364 8.213304e-02 0 0.17141059
323 1 Actg1 0.1540262 8.331436e-02 0 0.19813585
324 1 Gm11266 0.1538143 8.395577e-02 0 0.29723696
325 1 Prickle1 0.1534663 8.510346e-02 0 0.23050354
326 1 Ptpn4 0.1529844 8.728741e-02 0 0.25577778
327 1 Rybp 0.1529466 8.728741e-02 0 0.31135162
328 1 Itm2a 0.1528868 8.728741e-02 0 0.25466924
329 1 Fam98b 0.1528674 8.728741e-02 0 0.31745602
330 1 Pde4b 0.1528475 8.728741e-02 0 0.24929088
331 1 Btbd2 0.1527695 8.746362e-02 0 0.27965574
332 1 Fam96b 0.1524388 8.885228e-02 0 0.14057760
333 1 Chd9 0.1518260 9.226896e-02 0 0.26430730
334 1 Polr2f 0.1509082 9.654140e-02 0 0.08632195
335 1 Kcnv1 0.1507933 9.697598e-02 0 0.50052974
336 1 Igfbp4 0.1503835 9.911297e-02 0 0.26220639
337 1 Cntnap2 0.1501506 9.963563e-02 0 0.21980518
338 1 Myocd 0.1498322 1.014389e-01 0 0.86190551
339 1 Tmem128 0.1496099 1.024219e-01 0 0.21076956
340 1 X1600014C10Rik 0.1495932 1.024219e-01 0 0.35658238
341 1 H2afv 0.1494887 1.028159e-01 0 0.13452553
342 1 Hba.a1 0.1490678 1.034034e-01 0 0.24619288
343 1 Eef1akmt1 0.1490374 1.034034e-01 0 0.13143220
344 1 Mphosph8 0.1489404 1.036223e-01 0 0.14400395
345 1 Trappc1 0.1489110 1.036223e-01 0 0.14495695
346 1 Bola2 0.1488703 1.036223e-01 0 0.10057215
347 1 Atp5e 0.1488138 1.037029e-01 0 0.19470655
348 1 Gm43738 0.1486639 1.041170e-01 0 0.29171357
349 1 Ndufa11 0.1484710 1.045365e-01 0 0.13796083
350 1 Smim18 0.1484235 1.045365e-01 0 0.25998625
351 1 Bex4 0.1482508 1.045365e-01 0 0.02698917
352 1 Rara 0.1480521 1.054197e-01 0 0.87902800
353 1 Ndufs6 0.1477372 1.059898e-01 0 0.09997795
354 1 Bcar1 0.1474326 1.070932e-01 0 0.25748576
355 1 Csnk2a1 0.1472493 1.073142e-01 0 0.17183070
356 1 Dusp14 0.1466454 1.106914e-01 0 0.58853628
357 1 Snrpb2 0.1461076 1.131580e-01 0 0.20076042
358 1 Zswim4 0.1457403 1.145566e-01 0 0.40116514
359 1 Ralb 0.1455356 1.157684e-01 0 0.38470025
360 1 Morf4l1 0.1453371 1.169468e-01 0 0.12599869
361 1 Chd4 0.1448418 1.201128e-01 0 0.17983513
362 1 Eif4ebp2 0.1443908 1.223222e-01 0 0.15090560
363 1 Prex1 0.1443464 1.223528e-01 0 0.64243954
364 1 Rps29 0.1441031 1.236285e-01 0 0.23031547
365 1 Hbb.bs 0.1435447 1.264763e-01 0 0.14423374
366 1 Ndufa5 0.1435014 1.265038e-01 0 0.11474550
367 1 Tmed7 0.1433370 1.271878e-01 0 0.17351150
368 1 Adamts17 0.1428935 1.295659e-01 0 0.21970203
369 1 Tmem178b 0.1426106 1.308690e-01 0 0.04533777
370 1 Sln 0.1422944 1.328511e-01 0 0.37033212
371 1 Pcp4 0.1416944 1.365014e-01 0 0.32137387
372 1 Ddx25 0.1416696 1.365014e-01 0 0.14125154
373 1 Baiap2l1 0.1413037 1.386797e-01 0 1.07747261
374 1 Tmem222 0.1412632 1.386797e-01 0 0.17643405
375 1 Boc 0.1410071 1.405851e-01 0 0.81045945
376 1 Pag1 0.1406963 1.426587e-01 0 0.34697216
377 1 Rtn4rl1 0.1399669 1.460633e-01 0 0.63325572
378 1 Tmem214 0.1398709 1.460633e-01 0 0.32619762
379 1 Laptm4b 0.1398343 1.460633e-01 0 0.80059546
380 1 Zdhhc2 0.1397876 1.460633e-01 0 0.74532609
381 1 Cox17 0.1397756 1.460633e-01 0 0.19810774
382 1 Fkbp5 0.1397290 1.460633e-01 0 0.20638485
383 1 Snrpg 0.1396610 1.460633e-01 0 0.12833465
384 1 Tigd2 0.1396574 1.460633e-01 0 0.29428399
385 1 Nt5dc2 0.1396042 1.460633e-01 0 0.45526285
386 1 Rnf121 0.1394879 1.464515e-01 0 0.11661353
387 1 X1810041L15Rik 0.1394192 1.467429e-01 0 0.57771942
388 1 Fam131b 0.1392981 1.467845e-01 0 0.28079917
389 1 Pcdh19 0.1389677 1.482100e-01 0 0.37795879
390 1 Mapk11 0.1387758 1.493115e-01 0 0.28218854
391 1 Ndufb4 0.1386285 1.500097e-01 0 0.13278025
392 1 Tshz3 0.1384993 1.504059e-01 0 0.21632384
393 1 X4930452B06Rik 0.1384785 1.504059e-01 0 1.58605173
394 1 Snrpb 0.1383426 1.511109e-01 0 0.12047449
395 1 Nxph3 0.1382607 1.511109e-01 0 0.63726411
396 1 Atp2b2 0.1374796 1.571708e-01 0 0.40497307
397 1 Fis1 0.1374043 1.575583e-01 0 0.08315116
398 1 Smim11 0.1370936 1.595521e-01 0 0.22203238
399 1 Ubald2 0.1369603 1.605140e-01 0 0.13118681
400 1 Srek1ip1 0.1367495 1.622474e-01 0 0.25181162
401 2 Rnd2 -0.4411570 2.276296e-15 0 -0.71602945
402 2 Fat3 -0.3920372 7.952912e-12 0 -0.49746970
403 2 Akirin2 -0.3578265 1.004982e-09 0 -0.44708226
404 2 Tmem176b -0.3299643 3.771584e-08 0 -0.52656169
405 2 Tpm3.rs7 -0.3294989 3.771584e-08 0 -0.49128964
406 2 Necab3 -0.3225685 8.273728e-08 0 -0.54255970
407 2 Alcam -0.3153837 1.770072e-07 0 -0.43922226
408 2 Tbr1 -0.2873052 5.223764e-06 0 -0.34863308
409 2 Klhl29 -0.2787411 1.294764e-05 0 -0.50900417
410 2 Hmgb3 -0.2699134 2.794622e-05 0 -0.25803900
411 2 Airn -0.2668735 3.760591e-05 0 -1.23149612
412 2 Eef1a2 -0.2585808 8.172944e-05 0 -0.88080996
413 2 Me1 -0.2572127 8.924397e-05 0 -0.63650782
414 2 Mgll -0.2564792 9.384147e-05 0 -0.45332306
415 2 Zfp804a -0.2538870 1.188522e-04 0 -0.46575236
416 2 Slc35f4 -0.2537458 1.188522e-04 0 -0.80570310
417 2 Kcnh7 -0.2523884 1.302814e-04 0 -0.44733664
418 2 Glp2r -0.2471585 2.139116e-04 0 -0.35983331
419 2 Btbd11 -0.2465387 2.227118e-04 0 -0.59427668
420 2 Tmem178 -0.2445731 2.603149e-04 0 -0.15104023
421 2 Kcnt2 -0.2432086 2.926287e-04 0 -0.45415418
422 2 Ccser1 -0.2395872 3.624036e-04 0 -0.21896740
423 2 Pcdh9 -0.2349072 5.312439e-04 0 -0.21511597
424 2 Nxph4 -0.2348654 5.312439e-04 0 -0.46231241
425 2 Pcbp1 -0.2330489 6.071585e-04 0 -0.24616696
426 2 Wnt7b -0.2320767 6.463130e-04 0 -0.32823485
427 2 X4833418N02Rik -0.2290690 8.378593e-04 0 -0.61793352
428 2 Ddah1 -0.2279122 9.082068e-04 0 -0.45550085
429 2 Vcan -0.2262585 1.003402e-03 0 -0.46188461
430 2 Pttg1 -0.2241597 1.206828e-03 0 -0.81633983
431 2 Eif4a1 -0.2232316 1.264208e-03 0 -0.45728645
432 2 Lypd6 -0.2201926 1.634888e-03 0 -0.44198683
433 2 Slit1 -0.2191946 1.747581e-03 0 -0.42018111
434 2 Ngfr -0.2166436 2.181150e-03 0 -0.48224168
435 2 Gadd45g -0.2159415 2.296634e-03 0 -0.26941855
436 2 Dcc -0.2151350 2.362935e-03 0 -0.30618565
437 2 Dact1 -0.2106020 3.380021e-03 0 -0.31138312
438 2 Nfia -0.2093300 3.690055e-03 0 -0.20437947
439 2 Nhlh1 -0.2083925 3.848027e-03 0 -1.08318362
440 2 Rcor2 -0.2070127 4.214257e-03 0 -0.32594178
441 2 Cnr1 -0.2048150 4.952630e-03 0 -0.22114131
442 2 Nkd1 -0.2036582 5.420418e-03 0 -0.31376172
443 2 Fam69a -0.2025082 5.926484e-03 0 -0.30172294
444 2 Epha3 -0.2009094 6.480751e-03 0 -0.21276778
445 2 Dscam -0.1990074 7.190806e-03 0 -0.23084660
446 2 Ttc7 -0.1989448 7.190806e-03 0 -0.87499936
447 2 Aff2 -0.1985476 7.371963e-03 0 -0.27208450
448 2 Adamts18 -0.1984386 7.376434e-03 0 -0.32523533
449 2 Ncor1 -0.1964280 8.239449e-03 0 -0.25074715
450 2 Rab39 -0.1955762 8.623059e-03 0 -0.32821824
451 2 Sgcz -0.1955619 8.623059e-03 0 -0.79823063
452 2 Lcorl -0.1951645 8.799141e-03 0 -0.20412586
453 2 Higd1a -0.1931787 1.013363e-02 0 -0.13053823
454 2 Sfxn1 -0.1927293 1.043603e-02 0 -0.23611785
455 2 Rab3c -0.1920842 1.092085e-02 0 -0.22163251
456 2 Aff3 -0.1913384 1.139449e-02 0 -0.16007305
457 2 Lpp -0.1892143 1.300906e-02 0 -0.36001600
458 2 Smap1 -0.1890469 1.300906e-02 0 -0.24879350
459 2 Epha4 -0.1879045 1.393548e-02 0 -0.18840904
460 2 Tmem50b -0.1878773 1.393548e-02 0 -0.34579403
461 2 Tnks2 -0.1873839 1.427546e-02 0 -0.25954419
462 2 Vat1 -0.1869974 1.448533e-02 0 -0.34643001
463 2 Fabp7 -0.1861258 1.535699e-02 0 -0.30531366
464 2 Rbfox3 -0.1858901 1.546425e-02 0 -0.15332347
465 2 Neo1 -0.1842319 1.705804e-02 0 -0.17904854
466 2 Hbb.bt -0.1841709 1.705804e-02 0 -0.61889653
467 2 Hypk -0.1838964 1.721604e-02 0 -0.22945778
468 2 Stk40 -0.1837977 1.721604e-02 0 -0.44241082
469 2 Rdh5 -0.1836990 1.721604e-02 0 -0.28654515
470 2 Stk39 -0.1834471 1.724852e-02 0 -0.30722544
471 2 Vrk2 -0.1833112 1.724852e-02 0 -0.32600848
472 2 Sap30 -0.1810694 1.990252e-02 0 -0.16339897
473 2 Cox5b -0.1810009 1.990252e-02 0 -0.14959702
474 2 X2010107E04Rik -0.1797048 2.163829e-02 0 -0.13275819
475 2 Gm10131 -0.1781682 2.396922e-02 0 -0.23331333
476 2 Gm10320 -0.1781602 2.396922e-02 0 -1.60229359
477 2 Ppp1r14a -0.1774112 2.510862e-02 0 -0.35167875
478 2 Snrpn -0.1767121 2.620001e-02 0 -0.24864434
479 2 Eid1 -0.1764509 2.658378e-02 0 -0.14528985
480 2 Yeats4 -0.1762094 2.693288e-02 0 -0.07838677
481 2 Trappc6b -0.1756745 2.775429e-02 0 -0.12186465
482 2 Mmp17 -0.1755893 2.778891e-02 0 -0.48650300
483 2 Crabp1 -0.1753698 2.810805e-02 0 -0.48025137
484 2 Arid4a -0.1746853 2.929463e-02 0 -0.16133455
485 2 Cab39l -0.1743118 2.997604e-02 0 -0.38340017
486 2 Nfe2l3 -0.1736102 3.097128e-02 0 -0.34784475
487 2 Cap1 -0.1735833 3.097128e-02 0 -0.17730278
488 2 Fat4 -0.1734101 3.097128e-02 0 -0.28882798
489 2 H2afy2 -0.1727761 3.184818e-02 0 -0.13380026
490 2 Sema7a -0.1726924 3.189398e-02 0 -0.66007786
491 2 Fam96a -0.1722935 3.267503e-02 0 -0.24011122
492 2 Gtf3a -0.1714647 3.412267e-02 0 -0.28519266
493 2 Cops9 -0.1710006 3.496956e-02 0 -0.09429890
494 2 St18 -0.1709449 3.496956e-02 0 -0.35421704
495 2 Hbb.y -0.1700269 3.707461e-02 0 -0.78926208
496 2 Ntf3 -0.1692109 3.865501e-02 0 -0.85374739
497 2 Lrfn5 -0.1690142 3.904043e-02 0 -0.12982170
498 2 Gm2000 -0.1683149 4.036359e-02 0 -0.19941445
499 2 Nkain3 -0.1669972 4.364997e-02 0 -0.18708833
500 2 Ndn -0.1661224 4.590183e-02 0 -0.34670656
501 2 Hmg20b -0.1656456 4.690456e-02 0 -0.34990372
502 2 Kctd8 -0.1653867 4.738665e-02 0 -0.29064360
503 2 Lhfp -0.1642998 5.075077e-02 0 -0.26519087
504 2 Ier3ip1 -0.1642715 5.075077e-02 0 -0.18283423
505 2 Lhx9 -0.1637753 5.208286e-02 0 -0.49523456
506 2 Slc17a7 -0.1634306 5.315753e-02 0 -0.37078308
507 2 Pcbp4 -0.1630118 5.431873e-02 0 -0.09870609
508 2 Bcas3os1 -0.1621862 5.657726e-02 0 -1.73454326
509 2 Ppp1r1b -0.1621531 5.657726e-02 0 -0.34779065
510 2 U2af1 -0.1612914 5.944737e-02 0 -0.08799859
511 2 Slc44a5 -0.1608246 6.044149e-02 0 -0.22134424
512 2 X9330111N05Rik -0.1594587 6.498497e-02 0 -0.31883319
513 2 Rpl38 -0.1579288 7.065156e-02 0 -0.19817423
514 2 Alyref -0.1573427 7.305509e-02 0 -0.34281340
515 2 Gfpt1 -0.1572068 7.317366e-02 0 -0.35153345
516 2 Mrpl22 -0.1568877 7.398874e-02 0 -0.22231450
517 2 A930004D18Rik -0.1567611 7.434989e-02 0 -0.59244464
518 2 Ckap5 -0.1560521 7.642267e-02 0 -0.17254888
519 2 Ddx24 -0.1553297 7.916913e-02 0 -0.15608934
520 2 Hs3st5 -0.1547885 8.101293e-02 0 -0.72980921
521 2 Cxxc5 -0.1545235 8.169946e-02 0 -0.38901299
522 2 Rps27rt -0.1543448 8.208665e-02 0 -0.17141059
523 2 Actg1 -0.1540292 8.329741e-02 0 -0.19813585
524 2 Gm11266 -0.1538113 8.397271e-02 0 -0.29723696
525 2 Prickle1 -0.1534599 8.513983e-02 0 -0.23050354
526 2 Ptpn4 -0.1529762 8.732358e-02 0 -0.25577778
527 2 Rybp -0.1529496 8.732358e-02 0 -0.31135162
528 2 Itm2a -0.1528973 8.732358e-02 0 -0.25466924
529 2 Fam98b -0.1528669 8.732358e-02 0 -0.31745602
530 2 Pde4b -0.1528414 8.732358e-02 0 -0.24929088
531 2 Btbd2 -0.1527780 8.741391e-02 0 -0.27965574
532 2 Fam96b -0.1524390 8.885086e-02 0 -0.14057760
533 2 Chd9 -0.1518216 9.229570e-02 0 -0.26430730
534 2 Polr2f -0.1509182 9.647721e-02 0 -0.08632195
535 2 Kcnv1 -0.1507782 9.707306e-02 0 -0.50052974
536 2 Igfbp4 -0.1503986 9.905870e-02 0 -0.26220639
537 2 Cntnap2 -0.1501503 9.963751e-02 0 -0.21980518
538 2 Myocd -0.1498479 1.013342e-01 0 -0.86190551
539 2 Tmem128 -0.1496077 1.023962e-01 0 -0.21076956
540 2 X1600014C10Rik -0.1495970 1.023962e-01 0 -0.35658238
541 2 H2afv -0.1494983 1.027508e-01 0 -0.13452553
542 2 Hba.a1 -0.1490698 1.033397e-01 0 -0.24619288
543 2 Eef1akmt1 -0.1490467 1.033397e-01 0 -0.13143220
544 2 Mphosph8 -0.1489356 1.036466e-01 0 -0.14400395
545 2 Trappc1 -0.1489043 1.036466e-01 0 -0.14495695
546 2 Bola2 -0.1488668 1.036466e-01 0 -0.10057215
547 2 Atp5e -0.1488163 1.036859e-01 0 -0.19470655
548 2 Gm43738 -0.1486565 1.041679e-01 0 -0.29171357
549 2 Ndufa11 -0.1484711 1.045878e-01 0 -0.13796083
550 2 Smim18 -0.1484339 1.045878e-01 0 -0.25998625
551 2 Bex4 -0.1482433 1.045878e-01 0 -0.02698917
552 2 Rara -0.1480282 1.054674e-01 0 -0.87902800
553 2 Ndufs6 -0.1477370 1.059910e-01 0 -0.09997795
554 2 Bcar1 -0.1474437 1.070992e-01 0 -0.25748576
555 2 Csnk2a1 -0.1472509 1.073028e-01 0 -0.17183070
556 2 Dusp14 -0.1466447 1.106960e-01 0 -0.58853628
557 2 Snrpb2 -0.1461056 1.131696e-01 0 -0.20076042
558 2 Zswim4 -0.1457478 1.145010e-01 0 -0.40116514
559 2 Ralb -0.1455408 1.157298e-01 0 -0.38470025
560 2 Morf4l1 -0.1453375 1.169432e-01 0 -0.12599869
561 2 Chd4 -0.1448328 1.201579e-01 0 -0.17983513
562 2 Eif4ebp2 -0.1443864 1.223566e-01 0 -0.15090560
563 2 Prex1 -0.1443435 1.223752e-01 0 -0.64243954
564 2 Rps29 -0.1441023 1.236344e-01 0 -0.23031547
565 2 Hbb.bs -0.1435340 1.265628e-01 0 -0.14423374
566 2 Ndufa5 -0.1434928 1.265729e-01 0 -0.11474550
567 2 Tmed7 -0.1433340 1.272122e-01 0 -0.17351150
568 2 Adamts17 -0.1428900 1.296332e-01 0 -0.21970203
569 2 Tmem178b -0.1426121 1.308566e-01 0 -0.04533777
570 2 Sln -0.1422902 1.328862e-01 0 -0.37033212
571 2 Pcp4 -0.1416941 1.364816e-01 0 -0.32137387
572 2 Ddx25 -0.1416720 1.364816e-01 0 -0.14125154
573 2 Baiap2l1 -0.1413021 1.386559e-01 0 -1.07747261
574 2 Tmem222 -0.1412660 1.386559e-01 0 -0.17643405
575 2 Boc -0.1410281 1.403999e-01 0 -0.81045945
576 2 Pag1 -0.1407007 1.426200e-01 0 -0.34697216
577 2 Rtn4rl1 -0.1399455 1.461146e-01 0 -0.63325572
578 2 Tmem214 -0.1398635 1.461146e-01 0 -0.32619762
579 2 Laptm4b -0.1398405 1.461146e-01 0 -0.80059546
580 2 Zdhhc2 -0.1397790 1.461146e-01 0 -0.74532609
581 2 Cox17 -0.1397697 1.461146e-01 0 -0.19810774
582 2 Fkbp5 -0.1397188 1.461146e-01 0 -0.20638485
583 2 Snrpg -0.1396592 1.461146e-01 0 -0.12833465
584 2 Tigd2 -0.1396514 1.461146e-01 0 -0.29428399
585 2 Nt5dc2 -0.1396036 1.461146e-01 0 -0.45526285
586 2 Rnf121 -0.1394838 1.464889e-01 0 -0.11661353
587 2 X1810041L15Rik -0.1394285 1.466582e-01 0 -0.57771942
588 2 Fam131b -0.1392925 1.468440e-01 0 -0.28079917
589 2 Pcdh19 -0.1389782 1.481137e-01 0 -0.37795879
590 2 Mapk11 -0.1387840 1.492364e-01 0 -0.28218854
591 2 Ndufb4 -0.1386352 1.499475e-01 0 -0.13278025
592 2 Tshz3 -0.1385019 1.503419e-01 0 -0.21632384
593 2 X4930452B06Rik -0.1384854 1.503419e-01 0 -1.58605173
594 2 Snrpb -0.1383325 1.511031e-01 0 -0.12047449
595 2 Nxph3 -0.1382615 1.511031e-01 0 -0.63726411
596 2 Atp2b2 -0.1374798 1.571689e-01 0 -0.40497307
597 2 Fis1 -0.1374032 1.575690e-01 0 -0.08315116
598 2 Smim11 -0.1371004 1.594861e-01 0 -0.22203238
599 2 Ubald2 -0.1369566 1.605502e-01 0 -0.13118681
600 2 Srek1ip1 -0.1367367 1.623742e-01 0 -0.25181162
601 2 Rpl26 0.7828426 2.007887e-51 0 1.57515134
602 2 Rpl35a 0.6930576 4.184848e-40 0 1.24898088
603 2 Uba52 0.5226004 4.520972e-22 0 0.94946200
604 2 Nrp1 0.4696631 1.449069e-17 0 1.10517320
605 2 Hcn1 0.3625122 6.474560e-10 0 1.08301395
606 2 Pantr1 0.3607812 7.320071e-10 0 0.80322987
607 2 Gstp1 0.3518196 2.165691e-09 0 0.62139975
608 2 Btg1 0.3459795 4.538815e-09 0 0.62262518
609 2 Fgfr2 0.3257570 5.795983e-08 0 0.73656272
610 2 Gm48091 0.3208886 9.687245e-08 0 0.80366280
611 2 Pcdh8 0.3189455 1.177402e-07 0 0.65834688
612 2 Nr4a2 0.3125882 2.406825e-07 0 1.55914852
613 2 Ryr3 0.2861301 5.718789e-06 0 0.38400773
614 2 Glo1 0.2772189 1.475729e-05 0 0.32896127
615 2 Shisa9 0.2756894 1.685042e-05 0 1.29465903
616 2 Fos 0.2713354 2.650373e-05 0 0.81491072
617 2 Cd200 0.2702142 2.794622e-05 0 0.41826689
618 2 Msra 0.2698538 2.794622e-05 0 0.37642731
619 2 Xist 0.2645663 4.689303e-05 0 0.21820655
620 2 Wasf1 0.2640077 4.825074e-05 0 0.35028819
621 2 Crym 0.2587836 8.172944e-05 0 0.50575693
622 2 Gabra2 0.2577862 8.639319e-05 0 0.55195273
623 2 Btbd9 0.2530610 1.244864e-04 0 0.21456202
624 2 Unc5d 0.2472737 2.139116e-04 0 0.99447339
625 2 Ssbp2 0.2449342 2.565859e-04 0 0.43966196
626 2 Zfp608 0.2419674 3.247943e-04 0 0.49937452
627 2 Erh 0.2413593 3.381711e-04 0 0.34071185
628 2 Raly 0.2408616 3.483071e-04 0 0.48469271
629 2 Slc16a2 0.2403445 3.594750e-04 0 0.32388771
630 2 Stmn4 0.2401499 3.594750e-04 0 0.30591176
631 2 Dlg2 0.2396362 3.624036e-04 0 0.33412509
632 2 Klhl24 0.2394989 3.624036e-04 0 0.26915813
633 2 Sla 0.2355166 5.267088e-04 0 0.40947014
634 2 St6galnac5 0.2353696 5.267088e-04 0 0.79039470
635 2 Fgf13 0.2347523 5.312439e-04 0 0.29957368
636 2 Dlgap2 0.2340611 5.590706e-04 0 0.58420474
637 2 Lamtor3 0.2328012 6.119840e-04 0 0.45660421
638 2 Ldb2 0.2299760 7.797888e-04 0 0.18277773
639 2 Rgs7bp 0.2289019 8.385266e-04 0 0.46136373
640 2 Cdk14 0.2275432 9.269817e-04 0 0.60195604
641 2 Rgs4 0.2270104 9.611891e-04 0 1.05661205
642 2 Mycl 0.2262836 1.003402e-03 0 0.25517353
643 2 Pigt 0.2239211 1.217344e-03 0 0.38317223
644 2 Tnnt1 0.2232832 1.264208e-03 0 1.51510847
645 2 Sh3rf3 0.2223139 1.359579e-03 0 0.71212302
646 2 Fam131c 0.2195833 1.707569e-03 0 0.50043032
647 2 Gm17750 0.2153237 2.362935e-03 0 0.37451733
648 2 Zfp385b 0.2152180 2.362935e-03 0 1.01914318
649 2 Spock1 0.2150979 2.362935e-03 0 0.27243287
650 2 Gm44790 0.2138094 2.624213e-03 0 0.46109281
651 2 Eml1 0.2133367 2.706936e-03 0 0.49580939
652 2 Ntrk3 0.2113780 3.189960e-03 0 0.29238439
653 2 Tmeff2 0.2098578 3.570923e-03 0 0.63366960
654 2 Lingo1 0.2092392 3.690055e-03 0 0.32363975
655 2 Rgs7 0.2088273 3.785715e-03 0 0.50748659
656 2 Ncdn 0.2085899 3.824757e-03 0 0.33167474
657 2 Magi1 0.2082822 3.848027e-03 0 0.55544260
658 2 Cpq 0.2071255 4.214257e-03 0 0.45147205
659 2 Ube2e3 0.2068305 4.238758e-03 0 0.18538121
660 2 Dync1i1 0.2055310 4.700415e-03 0 0.28001247
661 2 Elmod1 0.2020152 6.089397e-03 0 0.33924307
662 2 Gm40418 0.2019678 6.089397e-03 0 1.00196057
663 2 Stk25 0.2015587 6.246908e-03 0 0.25645309
664 2 Rnf150 0.2012291 6.365298e-03 0 0.39764524
665 2 Vav3 0.2006276 6.577322e-03 0 0.63535035
666 2 Nrp2 0.2000248 6.860371e-03 0 0.84879141
667 2 Glra2 0.1995359 7.047146e-03 0 0.31248709
668 2 Ntm 0.1994659 7.047146e-03 0 0.11491730
669 2 Lyrm9 0.1993907 7.047146e-03 0 1.04917745
670 2 Chsy3 0.1982109 7.455624e-03 0 0.54723834
671 2 Afap1 0.1978803 7.601566e-03 0 0.72467466
672 2 Insm1 0.1976726 7.670979e-03 0 0.67474095
673 2 Jun 0.1971007 7.981593e-03 0 0.39742424
674 2 Nrg1 0.1966691 8.207431e-03 0 0.36396237
675 2 Camk2b 0.1965432 8.226889e-03 0 0.37424981
676 2 Pggt1b 0.1958951 8.545202e-03 0 0.50473799
677 2 Klhdc4 0.1955013 8.623059e-03 0 0.61250522
678 2 Efna5 0.1945286 9.204387e-03 0 0.45203288
679 2 Dlgap1 0.1942252 9.366381e-03 0 0.42564188
680 2 Dynll2 0.1916165 1.126271e-02 0 0.16343170
681 2 Pgk1 0.1912201 1.139449e-02 0 0.36364730
682 2 Bloc1s1 0.1912047 1.139449e-02 0 0.33457090
683 2 Nr4a3 0.1909133 1.158435e-02 0 0.38224660
684 2 Hnrnpa1 0.1906458 1.175472e-02 0 0.22896156
685 2 Atp5l 0.1905493 1.176334e-02 0 0.22804386
686 2 Ccnd2 0.1891100 1.300906e-02 0 0.25660314
687 2 Nr2f2 0.1879053 1.393548e-02 0 0.98414448
688 2 Zbtb16 0.1878519 1.393548e-02 0 0.79304337
689 2 Gm2164 0.1874797 1.426142e-02 0 0.85319962
690 2 Snrnp48 0.1869704 1.448533e-02 0 0.23402910
691 2 Prcp 0.1869540 1.448533e-02 0 0.51523122
692 2 Csrnp3 0.1860585 1.535699e-02 0 0.27861526
693 2 Opcml 0.1845007 1.695052e-02 0 0.37422735
694 2 Kcnk10 0.1844529 1.695052e-02 0 0.29067023
695 2 Chp1 0.1844444 1.695052e-02 0 0.26331136
696 2 Asnsd1 0.1844125 1.695052e-02 0 0.45835879
697 2 Psd 0.1840969 1.705804e-02 0 0.49864314
698 2 Igfbp3 0.1836720 1.721604e-02 0 0.49410243
699 2 Ptprr 0.1835774 1.724138e-02 0 0.84088273
700 2 Epha6 0.1833884 1.724852e-02 0 1.26382484
701 2 Gm30382 0.1832727 1.724852e-02 0 0.62577434
702 2 Cntn1 0.1826716 1.797649e-02 0 0.38961775
703 2 Mief1 0.1818818 1.901098e-02 0 0.41984198
704 2 Frmd4b 0.1814788 1.950534e-02 0 0.16555279
705 2 Snx10 0.1813776 1.954781e-02 0 0.31792690
706 2 Asic2 0.1804006 2.073444e-02 0 0.25466896
707 2 Tsnax 0.1798066 2.158833e-02 0 0.16361773
708 2 Ckmt1 0.1784026 2.378661e-02 0 0.36194957
709 2 Gps1 0.1779677 2.419352e-02 0 0.48103220
710 2 Mast2 0.1767394 2.620001e-02 0 0.22886266
711 2 B3galt2 0.1758063 2.762266e-02 0 0.37387360
712 2 Glp1r 0.1749847 2.878828e-02 0 1.29813641
713 2 Rgs6 0.1738745 3.081959e-02 0 0.27342864
714 2 Cnih3 0.1737056 3.097128e-02 0 0.19392913
715 2 Dpysl4 0.1735188 3.097128e-02 0 0.34080199
716 2 Lix1 0.1734335 3.097128e-02 0 0.24379550
717 2 Cacnb4 0.1732371 3.122133e-02 0 0.32715324
718 2 Cdh2 0.1730790 3.143878e-02 0 0.15879849
719 2 Pou3f2 0.1728066 3.184818e-02 0 1.28397209
720 2 Pak3 0.1722393 3.267503e-02 0 0.22725958
721 2 Tmem108 0.1720884 3.288774e-02 0 0.10052886
722 2 Adgrl3 0.1714698 3.412267e-02 0 0.23838521
723 2 Pak7 0.1709449 3.496956e-02 0 0.21089453
724 2 Fut9 0.1702230 3.671149e-02 0 0.26154758
725 2 Trim36 0.1699000 3.725189e-02 0 0.67610277
726 2 Rtl8a 0.1695195 3.813317e-02 0 0.21199428
727 2 Kcnmb4 0.1692915 3.860094e-02 0 0.34607968
728 2 Lmo7 0.1686460 3.974968e-02 0 0.35459204
729 2 Rpgr 0.1686460 3.974968e-02 0 0.37719879
730 2 Bcl6b 0.1684924 4.002046e-02 0 0.55285610
731 2 Sdhc 0.1678888 4.145304e-02 0 0.15411969
732 2 Snap25 0.1677497 4.169212e-02 0 0.25946972
733 2 Gm9885 0.1672221 4.313101e-02 0 0.40777547
734 2 Rint1 0.1667180 4.434903e-02 0 0.31311835
735 2 Sept6 0.1664524 4.501458e-02 0 0.28471311
736 2 Oma1 0.1660362 4.599204e-02 0 0.66865123
737 2 Slc35f1 0.1658691 4.635192e-02 0 0.24250790
738 2 Fosl2 0.1654323 4.738665e-02 0 0.47513449
739 2 Clpb 0.1642541 5.075077e-02 0 0.35225590
740 2 Gm10260 0.1639247 5.174330e-02 0 0.23336764
741 2 Mea1 0.1632112 5.377300e-02 0 0.73359774
742 2 Pou3f3 0.1625600 5.563649e-02 0 0.52217593
743 2 Cdh8 0.1625596 5.563649e-02 0 0.58109438
744 2 C030034I22Rik 0.1622182 5.657726e-02 0 0.56113965
745 2 Crtc1 0.1620612 5.672080e-02 0 0.32146464
746 2 Ctnnd2 0.1612823 5.944737e-02 0 0.17132854
747 2 Commd1 0.1609915 6.043641e-02 0 0.23330268
748 2 Dusp8 0.1609237 6.044149e-02 0 0.23123799
749 2 Nol4 0.1608261 6.044149e-02 0 0.15319369
750 2 Dap 0.1606718 6.076637e-02 0 0.23228463
751 2 Cdk19 0.1606385 6.076637e-02 0 0.32241950
752 2 Zfp277 0.1602186 6.233772e-02 0 0.18222792
753 2 Fam135b 0.1601492 6.240331e-02 0 0.49787642
754 2 Diaph3 0.1597243 6.403619e-02 0 0.69315519
755 2 Cep57l1 0.1592247 6.580262e-02 0 0.50764025
756 2 Snx21 0.1589835 6.666323e-02 0 0.43319094
757 2 Ntrk2 0.1584787 6.877776e-02 0 0.24868556
758 2 Ahcyl2 0.1579997 7.065156e-02 0 0.39857716
759 2 Mtus1 0.1579433 7.065156e-02 0 0.32594782
760 2 D130020L05Rik 0.1573362 7.305509e-02 0 1.54913697
761 2 Magee2 0.1572285 7.317366e-02 0 0.47897240
762 2 Paxx 0.1570876 7.350847e-02 0 0.15289852
763 2 Dhfr 0.1569884 7.374421e-02 0 0.95228582
764 2 Zfp704 0.1567124 7.434989e-02 0 0.25996609
765 2 Gm30054 0.1563421 7.598702e-02 0 1.02783611
766 2 Snhg10 0.1562553 7.615000e-02 0 0.78649630
767 2 Gtf2h3 0.1561913 7.615000e-02 0 0.34844018
768 2 Shtn1 0.1561558 7.615000e-02 0 0.14371495
769 2 Hax1 0.1556535 7.825361e-02 0 0.19926078
770 2 Stxbp5l 0.1554517 7.904770e-02 0 0.71053653
771 2 X4933404O12Rik 0.1554030 7.904770e-02 0 0.60493265
772 2 Igsf3 0.1552294 7.943626e-02 0 0.26474386
773 2 Rell2 0.1551582 7.954795e-02 0 0.27945422
774 2 Tfdp1 0.1550273 7.998417e-02 0 0.20307052
775 2 Tamm41 0.1545646 8.169946e-02 0 0.39566047
776 2 Crlf1 0.1544794 8.169946e-02 0 0.64715042
777 2 Fut8 0.1544642 8.169946e-02 0 0.43124548
778 2 Gm21949 0.1540631 8.329741e-02 0 0.53590643
779 2 Zkscan3 0.1539464 8.348668e-02 0 0.24397057
780 2 Nr4a1 0.1536677 8.447684e-02 0 0.71999816
781 2 Spast 0.1536247 8.447684e-02 0 0.22873782
782 2 Itpa 0.1525185 8.866185e-02 0 0.13673904
783 2 Gm38948 0.1513221 9.511377e-02 0 0.37127192
784 2 Rusc2 0.1510813 9.619588e-02 0 0.25936942
785 2 Ypel1 0.1510380 9.619588e-02 0 0.17766308
786 2 Gpr137c 0.1510094 9.619588e-02 0 0.23583596
787 2 Tcf4 0.1503784 9.905870e-02 0 0.32236888
788 2 Rgl1 0.1503138 9.917564e-02 0 0.56341013
789 2 Eif4b 0.1501503 9.963751e-02 0 0.15901624
790 2 Dhrs13 0.1494255 1.029326e-01 0 0.23594266
791 2 Sik1 0.1492612 1.033397e-01 0 0.63223288
792 2 Pou3f1 0.1491085 1.033397e-01 0 0.54571045
793 2 Rangap1 0.1490838 1.033397e-01 0 0.19146620
794 2 Gm29478 0.1490499 1.033397e-01 0 1.59813122
795 2 Dbpht2 0.1490499 1.033397e-01 0 1.58991377
796 2 Dmac2 0.1487502 1.038322e-01 0 0.47524745
797 2 Actr6 0.1484507 1.045878e-01 0 0.27628804
798 2 Nup43 0.1483971 1.045878e-01 0 0.36551302
799 2 Pja1 0.1483225 1.045878e-01 0 0.04782317
800 2 Resp18 0.1482590 1.045878e-01 0 1.62870311Cluster 511 e15.0
OriginalCluster CellNumber COTANClusterNumber Accuracy
1 Cl525E15.0 826 3 0.786585365853659
2 Cl511E15.0 540 2 0.916666666666667
3 Cl184E15.0 322 2 0.734375
4 Cl432E13.5 536 2 0.88785046728972
5 Cl510E15.0 402 2 0.825
6 Cl511E15.0 540 2 <NA>cells <- getClusterizationData(e15.0,clName = "CL_original.clusters")[[1]][getClusterizationData(e15.0,clName = "CL_original.clusters")[[1]] == "511"]
cells <-names(cells)
cl511e15.0 <- automaticCOTANObjectCreation(raw = getRawData(e15.0)[,cells],
GEO = "Loom",
sequencingMethod = "10X",
sampleCondition = "cl511e15.0",
cores = 10,saveObj = T,
outDir = "Data/MouseCortexFromLoom/NotCTSingleClusters/",
calcCoex = T)cl511e15.0GDI <- calculateGDI(cl511e15.0)
subsetGDIcl511e15.0 <- cl511e15.0GDI[cl511e15.0GDI$sum.raw.norm > 5,]
top.GDI.genes <- rownames(subsetGDIcl511e15.0[order(subsetGDIcl511e15.0$GDI,decreasing = T),])[1:25]
GDIPlot(cl511e15.0,genes = list("topGDI"=top.GDI.genes),GDIIn = cl511e15.0GDI)
list.cl.CT <- cellsUniformClustering(cl511e15.0, GDIThreshold = 1.43, cores = 10L,
saveObj = TRUE, outDir = outDir)
cl511e15.0 <- addClusterization(cl511e15.0, clName = "split",
clusters = list.cl.CT$clusters,
coexDF = list.cl.CT$coex, override = TRUE)
table(list.cl.CT$clusters)c(mergedClusters, mergedCoexDF) %<-%
mergeUniformCellsClusters(cl511e15.0, clusters = list.cl.CT$clusters,
GDIThreshold = 1.43, batchSize = 4L, cores = 10L,
saveObj = TRUE, outDir = outDir)
cl511e15.0 <- addClusterization(cl511e15.0, clName = "merge",
clusters = mergedClusters,
coexDF = mergedCoexDF,
override = TRUE)
saveRDS(cl511e15.0,paste0(outDir,"cl511e15.0.cotan.RDS"))
table(str_split(names(mergedClusters),pattern = "_",simplify = T)[,1],mergedClusters)data <- getNormalizedData(cl511e15.0)
data <- data[!rowSums(as.matrix(data)) < 1,]
data <- log(data*10000+1)
row_stdev <- apply(data, 1, sd, na.rm=TRUE)
row_stdev <- row_stdev[order(row_stdev,decreasing = T)]
genes.to.keep <- c(names(row_stdev[1:100]),top.GDI.genes)
data.small <- data[rownames(data) %in% genes.to.keep,]
#data <- t(as.matrix(data))
data.small <- t(as.matrix(data.small))
COTAN_Cl.code <- getClusterizationData(cl511e15.0)[[1]]
#COTAN_Cl.code[COTAN_Cl.code == "A549"] <- 0
#COTAN_Cl.code[COTAN_Cl.code == "CCL-185-IG"] <- 1
COTAN_Cl.code <- as.numeric(COTAN_Cl.code)-1
data.small <- cbind(data.small,COTAN_Cl.code)
data.small <- as.data.frame(data.small)
# Split the data into training and test set
set.seed(123)
training.samples <- data.small[,"COTAN_Cl.code"] %>%
createDataPartition(p = 0.8, list = FALSE)
train.data <- data.small[training.samples, ]
test.data <- data.small[-training.samples, ]
head(train.data) Flrt2 Smarca2 Srgap1 Sla Cadps
10X74_4_A_1:CAGCGTCTCCTCGTx 0.000000 0.000000 0.000000 0.000000 0.000000
10X74_4_A_1:GTCCACTGTCCTCGx 0.000000 0.000000 0.000000 10.471506 0.000000
10X64_3_A_1:ACGCCGGAGGATTCx 9.207514 9.207514 10.306059 0.000000 9.207514
10X73_3_A_1:GTTAACCTTGTCGAx 8.878654 8.878654 9.571731 0.000000 0.000000
10X74_4_A_1:CGTGATGAGAAGGCx 8.985081 9.678166 10.371281 0.000000 0.000000
10X73_3_A_1:AAGCACTGCTTCGCx 0.000000 9.028611 10.127143 9.721698 9.028611
Kcnk10 Itpr1 Klhl29 Elmod1 Nin
10X74_4_A_1:CAGCGTCTCCTCGTx 0.000000 0 10.627557 9.528994 10.915233
10X74_4_A_1:GTCCACTGTCCTCGx 0.000000 0 9.778387 0.000000 9.778387
10X64_3_A_1:ACGCCGGAGGATTCx 9.207514 0 9.900611 0.000000 9.207514
10X73_3_A_1:GTTAACCTTGTCGAx 0.000000 0 0.000000 8.878654 0.000000
10X74_4_A_1:CGTGATGAGAAGGCx 0.000000 0 8.985081 8.985081 8.985081
10X73_3_A_1:AAGCACTGCTTCGCx 10.127143 0 0.000000 9.028611 0.000000
Kcnn2 Adgrb3 Foxp1 Alcam Mtss1
10X74_4_A_1:CAGCGTCTCCTCGTx 0.000000 9.528994 0.000000 9.528994 0.000000
10X74_4_A_1:GTCCACTGTCCTCGx 0.000000 0.000000 0.000000 0.000000 0.000000
10X64_3_A_1:ACGCCGGAGGATTCx 0.000000 11.153338 9.207514 10.593733 9.207514
10X73_3_A_1:GTTAACCTTGTCGAx 9.571731 10.264844 9.571731 0.000000 8.878654
10X74_4_A_1:CGTGATGAGAAGGCx 0.000000 10.083610 8.985081 8.985081 10.083610
10X73_3_A_1:AAGCACTGCTTCGCx 0.000000 0.000000 9.028611 0.000000 9.028611
Fam213a Ralgps2 Ptn Cadm2 Frmd4a
10X74_4_A_1:CAGCGTCTCCTCGTx 9.528994 0.000000 0.000000 10.222104 9.528994
10X74_4_A_1:GTCCACTGTCCTCGx 0.000000 9.778387 0.000000 0.000000 0.000000
10X64_3_A_1:ACGCCGGAGGATTCx 0.000000 9.207514 9.207514 9.207514 9.207514
10X73_3_A_1:GTTAACCTTGTCGAx 0.000000 0.000000 11.586574 10.487980 8.878654
10X74_4_A_1:CGTGATGAGAAGGCx 0.000000 0.000000 0.000000 8.985081 0.000000
10X73_3_A_1:AAGCACTGCTTCGCx 0.000000 9.028611 0.000000 10.127143 10.820270
Nkain2 Tenm3 Grip1 Tanc2 Syt11
10X74_4_A_1:CAGCGTCTCCTCGTx 0.000000 0.000000 10.915233 0.000000 0.000000
10X74_4_A_1:GTCCACTGTCCTCGx 9.778387 10.876962 9.778387 9.778387 9.778387
10X64_3_A_1:ACGCCGGAGGATTCx 0.000000 9.207514 0.000000 0.000000 9.207514
10X73_3_A_1:GTTAACCTTGTCGAx 0.000000 0.000000 8.878654 8.878654 8.878654
10X74_4_A_1:CGTGATGAGAAGGCx 0.000000 9.678166 8.985081 8.985081 0.000000
10X73_3_A_1:AAGCACTGCTTCGCx 0.000000 10.127143 0.000000 9.028611 0.000000
Srgap3 Pak7 Mapk10 Sobp Bhlhe22
10X74_4_A_1:CAGCGTCTCCTCGTx 9.528994 0.000000 10.222104 9.528994 0.000000
10X74_4_A_1:GTCCACTGTCCTCGx 10.471506 9.778387 0.000000 0.000000 9.778387
10X64_3_A_1:ACGCCGGAGGATTCx 9.900611 0.000000 0.000000 0.000000 0.000000
10X73_3_A_1:GTTAACCTTGTCGAx 9.571731 8.878654 10.487980 8.878654 0.000000
10X74_4_A_1:CGTGATGAGAAGGCx 9.678166 0.000000 8.985081 9.678166 0.000000
10X73_3_A_1:AAGCACTGCTTCGCx 0.000000 10.820270 0.000000 0.000000 9.721698
Epha3 Adgrl3 Dok5 Satb2 Hs6st2
10X74_4_A_1:CAGCGTCTCCTCGTx 0.000000 0.000000 0.000000 0.00000 0.000000
10X74_4_A_1:GTCCACTGTCCTCGx 0.000000 10.471506 0.000000 0.00000 0.000000
10X64_3_A_1:ACGCCGGAGGATTCx 0.000000 0.000000 0.000000 0.00000 9.207514
10X73_3_A_1:GTTAACCTTGTCGAx 9.571731 9.571731 10.487980 11.36343 8.878654
10X74_4_A_1:CGTGATGAGAAGGCx 8.985081 8.985081 0.000000 0.00000 0.000000
10X73_3_A_1:AAGCACTGCTTCGCx 0.000000 0.000000 9.028611 0.00000 12.024229
X5730522E02Rik Msra Spock1 Enc1
10X74_4_A_1:CAGCGTCTCCTCGTx 9.528994 0.000000 9.528994 0.00000
10X74_4_A_1:GTCCACTGTCCTCGx 0.000000 0.000000 0.000000 10.47151
10X64_3_A_1:ACGCCGGAGGATTCx 0.000000 0.000000 0.000000 0.00000
10X73_3_A_1:GTTAACCTTGTCGAx 0.000000 0.000000 8.878654 10.26484
10X74_4_A_1:CGTGATGAGAAGGCx 10.371281 8.985081 0.000000 0.00000
10X73_3_A_1:AAGCACTGCTTCGCx 10.414815 10.820270 10.414815 0.00000
Fam110b Sybu Lmo1 Dscam Rab3c
10X74_4_A_1:CAGCGTCTCCTCGTx 9.528994 10.627557 9.528994 10.222104 0.000000
10X74_4_A_1:GTCCACTGTCCTCGx 0.000000 10.471506 0.000000 9.778387 0.000000
10X64_3_A_1:ACGCCGGAGGATTCx 0.000000 9.207514 0.000000 0.000000 0.000000
10X73_3_A_1:GTTAACCTTGTCGAx 8.878654 8.878654 8.878654 8.878654 8.878654
10X74_4_A_1:CGTGATGAGAAGGCx 8.985081 0.000000 8.985081 8.985081 8.985081
10X73_3_A_1:AAGCACTGCTTCGCx 0.000000 0.000000 9.028611 0.000000 9.028611
Mir124.2hg Clstn2 Fat3 Kcnh7 Usp29
10X74_4_A_1:CAGCGTCTCCTCGTx 0.000000 10.222104 10.627557 10.222104 0.000000
10X74_4_A_1:GTCCACTGTCCTCGx 10.471506 10.876962 9.778387 0.000000 0.000000
10X64_3_A_1:ACGCCGGAGGATTCx 9.207514 10.306059 10.816872 9.207514 0.000000
10X73_3_A_1:GTTAACCTTGTCGAx 8.878654 8.878654 9.571731 8.878654 0.000000
10X74_4_A_1:CGTGATGAGAAGGCx 8.985081 0.000000 0.000000 0.000000 0.000000
10X73_3_A_1:AAGCACTGCTTCGCx 0.000000 0.000000 10.414815 10.127143 9.028611
Cd47 Ryr3 Neto2 Ppm1e Mdga2
10X74_4_A_1:CAGCGTCTCCTCGTx 10.222104 0.000000 9.528994 0.000000 9.528994
10X74_4_A_1:GTCCACTGTCCTCGx 0.000000 0.000000 9.778387 9.778387 10.471506
10X64_3_A_1:ACGCCGGAGGATTCx 9.207514 0.000000 0.000000 9.207514 10.306059
10X73_3_A_1:GTTAACCTTGTCGAx 0.000000 8.878654 9.571731 11.517582 0.000000
10X74_4_A_1:CGTGATGAGAAGGCx 9.678166 10.083610 8.985081 9.678166 10.083610
10X73_3_A_1:AAGCACTGCTTCGCx 0.000000 10.414815 9.721698 9.721698 9.721698
Serpini1 Ralyl Nrcam Robo2 Csrnp3
10X74_4_A_1:CAGCGTCTCCTCGTx 0.000000 10.222104 0.000000 0.000000 10.627557
10X74_4_A_1:GTCCACTGTCCTCGx 0.000000 10.471506 10.471506 0.000000 0.000000
10X64_3_A_1:ACGCCGGAGGATTCx 9.207514 0.000000 9.900611 10.593733 10.306059
10X73_3_A_1:GTTAACCTTGTCGAx 9.571731 8.878654 9.977173 8.878654 9.571731
10X74_4_A_1:CGTGATGAGAAGGCx 8.985081 10.371281 8.985081 0.000000 0.000000
10X73_3_A_1:AAGCACTGCTTCGCx 0.000000 10.637953 0.000000 0.000000 0.000000
Hist3h2ba Jakmip1 Edil3 Enox1 Rprm
10X74_4_A_1:CAGCGTCTCCTCGTx 10.62756 0.000000 0.000000 10.222104 10.627557
10X74_4_A_1:GTCCACTGTCCTCGx 0.00000 0.000000 10.471506 9.778387 0.000000
10X64_3_A_1:ACGCCGGAGGATTCx 10.30606 9.207514 9.900611 9.207514 0.000000
10X73_3_A_1:GTTAACCTTGTCGAx 10.95797 9.571731 0.000000 0.000000 8.878654
10X74_4_A_1:CGTGATGAGAAGGCx 10.93088 10.083610 8.985081 10.594419 10.594419
10X73_3_A_1:AAGCACTGCTTCGCx 11.10795 0.000000 9.028611 9.721698 9.028611
Olfm1 Tmem178b Gng3 Cntn2 Scg3
10X74_4_A_1:CAGCGTCTCCTCGTx 0.000000 0.000000 9.528994 0.000000 0.000000
10X74_4_A_1:GTCCACTGTCCTCGx 9.778387 0.000000 9.778387 0.000000 9.778387
10X64_3_A_1:ACGCCGGAGGATTCx 9.207514 0.000000 0.000000 0.000000 0.000000
10X73_3_A_1:GTTAACCTTGTCGAx 8.878654 8.878654 10.670297 8.878654 8.878654
10X74_4_A_1:CGTGATGAGAAGGCx 0.000000 0.000000 8.985081 0.000000 9.678166
10X73_3_A_1:AAGCACTGCTTCGCx 0.000000 9.028611 0.000000 9.028611 0.000000
Gnao1 Serp2 Pcdh9 Trim2 Nrg1
10X74_4_A_1:CAGCGTCTCCTCGTx 9.528994 10.222104 10.222104 9.528994 0.000000
10X74_4_A_1:GTCCACTGTCCTCGx 9.778387 9.778387 9.778387 0.000000 0.000000
10X64_3_A_1:ACGCCGGAGGATTCx 9.207514 0.000000 10.816872 0.000000 0.000000
10X73_3_A_1:GTTAACCTTGTCGAx 9.571731 9.571731 10.264844 9.571731 9.571731
10X74_4_A_1:CGTGATGAGAAGGCx 8.985081 9.678166 9.678166 8.985081 8.985081
10X73_3_A_1:AAGCACTGCTTCGCx 9.028611 9.721698 10.127143 9.721698 9.028611
Ppfia2 Cacna2d1 Uqcrq Ndufs6 Ppp1cb
10X74_4_A_1:CAGCGTCTCCTCGTx 0.000000 0.000000 0.000000 9.528994 10.222104
10X74_4_A_1:GTCCACTGTCCTCGx 0.000000 0.000000 0.000000 0.000000 0.000000
10X64_3_A_1:ACGCCGGAGGATTCx 0.000000 9.900611 9.900611 10.593733 9.207514
10X73_3_A_1:GTTAACCTTGTCGAx 10.670297 11.181114 10.957974 9.571731 8.878654
10X74_4_A_1:CGTGATGAGAAGGCx 9.678166 0.000000 8.985081 0.000000 0.000000
10X73_3_A_1:AAGCACTGCTTCGCx 9.028611 0.000000 10.414815 9.028611 0.000000
Ndufaf2 Hmgb3 Rps10 Rae1 Snrpb
10X74_4_A_1:CAGCGTCTCCTCGTx 0.000000 9.528994 0.00000 0.000000 10.222104
10X74_4_A_1:GTCCACTGTCCTCGx 0.000000 0.000000 10.87696 0.000000 9.778387
10X64_3_A_1:ACGCCGGAGGATTCx 0.000000 9.207514 10.81687 0.000000 9.900611
10X73_3_A_1:GTTAACCTTGTCGAx 9.977173 9.977173 10.82444 0.000000 10.824445
10X74_4_A_1:CGTGATGAGAAGGCx 10.594419 0.000000 10.77674 8.985081 9.678166
10X73_3_A_1:AAGCACTGCTTCGCx 9.028611 0.000000 10.12714 9.028611 9.721698
Mbd3 Eif3c Rpl12 Rpl13a Rps12
10X74_4_A_1:CAGCGTCTCCTCGTx 10.222104 9.528994 0.000000 0.00000 9.528994
10X74_4_A_1:GTCCACTGTCCTCGx 9.778387 10.876962 10.876962 10.87696 9.778387
10X64_3_A_1:ACGCCGGAGGATTCx 0.000000 9.207514 10.999190 11.28687 10.593733
10X73_3_A_1:GTTAACCTTGTCGAx 9.977173 0.000000 8.878654 10.82444 10.264844
10X74_4_A_1:CGTGATGAGAAGGCx 0.000000 8.985081 10.930884 10.93088 10.371281
10X73_3_A_1:AAGCACTGCTTCGCx 0.000000 9.028611 9.721698 10.97442 10.414815
Rpl39 Rps3 Snrpd2 Rps21 Uqcrh
10X74_4_A_1:CAGCGTCTCCTCGTx 0.000000 10.22210 9.528994 9.528994 9.528994
10X74_4_A_1:GTCCACTGTCCTCGx 0.000000 10.87696 0.000000 0.000000 9.778387
10X64_3_A_1:ACGCCGGAGGATTCx 0.000000 10.81687 9.207514 10.593733 10.593733
10X73_3_A_1:GTTAACCTTGTCGAx 9.571731 11.07575 10.670297 8.878654 9.571731
10X74_4_A_1:CGTGATGAGAAGGCx 0.000000 11.46987 10.776736 10.371281 0.000000
10X73_3_A_1:AAGCACTGCTTCGCx 9.028611 10.41482 0.000000 10.127143 9.721698
Rpl38 Rps25 Pfdn5 Saraf Rps28
10X74_4_A_1:CAGCGTCTCCTCGTx 0.000000 10.62756 0.000000 0.000000 9.528994
10X74_4_A_1:GTCCACTGTCCTCGx 0.000000 10.47151 9.778387 0.000000 10.471506
10X64_3_A_1:ACGCCGGAGGATTCx 10.306059 10.59373 10.593733 9.207514 10.593733
10X73_3_A_1:GTTAACCTTGTCGAx 8.878654 10.67030 10.264844 8.878654 9.571731
10X74_4_A_1:CGTGATGAGAAGGCx 9.678166 11.18219 10.776736 9.678166 11.064413
10X73_3_A_1:AAGCACTGCTTCGCx 10.637953 10.12714 11.225729 9.028611 10.974418
Rps27 Ndufa7 Gnaq Rpl34 Gm2000
10X74_4_A_1:CAGCGTCTCCTCGTx 11.320692 0.000000 0.000000 9.528994 0.000000
10X74_4_A_1:GTCCACTGTCCTCGx 9.778387 9.778387 9.778387 9.778387 0.000000
10X64_3_A_1:ACGCCGGAGGATTCx 11.153338 0.000000 9.207514 9.207514 10.306059
10X73_3_A_1:GTTAACCTTGTCGAx 10.670297 8.878654 10.264844 10.957974 9.571731
10X74_4_A_1:CGTGATGAGAAGGCx 10.776736 10.594419 0.000000 10.371281 10.594419
10X73_3_A_1:AAGCACTGCTTCGCx 10.974418 0.000000 9.721698 10.820270 9.028611
Rpl27 Pdia3 Rpl35 Sbf2 Atp5e
10X74_4_A_1:CAGCGTCTCCTCGTx 10.627557 9.528994 10.22210 0.000000 0.000000
10X74_4_A_1:GTCCACTGTCCTCGx 0.000000 10.876962 0.00000 10.471506 9.778387
10X64_3_A_1:ACGCCGGAGGATTCx 10.816872 9.207514 10.30606 0.000000 9.900611
10X73_3_A_1:GTTAACCTTGTCGAx 9.977173 9.571731 11.07575 9.977173 9.977173
10X74_4_A_1:CGTGATGAGAAGGCx 10.930884 8.985081 11.28755 8.985081 9.678166
10X73_3_A_1:AAGCACTGCTTCGCx 10.127143 10.820270 11.10795 0.000000 9.028611
X4930402H24Rik Ppm1l Itfg1 Large1
10X74_4_A_1:CAGCGTCTCCTCGTx 9.528994 0.000000 0.000000 0.000000
10X74_4_A_1:GTCCACTGTCCTCGx 9.778387 0.000000 10.876962 9.778387
10X64_3_A_1:ACGCCGGAGGATTCx 0.000000 0.000000 9.207514 9.207514
10X73_3_A_1:GTTAACCTTGTCGAx 9.977173 0.000000 9.977173 0.000000
10X74_4_A_1:CGTGATGAGAAGGCx 8.985081 8.985081 0.000000 0.000000
10X73_3_A_1:AAGCACTGCTTCGCx 0.000000 9.028611 0.000000 0.000000
Ktn1 Nipsnap3b Tmem57 Timm8b Swi5
10X74_4_A_1:CAGCGTCTCCTCGTx 0.000000 0.000000 9.528994 9.528994 0.000000
10X74_4_A_1:GTCCACTGTCCTCGx 10.876962 0.000000 9.778387 0.000000 0.000000
10X64_3_A_1:ACGCCGGAGGATTCx 0.000000 9.207514 0.000000 9.900611 10.816872
10X73_3_A_1:GTTAACCTTGTCGAx 8.878654 9.571731 8.878654 9.571731 9.977173
10X74_4_A_1:CGTGATGAGAAGGCx 0.000000 0.000000 8.985081 8.985081 0.000000
10X73_3_A_1:AAGCACTGCTTCGCx 9.028611 9.721698 9.721698 10.414815 9.721698
Acat2 Hmgcs1 Prmt2 Kif1a Camta1
10X74_4_A_1:CAGCGTCTCCTCGTx 9.528994 9.528994 0.000000 0.000000 9.528994
10X74_4_A_1:GTCCACTGTCCTCGx 0.000000 9.778387 0.000000 0.000000 0.000000
10X64_3_A_1:ACGCCGGAGGATTCx 10.306059 0.000000 0.000000 0.000000 9.207514
10X73_3_A_1:GTTAACCTTGTCGAx 8.878654 9.977173 0.000000 9.571731 9.571731
10X74_4_A_1:CGTGATGAGAAGGCx 8.985081 8.985081 9.678166 0.000000 0.000000
10X73_3_A_1:AAGCACTGCTTCGCx 9.721698 0.000000 0.000000 0.000000 9.028611
Tnrc6c Kifap3 COTAN_Cl.code
10X74_4_A_1:CAGCGTCTCCTCGTx 0.000000 10.915233 0
10X74_4_A_1:GTCCACTGTCCTCGx 0.000000 10.471506 0
10X64_3_A_1:ACGCCGGAGGATTCx 0.000000 0.000000 1
10X73_3_A_1:GTTAACCTTGTCGAx 8.878654 8.878654 1
10X74_4_A_1:CGTGATGAGAAGGCx 0.000000 0.000000 1
10X73_3_A_1:AAGCACTGCTTCGCx 10.127143 0.000000 1# Fit the model
model <- glm( COTAN_Cl.code ~., data = train.data, family = binomial,control = list(maxit = 50))
# Summarize the model
summary(model)
Call:
glm(formula = COTAN_Cl.code ~ ., family = binomial, data = train.data,
control = list(maxit = 50))
Coefficients:
Estimate Std. Error z value Pr(>|z|)
(Intercept) -7.945e+01 1.249e+06 0 1
Flrt2 9.669e-02 4.410e+04 0 1
Smarca2 5.568e-01 4.302e+04 0 1
Srgap1 4.766e-01 4.205e+04 0 1
Sla 2.602e-01 5.163e+04 0 1
Cadps 5.389e-01 6.198e+04 0 1
Kcnk10 -1.342e+00 4.222e+04 0 1
Itpr1 -4.206e-01 3.758e+04 0 1
Klhl29 4.027e-02 4.655e+04 0 1
Elmod1 2.079e-01 5.005e+04 0 1
Nin -6.937e-01 4.213e+04 0 1
Kcnn2 -6.294e-01 4.782e+04 0 1
Adgrb3 1.102e-01 4.018e+04 0 1
Foxp1 -5.355e-01 4.032e+04 0 1
Alcam 4.855e-02 3.849e+04 0 1
Mtss1 5.612e-01 5.163e+04 0 1
Fam213a -3.578e-01 4.409e+04 0 1
Ralgps2 -4.821e-01 4.810e+04 0 1
Ptn 4.191e-01 4.797e+04 0 1
Cadm2 -3.072e-01 4.587e+04 0 1
Frmd4a -2.013e-01 4.167e+04 0 1
Nkain2 2.208e-02 4.750e+04 0 1
Tenm3 3.983e-02 3.346e+04 0 1
Grip1 -9.333e-02 3.512e+04 0 1
Tanc2 -8.738e-02 4.168e+04 0 1
Syt11 2.753e-01 4.338e+04 0 1
Srgap3 -8.834e-02 3.477e+04 0 1
Pak7 -2.762e-01 4.729e+04 0 1
Mapk10 -3.358e-01 4.754e+04 0 1
Sobp -2.577e-01 4.338e+04 0 1
Bhlhe22 -4.408e-02 3.406e+04 0 1
Epha3 5.588e-02 4.989e+04 0 1
Adgrl3 -5.449e-01 4.915e+04 0 1
Dok5 7.224e-01 4.131e+04 0 1
Satb2 1.647e-03 4.448e+04 0 1
Hs6st2 -3.578e-01 5.633e+04 0 1
X5730522E02Rik 5.379e-01 6.060e+04 0 1
Msra -1.336e-01 3.967e+04 0 1
Spock1 4.897e-01 5.340e+04 0 1
Enc1 -9.539e-01 3.439e+04 0 1
Fam110b -5.607e-01 5.919e+04 0 1
Sybu 3.880e-01 4.917e+04 0 1
Lmo1 -1.989e-01 4.912e+04 0 1
Dscam 2.017e-01 4.326e+04 0 1
Rab3c -7.815e-01 5.240e+04 0 1
Mir124.2hg -4.134e-01 4.864e+04 0 1
Clstn2 4.551e-01 5.271e+04 0 1
Fat3 -8.711e-01 2.733e+04 0 1
Kcnh7 -5.668e-01 4.513e+04 0 1
Usp29 4.330e-01 4.419e+04 0 1
Cd47 -2.179e-01 5.528e+04 0 1
Ryr3 -6.230e-01 3.575e+04 0 1
Neto2 -8.651e-01 4.378e+04 0 1
Ppm1e 9.175e-01 3.048e+04 0 1
Mdga2 -5.625e-01 4.444e+04 0 1
Serpini1 -1.806e-01 3.139e+04 0 1
Ralyl -5.850e-01 3.726e+04 0 1
Nrcam 5.969e-01 5.130e+04 0 1
Robo2 1.562e-01 5.022e+04 0 1
Csrnp3 3.255e-01 4.258e+04 0 1
Hist3h2ba 9.792e-01 6.362e+04 0 1
Jakmip1 6.290e-01 4.494e+04 0 1
Edil3 2.458e-01 5.274e+04 0 1
Enox1 -3.492e-01 3.551e+04 0 1
Rprm -6.761e-01 4.755e+04 0 1
Olfm1 -6.009e-01 3.843e+04 0 1
Tmem178b -3.975e-01 3.395e+04 0 1
Gng3 -5.421e-01 5.404e+04 0 1
Cntn2 -1.805e-01 3.823e+04 0 1
Scg3 1.909e-01 4.486e+04 0 1
Gnao1 1.284e+00 4.718e+04 0 1
Serp2 1.339e+00 5.653e+04 0 1
Pcdh9 4.828e-01 4.228e+04 0 1
Trim2 1.045e+00 3.278e+04 0 1
Nrg1 -1.721e-01 3.936e+04 0 1
Ppfia2 -5.492e-01 4.253e+04 0 1
Cacna2d1 -3.999e-01 4.381e+04 0 1
Uqcrq 1.761e+00 4.632e+04 0 1
Ndufs6 -5.486e-02 6.232e+04 0 1
Ppp1cb 3.328e-01 3.466e+04 0 1
Ndufaf2 2.087e-01 4.163e+04 0 1
Hmgb3 1.739e-01 6.558e+04 0 1
Rps10 1.753e+00 7.688e+04 0 1
Rae1 4.493e-01 4.665e+04 0 1
Snrpb 1.501e-01 5.735e+04 0 1
Mbd3 -1.508e-01 4.537e+04 0 1
Eif3c 3.066e-01 2.789e+04 0 1
Rpl12 5.480e-01 6.321e+04 0 1
Rpl13a 1.490e+00 6.668e+04 0 1
Rps12 4.958e-01 4.057e+04 0 1
Rpl39 7.737e-02 4.342e+04 0 1
Rps3 -8.192e-01 8.276e+04 0 1
Snrpd2 -1.881e-02 4.609e+04 0 1
Rps21 6.968e-01 6.075e+04 0 1
Uqcrh 7.500e-01 5.003e+04 0 1
Rpl38 1.977e+00 5.107e+04 0 1
Rps25 7.018e-01 7.171e+04 0 1
Pfdn5 9.737e-01 5.047e+04 0 1
Saraf -2.046e-02 4.546e+04 0 1
Rps28 6.424e-01 5.766e+04 0 1
Rps27 1.096e+00 6.508e+04 0 1
Ndufa7 -3.613e-02 6.935e+04 0 1
Gnaq -1.607e+00 4.105e+04 0 1
Rpl34 7.638e-01 7.047e+04 0 1
Gm2000 1.596e+00 6.006e+04 0 1
Rpl27 6.610e-01 8.154e+04 0 1
Pdia3 5.276e-02 4.427e+04 0 1
Rpl35 5.017e-01 6.780e+04 0 1
Sbf2 -7.538e-01 4.982e+04 0 1
Atp5e -3.677e-02 4.550e+04 0 1
X4930402H24Rik -2.239e-01 4.575e+04 0 1
Ppm1l -2.472e-02 4.542e+04 0 1
Itfg1 -5.769e-01 3.699e+04 0 1
Large1 -1.508e+00 5.156e+04 0 1
Ktn1 1.685e-01 3.577e+04 0 1
Nipsnap3b 5.160e-01 4.255e+04 0 1
Tmem57 3.480e-01 3.485e+04 0 1
Timm8b 1.778e-01 3.494e+04 0 1
Swi5 4.639e-01 6.260e+04 0 1
Acat2 -1.723e-01 3.157e+04 0 1
Hmgcs1 -2.428e-01 4.074e+04 0 1
Prmt2 5.547e-01 3.435e+04 0 1
Kif1a -1.959e+00 3.366e+04 0 1
Camta1 -2.208e-01 3.990e+04 0 1
Tnrc6c -4.644e-01 5.866e+04 0 1
Kifap3 -2.284e-01 4.404e+04 0 1
(Dispersion parameter for binomial family taken to be 1)
Null deviance: 5.1795e+02 on 431 degrees of freedom
Residual deviance: 4.0943e-10 on 306 degrees of freedom
AIC: 252
Number of Fisher Scoring iterations: 28# Make predictions
probabilities <- model %>% predict(test.data, type = "response")
predicted.classes <- ifelse(probabilities > 0.5, "1", "0")
# Model accuracy
accuracy <- mean(predicted.classes == test.data$COTAN_Cl.code)
result.df[nrow(result.df),"Accuracy"] <- accuracy
accuracy[1] 0.9166667So also in this case a logistic regression confirm the difference in cell population detected by COTAN.
cl511e15.0ClsMarkers <- findClustersMarkers(cl511e15.0,n = 200,adjustmentMethod = "BH")
cl511e15.0ClsMarkers CL Gene DEA adjPVal IsMarker logFoldCh
1 1 Rps12 -0.4631574 6.179304e-23 0 -0.6825116
2 1 Atp5e -0.4421507 5.491674e-21 0 -0.6826112
3 1 Rpl12 -0.4249280 2.145989e-19 0 -0.5752903
4 1 Gm2000 -0.4178094 8.266734e-19 0 -0.7062262
5 1 Rpl27 -0.4101463 3.545306e-18 0 -0.4851285
6 1 Rpl35 -0.4095642 3.545306e-18 0 -0.6420850
7 1 Rpl38 -0.3944000 8.478137e-17 0 -0.4901851
8 1 Rpl34 -0.3839938 6.783729e-16 0 -0.5340951
9 1 Rpl13a -0.3816076 9.935167e-16 0 -0.4674161
10 1 Rps27 -0.3776191 2.046247e-15 0 -0.5241613
11 1 Rps3 -0.3674962 1.463958e-14 0 -0.5091646
12 1 Rps21 -0.3610531 4.848936e-14 0 -0.4306092
13 1 Rps13 -0.3572065 9.536353e-14 0 -0.4967312
14 1 Rps29 -0.3548193 1.410408e-13 0 -0.4107293
15 1 Uqcrh -0.3468007 6.147911e-13 0 -0.4208264
16 1 Rps15a -0.3458429 6.912919e-13 0 -0.5734880
17 1 Pfdn5 -0.3412558 1.543625e-12 0 -0.4357714
18 1 Uqcr10 -0.3369860 3.225511e-12 0 -0.4964385
19 1 Rps26 -0.3311185 8.957326e-12 0 -0.5340777
20 1 Rps18 -0.3305680 9.404136e-12 0 -0.4596902
21 1 Tpt1 -0.3299757 9.821432e-12 0 -0.4076206
22 1 Pomp -0.3298025 9.821432e-12 0 -0.4368943
23 1 Uqcrq -0.3293949 1.011334e-11 0 -0.4547596
24 1 Rps10 -0.3272393 1.429376e-11 0 -0.4795864
25 1 Timm8b -0.3243765 2.202010e-11 0 -0.4229584
26 1 Rps25 -0.3237942 2.352031e-11 0 -0.4375944
27 1 Pfn1 -0.3207294 3.901832e-11 0 -0.4524917
28 1 Atp6v1g1 -0.3200480 4.247356e-11 0 -0.3852555
29 1 Snrpd2 -0.3191408 4.809087e-11 0 -0.4236104
30 1 Hist3h2ba -0.3189606 4.809087e-11 0 -0.4143786
31 1 Rpl37 -0.3182726 5.113078e-11 0 -0.5620636
32 1 Ndufs6 -0.3181898 5.113078e-11 0 -0.4034311
33 1 Atp5o.1 -0.3180827 5.113078e-11 0 -0.4328550
34 1 Snrpd1 -0.3153742 7.959216e-11 0 -0.4110424
35 1 Dynlrb1 -0.3138158 1.013177e-10 0 -0.4016523
36 1 Uqcr11 -0.3127960 1.175129e-10 0 -0.3977030
37 1 Rpl35a -0.3107331 1.629691e-10 0 -0.4733195
38 1 Btf3 -0.3105683 1.633253e-10 0 -0.3262416
39 1 Swi5 -0.3089875 2.084660e-10 0 -0.3992487
40 1 Rps20 -0.3085851 2.163449e-10 0 -0.4357840
41 1 Rps28 -0.3084818 2.163449e-10 0 -0.3976983
42 1 Rpl31 -0.3080980 2.255272e-10 0 -0.3883420
43 1 Ndufa7 -0.3058711 3.210511e-10 0 -0.3983718
44 1 Tbca -0.3008359 7.277351e-10 0 -0.4041754
45 1 Snrpb -0.3004162 7.631375e-10 0 -0.3556668
46 1 Rplp2 -0.2994340 8.784554e-10 0 -0.3876488
47 1 Rpl28 -0.2980796 1.052945e-09 0 -0.4146471
48 1 Uqcc2 -0.2963589 1.340886e-09 0 -0.5371598
49 1 Rpl36 -0.2959873 1.397320e-09 0 -0.3646947
50 1 Edf1 -0.2907873 3.178356e-09 0 -0.3900142
51 1 Fkbp3 -0.2887652 4.309332e-09 0 -0.3556366
52 1 Rps24 -0.2855195 6.948539e-09 0 -0.4770224
53 1 Gpx4 -0.2835266 9.334702e-09 0 -0.3245309
54 1 Bex3 -0.2811619 1.303730e-08 0 -0.3180195
55 1 Rps16 -0.2797315 1.599893e-08 0 -0.4247866
56 1 Tomm7 -0.2794463 1.619178e-08 0 -0.4093449
57 1 Hspe1 -0.2791884 1.656933e-08 0 -0.3462706
58 1 Chchd1 -0.2776055 2.048508e-08 0 -0.4354694
59 1 Rpl17 -0.2772519 2.129819e-08 0 -0.5191041
60 1 Atp5k -0.2762977 2.391943e-08 0 -0.4740455
61 1 Svbp -0.2760335 2.454234e-08 0 -0.3014819
62 1 Atp5c1 -0.2745657 3.024473e-08 0 -0.2363772
63 1 Eif3k -0.2733174 3.508935e-08 0 -0.3840566
64 1 Sumo1 -0.2733073 3.508935e-08 0 -0.2914956
65 1 Timm13 -0.2727718 3.702865e-08 0 -0.3686286
66 1 Mrpl30 -0.2720558 4.017398e-08 0 -0.4749261
67 1 Sem1 -0.2709400 4.629720e-08 0 -0.3741535
68 1 Usmg5 -0.2698157 5.342106e-08 0 -0.3823320
69 1 Rpl22 -0.2684437 6.472822e-08 0 -0.3428325
70 1 Snrpg -0.2676395 7.204825e-08 0 -0.3005801
71 1 Snrpf -0.2669220 7.916026e-08 0 -0.3441404
72 1 Txn1 -0.2665875 8.218961e-08 0 -0.3887734
73 1 Rps3a1 -0.2649592 1.008742e-07 0 -0.4636491
74 1 Nol7 -0.2647717 1.025205e-07 0 -0.4529087
75 1 Myl12b -0.2633126 1.217868e-07 0 -0.3769849
76 1 Rpl7a -0.2628953 1.276785e-07 0 -0.3803800
77 1 Cirbp -0.2626861 1.302382e-07 0 -0.2427524
78 1 Ndufv3 -0.2624217 1.339336e-07 0 -0.3777157
79 1 Rps27l -0.2612837 1.563403e-07 0 -0.5679664
80 1 Rpl37a -0.2606170 1.704016e-07 0 -0.5219644
81 1 Cycs -0.2595830 1.938262e-07 0 -0.3851088
82 1 Rpl36a -0.2587267 2.134566e-07 0 -0.2850982
83 1 Anapc13 -0.2587054 2.134566e-07 0 -0.4999552
84 1 Smdt1 -0.2574564 2.478866e-07 0 -0.3049345
85 1 Sdhb -0.2573936 2.478866e-07 0 -0.3655544
86 1 Mrpl52 -0.2566519 2.729649e-07 0 -0.3746260
87 1 Ranbp1 -0.2564555 2.745307e-07 0 -0.2617357
88 1 X0610012G03Rik -0.2564191 2.745307e-07 0 -0.4450968
89 1 Csnk2b -0.2562342 2.750654e-07 0 -0.3913248
90 1 Rps17 -0.2562178 2.750654e-07 0 -0.4469891
91 1 Chchd2 -0.2560472 2.793599e-07 0 -0.4363077
92 1 Rpl21 -0.2552685 3.066352e-07 0 -0.3799537
93 1 Hmgb1 -0.2548369 3.231737e-07 0 -0.3340397
94 1 Mrpl28 -0.2536164 3.806468e-07 0 -0.4316112
95 1 Rtraf -0.2534402 3.869427e-07 0 -0.2697156
96 1 Cops9 -0.2500670 5.951063e-07 0 -0.3814245
97 1 Atox1 -0.2499292 5.970482e-07 0 -0.4098502
98 1 Rplp1 -0.2493355 6.431863e-07 0 -0.4307723
99 1 Hnrnpc -0.2478595 7.764310e-07 0 -0.2664530
100 1 Mrps17 -0.2474809 8.116952e-07 0 -0.4752512
101 1 Vapa -0.2468766 8.721894e-07 0 -0.2749610
102 1 Hmgn1 -0.2467652 8.754427e-07 0 -0.2649146
103 1 Rps23 -0.2450458 1.067455e-06 0 -0.4578971
104 1 Atp5h -0.2448166 1.093425e-06 0 -0.3256882
105 1 Tmem256 -0.2442493 1.164429e-06 0 -0.3865038
106 1 Dctpp1 -0.2439550 1.203392e-06 0 -0.2977997
107 1 Hnrnpab -0.2435611 1.243292e-06 0 -0.2954051
108 1 Pcbp2 -0.2424633 1.432268e-06 0 -0.3170388
109 1 Tceal9 -0.2415600 1.595730e-06 0 -0.2648281
110 1 Lamtor5 -0.2396741 2.026750e-06 0 -0.4350606
111 1 Ndufb10 -0.2369256 2.845753e-06 0 -0.2863959
112 1 Cox7c -0.2369182 2.845753e-06 0 -0.2824851
113 1 Oaz1 -0.2366414 2.932600e-06 0 -0.2739040
114 1 Scand1 -0.2362110 3.045776e-06 0 -0.4189525
115 1 Polr2j -0.2362091 3.045776e-06 0 -0.2842206
116 1 Rpl10 -0.2359108 3.147805e-06 0 -0.4748902
117 1 Pfdn4 -0.2355480 3.280891e-06 0 -0.4199890
118 1 Rps19 -0.2350084 3.456874e-06 0 -0.5025216
119 1 Rpl10a -0.2349587 3.458358e-06 0 -0.3144984
120 1 Nme1 -0.2348907 3.468223e-06 0 -0.2836137
121 1 Arpc3 -0.2343649 3.670787e-06 0 -0.3467814
122 1 Ran -0.2336881 3.939102e-06 0 -0.2541407
123 1 Rnf7 -0.2330448 4.257928e-06 0 -0.3808571
124 1 Bex2 -0.2329246 4.299934e-06 0 -0.2931452
125 1 Snrpd3 -0.2324171 4.517130e-06 0 -0.4085823
126 1 Gm10260 -0.2324063 4.517130e-06 0 -0.3556503
127 1 Cox7b -0.2323683 4.517130e-06 0 -0.2699185
128 1 H2afz -0.2321814 4.601751e-06 0 -0.3482270
129 1 Ddah2 -0.2317266 4.853274e-06 0 -0.3249683
130 1 Tbcb -0.2312374 5.112467e-06 0 -0.2296635
131 1 Atp5j2 -0.2304235 5.636766e-06 0 -0.2909852
132 1 Cox6b1 -0.2303935 5.636766e-06 0 -0.2710346
133 1 Atp5j -0.2299245 5.889998e-06 0 -0.2785515
134 1 Uqcrfs1 -0.2295070 6.115004e-06 0 -0.2729393
135 1 Txnl4a -0.2284923 6.924840e-06 0 -0.4264706
136 1 Mrps24 -0.2284003 6.969881e-06 0 -0.4010231
137 1 X1110004F10Rik -0.2278742 7.413813e-06 0 -0.2576501
138 1 Mif -0.2278143 7.431771e-06 0 -0.3175502
139 1 Mrpl18 -0.2263196 8.711184e-06 0 -0.3538738
140 1 Crip2 -0.2262740 8.717744e-06 0 -0.2328728
141 1 Hsbp1 -0.2253209 9.566588e-06 0 -0.2581882
142 1 Rpl19 -0.2253162 9.566588e-06 0 -0.3885120
143 1 Rps11 -0.2251889 9.657436e-06 0 -0.3842770
144 1 Rpl23a -0.2250230 9.813642e-06 0 -0.4333352
145 1 Ubl5 -0.2248595 9.969336e-06 0 -0.3088737
146 1 Ndufab1 -0.2238181 1.114580e-05 0 -0.3859670
147 1 Atp5g1 -0.2231727 1.188843e-05 0 -0.2660431
148 1 Rps6 -0.2231526 1.188843e-05 0 -0.3939822
149 1 Eif3h -0.2230063 1.205170e-05 0 -0.2308491
150 1 Pdcd5 -0.2227795 1.232027e-05 0 -0.3465369
151 1 Zfp706 -0.2225782 1.248254e-05 0 -0.2112568
152 1 Abracl -0.2213980 1.419549e-05 0 -0.2750669
153 1 Pfdn6 -0.2209395 1.476171e-05 0 -0.4071708
154 1 Prdx5 -0.2209157 1.476171e-05 0 -0.2559431
155 1 Calm3 -0.2207705 1.494358e-05 0 -0.2573251
156 1 Rex1bd -0.2205505 1.528890e-05 0 -0.4203590
157 1 Esd -0.2203731 1.556032e-05 0 -0.2975594
158 1 Psma2 -0.2203299 1.557673e-05 0 -0.2819089
159 1 Dynll1 -0.2199227 1.610340e-05 0 -0.3676117
160 1 Rpl15 -0.2194056 1.680821e-05 0 -0.2895195
161 1 Glrx3 -0.2183435 1.868363e-05 0 -0.1083442
162 1 Selenow -0.2181378 1.885712e-05 0 -0.3930863
163 1 Gpx1 -0.2178310 1.949947e-05 0 -0.5381608
164 1 Ndufa2 -0.2176474 1.980926e-05 0 -0.3264260
165 1 Sec61b -0.2175938 1.983788e-05 0 -0.3811968
166 1 Mrpl58 -0.2174523 1.995077e-05 0 -0.4914635
167 1 Psma7 -0.2172906 2.020019e-05 0 -0.2739562
168 1 Bcas2 -0.2172874 2.020019e-05 0 -0.3158613
169 1 Srp14 -0.2170688 2.066579e-05 0 -0.2990073
170 1 Nop10 -0.2166143 2.148915e-05 0 -0.3118031
171 1 Rpl27a -0.2166118 2.148915e-05 0 -0.2738241
172 1 Eif2s2 -0.2163760 2.189740e-05 0 -0.2296548
173 1 Trappc2l -0.2156588 2.366951e-05 0 -0.3406024
174 1 H3f3a -0.2155267 2.374037e-05 0 -0.3079225
175 1 Gtf2h5 -0.2153756 2.409031e-05 0 -0.3434282
176 1 Sub1 -0.2151238 2.465546e-05 0 -0.2508421
177 1 Naca -0.2145087 2.636167e-05 0 -0.3565910
178 1 Rpl7 -0.2135409 2.888891e-05 0 -0.3706477
179 1 Ppdpf -0.2133283 2.942934e-05 0 -0.3391216
180 1 Rpl24 -0.2132538 2.959067e-05 0 -0.4690503
181 1 Gm10076 -0.2127651 3.115539e-05 0 -0.4772046
182 1 Ndufb2 -0.2126279 3.145520e-05 0 -0.3525210
183 1 Cox7a2 -0.2122745 3.258735e-05 0 -0.2379424
184 1 Rpl18 -0.2119888 3.360081e-05 0 -0.2748972
185 1 Rpl5 -0.2112880 3.615233e-05 0 -0.2924973
186 1 Jund -0.2110193 3.712070e-05 0 -0.2279356
187 1 Ndufc1 -0.2110091 3.712070e-05 0 -0.3252872
188 1 Ndufb4 -0.2104183 3.954536e-05 0 -0.3979775
189 1 Rps27a -0.2103446 3.976090e-05 0 -0.4295827
190 1 Slirp -0.2102817 3.992712e-05 0 -0.4121032
191 1 Fau -0.2100702 4.080285e-05 0 -0.4027868
192 1 Ndufb8 -0.2095109 4.343912e-05 0 -0.2659853
193 1 Txndc17 -0.2090668 4.521167e-05 0 -0.3694520
194 1 Rpl32 -0.2083948 4.832366e-05 0 -0.5548520
195 1 Ap2s1 -0.2082741 4.880111e-05 0 -0.2605882
196 1 Gabarap -0.2080173 4.988644e-05 0 -0.2959616
197 1 Smarcb1 -0.2080058 4.988644e-05 0 -0.2851375
198 1 H2afj -0.2078339 5.073976e-05 0 -0.3315896
199 1 Cacybp -0.2065095 5.741582e-05 0 -0.2614856
200 1 Grm8 -0.2057302 6.118469e-05 0 -0.4215947
201 1 Spock1 0.3251712 1.987472e-11 0 0.4817711
202 1 Itfg1 0.2992721 8.834105e-10 0 0.3776583
203 1 Serinc1 0.2965515 1.325342e-09 0 0.3825097
204 1 Mdga2 0.2874687 5.199010e-09 0 0.4623846
205 1 Ctsz 0.2824571 1.084179e-08 0 0.3565810
206 1 Ryr3 0.2794415 1.619178e-08 0 0.4376830
207 1 Ntrk3 0.2778532 2.002950e-08 0 0.3451647
208 1 Mef2c 0.2768192 2.241673e-08 0 0.3636640
209 1 Atp6ap2 0.2740521 3.223350e-08 0 0.3668009
210 1 Sec11a 0.2731492 3.545140e-08 0 0.3837498
211 1 Kat6b 0.2721583 4.007938e-08 0 0.4746228
212 1 Atp6ap1 0.2712290 4.490246e-08 0 0.4142084
213 1 Ctnnd2 0.2699332 5.314820e-08 0 0.3439896
214 1 E2f7 0.2657007 9.256857e-08 0 0.8375014
215 1 Sez6 0.2651659 9.898526e-08 0 0.3790612
216 1 Tspan6 0.2641584 1.109053e-07 0 0.3765847
217 1 App 0.2634301 1.217868e-07 0 0.3262137
218 1 Mmp16 0.2632929 1.217868e-07 0 0.4886848
219 1 Pcdh7 0.2605192 1.710786e-07 0 0.5049982
220 1 Tspan3 0.2587958 2.134566e-07 0 0.2605555
221 1 Aplp1 0.2586314 2.136606e-07 0 0.3496143
222 1 Tmem131l 0.2581351 2.272127e-07 0 0.3784208
223 1 Tspan14 0.2564934 2.745307e-07 0 0.3872160
224 1 Igfbp2 0.2563489 2.748074e-07 0 0.3220609
225 1 Arpp21 0.2559159 2.821614e-07 0 0.4396613
226 1 Cadm1 0.2524424 4.414279e-07 0 0.4311111
227 1 Slc1a3 0.2518736 4.739210e-07 0 0.5677610
228 1 Qsox1 0.2518176 4.739210e-07 0 0.9440026
229 1 Srgap1 0.2516320 4.824444e-07 0 0.3802237
230 1 Dclk2 0.2499866 5.970152e-07 0 0.4091429
231 1 Nin 0.2489162 6.763137e-07 0 0.3054527
232 1 Txndc12 0.2468470 8.721894e-07 0 0.4258825
233 1 Ssbp2 0.2459584 9.673892e-07 0 0.3774376
234 1 Hspa5 0.2459273 9.673892e-07 0 0.3800562
235 1 St7 0.2456147 1.002214e-06 0 0.4031442
236 1 Rpn2 0.2451179 1.064678e-06 0 0.3923588
237 1 Tusc3 0.2444387 1.142901e-06 0 0.3801631
238 1 Tanc2 0.2438393 1.213928e-06 0 0.3503723
239 1 Cntn1 0.2437268 1.224079e-06 0 0.4232511
240 1 Kirrel3 0.2422930 1.455623e-06 0 0.4714545
241 1 Stmn4 0.2398730 1.986851e-06 0 0.3311401
242 1 Nfasc 0.2394718 2.068456e-06 0 0.4271409
243 1 Copa 0.2370049 2.845753e-06 0 0.3776922
244 1 Tmem59 0.2363463 3.029398e-06 0 0.2633921
245 1 Psap 0.2354093 3.320500e-06 0 0.3226806
246 1 Slc8a1 0.2351693 3.405560e-06 0 0.2340766
247 1 Nrg3 0.2345848 3.588172e-06 0 0.3859916
248 1 Cdh2 0.2342571 3.700757e-06 0 0.3735728
249 1 Nptn 0.2336952 3.939102e-06 0 0.3492779
250 1 Scg5 0.2327820 4.355076e-06 0 0.3128342
251 1 Sgip1 0.2314536 4.999485e-06 0 0.3421051
252 1 Arl6ip1 0.2302790 5.689163e-06 0 0.3017192
253 1 Aig1 0.2299854 5.875742e-06 0 0.2858523
254 1 Dnajc1 0.2298029 5.950542e-06 0 0.3192334
255 1 Eya3 0.2295743 6.094840e-06 0 0.4881567
256 1 Scn2a 0.2275217 7.673573e-06 0 0.3877597
257 1 Neto2 0.2272724 7.854626e-06 0 0.3386953
258 1 Ccnl2 0.2272571 7.854626e-06 0 0.2805397
259 1 Snd1 0.2266029 8.489998e-06 0 0.4687846
260 1 Itch 0.2264309 8.632912e-06 0 0.4055109
261 1 Smg5 0.2258127 9.194418e-06 0 0.4186320
262 1 Dhcr24 0.2257498 9.221748e-06 0 0.5983321
263 1 Atp2b1 0.2256716 9.267149e-06 0 0.3856881
264 1 Ctsb 0.2253026 9.566588e-06 0 0.3407802
265 1 Nav3 0.2247291 1.008567e-05 0 0.2492735
266 1 Fam214a 0.2245914 1.021286e-05 0 0.5798609
267 1 Hs2st1 0.2245436 1.022577e-05 0 0.4343860
268 1 Acvr1 0.2237108 1.124361e-05 0 0.4732941
269 1 Gm43507 0.2233813 1.166148e-05 0 0.6365634
270 1 Tmtc1 0.2227560 1.232027e-05 0 0.5203901
271 1 Slc39a10 0.2227061 1.234105e-05 0 0.4692922
272 1 Chga 0.2220755 1.322746e-05 0 0.4003207
273 1 Nell2 0.2219452 1.338310e-05 0 0.3165228
274 1 Tox 0.2217236 1.369482e-05 0 0.2845122
275 1 Tmem185b 0.2212082 1.446869e-05 0 0.6700758
276 1 Arnt 0.2211667 1.447939e-05 0 0.5088107
277 1 Ttc17 0.2209047 1.476171e-05 0 0.4843724
278 1 Anks1b 0.2202085 1.574453e-05 0 0.2459429
279 1 Tmbim6 0.2201693 1.575400e-05 0 0.2638407
280 1 Slc38a10 0.2199521 1.610340e-05 0 0.3700007
281 1 Olfm2 0.2198541 1.617231e-05 0 0.3518482
282 1 Kcnq5 0.2195847 1.664727e-05 0 0.4272948
283 1 Kcnk10 0.2194963 1.675960e-05 0 0.3138762
284 1 P3h4 0.2194473 1.679117e-05 0 0.8099715
285 1 Tmem35a 0.2192435 1.707587e-05 0 0.4109415
286 1 Boc 0.2191374 1.722917e-05 0 0.6010687
287 1 Akt3 0.2187568 1.797847e-05 0 0.2628117
288 1 Por 0.2186967 1.800140e-05 0 0.4889486
289 1 Carmil1 0.2186805 1.800140e-05 0 0.2887406
290 1 Mtdh 0.2182782 1.875823e-05 0 0.2807799
291 1 Slc6a15 0.2181696 1.885712e-05 0 0.4716892
292 1 Leprot 0.2181468 1.885712e-05 0 0.2951880
293 1 Slc20a1 0.2176376 1.980926e-05 0 0.4314969
294 1 Klf12 0.2175271 1.992265e-05 0 0.4983598
295 1 H2.D1 0.2174530 1.995077e-05 0 0.3639213
296 1 Saraf 0.2170315 2.068118e-05 0 0.3081942
297 1 Tmem184c 0.2168042 2.118017e-05 0 0.3225185
298 1 Fgf14 0.2165924 2.148915e-05 0 0.2876250
299 1 Tmem108 0.2165529 2.151223e-05 0 0.3562990
300 1 Lrp11 0.2160417 2.271805e-05 0 0.3773354
301 1 Ldb2 0.2156172 2.366951e-05 0 0.2939618
302 1 Syt1 0.2155833 2.366951e-05 0 0.3450811
303 1 Cacna1c 0.2155815 2.366951e-05 0 0.3207911
304 1 Csmd2 0.2151751 2.459131e-05 0 0.3452957
305 1 Grik2 0.2145339 2.636167e-05 0 0.4514875
306 1 Rcn2 0.2144294 2.652000e-05 0 0.2854721
307 1 Grin2b 0.2143889 2.655527e-05 0 0.3129156
308 1 Os9 0.2141573 2.720820e-05 0 0.3525981
309 1 Fnbp1l 0.2141115 2.726253e-05 0 0.2614826
310 1 Elovl5 0.2136834 2.859818e-05 0 0.5763508
311 1 Rnf145 0.2135605 2.888891e-05 0 0.3942400
312 1 Tnrc6c 0.2134860 2.897903e-05 0 0.2655012
313 1 Ift172 0.2131423 2.988534e-05 0 0.7273950
314 1 Setbp1 0.2126505 3.145520e-05 0 0.2808616
315 1 Lrpap1 0.2123968 3.222429e-05 0 0.2556996
316 1 Cdkl5 0.2119231 3.375163e-05 0 0.3911032
317 1 Tmem63b 0.2116532 3.473486e-05 0 0.3875314
318 1 Clstn2 0.2109563 3.723062e-05 0 0.3872830
319 1 Calr 0.2092966 4.440350e-05 0 0.2802238
320 1 Cdc14b 0.2092583 4.446097e-05 0 0.7198813
321 1 Dock3 0.2090612 4.521167e-05 0 0.3741515
322 1 Ddx50 0.2090289 4.523908e-05 0 0.2860189
323 1 Ormdl3 0.2087933 4.635939e-05 0 0.3832619
324 1 Foxp2 0.2083850 4.832366e-05 0 0.5684095
325 1 Ntrk2 0.2080868 4.972509e-05 0 0.5329103
326 1 Magi1 0.2076794 5.148581e-05 0 0.4553671
327 1 Rgma 0.2076559 5.148581e-05 0 0.5780725
328 1 Ergic2 0.2075656 5.187083e-05 0 0.2655840
329 1 Zfp846 0.2071862 5.404855e-05 0 0.2995412
330 1 Sybu 0.2070890 5.449645e-05 0 0.3264942
331 1 Dync1i1 0.2069879 5.481618e-05 0 0.3032658
332 1 Camkv 0.2069864 5.481618e-05 0 0.4211762
333 1 Llgl1 0.2068048 5.581613e-05 0 0.4266499
334 1 Alg6 0.2066856 5.642350e-05 0 0.9009502
335 1 Lnpk 0.2063438 5.814647e-05 0 0.3247704
336 1 Gm20517 0.2063231 5.814647e-05 0 1.1410193
337 1 Spon1 0.2063231 5.814647e-05 0 1.0616953
338 1 Trpm3 0.2061229 5.929493e-05 0 0.6898117
339 1 Pgrmc1 0.2061031 5.929493e-05 0 0.3026805
340 1 Ctsl 0.2060444 5.952276e-05 0 0.2874709
341 1 B3galt1 0.2059271 6.015918e-05 0 0.3441872
342 1 B3galt2 0.2057494 6.118469e-05 0 0.3838402
343 1 Ldlrad4 0.2054385 6.309715e-05 0 0.3296407
344 1 Cpe 0.2052019 6.465516e-05 0 0.3516827
345 1 Emc3 0.2049225 6.619369e-05 0 0.3590846
346 1 Ttc19 0.2048293 6.671582e-05 0 0.4082099
347 1 Adamts18 0.2044224 6.971209e-05 0 0.3869474
348 1 Scube1 0.2040749 7.193151e-05 0 0.4709928
349 1 Fry 0.2033546 7.767694e-05 0 0.2718307
350 1 Csmd3 0.2030060 8.037958e-05 0 0.5650582
351 1 Cd200 0.2028440 8.133106e-05 0 0.2797321
352 1 Flrt2 0.2028171 8.133106e-05 0 0.4293102
353 1 Atraid 0.2028083 8.133106e-05 0 0.3129678
354 1 Alkbh1 0.2026368 8.267641e-05 0 0.4014083
355 1 Gm26835 0.2023977 8.449163e-05 0 0.4222330
356 1 Phactr1 0.2021293 8.687322e-05 0 0.2632504
357 1 Foxp1 0.2015481 9.229412e-05 0 0.2580225
358 1 Cacna1e 0.2014218 9.336938e-05 0 0.3844196
359 1 Ssr2 0.2012809 9.461454e-05 0 0.2615975
360 1 Dopey1 0.2009499 9.769588e-05 0 0.3199163
361 1 Hivep2 0.2003740 1.034248e-04 0 0.3244790
362 1 Gdpd1 0.1999223 1.085345e-04 0 0.2925950
363 1 Tmem132a 0.1998304 1.093707e-04 0 0.2428495
364 1 Ssh2 0.1996881 1.108396e-04 0 0.3329310
365 1 Cxadr 0.1995267 1.124015e-04 0 0.3356759
366 1 Zdhhc20 0.1994962 1.124015e-04 0 0.3232686
367 1 Cspg5 0.1994202 1.128686e-04 0 0.5253050
368 1 Ascc3 0.1988958 1.180109e-04 0 0.3602826
369 1 Myo9a 0.1987511 1.196295e-04 0 0.3474970
370 1 Nedd4l 0.1981704 1.269985e-04 0 0.2870636
371 1 Scaf8 0.1978388 1.307762e-04 0 0.3909157
372 1 Rbl2 0.1974549 1.356099e-04 0 0.7665457
373 1 Nemp1 0.1974446 1.356099e-04 0 0.5981904
374 1 B3galnt1 0.1973052 1.373818e-04 0 0.4204007
375 1 Slitrk5 0.1971875 1.388396e-04 0 0.4541803
376 1 Fat3 0.1970097 1.409003e-04 0 0.2584599
377 1 Pdia6 0.1960866 1.555464e-04 0 0.2786742
378 1 Rnf215 0.1960722 1.555464e-04 0 0.4738305
379 1 Serpini1 0.1960223 1.556320e-04 0 0.3356833
380 1 Plppr1 0.1957434 1.597088e-04 0 0.2795475
381 1 Sbf2 0.1955265 1.623747e-04 0 0.3006908
382 1 Rnf112 0.1954556 1.632493e-04 0 0.8890006
383 1 Trio 0.1952968 1.653238e-04 0 0.2908840
384 1 Slc38a9 0.1947229 1.752457e-04 0 0.3353488
385 1 Meg3 0.1946101 1.770021e-04 0 0.3784197
386 1 Adcy3 0.1943568 1.811160e-04 0 0.5909601
387 1 Epha7 0.1943252 1.813108e-04 0 0.4107213
388 1 St7l 0.1940574 1.849371e-04 0 0.3886257
389 1 Arxes1 0.1939779 1.860660e-04 0 0.4383596
390 1 Lrrtm3 0.1939585 1.860660e-04 0 0.5679511
391 1 R3hdm4 0.1936969 1.905676e-04 0 0.2734504
392 1 Tia1 0.1936105 1.919255e-04 0 0.2339791
393 1 Dst 0.1934045 1.958332e-04 0 0.2589698
394 1 Mycbp2 0.1933357 1.968488e-04 0 0.2335223
395 1 Mgat2 0.1927568 2.086952e-04 0 0.2780917
396 1 Gpc6 0.1926176 2.112865e-04 0 0.5501739
397 1 Trpv2 0.1925152 2.127680e-04 0 1.1914960
398 1 Lamp1 0.1923454 2.157697e-04 0 0.2363786
399 1 Ktn1 0.1923440 2.157697e-04 0 0.3159114
400 1 Tmem9b 0.1918165 2.269125e-04 0 0.3040203
401 2 Spock1 -0.3251727 1.986918e-11 0 -0.4817711
402 2 Itfg1 -0.2992747 8.830343e-10 0 -0.3776583
403 2 Serinc1 -0.2965425 1.327300e-09 0 -0.3825097
404 2 Mdga2 -0.2874719 5.196375e-09 0 -0.4623846
405 2 Ctsz -0.2824553 1.084481e-08 0 -0.3565810
406 2 Ryr3 -0.2794362 1.620516e-08 0 -0.4376830
407 2 Ntrk3 -0.2778571 2.001761e-08 0 -0.3451647
408 2 Mef2c -0.2768284 2.238544e-08 0 -0.3636640
409 2 Atp6ap2 -0.2740471 3.225774e-08 0 -0.3668009
410 2 Sec11a -0.2731475 3.546047e-08 0 -0.3837498
411 2 Kat6b -0.2721645 4.004189e-08 0 -0.4746228
412 2 Atp6ap1 -0.2712336 4.487202e-08 0 -0.4142084
413 2 Ctnnd2 -0.2699454 5.305199e-08 0 -0.3439896
414 2 E2f7 -0.2656917 9.269129e-08 0 -0.8375014
415 2 Sez6 -0.2651659 9.898528e-08 0 -0.3790612
416 2 Tspan6 -0.2641542 1.109735e-07 0 -0.3765847
417 2 App -0.2634345 1.218616e-07 0 -0.3262137
418 2 Mmp16 -0.2632887 1.218616e-07 0 -0.4886848
419 2 Pcdh7 -0.2605182 1.711040e-07 0 -0.5049982
420 2 Tspan3 -0.2587857 2.135807e-07 0 -0.2605555
421 2 Aplp1 -0.2586243 2.138782e-07 0 -0.3496143
422 2 Tmem131l -0.2581374 2.271400e-07 0 -0.3784208
423 2 Tspan14 -0.2564871 2.746660e-07 0 -0.3872160
424 2 Igfbp2 -0.2563473 2.748693e-07 0 -0.3220609
425 2 Arpp21 -0.2559070 2.825174e-07 0 -0.4396613
426 2 Cadm1 -0.2524469 4.411479e-07 0 -0.4311111
427 2 Slc1a3 -0.2518730 4.741182e-07 0 -0.5677610
428 2 Qsox1 -0.2517963 4.753354e-07 0 -0.9440026
429 2 Srgap1 -0.2516370 4.821080e-07 0 -0.3802237
430 2 Dclk2 -0.2499856 5.967449e-07 0 -0.4091429
431 2 Nin -0.2489245 6.755454e-07 0 -0.3054527
432 2 Txndc12 -0.2468445 8.724833e-07 0 -0.4258825
433 2 Ssbp2 -0.2459592 9.670182e-07 0 -0.3774376
434 2 Hspa5 -0.2459301 9.670182e-07 0 -0.3800562
435 2 St7 -0.2456164 1.001978e-06 0 -0.4031442
436 2 Rpn2 -0.2451161 1.064941e-06 0 -0.3923588
437 2 Tusc3 -0.2444311 1.144088e-06 0 -0.3801631
438 2 Tanc2 -0.2438380 1.214142e-06 0 -0.3503723
439 2 Cntn1 -0.2437246 1.224446e-06 0 -0.4232511
440 2 Kirrel3 -0.2422936 1.455520e-06 0 -0.4714545
441 2 Stmn4 -0.2398701 1.987621e-06 0 -0.3311401
442 2 Nfasc -0.2394724 2.068306e-06 0 -0.4271409
443 2 Copa -0.2370107 2.844142e-06 0 -0.3776922
444 2 Tmem59 -0.2363461 3.029473e-06 0 -0.2633921
445 2 Psap -0.2354175 3.316905e-06 0 -0.3226806
446 2 Slc8a1 -0.2351684 3.405950e-06 0 -0.2340766
447 2 Nrg3 -0.2345814 3.589783e-06 0 -0.3859916
448 2 Cdh2 -0.2342556 3.701484e-06 0 -0.3735728
449 2 Nptn -0.2336996 3.937207e-06 0 -0.3492779
450 2 Scg5 -0.2327845 4.353659e-06 0 -0.3128342
451 2 Sgip1 -0.2314531 4.999791e-06 0 -0.3421051
452 2 Arl6ip1 -0.2302800 5.688491e-06 0 -0.3017192
453 2 Aig1 -0.2299782 5.881194e-06 0 -0.2858523
454 2 Dnajc1 -0.2298092 5.945769e-06 0 -0.3192334
455 2 Eya3 -0.2295670 6.100529e-06 0 -0.4881567
456 2 Scn2a -0.2275122 7.682828e-06 0 -0.3877597
457 2 Neto2 -0.2272673 7.854185e-06 0 -0.3386953
458 2 Ccnl2 -0.2272576 7.854185e-06 0 -0.2805397
459 2 Snd1 -0.2266094 8.483010e-06 0 -0.4687846
460 2 Itch -0.2264373 8.625908e-06 0 -0.4055109
461 2 Smg5 -0.2258205 9.185318e-06 0 -0.4186320
462 2 Dhcr24 -0.2257463 9.225802e-06 0 -0.5983321
463 2 Atp2b1 -0.2256641 9.275968e-06 0 -0.3856881
464 2 Ctsb -0.2253017 9.567604e-06 0 -0.3407802
465 2 Nav3 -0.2247205 1.009659e-05 0 -0.2492735
466 2 Fam214a -0.2245869 1.021576e-05 0 -0.5798609
467 2 Hs2st1 -0.2245514 1.021576e-05 0 -0.4343860
468 2 Acvr1 -0.2237028 1.125479e-05 0 -0.4732941
469 2 Gm43507 -0.2233956 1.164069e-05 0 -0.6365634
470 2 Tmtc1 -0.2227576 1.231783e-05 0 -0.5203901
471 2 Slc39a10 -0.2227101 1.233483e-05 0 -0.4692922
472 2 Chga -0.2220672 1.324119e-05 0 -0.4003207
473 2 Nell2 -0.2219414 1.338939e-05 0 -0.3165228
474 2 Tox -0.2217279 1.368759e-05 0 -0.2845122
475 2 Tmem185b -0.2212111 1.446357e-05 0 -0.6700758
476 2 Arnt -0.2211700 1.447350e-05 0 -0.5088107
477 2 Ttc17 -0.2209115 1.475035e-05 0 -0.4843724
478 2 Anks1b -0.2201991 1.575077e-05 0 -0.2459429
479 2 Tmbim6 -0.2201709 1.575077e-05 0 -0.2638407
480 2 Slc38a10 -0.2199636 1.609008e-05 0 -0.3700007
481 2 Olfm2 -0.2198471 1.618613e-05 0 -0.3518482
482 2 Kcnq5 -0.2195901 1.663637e-05 0 -0.4272948
483 2 Kcnk10 -0.2195041 1.674338e-05 0 -0.3138762
484 2 P3h4 -0.2194235 1.681993e-05 0 -0.8099715
485 2 Tmem35a -0.2192482 1.706599e-05 0 -0.4109415
486 2 Boc -0.2191264 1.725252e-05 0 -0.6010687
487 2 Akt3 -0.2187650 1.796032e-05 0 -0.2628117
488 2 Por -0.2187058 1.800550e-05 0 -0.4889486
489 2 Carmil1 -0.2186786 1.800550e-05 0 -0.2887406
490 2 Mtdh -0.2182809 1.875207e-05 0 -0.2807799
491 2 Slc6a15 -0.2181638 1.884053e-05 0 -0.4716892
492 2 Leprot -0.2181450 1.884053e-05 0 -0.2951880
493 2 Slc20a1 -0.2176394 1.980493e-05 0 -0.4314969
494 2 Klf12 -0.2175232 1.993214e-05 0 -0.4983598
495 2 H2.D1 -0.2174584 1.994929e-05 0 -0.3639213
496 2 Saraf -0.2170244 2.069912e-05 0 -0.3081942
497 2 Tmem184c -0.2167978 2.119660e-05 0 -0.3225185
498 2 Fgf14 -0.2165954 2.148125e-05 0 -0.2876250
499 2 Tmem108 -0.2165627 2.148689e-05 0 -0.3562990
500 2 Lrp11 -0.2160405 2.272142e-05 0 -0.3773354
501 2 Ldb2 -0.2156147 2.367654e-05 0 -0.2939618
502 2 Cacna1c -0.2155847 2.367654e-05 0 -0.3207911
503 2 Syt1 -0.2155790 2.367654e-05 0 -0.3450811
504 2 Csmd2 -0.2151655 2.462000e-05 0 -0.3452957
505 2 Grik2 -0.2145322 2.631314e-05 0 -0.4514875
506 2 Rcn2 -0.2144319 2.651186e-05 0 -0.2854721
507 2 Grin2b -0.2143914 2.654737e-05 0 -0.3129156
508 2 Os9 -0.2141584 2.720479e-05 0 -0.3525981
509 2 Fnbp1l -0.2141045 2.728537e-05 0 -0.2614826
510 2 Elovl5 -0.2136772 2.861939e-05 0 -0.5763508
511 2 Rnf145 -0.2135561 2.893633e-05 0 -0.3942400
512 2 Tnrc6c -0.2134906 2.896283e-05 0 -0.2655012
513 2 Ift172 -0.2131292 2.993213e-05 0 -0.7273950
514 2 Setbp1 -0.2126523 3.147019e-05 0 -0.2808616
515 2 Lrpap1 -0.2123979 3.222011e-05 0 -0.2556996
516 2 Cdkl5 -0.2119296 3.372541e-05 0 -0.3911032
517 2 Tmem63b -0.2116461 3.476450e-05 0 -0.3875314
518 2 Clstn2 -0.2109588 3.721956e-05 0 -0.3872830
519 2 Calr -0.2093031 4.436976e-05 0 -0.2802238
520 2 Cdc14b -0.2092744 4.437711e-05 0 -0.7198813
521 2 Dock3 -0.2090558 4.523928e-05 0 -0.3741515
522 2 Ddx50 -0.2090289 4.523928e-05 0 -0.2860189
523 2 Ormdl3 -0.2087976 4.633580e-05 0 -0.3832619
524 2 Foxp2 -0.2083742 4.838465e-05 0 -0.5684095
525 2 Ntrk2 -0.2080832 4.974629e-05 0 -0.5329103
526 2 Magi1 -0.2076817 5.144462e-05 0 -0.4553671
527 2 Rgma -0.2076627 5.144462e-05 0 -0.5780725
528 2 Ergic2 -0.2075678 5.185736e-05 0 -0.2655840
529 2 Zfp846 -0.2071885 5.403425e-05 0 -0.2995412
530 2 Sybu -0.2070879 5.450360e-05 0 -0.3264942
531 2 Dync1i1 -0.2069837 5.486586e-05 0 -0.3032658
532 2 Camkv -0.2069786 5.486586e-05 0 -0.4211762
533 2 Llgl1 -0.2068022 5.583319e-05 0 -0.4266499
534 2 Alg6 -0.2066740 5.649948e-05 0 -0.9009502
535 2 Lnpk -0.2063485 5.810123e-05 0 -0.3247704
536 2 Gm20517 -0.2063298 5.810123e-05 0 -1.1410193
537 2 Spon1 -0.2063298 5.810123e-05 0 -1.0616953
538 2 Trpm3 -0.2061208 5.923166e-05 0 -0.6898117
539 2 Pgrmc1 -0.2061123 5.923166e-05 0 -0.3026805
540 2 Ctsl -0.2060428 5.953423e-05 0 -0.2874709
541 2 B3galt1 -0.2059237 6.018295e-05 0 -0.3441872
542 2 B3galt2 -0.2057491 6.121111e-05 0 -0.3838402
543 2 Ldlrad4 -0.2054362 6.311424e-05 0 -0.3296407
544 2 Cpe -0.2051983 6.468208e-05 0 -0.3516827
545 2 Emc3 -0.2049214 6.620182e-05 0 -0.3590846
546 2 Ttc19 -0.2048220 6.677153e-05 0 -0.4082099
547 2 Adamts18 -0.2044280 6.966750e-05 0 -0.3869474
548 2 Scube1 -0.2040851 7.184739e-05 0 -0.4709928
549 2 Fry -0.2033530 7.769159e-05 0 -0.2718307
550 2 Csmd3 -0.2030058 8.038151e-05 0 -0.5650582
551 2 Cd200 -0.2028380 8.131483e-05 0 -0.2797321
552 2 Flrt2 -0.2028239 8.131483e-05 0 -0.4293102
553 2 Atraid -0.2028083 8.131483e-05 0 -0.3129678
554 2 Alkbh1 -0.2026408 8.263928e-05 0 -0.4014083
555 2 Gm26835 -0.2023891 8.457433e-05 0 -0.4222330
556 2 Phactr1 -0.2021275 8.689090e-05 0 -0.2632504
557 2 Foxp1 -0.2015461 9.231480e-05 0 -0.2580225
558 2 Cacna1e -0.2014118 9.347565e-05 0 -0.3844196
559 2 Ssr2 -0.2012752 9.467585e-05 0 -0.2615975
560 2 Dopey1 -0.2009604 9.757977e-05 0 -0.3199163
561 2 Hivep2 -0.2003663 1.035141e-04 0 -0.3244790
562 2 Gdpd1 -0.1999246 1.085061e-04 0 -0.2925950
563 2 Tmem132a -0.1998393 1.092617e-04 0 -0.2428495
564 2 Ssh2 -0.1996800 1.109416e-04 0 -0.3329310
565 2 Cxadr -0.1995205 1.125124e-04 0 -0.3356759
566 2 Zdhhc20 -0.1994903 1.125124e-04 0 -0.3232686
567 2 Cspg5 -0.1994159 1.127918e-04 0 -0.5253050
568 2 Ascc3 -0.1988892 1.180975e-04 0 -0.3602826
569 2 Myo9a -0.1987439 1.197252e-04 0 -0.3474970
570 2 Nedd4l -0.1981619 1.271194e-04 0 -0.2870636
571 2 Scaf8 -0.1978457 1.306755e-04 0 -0.3909157
572 2 Rbl2 -0.1974622 1.356527e-04 0 -0.7665457
573 2 Nemp1 -0.1974417 1.356527e-04 0 -0.5981904
574 2 B3galnt1 -0.1973076 1.373451e-04 0 -0.4204007
575 2 Slitrk5 -0.1971726 1.390696e-04 0 -0.4541803
576 2 Fat3 -0.1970110 1.408803e-04 0 -0.2584599
577 2 Pdia6 -0.1960923 1.555679e-04 0 -0.2786742
578 2 Rnf215 -0.1960710 1.555679e-04 0 -0.4738305
579 2 Serpini1 -0.1960175 1.557135e-04 0 -0.3356833
580 2 Plppr1 -0.1957489 1.596118e-04 0 -0.2795475
581 2 Sbf2 -0.1955199 1.624925e-04 0 -0.3006908
582 2 Rnf112 -0.1954497 1.633550e-04 0 -0.8890006
583 2 Trio -0.1952979 1.653021e-04 0 -0.2908840
584 2 Slc38a9 -0.1947198 1.753063e-04 0 -0.3353488
585 2 Meg3 -0.1946128 1.769487e-04 0 -0.3784197
586 2 Adcy3 -0.1943549 1.811538e-04 0 -0.5909601
587 2 Epha7 -0.1943130 1.815532e-04 0 -0.4107213
588 2 St7l -0.1940499 1.850877e-04 0 -0.3886257
589 2 Arxes1 -0.1939825 1.859845e-04 0 -0.4383596
590 2 Lrrtm3 -0.1939625 1.859845e-04 0 -0.5679511
591 2 R3hdm4 -0.1936960 1.905873e-04 0 -0.2734504
592 2 Tia1 -0.1936068 1.920028e-04 0 -0.2339791
593 2 Dst -0.1934066 1.957878e-04 0 -0.2589698
594 2 Mycbp2 -0.1933442 1.966651e-04 0 -0.2335223
595 2 Mgat2 -0.1927482 2.088898e-04 0 -0.2780917
596 2 Gpc6 -0.1926238 2.112472e-04 0 -0.5501739
597 2 Trpv2 -0.1925211 2.126335e-04 0 -1.1914960
598 2 Lamp1 -0.1923446 2.157594e-04 0 -0.2363786
599 2 Ktn1 -0.1923444 2.157594e-04 0 -0.3159114
600 2 Tmem9b -0.1918146 2.269600e-04 0 -0.3040203
601 2 Rps12 0.4631549 6.183206e-23 0 0.6825116
602 2 Atp5e 0.4421521 5.489863e-21 0 0.6826112
603 2 Rpl12 0.4249284 2.145813e-19 0 0.5752903
604 2 Gm2000 0.4178124 8.261193e-19 0 0.7062262
605 2 Rpl27 0.4101575 3.538517e-18 0 0.4851285
606 2 Rpl35 0.4095728 3.538517e-18 0 0.6420850
607 2 Rpl38 0.3944075 8.464359e-17 0 0.4901851
608 2 Rpl34 0.3839933 6.784492e-16 0 0.5340951
609 2 Rpl13a 0.3816079 9.934717e-16 0 0.4674161
610 2 Rps27 0.3776182 2.046629e-15 0 0.5241613
611 2 Rps3 0.3675068 1.460826e-14 0 0.5091646
612 2 Rps21 0.3610482 4.853602e-14 0 0.4306092
613 2 Rps13 0.3572064 9.536627e-14 0 0.4967312
614 2 Rps29 0.3548155 1.411443e-13 0 0.4107293
615 2 Uqcrh 0.3468014 6.147145e-13 0 0.4208264
616 2 Rps15a 0.3458384 6.918806e-13 0 0.5734880
617 2 Pfdn5 0.3412500 1.545294e-12 0 0.4357714
618 2 Uqcr10 0.3369872 3.224794e-12 0 0.4964385
619 2 Rps26 0.3311064 8.977031e-12 0 0.5340777
620 2 Rps18 0.3305636 9.411567e-12 0 0.4596902
621 2 Tpt1 0.3299694 9.825250e-12 0 0.4076206
622 2 Pomp 0.3298004 9.825250e-12 0 0.4368943
623 2 Uqcrq 0.3294012 1.010187e-11 0 0.4547596
624 2 Rps10 0.3272417 1.428769e-11 0 0.4795864
625 2 Timm8b 0.3243726 2.203535e-11 0 0.4229584
626 2 Rps25 0.3237953 2.351562e-11 0 0.4375944
627 2 Pfn1 0.3207365 3.896942e-11 0 0.4524917
628 2 Atp6v1g1 0.3200504 4.245618e-11 0 0.3852555
629 2 Snrpd2 0.3191388 4.805527e-11 0 0.4236104
630 2 Hist3h2ba 0.3189649 4.805527e-11 0 0.4143786
631 2 Rpl37 0.3182724 5.123125e-11 0 0.5620636
632 2 Ndufs6 0.3181885 5.123125e-11 0 0.4034311
633 2 Atp5o.1 0.3180715 5.123125e-11 0 0.4328550
634 2 Snrpd1 0.3153652 7.971523e-11 0 0.4110424
635 2 Dynlrb1 0.3138211 1.012249e-10 0 0.4016523
636 2 Uqcr11 0.3127887 1.176600e-10 0 0.3977030
637 2 Rpl35a 0.3107299 1.630574e-10 0 0.4733195
638 2 Btf3 0.3105600 1.635550e-10 0 0.3262416
639 2 Swi5 0.3089918 2.083158e-10 0 0.3992487
640 2 Rps20 0.3085745 2.163595e-10 0 0.4357840
641 2 Rps28 0.3084814 2.163595e-10 0 0.3976983
642 2 Rpl31 0.3080905 2.258154e-10 0 0.3883420
643 2 Ndufa7 0.3058712 3.210445e-10 0 0.3983718
644 2 Tbca 0.3008336 7.280122e-10 0 0.4041754
645 2 Snrpb 0.3004187 7.628240e-10 0 0.3556668
646 2 Rplp2 0.2994367 8.780648e-10 0 0.3876488
647 2 Rpl28 0.2980768 1.053428e-09 0 0.4146471
648 2 Uqcc2 0.2963570 1.341309e-09 0 0.5371598
649 2 Rpl36 0.2959874 1.397297e-09 0 0.3646947
650 2 Edf1 0.2907784 3.182905e-09 0 0.3900142
651 2 Fkbp3 0.2887636 4.310446e-09 0 0.3556366
652 2 Rps24 0.2855186 6.949575e-09 0 0.4770224
653 2 Gpx4 0.2835273 9.333670e-09 0 0.3245309
654 2 Bex3 0.2811669 1.302731e-08 0 0.3180195
655 2 Rps16 0.2797322 1.599726e-08 0 0.4247866
656 2 Tomm7 0.2794532 1.620516e-08 0 0.4093449
657 2 Hspe1 0.2791867 1.657357e-08 0 0.3462706
658 2 Chchd1 0.2776050 2.048674e-08 0 0.4354694
659 2 Rpl17 0.2772637 2.125977e-08 0 0.5191041
660 2 Atp5k 0.2763011 2.390680e-08 0 0.4740455
661 2 Svbp 0.2760304 2.455412e-08 0 0.3014819
662 2 Atp5c1 0.2745608 3.026725e-08 0 0.2363772
663 2 Eif3k 0.2733197 3.506397e-08 0 0.3840566
664 2 Sumo1 0.2733121 3.506397e-08 0 0.2914956
665 2 Timm13 0.2727683 3.704806e-08 0 0.3686286
666 2 Mrpl30 0.2720637 4.012608e-08 0 0.4749261
667 2 Sem1 0.2709451 4.626165e-08 0 0.3741535
668 2 Usmg5 0.2698205 5.338295e-08 0 0.3823320
669 2 Rpl22 0.2684403 6.476015e-08 0 0.3428325
670 2 Snrpg 0.2676331 7.211655e-08 0 0.3005801
671 2 Snrpf 0.2669184 7.920313e-08 0 0.3441404
672 2 Txn1 0.2665795 8.228619e-08 0 0.3887734
673 2 Rps3a1 0.2649696 1.007190e-07 0 0.4636491
674 2 Nol7 0.2647710 1.025313e-07 0 0.4529087
675 2 Myl12b 0.2633170 1.218616e-07 0 0.3769849
676 2 Rpl7a 0.2628980 1.276278e-07 0 0.3803800
677 2 Cirbp 0.2626801 1.303533e-07 0 0.2427524
678 2 Ndufv3 0.2624191 1.339840e-07 0 0.3777157
679 2 Rps27l 0.2612859 1.562914e-07 0 0.5679664
680 2 Rpl37a 0.2606248 1.702086e-07 0 0.5219644
681 2 Cycs 0.2595888 1.936645e-07 0 0.3851088
682 2 Rpl36a 0.2587217 2.135807e-07 0 0.2850982
683 2 Anapc13 0.2587014 2.135807e-07 0 0.4999552
684 2 Smdt1 0.2574554 2.478030e-07 0 0.3049345
685 2 Sdhb 0.2573959 2.478030e-07 0 0.3655544
686 2 Mrpl52 0.2566472 2.731507e-07 0 0.3746260
687 2 Ranbp1 0.2564576 2.746660e-07 0 0.2617357
688 2 X0610012G03Rik 0.2564156 2.746660e-07 0 0.4450968
689 2 Csnk2b 0.2562380 2.751587e-07 0 0.3913248
690 2 Rps17 0.2562154 2.751587e-07 0 0.4469891
691 2 Chchd2 0.2560482 2.793180e-07 0 0.4363077
692 2 Rpl21 0.2552768 3.062727e-07 0 0.3799537
693 2 Hmgb1 0.2548389 3.230834e-07 0 0.3340397
694 2 Mrpl28 0.2536180 3.805588e-07 0 0.4316112
695 2 Rtraf 0.2534456 3.866532e-07 0 0.2697156
696 2 Cops9 0.2500709 5.947902e-07 0 0.3814245
697 2 Atox1 0.2499329 5.967449e-07 0 0.4098502
698 2 Rplp1 0.2493323 6.434789e-07 0 0.4307723
699 2 Hnrnpc 0.2478592 7.764553e-07 0 0.2664530
700 2 Mrps17 0.2474735 8.125236e-07 0 0.4752512
701 2 Vapa 0.2468733 8.724833e-07 0 0.2749610
702 2 Hmgn1 0.2467629 8.757159e-07 0 0.2649146
703 2 Rps23 0.2450356 1.068941e-06 0 0.4578971
704 2 Atp5h 0.2448179 1.093221e-06 0 0.3256882
705 2 Tmem256 0.2442495 1.164388e-06 0 0.3865038
706 2 Dctpp1 0.2439548 1.203424e-06 0 0.2977997
707 2 Hnrnpab 0.2435671 1.242278e-06 0 0.2954051
708 2 Pcbp2 0.2424629 1.432352e-06 0 0.3170388
709 2 Tceal9 0.2415540 1.597013e-06 0 0.2648281
710 2 Lamtor5 0.2396744 2.026684e-06 0 0.4350606
711 2 Ndufb10 0.2369275 2.844142e-06 0 0.2863959
712 2 Cox7c 0.2369225 2.844142e-06 0 0.2824851
713 2 Oaz1 0.2366477 2.930192e-06 0 0.2739040
714 2 Scand1 0.2362155 3.049012e-06 0 0.4189525
715 2 Polr2j 0.2362011 3.049012e-06 0 0.2842206
716 2 Rpl10 0.2359047 3.150343e-06 0 0.4748902
717 2 Pfdn4 0.2355440 3.282597e-06 0 0.4199890
718 2 Rps19 0.2350001 3.457301e-06 0 0.5025216
719 2 Rpl10a 0.2349610 3.457301e-06 0 0.3144984
720 2 Nme1 0.2348924 3.467459e-06 0 0.2836137
721 2 Arpc3 0.2343591 3.673533e-06 0 0.3467814
722 2 Ran 0.2336918 3.937207e-06 0 0.2541407
723 2 Rnf7 0.2330433 4.258758e-06 0 0.3808571
724 2 Bex2 0.2329252 4.299581e-06 0 0.2931452
725 2 Snrpd3 0.2324127 4.521549e-06 0 0.4085823
726 2 Gm10260 0.2324024 4.521549e-06 0 0.3556503
727 2 Cox7b 0.2323608 4.521549e-06 0 0.2699185
728 2 H2afz 0.2321811 4.601972e-06 0 0.3482270
729 2 Ddah2 0.2317245 4.854571e-06 0 0.3249683
730 2 Tbcb 0.2312379 5.112130e-06 0 0.2296635
731 2 Atp5j2 0.2304200 5.634610e-06 0 0.2909852
732 2 Cox6b1 0.2303965 5.634610e-06 0 0.2710346
733 2 Atp5j 0.2299308 5.885226e-06 0 0.2785515
734 2 Uqcrfs1 0.2295095 6.113070e-06 0 0.2729393
735 2 Txnl4a 0.2284938 6.923514e-06 0 0.4264706
736 2 Mrps24 0.2283968 6.972967e-06 0 0.4010231
737 2 X1110004F10Rik 0.2278692 7.418587e-06 0 0.2576501
738 2 Mif 0.2278012 7.444171e-06 0 0.3175502
739 2 Mrpl18 0.2263135 8.717060e-06 0 0.3538738
740 2 Crip2 0.2262746 8.717060e-06 0 0.2328728
741 2 Hsbp1 0.2253249 9.567604e-06 0 0.2581882
742 2 Rpl19 0.2253114 9.567604e-06 0 0.3885120
743 2 Rps11 0.2251894 9.656863e-06 0 0.3842770
744 2 Rpl23a 0.2250285 9.806820e-06 0 0.4333352
745 2 Ubl5 0.2248612 9.967272e-06 0 0.3088737
746 2 Ndufab1 0.2238209 1.114197e-05 0 0.3859670
747 2 Atp5g1 0.2231648 1.188149e-05 0 0.2660431
748 2 Rps6 0.2231573 1.188149e-05 0 0.3939822
749 2 Eif3h 0.2229958 1.206753e-05 0 0.2308491
750 2 Pdcd5 0.2227854 1.231783e-05 0 0.3465369
751 2 Zfp706 0.2225725 1.249138e-05 0 0.2112568
752 2 Abracl 0.2213934 1.420354e-05 0 0.2750669
753 2 Pfdn6 0.2209369 1.475035e-05 0 0.4071708
754 2 Prdx5 0.2209109 1.475035e-05 0 0.2559431
755 2 Calm3 0.2207639 1.495591e-05 0 0.2573251
756 2 Rex1bd 0.2205570 1.527669e-05 0 0.4203590
757 2 Esd 0.2203737 1.555921e-05 0 0.2975594
758 2 Psma2 0.2203365 1.556413e-05 0 0.2819089
759 2 Dynll1 0.2199209 1.610702e-05 0 0.3676117
760 2 Rpl15 0.2193999 1.681993e-05 0 0.2895195
761 2 Glrx3 0.2183361 1.870043e-05 0 0.1083442
762 2 Selenow 0.2181498 1.884053e-05 0 0.3930863
763 2 Gpx1 0.2178309 1.949979e-05 0 0.5381608
764 2 Ndufa2 0.2176492 1.980493e-05 0 0.3264260
765 2 Sec61b 0.2175909 1.984489e-05 0 0.3811968
766 2 Mrpl58 0.2174529 1.994929e-05 0 0.4914635
767 2 Psma7 0.2172964 2.021002e-05 0 0.2739562
768 2 Bcas2 0.2172834 2.021002e-05 0 0.3158613
769 2 Srp14 0.2170597 2.068867e-05 0 0.2990073
770 2 Nop10 0.2166123 2.148125e-05 0 0.3118031
771 2 Rpl27a 0.2166058 2.148125e-05 0 0.2738241
772 2 Eif2s2 0.2163714 2.190974e-05 0 0.2296548
773 2 Trappc2l 0.2156572 2.367654e-05 0 0.3406024
774 2 H3f3a 0.2155351 2.371636e-05 0 0.3079225
775 2 Gtf2h5 0.2153738 2.409548e-05 0 0.3434282
776 2 Sub1 0.2151160 2.467880e-05 0 0.2508421
777 2 Naca 0.2145240 2.631314e-05 0 0.3565910
778 2 Rpl7 0.2135255 2.894195e-05 0 0.3706477
779 2 Ppdpf 0.2133232 2.944698e-05 0 0.3391216
780 2 Rpl24 0.2132565 2.958106e-05 0 0.4690503
781 2 Gm10076 0.2127650 3.115580e-05 0 0.4772046
782 2 Ndufb2 0.2126237 3.147088e-05 0 0.3525210
783 2 Cox7a2 0.2122685 3.261049e-05 0 0.2379424
784 2 Rpl18 0.2119882 3.360348e-05 0 0.2748972
785 2 Rpl5 0.2112951 3.612182e-05 0 0.2924973
786 2 Jund 0.2110174 3.713592e-05 0 0.2279356
787 2 Ndufc1 0.2110056 3.713592e-05 0 0.3252872
788 2 Ndufb4 0.2104104 3.958197e-05 0 0.3979775
789 2 Rps27a 0.2103616 3.968123e-05 0 0.4295827
790 2 Slirp 0.2102777 3.994578e-05 0 0.4121032
791 2 Fau 0.2100576 4.086342e-05 0 0.4027868
792 2 Ndufb8 0.2095178 4.340397e-05 0 0.2659853
793 2 Txndc17 0.2090594 4.523928e-05 0 0.3694520
794 2 Rpl32 0.2084089 4.834087e-05 0 0.5548520
795 2 Ap2s1 0.2082742 4.880084e-05 0 0.2605882
796 2 Gabarap 0.2080185 4.986800e-05 0 0.2959616
797 2 Smarcb1 0.2080089 4.986800e-05 0 0.2851375
798 2 H2afj 0.2078390 5.070994e-05 0 0.3315896
799 2 Cacybp 0.2065126 5.739543e-05 0 0.2614856
800 2 Grm8 0.2057265 6.121111e-05 0 0.4215947Summary
result.df OriginalCluster CellNumber COTANClusterNumber Accuracy
1 Cl525E15.0 826 3 0.786585365853659
2 Cl511E15.0 540 2 0.916666666666667
3 Cl184E15.0 322 2 0.734375
4 Cl432E13.5 536 2 0.88785046728972
5 Cl510E15.0 402 2 0.825
6 Cl511E15.0 540 2 0.916666666666667Sys.time()[1] "2025-12-22 10:15:26 CET"sessionInfo()R version 4.5.2 (2025-10-31)
Platform: x86_64-pc-linux-gnu
Running under: Ubuntu 22.04.5 LTS
Matrix products: default
BLAS: /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.10.0
LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.10.0 LAPACK version 3.10.0
locale:
[1] LC_CTYPE=C.UTF-8 LC_NUMERIC=C LC_TIME=C.UTF-8
[4] LC_COLLATE=C.UTF-8 LC_MONETARY=C.UTF-8 LC_MESSAGES=C.UTF-8
[7] LC_PAPER=C.UTF-8 LC_NAME=C LC_ADDRESS=C
[10] LC_TELEPHONE=C LC_MEASUREMENT=C.UTF-8 LC_IDENTIFICATION=C
time zone: Europe/Rome
tzcode source: system (glibc)
attached base packages:
[1] stats graphics grDevices utils datasets methods base
other attached packages:
[1] nnet_7.3-20 COTAN_2.9.4 caret_7.0-1 lattice_0.22-7
[5] lubridate_1.9.4 forcats_1.0.0 stringr_1.5.1 dplyr_1.1.4
[9] purrr_1.2.0 readr_2.1.5 tibble_3.3.0 tidyverse_2.0.0
[13] tidyr_1.3.1 parallelDist_0.2.6 data.table_1.17.0 zeallot_0.2.0
[17] ggplot2_4.0.1
loaded via a namespace (and not attached):
[1] RcppAnnoy_0.0.22 splines_4.5.2
[3] later_1.4.2 polyclip_1.10-7
[5] hardhat_1.4.1 pROC_1.18.5
[7] rpart_4.1.24 fastDummies_1.7.5
[9] lifecycle_1.0.4 doParallel_1.0.17
[11] globals_0.18.0 MASS_7.3-65
[13] dendextend_1.19.0 magrittr_2.0.4
[15] plotly_4.11.0 rmarkdown_2.29
[17] yaml_2.3.10 httpuv_1.6.16
[19] Seurat_5.2.1 sctransform_0.4.2
[21] spam_2.11-1 sp_2.2-0
[23] spatstat.sparse_3.1-0 reticulate_1.42.0
[25] cowplot_1.1.3 pbapply_1.7-2
[27] RColorBrewer_1.1-3 abind_1.4-8
[29] GenomicRanges_1.60.0 Rtsne_0.17
[31] BiocGenerics_0.54.0 ipred_0.9-15
[33] GenomeInfoDbData_1.2.14 circlize_0.4.16
[35] lava_1.8.1 IRanges_2.42.0
[37] S4Vectors_0.46.0 ggrepel_0.9.6
[39] irlba_2.3.5.1 listenv_0.9.1
[41] spatstat.utils_3.1-4 goftest_1.2-3
[43] RSpectra_0.16-2 spatstat.random_3.4-1
[45] fitdistrplus_1.2-2 parallelly_1.45.0
[47] codetools_0.2-20 DelayedArray_0.34.1
[49] tidyselect_1.2.1 shape_1.4.6.1
[51] UCSC.utils_1.4.0 farver_2.1.2
[53] viridis_0.6.5 ScaledMatrix_1.16.0
[55] matrixStats_1.5.0 stats4_4.5.2
[57] spatstat.explore_3.4-2 jsonlite_2.0.0
[59] GetoptLong_1.0.5 gghalves_0.1.4
[61] progressr_0.15.1 ggridges_0.5.6
[63] survival_3.8-3 iterators_1.0.14
[65] foreach_1.5.2 tools_4.5.2
[67] ica_1.0-3 Rcpp_1.0.14
[69] glue_1.8.0 prodlim_2025.04.28
[71] gridExtra_2.3 SparseArray_1.8.0
[73] xfun_0.52 MatrixGenerics_1.20.0
[75] ggthemes_5.1.0 GenomeInfoDb_1.44.0
[77] withr_3.0.2 fastmap_1.2.0
[79] digest_0.6.37 rsvd_1.0.5
[81] timechange_0.3.0 R6_2.6.1
[83] mime_0.13 colorspace_2.1-1
[85] scattermore_1.2 tensor_1.5
[87] spatstat.data_3.1-6 generics_0.1.3
[89] recipes_1.3.0 class_7.3-23
[91] httr_1.4.7 htmlwidgets_1.6.4
[93] S4Arrays_1.8.0 uwot_0.2.3
[95] ModelMetrics_1.2.2.2 pkgconfig_2.0.3
[97] gtable_0.3.6 timeDate_4041.110
[99] ComplexHeatmap_2.24.0 lmtest_0.9-40
[101] S7_0.2.1 SingleCellExperiment_1.30.0
[103] XVector_0.48.0 htmltools_0.5.8.1
[105] dotCall64_1.2 zigg_0.0.2
[107] clue_0.3-66 Biobase_2.68.0
[109] SeuratObject_5.1.0 scales_1.4.0
[111] png_0.1-8 gower_1.0.2
[113] spatstat.univar_3.1-3 knitr_1.50
[115] tzdb_0.5.0 reshape2_1.4.4
[117] rjson_0.2.23 nlme_3.1-168
[119] proxy_0.4-27 zoo_1.8-14
[121] GlobalOptions_0.1.2 KernSmooth_2.23-26
[123] parallel_4.5.2 miniUI_0.1.2
[125] pillar_1.10.2 grid_4.5.2
[127] vctrs_0.6.5 RANN_2.6.2
[129] promises_1.3.2 BiocSingular_1.24.0
[131] beachmat_2.24.0 xtable_1.8-4
[133] cluster_2.1.8.1 evaluate_1.0.3
[135] cli_3.6.5 compiler_4.5.2
[137] rlang_1.1.6 crayon_1.5.3
[139] future.apply_1.20.0 labeling_0.4.3
[141] plyr_1.8.9 stringi_1.8.7
[143] deldir_2.0-4 viridisLite_0.4.2
[145] BiocParallel_1.42.0 assertthat_0.2.1
[147] lazyeval_0.2.2 spatstat.geom_3.4-1
[149] Matrix_1.7-4 RcppHNSW_0.6.0
[151] hms_1.1.3 patchwork_1.3.2
[153] future_1.58.0 shiny_1.11.0
[155] SummarizedExperiment_1.38.1 ROCR_1.0-11
[157] Rfast_2.1.5.1 igraph_2.1.4
[159] RcppParallel_5.1.10